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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:dopamine signaling pathway
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Accession:PW:0000394 term browser browse the term
Definition:Dopamine signaling plays important roles in processes such as motivation, learning and movement. It also plays several roles in the periphery as a modulator of renal, cardiovascular and endocrine systems. Dopamine signals to a family of at least 5 receptors that are classified into two subfamilies that couple to distinct G proteins to elicit diverse downstream events. Deregulation of the pathway has been implicated in several neuropsychiatric and neurological disorders.
Synonyms:related_synonym: Dopamine receptors;   dopamine receptor signaling pathway;   dopaminergic pathway
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dopamine signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdk5 cyclin dependent kinase 5 ISO RGD PMID:21927600 RGD:11041163 NCBI chr 5:24,612,595...24,628,737
Ensembl chr 5:24,623,239...24,628,528 		JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 ISO RGD PMID:21927600 RGD:11041163 NCBI chr18:61,687,307...61,723,391
Ensembl chr18:61,688,345...61,723,132 		JBrowse link
G Drd1 dopamine receptor D1 ISO heterodimer coupled to Galphaq RGD PMID:17314300 PMID:25671228 RGD:1625010, RGD:11041142 NCBI chr13:54,205,202...54,209,677
Ensembl chr13:54,205,202...54,209,724 		JBrowse link
G Drd2 dopamine receptor D2 ISO heterodimer coupled to Galphaq RGD PMID:12121979 PMID:25671228 PMID:16490190 PMID:17314300 RGD:1581445, RGD:11041142, RGD:1625068, RGD:1625010 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477 		JBrowse link
G Drd3 dopamine receptor D3 ISO RGD PMID:16490190 RGD:1625068 NCBI chr16:43,574,285...43,646,353
Ensembl chr16:43,574,389...43,643,295 		JBrowse link
G Drd4 dopamine receptor D4 ISO RGD PMID:17314300 RGD:1625010 NCBI chr 7:140,871,931...140,874,868
Ensembl chr 7:140,871,919...140,876,377 		JBrowse link
G Drd5 dopamine receptor D5 ISO RGD PMID:25671228 RGD:11041142 NCBI chr 5:38,476,742...38,479,868
Ensembl chr 5:38,476,710...38,479,861 		JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha ISO RGD PMID:21927600 RGD:11041163 NCBI chr19:4,242,173...4,245,418
Ensembl chr19:4,242,064...4,245,419 		JBrowse link
G Ppp1cb protein phosphatase 1 catalytic subunit beta ISO RGD PMID:21927600 RGD:11041163 NCBI chr 5:32,616,192...32,651,057
Ensembl chr 5:32,616,187...32,674,777 		JBrowse link
G Ppp1cc protein phosphatase 1 catalytic subunit gamma ISO RGD PMID:21927600 RGD:11041163 NCBI chr 5:122,296,338...122,313,336
Ensembl chr 5:122,296,341...122,313,336 		JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory inhibitor subunit 1B ISO RGD PMID:21927600 PMID:21303898 RGD:11041163, RGD:11041134 NCBI chr11:98,239,232...98,248,622
Ensembl chr11:98,239,230...98,248,622 		JBrowse link
G Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform ISO RGD PMID:21927600 RGD:11041163 NCBI chr11:51,989,651...52,013,576
Ensembl chr11:51,989,508...52,018,605 		JBrowse link
G Ppp2cb protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform ISO RGD PMID:21927600 RGD:11041163 NCBI chr 8:34,089,672...34,109,831
