PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: arachidonic acid metabolic pathway
Accession: PW:0000460
browse the term
Definition: Those metabolic reactions involved in the synthesis, utilization and/or conversion of arachidonic acid - a polyunsaturated, omega-6 fatty acid. It is a precursor in the production of eicosanoids and can also be converted to other metabolites, collectively known as the arachidonic acid cascade.
Synonyms: related_synonym: Arachidonic acid metabolism; arachidonic acid cascade; arachidonic acid metabolic process
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Akr1c3
aldo-keto reductase family 1, member C3
ISO
SMPDB
SMP:00075
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
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Alox12
arachidonate 12-lipoxygenase, 12S type
IEA ISO
KEGG SMPDB
SMP:00075 rno:00590
NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542
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Alox12b
arachidonate 12-lipoxygenase, 12R type
IEA ISO
KEGG SMPDB
SMP:00075 rno:00590
NCBI chr10:53,863,060...53,874,938
Ensembl chr10:53,863,060...53,874,938
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Alox12e
arachidonate 12-lipoxygenase, epidermal
IEA
KEGG
rno:00590
NCBI chr10:55,034,392...55,041,857
Ensembl chr10:55,034,392...55,041,928
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Alox15
arachidonate 15-lipoxygenase
IEA ISO
KEGG SMPDB
SMP:00075 rno:00590
NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
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Alox15b
arachidonate 15-lipoxygenase, type B
IEA ISO
KEGG SMPDB
SMP:00075 rno:00590
NCBI chr10:53,892,496...53,901,812
Ensembl chr10:53,892,466...53,901,812
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Alox5
arachidonate 5-lipoxygenase
IEA ISO
KEGG SMPDB
SMP:00075 rno:00590
NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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Cbr1
carbonyl reductase 1
IEA ISO
KEGG SMPDB
SMP:00075 rno:00590
NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393
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Cbr3
carbonyl reductase 3
IEA
KEGG
rno:00590
NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875
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Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
IEA
KEGG
rno:00590
NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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Cyp2b12
cytochrome P450, family 2, subfamily b, polypeptide 12
IEA
KEGG
rno:00590
NCBI chr 1:82,007,609...82,019,409
Ensembl chr 1:82,007,609...82,080,480
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Cyp2b2
cytochrome P450, family 2, subfamily b, polypeptide 2
IEA
KEGG
rno:00590
NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
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Cyp2b21
cytochrome P450, family 2, subfamily b, polypeptide 21
IEA
KEGG
rno:00590
NCBI chr 1:81,886,097...81,915,066
Ensembl chr 1:81,886,098...81,915,066
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
IEA ISO
KEGG SMPDB
SMP:00075 rno:00590
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
IEA
KEGG
rno:00590
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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Cyp2c12
cytochrome P450, family 2, subfamily c, polypeptide 12
IEA
KEGG
rno:00590
NCBI chr 1:238,699,859...238,757,011
Ensembl chr 1:238,699,854...238,757,019
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Cyp2c13
cytochrome P450, family 2, subfamily c, polypeptide 13
IEA
KEGG
rno:00590
NCBI chr 1:238,786,764...238,867,195
Ensembl chr 1:238,786,765...238,867,191
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Cyp2c22
cytochrome P450, family 2, subfamily c, polypeptide 22
IEA
KEGG
rno:00590
NCBI chr 1:238,991,698...239,031,323
Ensembl chr 1:238,991,610...239,021,738
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Cyp2c23
cytochrome P450, family 2, subfamily c, polypeptide 23
IEA
KEGG
rno:00590
NCBI chr 1:242,889,218...242,913,869
Ensembl chr 1:242,889,224...242,913,858
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Cyp2c7
cytochrome P450, family 2, subfamily c, polypeptide 7
