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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:renin-angiotensin cascade pathway
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Accession:PW:0000492 term browser browse the term
Definition:The renin-angiotensin cascade (RAS) generates a number of bioactive peptides with diverse physiological and pathophysiological functions. RAS exerts vasoconstriction, vasodilation or vascular remodeling, cell proliferation or anti-proliferation effects, depending on which angiotensin peptide generates the signaling. Some of these features are also shared by the kallikrein-kinin system (KKS); the two systems can interact and cross-talk.
Synonyms:related_synonym: KEGG:04614;   RAS system signaling pathway

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renin-angiotensin cascade pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 ISO
IEA
KEGG
RGD
PMID:15638741 mmu:04614, RGD:1581742 NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790
JBrowse link
G Ace2 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 ISO
IEA
KEGG
RGD
PMID:15638741 PMID:16520407 mmu:04614, RGD:1581742, RGD:1581931 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416
JBrowse link
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) ISO
IEA
KEGG
RGD
PMID:15638741 mmu:04614, RGD:1581742 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445
JBrowse link
G Agtr1a angiotensin II receptor, type 1a TAS
IEA
KEGG
RGD
PMID:16141358 mmu:04614, RGD:1581847 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850
JBrowse link
G Agtr1b angiotensin II receptor, type 1b TAS
IEA
KEGG
RGD
PMID:16141358 mmu:04614, RGD:1581847 NCBI chr 3:20,368,637...20,421,341
Ensembl chr 3:20,368,637...20,421,341
JBrowse link
G Agtr2 angiotensin II receptor, type 2 TAS
IEA
KEGG
RGD
PMID:15158138 mmu:04614, RGD:1581855 NCBI chr  X:21,350,863...21,355,072
Ensembl chr  X:21,350,783...21,355,403
JBrowse link
G Anpep alanyl (membrane) aminopeptidase ISO
IEA
KEGG
RGD
PMID:15638741 mmu:04614, RGD:1581742 NCBI chr 7:79,471,551...79,497,958
Ensembl chr 7:79,471,551...79,510,807
JBrowse link
G Atp6ap2 ATPase, H+ transporting, lysosomal accessory protein 2 ISO RGD PMID:18376005 RGD:5132617 NCBI chr  X:12,453,998...12,483,290
Ensembl chr  X:12,454,040...12,483,288
JBrowse link
G Cma1 chymase 1, mast cell ISO
IEA
KEGG
RGD
PMID:15638741 mmu:04614, RGD:1581742 NCBI chr14:56,178,908...56,182,132
Ensembl chr14:56,178,908...56,182,132
JBrowse link
G Cpa3 carboxypeptidase A3, mast cell IEA KEGG mmu:04614 NCBI chr 3:20,269,780...20,296,373
Ensembl chr 3:20,269,784...20,296,345
JBrowse link
G Ctsa cathepsin A IEA KEGG mmu:04614 NCBI chr 2:164,674,792...164,682,952
Ensembl chr 2:164,674,793...164,682,952
JBrowse link
G Ctsg cathepsin G IEA KEGG mmu:04614 NCBI chr14:56,337,342...56,340,031
Ensembl chr14:56,337,338...56,340,031
JBrowse link
G Enpep glutamyl aminopeptidase ISO
IEA
KEGG
RGD
PMID:15638741 mmu:04614, RGD:1581742 NCBI chr 3:129,062,826...129,126,398
Ensembl chr 3:129,062,824...129,126,369
JBrowse link
G Igf2r insulin-like growth factor 2 receptor ISO RGD PMID:16672920 RGD:1581739 NCBI chr17:12,901,293...12,988,593
Ensembl chr17:12,901,293...12,988,551
JBrowse link
G Lnpep leucyl/cystinyl aminopeptidase TAS
IEA
KEGG
RGD
PMID:15687842 mmu:04614, RGD:1581849 NCBI chr17:17,747,985...17,846,303
Ensembl chr17:17,741,672...17,845,312
JBrowse link
G Mas1 MAS1 oncogene TAS
IEA
KEGG
RGD
PMID:15687842 PMID:16520407 mmu:04614, RGD:1581849, RGD:1581931 NCBI chr17:13,056,981...13,087,037
Ensembl chr17:13,059,966...13,087,030
JBrowse link
G Mme membrane metallo endopeptidase ISO
IEA
KEGG
RGD
PMID:15638741 PMID:16520407 mmu:04614, RGD:1581742, RGD:1581931 NCBI chr 3:63,202,632...63,291,134
Ensembl chr 3:63,148,958...63,293,451
