Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:Interleukin-10 signaling pathway
go back to main search page
Accession:PW:0000515 term browser browse the term
Definition:Interleukin-10 signaling is involved in various immunomodulatory functions. It promotes the release of immune mediators and antigen presentation, exerting important anti-inflammatory effects that may primarily characterize this family member. Signaling by Il-10 and the other members of the family activate the intracellular Jak-Stat cascade.
Synonyms:related_synonym: Il-10 signaling pathway;   Interleukin-10 signaling;   interleukin-10-mediated signaling pathway
View Interactive Diagram


show annotations for term's descendants           Sort by:
Interleukin-10 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL10 interleukin 10 ISO RGD PMID:15032600 PMID:19428551 PMID:21115385 RGD:1580494 RGD:2311043 RGD:5688379 NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057 		JBrowse link
G IL10RA interleukin 10 receptor subunit alpha ISO RGD PMID:19428551 PMID:21115385 RGD:2311043 RGD:5688379 NCBI chr 5:15,675,775...15,688,935
Ensembl chr 5:15,677,547...15,682,163 		JBrowse link
G IL10RB interleukin 10 receptor subunit beta ISO RGD PMID:21115385 RGD:5688379 NCBI chr31:28,791,541...28,815,163
Ensembl chr31:27,892,394...27,915,637 		JBrowse link
G JAK1 Janus kinase 1 ISO RGD PMID:21115385 RGD:5688379 NCBI chr 5:45,251,653...45,408,571
Ensembl chr 5:45,251,653...45,408,571 		JBrowse link
G STAT1 signal transducer and activator of transcription 1 ISO RGD PMID:21115385 RGD:5688379 NCBI chr37:1,513,438...1,549,837
Ensembl chr37:1,507,219...1,550,178 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 ISO RGD PMID:19428551 PMID:21115385 RGD:2311043 RGD:5688379 NCBI chr 9:20,539,660...20,614,631
Ensembl chr 9:20,539,697...20,612,672 		JBrowse link
G TYK2 tyrosine kinase 2 ISO RGD PMID:21115385 RGD:5688379 NCBI chr20:50,747,145...50,770,008
Ensembl chr20:50,748,329...50,769,216 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4052
    signaling pathway 1939
      signaling pathway pertinent to immunity 418
        cytokine mediated signaling pathway 334
          Interleukin mediated signaling pathway 247
            interleukin-10 family mediated signaling pathway 7
              Interleukin-10 signaling pathway 7
paths to the root