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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:angiotensin IV signaling pathway
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Accession:PW:0000458 term browser browse the term
Definition:Angiotensin IV is derived from angiotensin III through the action of aminopeptidase N. The receptor for angiotensin IV has been shown to be the insulin-regulated membrane aminopeptidase. Studies suggest that angiotensin IV signaling activates a number of intracellular second messenger systems and plays a role in vascular remodeling and memory.


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angiotensin IV signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen ISO RGD PMID:11282364 RGD:1582105 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880 		JBrowse link
G ANPEP alanyl aminopeptidase, membrane ISO RGD PMID:15638741 PMID:16537183 RGD:1581649 RGD:1581742 NCBI chr 3:52,764,418...52,779,516
Ensembl chr 3:52,764,418...52,779,746 		JBrowse link
G LNPEP leucyl and cystinyl aminopeptidase ISO RGD PMID:11282364 PMID:12591177 RGD:1581864 RGD:1582105 NCBI chr 3:12,668,994...12,766,712
Ensembl chr 3:12,681,577...12,767,183 		JBrowse link
G RNPEP arginyl aminopeptidase ISO RGD PMID:16537183 RGD:1581649 NCBI chr 7:966,563...985,169
Ensembl chr 7:966,607...984,714 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4052
    signaling pathway 1939
      hormone signaling pathway 379
        peptide and protein hormone signaling pathway 273
          angiotensin signaling pathway 40
            angiotensin IV signaling pathway 4
Path 2
Term Annotations click to browse term
  pathway 4052
    regulatory pathway 2511
      homeostasis pathway 1305
        cardiovascular system homeostasis pathway 264
          renin-angiotensin cascade pathway 44
            angiotensin signaling pathway 40
              angiotensin IV signaling pathway 4
paths to the root