IEA
KEGG
rno:00590
NCBI chr 1:237,332,641...237,388,714
Ensembl chr 1:237,332,659...237,388,709
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Cyp2c79
cytochrome P450, family 2, subfamily c, polypeptide 79
ISO
SMPDB
SMP:00075
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
IEA ISO
KEGG SMPDB
SMP:00075 rno:00590
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Cyp2j16
cytochrome P450, family 2, subfamily j, polypeptide 16
IEA
KEGG
rno:00590
NCBI chr 5:111,089,438...111,138,918
Ensembl chr 5:111,088,674...111,139,013
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Cyp2j3
cytochrome P450, family 2, subfamily j, polypeptide 3
IEA
KEGG
rno:00590
NCBI chr 5:111,219,921...111,244,987
Ensembl chr 5:111,178,703...111,244,794
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Cyp2j4
cytochrome P450, family 2, subfamily j, polypeptide 4
IEA ISO
KEGG SMPDB
SMP:00075 rno:00590
NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
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Cyp2u1
cytochrome P450, family 2, subfamily u, polypeptide 1
IEA ISO
KEGG SMPDB
SMP:00075 rno:00590
NCBI chr 2:219,849,403...219,866,959
Ensembl chr 2:219,849,407...219,866,882
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Cyp4a1
cytochrome P450, family 4, subfamily a, polypeptide 1
IEA
KEGG
rno:00590
NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
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Cyp4a2
cytochrome P450, family 4, subfamily a, polypeptide 2
IEA
KEGG
rno:00590
NCBI chr 5:128,922,355...128,934,188
Ensembl chr 5:128,923,615...128,934,165
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Cyp4a3
cytochrome P450, family 4, subfamily a, polypeptide 3
IEA
KEGG
rno:00590
NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463
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Cyp4a8
cytochrome P450, family 4, subfamily a, polypeptide 8
IMP IEA
KEGG RGD
PMID:15618658
rno:00590, RGD:2303409
NCBI chr 5:128,702,130...128,733,476
Ensembl chr 5:128,702,131...128,733,476
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Cyp4f1
cytochrome P450, family 4, subfamily f, polypeptide 1
IEA
KEGG
rno:00590
NCBI chr 7:12,010,850...12,022,497
Ensembl chr 7:12,010,852...12,022,046
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Cyp4f17
cytochrome P450, family 4, subfamily f, polypeptide 17
IEA
KEGG
rno:00590
NCBI chr 7:11,518,985...11,536,208
Ensembl chr 7:11,433,371...11,536,181
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Cyp4f18
cytochrome P450, family 4, subfamily f, polypeptide 18
IEA ISO
KEGG SMPDB
SMP:00075 rno:00590
NCBI chr16:17,763,543...17,804,944
Ensembl chr16:17,707,317...17,804,940
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Cyp4f4
cytochrome P450, family 4, subfamily f, polypeptide 4
IEA
KEGG
rno:00590
NCBI chr 7:11,717,208...11,733,507
Ensembl chr 7:11,717,208...11,733,506
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Cyp4f40
cytochrome P450, family 4, subfamily f, polypeptide 40
IEA
KEGG
rno:00590
NCBI chr 7:11,691,648...11,707,437
Ensembl chr 7:11,692,086...11,706,229
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Cyp4f5
cytochrome P450, family 4, subfamily f, polypeptide 5
IEA
KEGG
rno:00590
NCBI chr 7:11,544,040...11,558,982
Ensembl chr 7:11,544,082...11,558,978
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Cyp4f6
cytochrome P450, family 4, subfamily f, polypeptide 6
IEA
KEGG
rno:00590
NCBI chr 7:12,030,276...12,058,020
Ensembl chr 7:12,030,301...12,057,782
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Ephx2
epoxide hydrolase 2
IEA ISO
KEGG SMPDB
SMP:00075 rno:00590
NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
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Ggt1
gamma-glutamyltransferase 1
IEA ISO
KEGG SMPDB
SMP:00075 rno:00590
NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
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Ggt5
gamma-glutamyltransferase 5
IEA
KEGG
rno:00590
NCBI chr20:13,043,255...13,071,523
Ensembl chr20:13,043,257...13,071,450
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Ggt6
gamma-glutamyl transferase 6
IEA
KEGG
rno:00590
NCBI chr10:57,051,977...57,054,900
Ensembl chr10:57,051,825...57,067,260
