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ONTOLOGY REPORT - ANNOTATIONS


Term:interleukin-6 signaling pathway
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Accession:PW:0000516 term browser browse the term
Definition:Interleukin-6 signaling is involved in a wide range of biological processes such as immune regulation, inflammation, hematopoiesis and oncogenesis. A signal transducer common to all family members, gp130 activates Jak-Stat and Raf/Mek/Erk signaling pathways.
Synonyms:exact_synonym: Reactome:R-HSA-1059683
 related_synonym: Il-6 signaling pathway;   PID:200146

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interleukin-6 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G A2m alpha-2-macroglobulin JBrowse link 6 121,636,165 121,679,238 RGD:6484113
G Adam10 a disintegrin and metallopeptidase domain 10 JBrowse link 9 70,678,944 70,780,229 RGD:5686846
G Adam17 a disintegrin and metallopeptidase domain 17 JBrowse link 12 21,323,509 21,373,632 RGD:5686834
RGD:5686846
G Akt1 thymoma viral proto-oncogene 1 JBrowse link 12 112,653,821 112,674,884 RGD:6484113
G Cebpb CCAAT/enhancer binding protein (C/EBP), beta JBrowse link 2 167,688,915 167,690,432 RGD:6484113
G Cebpd CCAAT/enhancer binding protein (C/EBP), delta JBrowse link 16 15,887,286 15,889,545 RGD:6484113
G Crp C-reactive protein, pentraxin-related JBrowse link 1 172,698,056 172,699,966 RGD:6484113
G Fgg fibrinogen gamma chain JBrowse link 3 83,007,724 83,015,056 RGD:6484113
G Fos FBJ osteosarcoma oncogene JBrowse link 12 85,473,890 85,477,274 RGD:6484113
G Foxo1 forkhead box O1 JBrowse link 3 52,268,337 52,350,109 RGD:6484113
G Gab1 growth factor receptor bound protein 2-associated protein 1 JBrowse link 8 80,764,431 80,880,519 RGD:6484113
G Gab2 growth factor receptor bound protein 2-associated protein 2 JBrowse link 7 97,081,751 97,308,951 RGD:6484113
G Grb2 growth factor receptor bound protein 2 JBrowse link 11 115,644,045 115,708,597 RGD:5686834
RGD:6484113
G Hck hemopoietic cell kinase JBrowse link 2 153,108,468 153,151,441 RGD:6484113
G Hsp90b1 heat shock protein 90, beta (Grp94), member 1 JBrowse link 10 86,690,841 86,705,444 RGD:6484113
G Il6 interleukin 6 JBrowse link 5 30,013,114 30,019,975 RGD:1580493
RGD:11062097
RGD:6484113
RGD:5686839
RGD:5686834
G Il6ra interleukin 6 receptor, alpha JBrowse link 3 89,869,324 89,913,196 RGD:5686834
RGD:6484113
RGD:5686839
G Il6st interleukin 6 signal transducer JBrowse link 13 112,464,070 112,506,860 RGD:5686834
RGD:6484113
RGD:5686900
RGD:5686839
G Irf1 interferon regulatory factor 1 JBrowse link 11 53,769,854 53,778,374 RGD:6484113
G Jak1 Janus kinase 1 JBrowse link 4 101,151,974 101,265,282 RGD:5686839
RGD:6484113
G Jak2 Janus kinase 2 JBrowse link 19 29,251,803 29,313,095 RGD:5686839
RGD:6484113
G Jun jun proto-oncogene JBrowse link 4 95,049,036 95,052,222 RGD:6484113
G Junb jun B proto-oncogene JBrowse link 8 84,976,909 84,978,748 RGD:6484113
G Lbp lipopolysaccharide binding protein JBrowse link 2 158,306,493 158,332,852 RGD:6484113
G Lmo4 LIM domain only 4 JBrowse link 3 144,188,530 144,205,255 RGD:6484113
G Map2k4 mitogen-activated protein kinase kinase 4 JBrowse link 11 65,688,244 65,788,359 RGD:6484113
G Map2k6 mitogen-activated protein kinase kinase 6 JBrowse link 11 110,399,102 110,525,522 RGD:6484113
G Mapk11 mitogen-activated protein kinase 11 JBrowse link 15 89,142,482 89,149,606 RGD:6484113
G Mapk14 mitogen-activated protein kinase 14 JBrowse link 17 28,691,342 28,748,405 RGD:6484113
G Mcl1 myeloid cell leukemia sequence 1 JBrowse link 3 95,656,944 95,663,179 RGD:6484113
G Mitf melanogenesis associated transcription factor JBrowse link 6 97,807,002 98,021,360 RGD:6484113
G Myc myelocytomatosis oncogene JBrowse link 15 61,985,341 61,990,361 RGD:6484113
G Pias1 protein inhibitor of activated STAT 1 JBrowse link 9 62,878,366 62,980,879 RGD:6484113
G Pias3 protein inhibitor of activated STAT 3 JBrowse link 3 96,696,361 96,706,070 RGD:6484113
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha JBrowse link 3 32,397,059 32,468,486 RGD:6484113
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 13 101,680,761 101,768,217 RGD:6484113
G Prkcd protein kinase C, delta JBrowse link 14 30,595,353 30,626,414 RGD:6484113
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 5 121,130,533 121,191,397 RGD:5686834
RGD:6484113
G Rac1 Rac family small GTPase 1 JBrowse link 5 143,505,481 143,528,031 RGD:6484113
G Socs3 suppressor of cytokine signaling 3 JBrowse link 11 117,966,079 117,970,336 RGD:6484113
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 17 80,393,752 80,480,453 RGD:5686834
RGD:6484113
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 12 69,583,761 69,681,852 RGD:5686834
G Stat1 signal transducer and activator of transcription 1 JBrowse link 1 52,119,438 52,161,865 RGD:5686834
RGD:6484113
RGD:5686839
G Stat3 signal transducer and activator of transcription 3 JBrowse link 11 100,886,806 100,939,594 RGD:5686834
RGD:6484113
RGD:5686839
G Timp1 tissue inhibitor of metalloproteinase 1 JBrowse link X 20,870,166 20,874,737 RGD:6484113
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 JBrowse link 14 78,277,446 78,308,043 RGD:6484113
G Tyk2 tyrosine kinase 2 JBrowse link 9 21,104,068 21,131,393 RGD:5686839
RGD:6484113
G Vav1 vav 1 oncogene JBrowse link 17 57,279,100 57,329,236 RGD:6484113

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6011
    signaling pathway 2476
      cytokine and chemokine mediated signaling pathway 335
        cytokine mediated signaling pathway 334
          Interleukin mediated signaling pathway 248
            interleukin-6 family mediated signaling pathway 48
              interleukin-6 signaling pathway 48
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.