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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:spermidine metabolic pathway
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Accession:PW:0000396 term browser browse the term
Definition:Polyamine metabolism plays important roles in a number of cellular processes. Spermidine and spermine are formed in two consecutive reactions carried out by distinct enzymes that employ the decarboxylated form of AdoMet as an aminopropyl donor.
Synonyms:related_synonym: SMP:00445



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spermidine metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amd1 S-adenosylmethionine decarboxylase 1 ISS
ISO
SMPDB
RGD
PMID:10430362 PMID:1415709 PMID:10712236 SMP:00445, RGD:1578320, RGD:7242912, RGD:7242911 NCBI chr10:40,287,458...40,302,188
Ensembl chr10:40,287,458...40,302,188
JBrowse link
G Mat2a methionine adenosyltransferase II, alpha ISO SMPDB SMP:00445 NCBI chr 6:72,432,796...72,439,556
Ensembl chr 6:72,432,799...72,439,558
JBrowse link
G Mat2b methionine adenosyltransferase II, beta ISO SMPDB SMP:00445 NCBI chr11:40,679,314...40,695,203
Ensembl chr11:40,679,314...40,695,203
JBrowse link
G Odc1 ornithine decarboxylase, structural 1 ISS
ISO
SMPDB
RGD
PMID:10430362 PMID:1415709 PMID:2292587 SMP:00445, RGD:1578320, RGD:7242912, RGD:7242932 NCBI chr12:17,544,808...17,551,502
Ensembl chr12:17,544,794...17,551,505
JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 ISO RGD PMID:2292587 RGD:7242932 NCBI chr  X:155,213,126...155,216,449
Ensembl chr  X:155,213,132...155,216,449
JBrowse link
G Sms spermine synthase ISO SMPDB SMP:00445 NCBI chr  X:157,443,851...157,492,287
Ensembl chr  X:157,443,855...157,492,287
JBrowse link
G Srm spermidine synthase ISO SMPDB
RGD
PMID:23073625 PMID:2292587 PMID:16931179 SMP:00445, RGD:7242425, RGD:7242932, RGD:7242920 NCBI chr 4:148,591,513...148,594,619
Ensembl chr 4:148,591,503...148,594,993
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6066
    classic metabolic pathway 1859
      biogenic amines and polyamines metabolic pathway 28
        polyamine metabolic pathway 13
          spermidine metabolic pathway 7
Path 2
Term Annotations click to browse term
  pathway 6066
    regulatory pathway 3683
      homeostasis pathway 1718
        organic chemical homeostasis pathway 453
          S-adenosylmethionine homeostasis pathway 286
            polyamine metabolic pathway 13
              spermidine metabolic pathway 7
paths to the root