JBrowse link
G Nln neurolysin (metallopeptidase M3 family) IEA KEGG mmu:04614 NCBI chr13:104,159,558...104,246,170
Ensembl chr13:104,159,565...104,246,122
JBrowse link
G Ren1 renin 1 structural ISO
IEA
KEGG
RGD
PMID:16672920 PMID:15638741 mmu:04614, RGD:1581739, RGD:1581742 NCBI chr 1:133,278,412...133,288,058
Ensembl chr 1:133,278,248...133,288,063
JBrowse link
G Ren2 renin 2 tandem duplication of Ren1 IEA KEGG mmu:04614
G Renbp renin binding protein ISO RGD PMID:11726282 RGD:5132613 NCBI chr  X:72,965,727...72,974,465
Ensembl chr  X:72,965,727...72,974,456
JBrowse link
G Rnpep arginyl aminopeptidase (aminopeptidase B) ISO RGD PMID:16537183 RGD:1581649 NCBI chr 1:135,190,437...135,212,222
Ensembl chr 1:135,190,450...135,211,822
JBrowse link
G Thop1 thimet oligopeptidase 1 IEA KEGG mmu:04614 NCBI chr10:80,905,917...80,918,194
Ensembl chr10:80,905,869...80,918,393
JBrowse link
angiotensin (1-7) signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 ISO RGD PMID:15283675 RGD:1598433 NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790
JBrowse link
G Ace2 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 ISO RGD PMID:15638741 RGD:1581742 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416
JBrowse link
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) ISO RGD PMID:15951342 RGD:1581938 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445
JBrowse link
G Mas1 MAS1 oncogene TAS RGD PMID:16520407 RGD:1581931 NCBI chr17:13,056,981...13,087,037
Ensembl chr17:13,059,966...13,087,030
JBrowse link
G Mme membrane metallo endopeptidase ISO RGD PMID:15638741 PMID:16520407 RGD:1581742, RGD:1581931 NCBI chr 3:63,202,632...63,291,134
Ensembl chr 3:63,148,958...63,293,451
JBrowse link
angiotensin II signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 ISO RGD PMID:15638741 RGD:1581742 NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790
JBrowse link
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) TAS RGD PMID:16141358 RGD:1581847 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445
JBrowse link
G Agtr1a angiotensin II receptor, type 1a ISO RGD PMID:15590154 RGD:1579760 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850
JBrowse link
G Agtr2 angiotensin II receptor, type 2 ISS RGD PMID:14657020 RGD:1566502 NCBI chr  X:21,350,863...21,355,072
Ensembl chr  X:21,350,783...21,355,403
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 ISS RGD PMID:14684844 RGD:1582323 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Cma1 chymase 1, mast cell ISO RGD PMID:15869764 RGD:1581745 NCBI chr14:56,178,908...56,182,132
Ensembl chr14:56,178,908...56,182,132
JBrowse link
G Jak2 Janus kinase 2 ISO RGD PMID:16269269 RGD:1600094 NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480
JBrowse link
G Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 ISS RGD PMID:12661921 RGD:1580992 NCBI chr 6:129,456,113...129,484,312
Ensembl chr 6:129,462,207...129,484,128
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase 1 ISS RGD PMID:14585963 RGD:1581775 NCBI chr17:24,292,654...24,370,957
Ensembl chr17:24,292,654...24,369,898
JBrowse link
G Pla2g6 phospholipase A2, group VI ISO RGD PMID:17613534 RGD:12910844 NCBI chr15:79,170,428...79,212,915
Ensembl chr15:79,170,428...79,212,590
JBrowse link
G Prkcz protein kinase C, zeta ISO RGD PMID:16113073 RGD:1642674 NCBI chr 4:155,344,575...155,445,885
Ensembl chr 4:155,344,586...155,445,818
JBrowse link
angiotensin II signaling pathway via AT1 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) TAS RGD PMID:16141358 RGD:1581847 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445
JBrowse link
G Agtr1a angiotensin II receptor, type 1a ISO
TAS
