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ONTOLOGY REPORT - ANNOTATIONS


Term:interleukin-6 signaling pathway
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Accession:PW:0000516 term browser browse the term
Definition:Interleukin-6 signaling is involved in a wide range of biological processes such as immune regulation, inflammation, hematopoiesis and oncogenesis. A signal transducer common to all family members, gp130 activates Jak-Stat and Raf/Mek/Erk signaling pathways.
Synonyms:exact_synonym: Reactome:R-HSA-1059683
 related_synonym: Il-6 signaling pathway;   PID:200146

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interleukin-6 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ADAM10 ADAM metallopeptidase domain 10 JBrowse link 30 23,605,724 23,732,038 RGD:9068941
G ADAM17 ADAM metallopeptidase domain 17 JBrowse link 17 6,589,874 6,638,788 RGD:9068941
G AKT1 AKT serine/threonine kinase 1 JBrowse link 8 72,317,399 72,335,686 RGD:9068941
G CEBPB CCAAT enhancer binding protein beta JBrowse link 24 36,661,294 36,663,162 RGD:9068941
G CEBPD CCAAT enhancer binding protein delta JBrowse link 35 74,994 77,816 RGD:9068941
G CRP C-reactive protein JBrowse link 38 22,396,787 22,398,180 RGD:9068941
G FGG fibrinogen gamma chain JBrowse link 15 52,261,215 52,270,077 RGD:9068941
G FOS Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 8 48,330,856 48,334,273 RGD:9068941
G FOXO1 forkhead box O1 JBrowse link 25 603,433 706,961 RGD:9068941
G GAB1 GRB2 associated binding protein 1 JBrowse link 19 10,269 117,808 RGD:9068941
G GAB2 GRB2 associated binding protein 2 JBrowse link 21 20,414,903 20,605,807 RGD:9068941
G GRB2 growth factor receptor bound protein 2 JBrowse link 9 5,108,128 5,182,091 RGD:9068941
G HCK HCK proto-oncogene, Src family tyrosine kinase JBrowse link 24 21,473,424 21,513,673 RGD:9068941
G HSP90B1 heat shock protein 90 beta family member 1 JBrowse link 15 42,456,793 42,474,122 RGD:9068941
G IL6 interleukin 6 JBrowse link 14 36,474,268 36,478,519 RGD:9068941
G IL6R interleukin 6 receptor JBrowse link 7 42,877,731 42,920,149 RGD:9068941
G IL6ST interleukin 6 signal transducer JBrowse link 2 43,214,050 43,273,014 RGD:9068941
G IRF1 interferon regulatory factor 1 JBrowse link 11 20,773,801 20,781,106 RGD:9068941
G JAK1 Janus kinase 1 JBrowse link 5 45,251,653 45,408,571 RGD:9068941
G JAK2 Janus kinase 2 JBrowse link 1 93,321,055 93,438,898 RGD:9068941
G JUN Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 50,966,698 50,968,939 RGD:9068941
G JUNB JunB proto-oncogene, AP-1 transcription factor subunit JBrowse link 20 49,358,904 49,360,746 RGD:9068941
G LBP lipopolysaccharide binding protein JBrowse link 24 26,810,369 26,833,515 RGD:9068941
G LMO4 LIM domain only 4 JBrowse link 6 60,892,478 60,909,910 RGD:9068941
G LOC477699 alpha-2-macroglobulin JBrowse link 27 36,654,328 36,695,775 RGD:9068941
G MAP2K4 mitogen-activated protein kinase kinase 4 JBrowse link 5 36,142,610 36,243,673 RGD:9068941
G MAP2K6 mitogen-activated protein kinase kinase 6 JBrowse link 9 15,840,714 15,962,400 RGD:9068941
G MAPK11 mitogen-activated protein kinase 11 JBrowse link 10 16,977,133 16,984,764 RGD:9068941
G MAPK14 mitogen-activated protein kinase 14 JBrowse link 12 5,145,647 5,221,558 RGD:9068941
G MCL1 MCL1 apoptosis regulator, BCL2 family member JBrowse link 17 59,759,605 59,763,111 RGD:9068941
G MITF melanocyte inducing transcription factor JBrowse link 20 21,772,147 21,873,545 RGD:9068941
G MYC MYC proto-oncogene, bHLH transcription factor JBrowse link 13 25,200,772 25,205,309 RGD:9068941
G PIAS1 protein inhibitor of activated STAT 1 JBrowse link 30 32,116,363 32,232,530 RGD:9068941
G PIAS3 protein inhibitor of activated STAT 3 JBrowse link 17 58,650,791 58,660,755 RGD:9068941
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha JBrowse link 34 12,600,140 12,681,905 RGD:9068941
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 53,447,802 53,527,563 RGD:9068941
G PRKCD protein kinase C delta JBrowse link 20 36,723,491 36,751,982 RGD:9068941
G PTPN11 protein tyrosine phosphatase non-receptor type 11 JBrowse link 26 9,989,218 10,072,245 RGD:9068941
G RAC1 Rac family small GTPase 1 JBrowse link 6 11,726,259 11,758,532 RGD:9068941
G SOCS3 suppressor of cytokine signaling 3 JBrowse link 9 2,859,267 2,859,944 RGD:9068941
G SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 17 31,007,940 31,181,569 RGD:9068941
G SOS2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 8 26,636,849 26,698,837 RGD:9068941
G STAT1 signal transducer and activator of transcription 1 JBrowse link 37 1,513,438 1,549,837 RGD:9068941
G STAT3 signal transducer and activator of transcription 3 JBrowse link 9 20,539,660 20,614,631 RGD:9068941
G TIMP1 TIMP metallopeptidase inhibitor 1 JBrowse link X 41,201,623 41,205,314 RGD:9068941
G TNFSF11 TNF superfamily member 11 JBrowse link 22 8,226,931 8,257,926 RGD:9068941
G TYK2 tyrosine kinase 2 JBrowse link 20 50,747,145 50,770,008 RGD:9068941
G VAV1 vav guanine nucleotide exchange factor 1 JBrowse link 20 53,482,239 53,532,399 RGD:9068941

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  pathway 5642
    signaling pathway 2414
      cytokine and chemokine mediated signaling pathway 335
        cytokine mediated signaling pathway 334
          Interleukin mediated signaling pathway 248
            interleukin-6 family mediated signaling pathway 48
              interleukin-6 signaling pathway 48
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.