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Ggt7
gamma-glutamyltransferase 7
IEA
KEGG
rno:00590
NCBI chr 3:143,978,073...144,004,597
Ensembl chr 3:143,978,082...144,001,492
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Gpx1
glutathione peroxidase 1
IEA ISO
KEGG SMPDB
SMP:00075 rno:00590
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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Gpx2
glutathione peroxidase 2
IEA
KEGG
rno:00590
NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
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Gpx3
glutathione peroxidase 3
IEA
KEGG
rno:00590
NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
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Gpx5
glutathione peroxidase 5
IEA
KEGG
rno:00590
NCBI chr17:43,436,126...43,443,074
Ensembl chr17:43,416,340...43,443,074
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Gpx6
glutathione peroxidase 6
IEA
KEGG
rno:00590
NCBI chr17:43,408,472...43,416,091
Ensembl chr17:43,408,472...43,416,091
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Gpx7
glutathione peroxidase 7
IEA
KEGG
rno:00590
NCBI chr 5:123,145,151...123,153,141
Ensembl chr 5:123,144,331...123,153,004
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Gpx8
glutathione peroxidase 8
IEA
KEGG
rno:00590
NCBI chr 2:44,676,448...44,680,042
Ensembl chr 2:44,676,454...44,680,195
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Hpgds
hematopoietic prostaglandin D synthase
IEA
KEGG
rno:00590
NCBI chr 4:94,368,426...94,397,931
Ensembl chr 4:94,373,342...94,397,883
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Lta4h
leukotriene A4 hydrolase
IEA ISO
KEGG SMPDB
SMP:00075 rno:00590
NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600
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Ltc4s
leukotriene C4 synthase
IEA ISO
KEGG SMPDB
SMP:00075 rno:00590
NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651
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Pla2g10
phospholipase A2, group X
IEA
KEGG
rno:00590
NCBI chr10:1,597,761...1,610,822
Ensembl chr10:1,597,761...1,609,000
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Pla2g12a
phospholipase A2, group XIIA
IEA
KEGG
rno:00590
NCBI chr 2:218,436,497...218,452,742
Ensembl chr 2:218,436,513...218,452,740
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Pla2g12b
phospholipase A2, group XIIB
IEA
KEGG
rno:00590
NCBI chr20:27,369,196...27,389,517
Ensembl chr20:27,370,266...27,388,743
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Pla2g1b
phospholipase A2 group IB
IEA
KEGG
rno:00590
NCBI chr12:41,142,193...41,151,967
Ensembl chr12:41,142,200...41,153,226
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Pla2g2a
phospholipase A2 group IIA
IEA
KEGG
rno:00590
NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014
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Pla2g2c
phospholipase A2, group IIC
IEA
KEGG
rno:00590
NCBI chr 5:150,959,365...150,981,388
Ensembl chr 5:150,959,182...150,981,377
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Pla2g2d
phospholipase A2, group IID
IEA
KEGG
rno:00590
NCBI chr 5:151,016,010...151,022,531
Ensembl chr 5:151,018,870...151,022,525
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Pla2g2f
phospholipase A2, group IIF
IEA
KEGG
rno:00590
NCBI chr 5:150,986,788...150,993,175
Ensembl chr 5:150,986,788...150,993,175
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Pla2g3
phospholipase A2, group III
IEA
KEGG
rno:00590
NCBI chr14:78,367,625...78,373,913
Ensembl chr14:78,368,105...78,373,913
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Pla2g4a
phospholipase A2 group 4A
IEA
KEGG
rno:00590
NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
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Pla2g4b
phospholipase A2 group IVB
IEA ISO
KEGG SMPDB
SMP:00075 rno:00590
NCBI chr 3:107,004,238...107,013,853
Ensembl chr 3:107,005,489...107,013,853
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Pla2g4e
phospholipase A2, group IVE
IEA
KEGG
rno:00590
NCBI chr 3:107,132,540...107,198,609
Ensembl chr 3:107,132,541...107,198,233
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Pla2g4f
