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Term:interleukin-6 signaling pathway
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Accession:PW:0000516 term browser browse the term
Definition:Interleukin-6 signaling is involved in a wide range of biological processes such as immune regulation, inflammation, hematopoiesis and oncogenesis. A signal transducer common to all family members, gp130 activates Jak-Stat and Raf/Mek/Erk signaling pathways.
Synonyms:exact_synonym: Reactome:R-HSA-1059683
 related_synonym: Il-6 signaling pathway;   PID:200146

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interleukin-6 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G A2M alpha-2-macroglobulin JBrowse link 5 62,406,928 62,483,690 RGD:9068941
G ADAM10 ADAM metallopeptidase domain 10 JBrowse link 1 113,289,480 113,407,940 RGD:9068941
G ADAM17 ADAM metallopeptidase domain 17 JBrowse link 3 126,795,513 126,853,995 RGD:9068941
G AKT1 AKT serine/threonine kinase 1 RGD:9068941
G CEBPB CCAAT enhancer binding protein beta JBrowse link 17 51,722,633 51,723,673 RGD:9068941
G CEBPD CCAAT enhancer binding protein delta JBrowse link 4 79,872,863 79,874,481 RGD:9068941
G CRP C-reactive protein, pentraxin-related JBrowse link 4 90,793,361 90,801,020 RGD:9068941
G FGG fibrinogen gamma chain JBrowse link 8 74,553,040 74,562,151 RGD:9068941
G FOS Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 7 98,449,508 98,451,971 RGD:9068941
G FOXO1 forkhead box O1 JBrowse link 11 15,317,222 15,410,059 RGD:9068941
G GAB1 GRB2 associated binding protein 1 JBrowse link 8 84,257,958 84,391,511 RGD:9068941
G GAB2 GRB2 associated binding protein 2 JBrowse link 9 12,663,658 12,851,423 RGD:9068941
G GRB2 growth factor receptor bound protein 2 JBrowse link 12 5,940,723 6,009,095 RGD:9068941
G HCK HCK proto-oncogene, Src family tyrosine kinase JBrowse link 17 35,708,549 35,751,590 RGD:9068941
G HSP90B1 heat shock protein 90 beta family member 1 JBrowse link 5 80,511,513 80,531,016 RGD:9068941
G IL6 interleukin 6 JBrowse link 9 91,506,421 91,510,830 RGD:9068941
G IL6R interleukin 6 receptor JBrowse link 4 95,322,426 95,381,393 RGD:9068941
G IL6ST interleukin 6 signal transducer JBrowse link 16 35,101,304 35,151,832 RGD:9068941
G IRF1 interferon regulatory factor 1 JBrowse link 2 134,776,122 134,783,646 RGD:9068941
G JAK1 Janus kinase 1 JBrowse link 6 147,320,288 147,567,188 RGD:9068941
G JAK2 Janus kinase 2 JBrowse link 1 216,849,744 217,002,310 RGD:9068941
G JUN Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 153,686,425 153,687,635 RGD:9068941
G JUNB JunB proto-oncogene, AP-1 transcription factor subunit JBrowse link 2 66,214,086 66,219,435 RGD:9068941
G LBP lipopolysaccharide binding protein JBrowse link 17 41,398,935 41,429,467 RGD:9068941
G LMO4 LIM domain only 4 JBrowse link 4 128,894,113 128,910,648 RGD:9068941
G MAP2K4 mitogen-activated protein kinase kinase 4 JBrowse link 12 56,402,029 56,516,217 RGD:9068941
G MAP2K6 mitogen-activated protein kinase kinase 6 JBrowse link 12 10,891,445 11,018,617 RGD:9068941
G MAPK11 mitogen-activated protein kinase 11 JBrowse link 5 420,848 428,103 RGD:9068941
G MAPK14 mitogen-activated protein kinase 14 JBrowse link 7 31,791,398 31,861,544 RGD:9068941
G MCL1 MCL1 apoptosis regulator, BCL2 family member JBrowse link 4 98,562,092 98,567,014 RGD:9068941
G MITF melanocyte inducing transcription factor JBrowse link 13 51,177,356 51,422,096 RGD:9068941
G MYC MYC proto-oncogene, bHLH transcription factor JBrowse link 4 12,455,141 12,460,360 RGD:9068941
G PIAS1 protein inhibitor of activated STAT 1 JBrowse link 1 165,957,114 166,087,242 RGD:9068941
G PIAS3 protein inhibitor of activated STAT 3 JBrowse link 4 99,463,418 99,475,141 RGD:9068941
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha JBrowse link 13 117,193,935 117,282,151 RGD:9068941
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 16 46,434,757 46,523,626 RGD:9068941
G PRKCD protein kinase C delta JBrowse link 13 35,290,835 35,323,245 RGD:9068941
G PTPN11 protein tyrosine phosphatase non-receptor type 11 JBrowse link 14 39,202,165 39,292,041 RGD:9068941
G RAC1 Rac family small GTPase 1 JBrowse link 3 4,781,776 4,803,510 RGD:9068941
G SOCS3 suppressor of cytokine signaling 3 JBrowse link 12 3,643,832 3,647,015 RGD:9068941
G SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 3 101,209,568 101,366,057 RGD:9068941
G SOS2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 1 179,907,578 180,014,941 RGD:9068941
G STAT1 signal transducer and activator of transcription 1 JBrowse link 15 95,593,201 95,646,324 RGD:9068941
G STAT3 signal transducer and activator of transcription 3 JBrowse link 12 20,407,316 20,471,091 RGD:9068941
G TIMP1 TIMP metallopeptidase inhibitor 1 JBrowse link X 42,103,251 42,106,289 RGD:9068941
G TNFSF11 TNF superfamily member 11 JBrowse link 11 24,468,011 24,505,421 RGD:9068941
G TYK2 tyrosine kinase 2 JBrowse link 2 69,157,774 69,183,555 RGD:9068941
G VAV1 vav guanine nucleotide exchange factor 1 JBrowse link 2 72,327,433 72,391,649 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5633
    signaling pathway 2422
      cytokine and chemokine mediated signaling pathway 331
        cytokine mediated signaling pathway 330
          Interleukin mediated signaling pathway 246
            interleukin-6 family mediated signaling pathway 48
              interleukin-6 signaling pathway 48
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.