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Term:interleukin-6 signaling pathway
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Accession:PW:0000516 term browser browse the term
Definition:Interleukin-6 signaling is involved in a wide range of biological processes such as immune regulation, inflammation, hematopoiesis and oncogenesis. A signal transducer common to all family members, gp130 activates Jak-Stat and Raf/Mek/Erk signaling pathways.
Synonyms:exact_synonym: Reactome:R-HSA-1059683
 related_synonym: Il-6 signaling pathway;   PID:200146

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interleukin-6 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adam10 ADAM metallopeptidase domain 10 JBrowse link NW_004955450 15,853,372 15,927,966 RGD:9068941
G Adam17 ADAM metallopeptidase domain 17 JBrowse link NW_004955487 5,180,241 5,218,298 RGD:9068941
G Akt1 AKT serine/threonine kinase 1 JBrowse link NW_004955538 3,208,711 3,224,386 RGD:9068941
G Cebpb CCAAT enhancer binding protein beta JBrowse link NW_004955445 8,060,432 8,061,289 RGD:9068941
G Cebpd CCAAT enhancer binding protein delta JBrowse link NW_004955454 7,711,010 7,711,680 RGD:9068941
G Fgg fibrinogen gamma chain JBrowse link NW_004955471 8,786,910 8,794,947 RGD:9068941
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link NW_004955523 307,181 310,728 RGD:9068941
G Foxo1 forkhead box O1 JBrowse link NW_004955431 5,797,359 5,890,758 RGD:9068941
G Gab1 GRB2 associated binding protein 1 JBrowse link NW_004955471 61,580 191,175 RGD:9068941
G Gab2 GRB2 associated binding protein 2 JBrowse link NW_004955414 13,640,713 13,754,401 RGD:9068941
G Grb2 growth factor receptor bound protein 2 JBrowse link NW_004955553 2,186,590 2,258,964 RGD:9068941
G Hck HCK proto-oncogene, Src family tyrosine kinase JBrowse link NW_004955422 28,934,512 28,986,998 RGD:9068941
G Hsp90b1 heat shock protein 90 beta family member 1 JBrowse link NW_004955405 38,629,691 38,645,202 RGD:9068941
G Il6 interleukin 6 JBrowse link NW_004955410 25,079,835 25,084,390 RGD:9068941
G Il6r interleukin 6 receptor JBrowse link NW_004955545 932,814 979,359 RGD:9068941
G Il6st interleukin 6 signal transducer JBrowse link NW_004955446 11,790,636 11,837,734 RGD:9068941
G Irf1 interferon regulatory factor 1 JBrowse link NW_004955408 3,882,282 3,887,965 RGD:9068941
G Jak1 Janus kinase 1 JBrowse link NW_004955423 25,501,989 25,581,826 RGD:9068941
G Jak2 Janus kinase 2 JBrowse link NW_004955434 9,227,897 9,341,208 RGD:9068941
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link NW_004955464 1,107,598 1,110,326 RGD:9068941
G Junb JunB proto-oncogene, AP-1 transcription factor subunit JBrowse link NW_004955415 31,876,508 31,878,289 RGD:9068941
G Lmo4 LIM domain only 4 JBrowse link NW_004955423 6,849,542 6,865,928 RGD:9068941
G LOC102021956 alpha-2-macroglobulin JBrowse link NW_004955413 6,019,457 6,062,366 RGD:9068941
G Map2k4 mitogen-activated protein kinase kinase 4 JBrowse link NW_004955467 5,188,036 5,295,570 RGD:9068941
G Map2k6 mitogen-activated protein kinase kinase 6 JBrowse link NW_004955478 3,331,607 3,448,840 RGD:9068941
G Mapk11 mitogen-activated protein kinase 11 JBrowse link NW_004955413 33,287,860 33,293,948 RGD:9068941
G Mapk14 mitogen-activated protein kinase 14 JBrowse link NW_004955437 3,836,331 3,884,083 RGD:9068941
G Mcl1 MCL1 apoptosis regulator, BCL2 family member JBrowse link NW_004955413 238,043 243,317 RGD:9068941
G Mitf melanocyte inducing transcription factor JBrowse link NW_004955421 17,948,117 18,157,379 RGD:9068941
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link NW_004955461 2,714,022 2,718,872 RGD:9068941
G Pias1 protein inhibitor of activated STAT 1 JBrowse link NW_004955450 7,896,741 7,991,045 RGD:9068941
G Pias3 protein inhibitor of activated STAT 3 JBrowse link NW_004955568 227,603 237,396 RGD:9068941
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha JBrowse link NW_004955420 8,355,415 8,427,024 RGD:9068941
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link NW_004955446 1,020,707 1,098,327 RGD:9068941
G Prkcd protein kinase C delta JBrowse link NW_004955430 3,125,066 3,151,857 RGD:9068941
G Ptpn11 protein tyrosine phosphatase non-receptor type 11 JBrowse link NW_004955482 8,934,734 9,031,230 RGD:9068941
G Rac1 Rac family small GTPase 1 JBrowse link NW_004955460 13,270,159 13,295,562 RGD:9068941
G Socs3 suppressor of cytokine signaling 3 JBrowse link NW_004955506 4,222,455 4,225,563 RGD:9068941
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link NW_004955441 6,649,895 6,724,271 RGD:9068941
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link NW_004955409 12,542,353 12,622,165 RGD:9068941
G Stat1 signal transducer and activator of transcription 1 JBrowse link NW_004955403 8,156,660 8,192,018 RGD:9068941
G Stat3 signal transducer and activator of transcription 3 JBrowse link NW_004955451 16,320,326 16,348,505 RGD:9068941
G Timp1 TIMP metallopeptidase inhibitor 1 JBrowse link NW_004955516 507,113 511,360 RGD:9068941
G Tnfsf11 TNF superfamily member 11 JBrowse link NW_004955518 431,401 462,063 RGD:9068941
G Tyk2 tyrosine kinase 2 JBrowse link NW_004955495 1,618,099 1,637,996 RGD:9068941
G Vav1 vav guanine nucleotide exchange factor 1 JBrowse link NW_004955495 2,697,508 2,755,468 RGD:9068941

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Path 1
Term Annotations click to browse term
  pathway 5435
    signaling pathway 2370
      cytokine and chemokine mediated signaling pathway 318
        cytokine mediated signaling pathway 317
          Interleukin mediated signaling pathway 234
            interleukin-6 family mediated signaling pathway 46
              interleukin-6 signaling pathway 46
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.