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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:spermidine metabolic pathway
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Accession:PW:0000396 term browser browse the term
Definition:Polyamine metabolism plays important roles in a number of cellular processes. Spermidine and spermine are formed in two consecutive reactions carried out by distinct enzymes that employ the decarboxylated form of AdoMet as an aminopropyl donor.
Synonyms:related_synonym: SMP:00445



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spermidine metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amd1 adenosylmethionine decarboxylase 1 IDA
ISO
IMP
SMPDB
RGD
PMID:10430362 PMID:1415709 PMID:10712236 SMP:00445, RGD:1578320, RGD:7242912, RGD:7242911 NCBI chr20:43,695,783...43,711,476
Ensembl chr20:43,697,237...43,711,476
JBrowse link
G Mat2a methionine adenosyltransferase 2A ISO SMPDB SMP:00445 NCBI chr 4:104,489,877...104,495,447
Ensembl chr 4:104,488,466...104,495,493
JBrowse link
G Mat2b methionine adenosyltransferase 2B ISO SMPDB SMP:00445 NCBI chr10:25,106,928...25,122,982
Ensembl chr10:25,106,930...25,122,777
JBrowse link
G Odc1 ornithine decarboxylase 1 IDA
ISO
IMP
SMPDB
RGD
PMID:10430362 PMID:2292587 PMID:1415709 SMP:00445, RGD:1578320, RGD:7242932, RGD:7242912 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 IMP RGD PMID:2292587 RGD:7242932 NCBI chr  X:40,158,354...40,161,641
Ensembl chr  X:40,157,046...40,196,813
JBrowse link
G Sms spermine synthase ISO SMPDB SMP:00445 NCBI chr  X:37,516,949...37,572,657
Ensembl chr  X:37,516,931...37,570,822
JBrowse link
G Srm spermidine synthase ISO
IMP
IDA
SMPDB
RGD
PMID:23073625 PMID:2292587 PMID:16931179 SMP:00445, RGD:7242425, RGD:7242932, RGD:7242920 NCBI chr 5:159,025,919...159,029,076
Ensembl chr 5:159,025,873...159,029,405
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6100
    classic metabolic pathway 1856
      biogenic amines and polyamines metabolic pathway 28
        polyamine metabolic pathway 13
          spermidine metabolic pathway 7
Path 2
Term Annotations click to browse term
  pathway 6100
    regulatory pathway 3876
      homeostasis pathway 1774
        organic chemical homeostasis pathway 440
          S-adenosylmethionine homeostasis pathway 291
            polyamine metabolic pathway 13
              spermidine metabolic pathway 7
paths to the root