RGD PMID:15590154 PMID:12446719 PMID:9287353 PMID:14559250 PMID:10977869 RGD:1579760, RGD:629553, RGD:5133683, RGD:2316188, RGD:1581825 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850
JBrowse link
G Agtr1b angiotensin II receptor, type 1b TAS RGD PMID:10977869 RGD:1581825 NCBI chr 3:20,368,637...20,421,341
Ensembl chr 3:20,368,637...20,421,341
JBrowse link
G Agtrap angiotensin II, type I receptor-associated protein ISO RGD PMID:17875818 RGD:2314353 NCBI chr 4:148,161,518...148,172,521
Ensembl chr 4:148,161,518...148,172,488
JBrowse link
G Arap1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 ISO RGD PMID:14559250 RGD:2316188 NCBI chr 7:100,997,268...101,061,793
Ensembl chr 7:100,997,274...101,061,793
JBrowse link
G Arrb1 arrestin, beta 1 ISO RGD PMID:16304060 RGD:5133417 NCBI chr 7:99,184,356...99,255,979
Ensembl chr 7:99,184,673...99,255,978
JBrowse link
G Arrb2 arrestin, beta 2 ISO RGD PMID:16304060 RGD:5133417 NCBI chr11:70,323,051...70,331,654
Ensembl chr11:70,323,461...70,331,654
JBrowse link
G Gna11 guanine nucleotide binding protein, alpha 11 ISO RGD PMID:16141358 RGD:1581847 NCBI chr10:81,364,558...81,380,996
Ensembl chr10:81,364,558...81,381,024
JBrowse link
G Gnaq guanine nucleotide binding protein, alpha q polypeptide ISO RGD PMID:16141358 RGD:1581847 NCBI chr19:16,110,048...16,365,884
Ensembl chr19:16,110,195...16,364,827
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO RGD PMID:16304060 RGD:5133417 NCBI chr19:4,336,027...4,356,350
Ensembl chr19:4,336,029...4,356,250
JBrowse link
G Grk3 G protein-coupled receptor kinase 3 ISO RGD PMID:16304060 RGD:5133417 NCBI chr 5:113,058,344...113,163,518
Ensembl chr 5:113,058,348...113,163,657
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 ISO RGD PMID:16304060 RGD:5133417 NCBI chr19:60,877,995...61,084,406
Ensembl chr19:60,878,187...61,084,406
JBrowse link
G Grk6 G protein-coupled receptor kinase 6 ISO RGD PMID:16304060 RGD:5133417 NCBI chr13:55,592,865...55,608,740
Ensembl chr13:55,592,885...55,608,740
JBrowse link
G Jak2 Janus kinase 2 ISO RGD PMID:9287353 PMID:9314843 RGD:5133683, RGD:6478796 NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480
JBrowse link
G Rgs2 regulator of G-protein signaling 2 ISO RGD PMID:12588881 RGD:5133418 NCBI chr 1:143,875,076...143,879,887
Ensembl chr 1:143,875,076...143,879,899
JBrowse link
G Tyk2 tyrosine kinase 2 ISO RGD PMID:9314843 RGD:6478796 NCBI chr 9:21,015,364...21,042,689
Ensembl chr 9:21,015,364...21,042,539
JBrowse link
angiotensin II signaling pathway via AT2 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) TAS
ISO
RGD PMID:16286564 PMID:22949090 PMID:16286568 RGD:1582434, RGD:7401256, RGD:1582435 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445
JBrowse link
G Agtr2 angiotensin II receptor, type 2 TAS
ISO
RGD PMID:10977869 PMID:22949090 RGD:1581825, RGD:7401256 NCBI chr  X:21,350,863...21,355,072
Ensembl chr  X:21,350,783...21,355,403
JBrowse link
G Cnksr1 connector enhancer of kinase suppressor of Ras 1 ISO RGD PMID:20889352 RGD:5133679 NCBI chr 4:133,955,352...133,965,737
Ensembl chr 4:133,955,352...133,965,710
JBrowse link
G Dusp1 dual specificity phosphatase 1 ISO RGD PMID:18804122 RGD:5133675 NCBI chr17:26,724,565...26,727,446
Ensembl chr17:26,724,564...26,781,102
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 ISO RGD PMID:20889352 RGD:5133679 NCBI chr10:128,403,392...128,425,504
Ensembl chr10:128,403,392...128,425,521
JBrowse link
G Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2 ISO RGD PMID:22949090 RGD:7401256 NCBI chr 9:107,491,324...107,512,617
Ensembl chr 9:107,491,324...107,512,566
JBrowse link
G Gnai3 guanine nucleotide binding protein (G protein), alpha inhibiting 3 ISO RGD PMID:22949090 RGD:7401256 NCBI chr 3:108,014,591...108,053,468
Ensembl chr 3:108,014,596...108,053,462
JBrowse link
