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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:spermidine metabolic pathway
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Accession:PW:0000396 term browser browse the term
Definition:Polyamine metabolism plays important roles in a number of cellular processes. Spermidine and spermine are formed in two consecutive reactions carried out by distinct enzymes that employ the decarboxylated form of AdoMet as an aminopropyl donor.
Synonyms:related_synonym: spermidine metabolic process


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spermidine metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amd1 adenosylmethionine decarboxylase 1 IDA
IMP
ISO		 SMPDB
RGD		 PMID:10430362 PMID:10712236 PMID:1415709 SMP:00445, RGD:1578320, RGD:7242911, RGD:7242912 NCBI chr20:43,695,783...43,711,476
Ensembl chr20:43,697,237...43,711,476 		JBrowse link
G Mat2a methionine adenosyltransferase 2A ISO SMPDB SMP:00445 NCBI chr 4:104,489,877...104,495,447
Ensembl chr 4:104,488,466...104,495,493 		JBrowse link
G Mat2b methionine adenosyltransferase 2 non-catalytic beta subunit ISO SMPDB SMP:00445 NCBI chr10:25,106,928...25,122,982
Ensembl chr10:25,106,930...25,122,777 		JBrowse link
G Odc1 ornithine decarboxylase 1 IDA
IMP
ISO		 SMPDB
RGD		 PMID:10430362 PMID:1415709 PMID:2292587 SMP:00445, RGD:1578320, RGD:7242912, RGD:7242932 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 IMP RGD PMID:2292587 RGD:7242932 NCBI chr  X:40,158,354...40,161,641
Ensembl chr  X:40,157,046...40,196,813 		JBrowse link
G Sms spermine synthase ISO SMPDB SMP:00445 NCBI chr  X:37,516,949...37,572,657
Ensembl chr  X:37,516,931...37,570,822 		JBrowse link
G Srm spermidine synthase ISO
IDA
IMP		 SMPDB
RGD		 PMID:23073625 PMID:16931179 PMID:2292587 SMP:00445, RGD:7242425, RGD:7242920, RGD:7242932 NCBI chr 5:159,025,875...159,029,076
Ensembl chr 5:159,025,873...159,029,405 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    classic metabolic pathway 1854
      biogenic amines and polyamines metabolic pathway 28
        polyamine metabolic pathway 13
          spermidine metabolic pathway 7
Path 2
Term Annotations click to browse term
  pathway 6092
    regulatory pathway 3867
      homeostasis pathway 1773
        organic chemical homeostasis pathway 438
          S-adenosylmethionine homeostasis pathway 289
            polyamine metabolic pathway 13
              spermidine metabolic pathway 7
paths to the root