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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:altered peptide and protein hormone signaling pathway
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Accession:PW:0000511 term browser browse the term


show annotations for term's descendants           Sort by:
altered insulin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ins2 insulin 2 ISO RGD PMID:9809695 RGD:2313694 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Insr insulin receptor ISO RGD PMID:9809695 RGD:2313694 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
altered insulin-like growth factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Igf1 insulin-like growth factor 1 IEP RGD PMID:15996002 RGD:1580474 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
altered leptin system pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Insr insulin receptor IMP increased basal hypothalamic leptin signaling without changes in leptin receptor expression after antisense-mediated hypothalamus-specific Insr knock-down RGD PMID:17585961 RGD:2290473 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Lep leptin TAS RGD PMID:11102451 RGD:61790 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lepr leptin receptor TAS
ISO		 RGD PMID:11102451 PMID:17229951 RGD:61790, RGD:1600611 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Lepr_v2 leptin receptor, variant 2 ISO RGD PMID:17578380 RGD:2290292
altered melanocortin system pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agrp agouti related neuropeptide ISO RGD PMID:15189116 RGD:1357925 NCBI chr19:33,447,992...33,523,068
Ensembl chr19:33,447,992...33,449,584 		JBrowse link
G Mc4r melanocortin 4 receptor ISS RGD PMID:15189116 RGD:1357925 NCBI chr18:60,419,832...60,421,719
Ensembl chr18:60,419,832...60,421,719 		JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 ISS
ISO		 RGD PMID:11874690 PMID:15189116 RGD:1357926, RGD:1357925 NCBI chr 2:4,395,543...4,442,434
Ensembl chr 2:4,395,543...4,442,434 		JBrowse link
G Pomc proopiomelanocortin ISS
ISO		 RGD PMID:15189116 PMID:11874690 RGD:1357925, RGD:1357926 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Sdc1 syndecan 1 ISO RGD PMID:15189116 RGD:1357925 NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6100
    signaling pathway 2646
      hormone signaling pathway 624
        peptide and protein hormone signaling pathway 439
          altered peptide and protein hormone signaling pathway 11
            altered adiponectin signaling pathway 0
            altered glucagon signaling pathway 0
            altered insulin signaling pathway 2
            altered insulin-like growth factor signaling pathway 1
            altered leptin system pathway 4
            altered melanocortin system pathway 5
            altered orexin/hypocretin signaling pathway 0
            altered vasopressin signaling pathway + 0
paths to the root