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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:coagulation cascade pathway
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Accession:PW:0000474 term browser browse the term
Definition:The coagulation cascade is the series of events proceeding via the tissue factor (extrinsic) or the contact activation (intrinsic) pathway and converging in the formation of fibrin clots. Several anticoagulation systems are in place to modulate the pathway. The coagulation cascade and the complement pathway of immune responses are connected in a cross talk.
Synonyms:related_synonym: Formation of Fibrin Clot (Clotting Cascade);   blood coagulation, fibrin clot formation;   secondary hemostasis
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coagulation cascade pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin IEA KEGG rno:04610 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Apoh apolipoprotein H ISS RGD PMID:15507263 RGD:1578489 NCBI chr10:93,342,435...93,356,334
Ensembl chr10:93,310,977...93,356,329 		JBrowse link
G Bdkrb1 bradykinin receptor B1 IEA KEGG rno:04610 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747 		JBrowse link
G Bdkrb2 bradykinin receptor B2 IEA KEGG rno:04610 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
G C1qa complement C1q A chain IEA KEGG rno:04610 NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534 		JBrowse link
G C1qb complement C1q B chain IEA KEGG rno:04610 NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407 		JBrowse link
G C1qc complement C1q C chain IEA KEGG rno:04610 NCBI chr 5:149,127,412...149,130,757
Ensembl chr 5:149,127,415...149,131,017 		JBrowse link
G C1r complement C1r IEA KEGG rno:04610 NCBI chr 4:157,412,718...157,423,483
Ensembl chr 4:157,412,692...157,423,484 		JBrowse link
G C1s complement C1s IEA KEGG rno:04610 NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303 		JBrowse link
G C2 complement C2 IEA KEGG rno:04610 NCBI chr20:3,951,474...3,970,376
Ensembl chr20:3,951,474...3,976,505 		JBrowse link
G C3 complement C3 IEA KEGG rno:04610 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G C3ar1 complement C3a receptor 1 IEA KEGG rno:04610 NCBI chr 4:156,074,747...156,084,680
Ensembl chr 4:156,075,389...156,084,701 		JBrowse link
G C4b complement C4B IEA KEGG rno:04610 NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681 		JBrowse link
G C4bpa complement component 4 binding protein, alpha IEA KEGG rno:04610 NCBI chr13:42,075,715...42,111,205
Ensembl chr13:42,075,717...42,111,205 		JBrowse link
G C4bpb complement component 4 binding protein, beta IEA KEGG rno:04610 NCBI chr13:42,120,798...42,131,515
Ensembl chr13:42,120,798...42,131,817 		JBrowse link
G C5 complement C5 IEA KEGG rno:04610 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994 		JBrowse link
G C5ar1 complement C5a receptor 1 IEA KEGG rno:04610 NCBI chr 1:76,948,622...76,959,826 JBrowse link
G C6 complement C6 IEA KEGG rno:04610 NCBI chr 2:53,846,028...53,921,279
Ensembl chr 2:53,851,985...53,921,275 		JBrowse link
G C7 complement C7 IEA KEGG rno:04610 NCBI chr 2:54,088,116...54,165,102
Ensembl chr 2:54,088,116...54,158,535 		JBrowse link
G C8a complement C8 alpha chain IEA KEGG rno:04610 NCBI chr 5:119,583,168...119,637,675
Ensembl chr 5:119,583,174...119,637,754 		JBrowse link
G C8b complement C8 beta chain IEA KEGG rno:04610 NCBI chr 5:119,535,009...119,572,565
Ensembl chr 5:119,535,146...119,572,565 		JBrowse link
G C8g complement C8 gamma chain IEA KEGG rno:04610 NCBI chr 3:8,320,503...8,322,087
Ensembl chr 3:8,305,920...8,323,495 		JBrowse link
G C9 complement C9 IEA KEGG rno:04610 NCBI chr 2:55,573,094...55,621,345
Ensembl chr 2:55,572,992...55,621,338 		JBrowse link
G Cd46 CD46 molecule IEA KEGG rno:04610 NCBI chr13:106,575,586...106,606,325
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Cd55 CD55 molecule (Cromer blood group) IEA KEGG rno:04610 NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831 		JBrowse link