G Mtus1 mitochondrial tumor suppressor 1 ISO RGD PMID:20889352 RGD:5133679 NCBI chr 8:41,443,949...41,587,347
Ensembl chr 8:41,443,951...41,586,763
JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 TAS RGD PMID:18804122 RGD:5133675 NCBI chr 6:124,697,670...124,715,672
Ensembl chr 6:124,697,670...124,715,677
JBrowse link
G Slc9a6 solute carrier family 9 (sodium/hydrogen exchanger), member 6 ISO RGD PMID:20889352 RGD:5133679 NCBI chr  X:55,654,921...55,709,590
Ensembl chr  X:55,655,117...55,709,590
JBrowse link
G Timp3 tissue inhibitor of metalloproteinase 3 ISO RGD PMID:20889352 RGD:5133679 NCBI chr10:86,136,276...86,185,369
Ensembl chr10:86,136,236...86,185,370
JBrowse link
G Zbtb16 zinc finger and BTB domain containing 16 ISO RGD PMID:20889352 RGD:5133679 NCBI chr 9:48,563,097...48,747,525
Ensembl chr 9:48,565,597...48,747,522
JBrowse link
angiotensin III signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) ISO RGD PMID:11295571 RGD:1582124 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445
JBrowse link
G Agtr1a angiotensin II receptor, type 1a ISO RGD PMID:11295571 RGD:1582124 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850
JBrowse link
G Agtr1b angiotensin II receptor, type 1b ISO RGD PMID:11295571 RGD:1582124 NCBI chr 3:20,368,637...20,421,341
Ensembl chr 3:20,368,637...20,421,341
JBrowse link
G Agtr2 angiotensin II receptor, type 2 ISO RGD PMID:11295571 RGD:1582124 NCBI chr  X:21,350,863...21,355,072
Ensembl chr  X:21,350,783...21,355,403
JBrowse link
G Aplnr apelin receptor ISO RGD PMID:11295571 RGD:1582124 NCBI chr 2:84,966,704...84,970,267
Ensembl chr 2:84,966,569...84,970,267
JBrowse link
G Enpep glutamyl aminopeptidase ISO RGD PMID:16537183 RGD:1581649 NCBI chr 3:129,062,826...129,126,398
Ensembl chr 3:129,062,824...129,126,369
JBrowse link
angiotensin III signaling pathway via AT1 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) ISO RGD PMID:11100981 RGD:1582152 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445
JBrowse link
G Agtr1a angiotensin II receptor, type 1a ISO RGD PMID:11100981 RGD:1582152 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850
JBrowse link
G Agtr1b angiotensin II receptor, type 1b ISO RGD PMID:11100981 RGD:1582152 NCBI chr 3:20,368,637...20,421,341
Ensembl chr 3:20,368,637...20,421,341
JBrowse link
angiotensin III signaling pathway via AT2 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) ISO RGD PMID:16380540 RGD:1582118 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445
JBrowse link
G Agtr2 angiotensin II receptor, type 2 ISO RGD PMID:16380540 RGD:1582118 NCBI chr  X:21,350,863...21,355,072
Ensembl chr  X:21,350,783...21,355,403
JBrowse link
angiotensin IV signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) ISO RGD PMID:11282364 RGD:1582105 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445
JBrowse link
G Anpep alanyl (membrane) aminopeptidase ISO RGD PMID:16537183 RGD:1581649 NCBI chr 7:79,471,551...79,497,958
Ensembl chr 7:79,471,551...79,510,807
JBrowse link
G Lnpep leucyl/cystinyl aminopeptidase ISO RGD PMID:12591177 RGD:1581864 NCBI chr17:17,747,985...17,846,303
Ensembl chr17:17,741,672...17,845,312
JBrowse link
G Rnpep arginyl aminopeptidase (aminopeptidase B) ISO RGD PMID:16537183 RGD:1581649 NCBI chr 1:135,190,437...135,212,222
Ensembl chr 1:135,190,450...135,211,822
JBrowse link
angiotensin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) ISS RGD PMID:12676165 RGD:1566511 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6068
    classic metabolic pathway 1859
      peptide and protein metabolic pathway 78
        peptide and protein hormone metabolic pathway 62
          renin-angiotensin cascade pathway 52
            angiotensin signaling pathway + 42
paths to the root