phospholipase A2, group IVF
IEA
KEGG
rno:00590
NCBI chr 3:107,249,053...107,266,201
Ensembl chr 3:107,250,075...107,264,689
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Pla2g5
phospholipase A2, group V
IEA
KEGG
rno:00590
NCBI chr 5:151,041,339...151,109,433
Ensembl chr 5:151,041,340...151,062,658
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Pla2g6
phospholipase A2 group VI
IEA
KEGG
rno:00590
NCBI chr 7:110,851,378...110,891,557
Ensembl chr 7:110,851,378...110,891,114
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Plb1
phospholipase B1
IEA
KEGG
rno:00590
NCBI chr 6:24,087,051...24,227,167
Ensembl chr 6:24,089,214...24,210,117
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Prxl2b
peroxiredoxin like 2B
ISO
SMPDB
SMP:00075
NCBI chr 5:165,462,610...165,465,213
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Ptgds
prostaglandin D2 synthase
IEA ISO
KEGG SMPDB
SMP:00075 rno:00590
NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833
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Ptges
prostaglandin E synthase
IEA ISO
KEGG SMPDB
SMP:00075 rno:00590
NCBI chr 3:14,177,892...14,189,236
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Ptges2
prostaglandin E synthase 2
IEA
KEGG
rno:00590
NCBI chr 3:15,690,501...15,697,688
Ensembl chr 3:15,690,501...15,697,688
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Ptgis
prostaglandin I2 synthase
IEA ISO
KEGG SMPDB
SMP:00075 rno:00590
NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451
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Ptgs1
prostaglandin-endoperoxide synthase 1
IEA ISO
KEGG SMPDB
SMP:00075 rno:00590
NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
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Ptgs2
prostaglandin-endoperoxide synthase 2
IEA ISO
KEGG SMPDB
SMP:00075 rno:00590
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Tbxas1
thromboxane A synthase 1
IEA ISO
KEGG SMPDB
SMP:00075 rno:00590
NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096
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Anxa1
annexin A1
ISO
RGD
PMID:18761105
RGD:8552898
NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
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Mknk1
MAPK interacting serine/threonine kinase 1
ISO
RGD
PMID:18761105
RGD:8552898
NCBI chr 5:129,318,128...129,357,641
Ensembl chr 5:129,318,170...129,357,639
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Pla2g4a
phospholipase A2 group 4A
ISO
RGD
PMID:22679221 PMID:18761105
RGD:8552712 , RGD:8552898
NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
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Ptgs1
prostaglandin-endoperoxide synthase 1
ISO
RGD
PMID:23063076 PMID:22679221
RGD:8552701 , RGD:8552712
NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
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Ptgs2
prostaglandin-endoperoxide synthase 2
ISO
RGD
PMID:23063076 PMID:22679221
RGD:8552701 , RGD:8552712
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Vim
vimentin
ISO
RGD
PMID:18761105
RGD:8552898
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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Cyp2b12
cytochrome P450, family 2, subfamily b, polypeptide 12
IDA
RGD
PMID:9535921
RGD:2301469
NCBI chr 1:82,007,609...82,019,409
Ensembl chr 1:82,007,609...82,080,480
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Cyp4a1
cytochrome P450, family 4, subfamily a, polypeptide 1
IMP
RGD
PMID:12857783
RGD:1625451
NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
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Cyp4a2
cytochrome P450, family 4, subfamily a, polypeptide 2
IMP
RGD
PMID:12857783
RGD:1625451
NCBI chr 5:128,922,355...128,934,188
Ensembl chr 5:128,923,615...128,934,165
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Cyp4a3
cytochrome P450, family 4, subfamily a, polypeptide 3
IMP
RGD
PMID:12857783
RGD:1625451
NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463
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Cyp4f1
cytochrome P450, family 4, subfamily f, polypeptide 1
IDA
RGD
PMID:14634044
RGD:2301710
NCBI chr 7:12,010,850...12,022,497
Ensembl chr 7:12,010,852...12,022,046