G Cd59b CD59b molecule IEA KEGG rno:04610 NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847 		JBrowse link
G Cfb complement factor B IEA KEGG rno:04610 NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505 		JBrowse link
G Cfd complement factor D IEA KEGG rno:04610 NCBI chr 7:9,813,148...9,814,871
Ensembl chr 7:9,813,150...9,815,053 		JBrowse link
G Cfh complement factor H IEA KEGG rno:04610 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838 		JBrowse link
G Cfi complement factor I IEA KEGG rno:04610 NCBI chr 2:218,389,079...218,430,565
Ensembl chr 2:218,387,990...218,430,561 		JBrowse link
G Cpb2 carboxypeptidase B2 IEA KEGG rno:04610 NCBI chr15:50,557,722...50,606,569
Ensembl chr15:50,557,717...50,606,556 		JBrowse link
G Cr1l complement C3b/C4b receptor 1 like IEA KEGG rno:04610 NCBI chr13:106,606,952...106,660,442
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Cr2 complement C3d receptor 2 IEA KEGG rno:04610 NCBI chr13:106,678,579...106,716,595
Ensembl chr13:106,685,413...106,716,235 		JBrowse link
G F10 coagulation factor X ISO
IDA
IEA		 KEGG
RGD		 PMID:12356487 PMID:10048754 PMID:26018600 PMID:12787532 rno:04610, RGD:1580376, RGD:2290183, RGD:11342779, RGD:11352277 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141 		JBrowse link
G F11 coagulation factor XI IDA
ISO		 RGD PMID:10048754 PMID:26018600 PMID:12787532 RGD:2290183, RGD:11342779, RGD:11352277 NCBI chr16:46,987,988...47,009,015
Ensembl chr16:46,986,107...47,008,437 		JBrowse link
G F12 coagulation factor XII IDA
IEA
ISO		 KEGG
RGD		 PMID:10048754 PMID:26018600 PMID:12787532 rno:04610, RGD:2290183, RGD:11342779, RGD:11352277 NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530 		JBrowse link
G F13a1 coagulation factor XIII A1 chain IEA
ISO		 KEGG
RGD		 PMID:16102057 rno:04610, RGD:11352259 NCBI chr17:27,815,723...27,992,494
Ensembl chr17:27,815,702...27,992,700 		JBrowse link
G F13b coagulation factor XIII B chain IEA
ISO		 KEGG
RGD		 PMID:16102057 rno:04610, RGD:11352259 NCBI chr13:51,130,908...51,156,383
Ensembl chr13:51,130,920...51,156,381 		JBrowse link
G F2 coagulation factor II, thrombin TAS
IDA
IEA
ISO		 KEGG
RGD		 PMID:15975137 PMID:10048754 PMID:26018600 PMID:12787532 rno:04610, RGD:1578509, RGD:2290183, RGD:11342779, RGD:11352277 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G F2r coagulation factor II (thrombin) receptor IEA KEGG rno:04610 NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870 		JBrowse link
G F3 coagulation factor III, tissue factor IEA
ISO		 KEGG
RGD		 PMID:26018600 PMID:12787532 rno:04610, RGD:11342779, RGD:11352277 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G F5 coagulation factor V ISO
IDA
IEA		 KEGG
RGD		 PMID:15147718 PMID:10048754 PMID:26018600 PMID:12787532 rno:04610, RGD:1580372, RGD:2290183, RGD:11342779, RGD:11352277 NCBI chr13:76,513,509...76,583,106
Ensembl chr13:76,513,255...76,582,317 		JBrowse link
G F7 coagulation factor VII ISO
IDA
IEA		 KEGG
RGD		 PMID:12356487 PMID:10048754 PMID:26018600 PMID:12787532 rno:04610, RGD:1580376, RGD:2290183, RGD:11342779, RGD:11352277 NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610 		JBrowse link
G F8 coagulation factor VIII IMP
IDA
IEA
ISO		 KEGG
RGD		 PMID:2513867 PMID:10048754 PMID:26018600 PMID:12787532 rno:04610, RGD:1582368, RGD:2290183, RGD:11342779, RGD:11352277 NCBI chr18:140,848...172,330
Ensembl chr18:140,955...171,857 		JBrowse link
G F9 coagulation factor IX ISO
IDA
IEA		 KEGG
RGD		 PMID:12356487 PMID:10048754 PMID:26018600 PMID:12787532 rno:04610, RGD:1580376, RGD:2290183, RGD:11342779, RGD:11352277 NCBI chr  X:138,352,334...138,396,835
Ensembl chr  X:138,352,298...138,396,835 		JBrowse link
G Fga fibrinogen alpha chain IEA
ISO		 KEGG
RGD		 PMID:16102057 rno:04610, RGD:11352259 NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528 		JBrowse link
G Fgb fibrinogen beta chain IEA
ISO		 KEGG