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Alox5
arachidonate 5-lipoxygenase
ISO IMP
RGD
PMID:17517102 PMID:7665580
RGD:2313910 , RGD:39128168
NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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Alox5ap
arachidonate 5-lipoxygenase activating protein
ISO IDA
RGD
PMID:18945963 PMID:2300173
RGD:2313900 , RGD:69749
NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986
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Lta4h
leukotriene A4 hydrolase
ISO
RGD
PMID:17517102
RGD:2313910
NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600
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Ltc4s
leukotriene C4 synthase
ISO
RGD
PMID:17517102
RGD:2313910
NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651
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Alox12
arachidonate 12-lipoxygenase, 12S type
ISS IMP
RGD
PMID:15896353 PMID:15105833
RGD:1578308 , RGD:2313858
NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542
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Alox12b
arachidonate 12-lipoxygenase, 12R type
ISS
RGD
PMID:12432922
RGD:1578309
NCBI chr10:53,863,060...53,874,938
Ensembl chr10:53,863,060...53,874,938
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Alox12e
arachidonate 12-lipoxygenase, epidermal
ISS
RGD
PMID:12432922
RGD:1578309
NCBI chr10:55,034,392...55,041,857
Ensembl chr10:55,034,392...55,041,928
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Alox15
arachidonate 15-lipoxygenase
IDA
RGD
PMID:8117750
RGD:70288
NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
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Alox15b
arachidonate 15-lipoxygenase, type B
ISS
RGD
PMID:12432923
RGD:1578310
NCBI chr10:53,892,496...53,901,812
Ensembl chr10:53,892,466...53,901,812
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Alox5
arachidonate 5-lipoxygenase
IMP ISO
RGD
PMID:15107407 PMID:17517102
RGD:1578311 , RGD:2313910
NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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Alox5ap
arachidonate 5-lipoxygenase activating protein
ISO IDA
RGD
PMID:17517102 PMID:18945963 PMID:2300173
RGD:2313910 , RGD:2313900 , RGD:69749
NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986
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Lta4h
leukotriene A4 hydrolase
ISO
RGD
PMID:17517102
RGD:2313910
NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600
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Ltc4s
leukotriene C4 synthase
ISO
RGD
PMID:17517102
RGD:2313910
NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651
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Akr1a1
aldo-keto reductase family 1 member A1
ISO
RGD
PMID:23747692
RGD:8552778
NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674
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Akr1b1
aldo-keto reductase family 1 member B1
ISO
RGD
PMID:23747692
RGD:8552778
NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
G
Akr1c3
aldo-keto reductase family 1, member C3
TAS
RGD
PMID:12432932
RGD:8552774
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
G
Cbr1
carbonyl reductase 1
ISO
RGD
PMID:12432932
RGD:8552774
NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393
G
Hpgds
hematopoietic prostaglandin D synthase
ISO
RGD
PMID:23063076 PMID:22679221
RGD:8552701 , RGD:8552712
NCBI chr 4:94,368,426...94,397,931
Ensembl chr 4:94,373,342...94,397,883
G
Prxl2b
peroxiredoxin like 2B
ISO
RGD
PMID:18006499
RGD:8552775
NCBI chr 5:165,462,610...165,465,213
G
Ptgds
prostaglandin D2 synthase
ISO
RGD
PMID:23063076 PMID:22679221
RGD:8552701 , RGD:8552712
NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833
G
Ptges
prostaglandin E synthase
ISO
RGD
PMID:23063076 PMID:22679221
RGD:8552701 , RGD:8552712
NCBI chr 3:14,177,892...14,189,236
G
Ptges2
prostaglandin E synthase 2
ISO
RGD
PMID:23063076 PMID:22679221
RGD:8552701 , RGD:8552712
NCBI chr 3:15,690,501...15,697,688
Ensembl chr 3:15,690,501...15,697,688
G
Ptges3
prostaglandin E synthase 3
ISO
RGD
PMID:23063076 PMID:22679221
RGD:8552701 , RGD:8552712
NCBI chr 7:490,698...507,759
Ensembl chr 7:490,656...508,084
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all