RGD		 PMID:16102057 rno:04610, RGD:11352259 NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979 		JBrowse link
G Fgg fibrinogen gamma chain IEA
ISO		 KEGG
RGD		 PMID:16102057 rno:04610, RGD:11352259 NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322 		JBrowse link
G Klkb1 kallikrein B1 IEA KEGG rno:04610 NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053 		JBrowse link
G Kng2 kininogen 2 IEA KEGG rno:04610 NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971 		JBrowse link
G Kng2l1 kininogen 2-like 1 IEA KEGG rno:04610 NCBI chr11:77,978,795...78,002,976
Ensembl chr11:77,909,612...78,002,971 		JBrowse link
G Masp1 MBL associated serine protease 1 IEA KEGG rno:04610 NCBI chr11:77,334,794...77,405,271
Ensembl chr11:77,334,859...77,402,974 		JBrowse link
G Masp2 MBL associated serine protease 2 IEA KEGG rno:04610 NCBI chr 5:159,035,892...159,049,561
Ensembl chr 5:159,035,911...159,049,580 		JBrowse link
G Mbl1 mannose binding lectin 1 IEA KEGG rno:04610 NCBI chr16:17,029,146...17,035,187
Ensembl chr16:17,029,118...17,035,174 		JBrowse link
G Mbl2 mannose binding lectin 2 IEA KEGG rno:04610 NCBI chr 1:228,016,439...228,024,736 JBrowse link
G Plat plasminogen activator, tissue type IEA KEGG rno:04610 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Plau plasminogen activator, urokinase IEA KEGG rno:04610 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Plaur plasminogen activator, urokinase receptor IEA KEGG rno:04610 NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595 		JBrowse link
G Plg plasminogen IEA KEGG rno:04610 NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786 		JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa IEA
ISO		 KEGG
RGD		 PMID:12787532 rno:04610, RGD:11352277 NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133 		JBrowse link
G Pros1 protein S IEA KEGG rno:04610 NCBI chr11:230,597...311,288
Ensembl chr11:230,696...311,286 		JBrowse link
G Proz protein Z, vitamin K-dependent plasma glycoprotein ISO RGD PMID:23690629 RGD:11352284 NCBI chr16:76,450,013...76,463,558
Ensembl chr16:76,450,013...76,463,480 		JBrowse link
G Serpina1 serpin family A member 1 IEA KEGG rno:04610 NCBI chr 6:122,866,314...122,888,339
Ensembl chr 6:122,866,312...122,888,339 		JBrowse link
G Serpina10 serpin family A member 10 ISO RGD PMID:23690629 RGD:11352284 NCBI chr 6:122,756,106...122,764,544
Ensembl chr 6:122,756,108...122,764,544 		JBrowse link
G Serpina5 serpin family A member 5 IEA KEGG rno:04610 NCBI chr 6:123,009,224...123,028,412
Ensembl chr 6:123,023,306...123,028,407 		JBrowse link
G Serpinc1 serpin family C member 1 IEA
ISO		 KEGG
RGD		 PMID:12787532 rno:04610, RGD:11352277 NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293 		JBrowse link
G Serpind1 serpin family D member 1 IEA KEGG rno:04610 NCBI chr11:83,664,517...83,675,593
Ensembl chr11:83,664,518...83,675,519 		JBrowse link
G Serpine1 serpin family E member 1 IEA KEGG rno:04610 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Serpinf2 serpin family F member 2 IEA KEGG rno:04610 NCBI chr10:60,272,400...60,280,506
Ensembl chr10:60,272,400...60,281,243 		JBrowse link
G Serping1 serpin family G member 1 IEA
ISO		 KEGG
RGD		 PMID:26018600 PMID:12787532 rno:04610, RGD:11342779, RGD:11352277 NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034 		JBrowse link
G Tfpi tissue factor pathway inhibitor IEA
ISO		 KEGG
RGD		 PMID:26018600 PMID:12787532 rno:04610, RGD:11342779, RGD:11352277 NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880 		JBrowse link
G Thbd thrombomodulin IEA KEGG rno:04610 NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193 		JBrowse link
G Vwf von Willebrand factor IEA KEGG rno:04610 NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    regulatory pathway 3871
      homeostasis pathway 1773
        cardiovascular system homeostasis pathway 423
          hemostasis pathway 79
            coagulation cascade pathway 73
              altered coagulation cascade pathway 0
paths to the root