Ensembl chr 8:34,089,653...34,109,469 		JBrowse link
G Ppp2r3a protein phosphatase 2, regulatory subunit B'', alpha ISO RGD PMID:21927600 RGD:11041163 NCBI chr 9:100,982,188...101,129,031
Ensembl chr 9:100,982,283...101,128,994 		JBrowse link
G Ppp2r5d protein phosphatase 2, regulatory subunit B', delta ISO RGD PMID:21927600 RGD:11041163 NCBI chr17:46,993,917...47,015,952
Ensembl chr17:46,993,917...47,016,037 		JBrowse link
G Ppp3ca protein phosphatase 3, catalytic subunit, alpha isoform ISO RGD PMID:21927600 RGD:11041163 NCBI chr 3:136,375,778...136,643,488
Ensembl chr 3:136,375,885...136,643,488 		JBrowse link
G Ppp3cb protein phosphatase 3, catalytic subunit, beta isoform ISO RGD PMID:21927600 RGD:11041163 NCBI chr14:20,549,432...20,596,641
Ensembl chr14:20,549,432...20,596,641 		JBrowse link
G Ppp3cc protein phosphatase 3, catalytic subunit, gamma isoform ISO RGD PMID:21927600 RGD:11041163 NCBI chr14:70,455,314...70,526,979
Ensembl chr14:70,455,314...70,526,920 		JBrowse link
G Prkaca protein kinase, cAMP dependent, catalytic, alpha ISO RGD PMID:21927600 RGD:11041163 NCBI chr 8:84,699,607...84,723,073
Ensembl chr 8:84,699,622...84,723,072 		JBrowse link
G Prkacb protein kinase, cAMP dependent, catalytic, beta ISO RGD PMID:21927600 RGD:11041163 NCBI chr 3:146,435,334...146,518,691
Ensembl chr 3:146,435,329...146,518,745 		JBrowse link
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 ISO RGD PMID:21303898 RGD:11041134 NCBI chr 7:46,727,543...46,783,774
Ensembl chr 7:46,727,543...46,783,432 		JBrowse link
G Src Rous sarcoma oncogene ISO RGD PMID:16529858 RGD:1581410 NCBI chr 2:157,265,828...157,313,758
Ensembl chr 2:157,260,364...157,313,782 		JBrowse link
dopamine signaling pathway via D1 family of receptors term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy2 adenylate cyclase 2 ISO SMPDB SMP:00308 NCBI chr13:68,768,162...69,147,719
Ensembl chr13:68,768,162...69,147,660 		JBrowse link
G Adcy5 adenylate cyclase 5 ISO RGD PMID:26468202 RGD:11041137 NCBI chr16:34,974,933...35,126,108
Ensembl chr16:34,975,247...35,126,108 		JBrowse link
G Arrb1 arrestin, beta 1 ISO RGD PMID:21303898 PMID:21303898 RGD:11041134, RGD:11041134 NCBI chr 7:99,184,356...99,255,979
Ensembl chr 7:99,184,673...99,255,978 		JBrowse link
G Arrb2 arrestin, beta 2 ISO RGD PMID:21303898 RGD:11041134 NCBI chr11:70,323,051...70,331,654
Ensembl chr11:70,323,461...70,331,654 		JBrowse link
G Drd1 dopamine receptor D1 ISO SMPDB
RGD		 PMID:21303898 SMP:00308, RGD:11041134 NCBI chr13:54,205,202...54,209,677
Ensembl chr13:54,205,202...54,209,724 		JBrowse link
G Drd5 dopamine receptor D5 ISO RGD PMID:21303898 RGD:11041134 NCBI chr 5:38,476,742...38,479,868
Ensembl chr 5:38,476,710...38,479,861 		JBrowse link
G Gnal guanine nucleotide binding protein, alpha stimulating, olfactory type ISO RGD PMID:24144882 RGD:11041135 NCBI chr18:67,221,369...67,359,863
Ensembl chr18:67,221,287...67,359,863 		JBrowse link
G Gnas GNAS complex locus ISO SMPDB SMP:00308 NCBI chr 2:174,126,113...174,188,537
Ensembl chr 2:174,126,113...174,188,537 		JBrowse link
G Gnb1 guanine nucleotide binding protein (G protein), beta 1 ISO SMPDB SMP:00308 NCBI chr 4:155,575,514...155,643,726
Ensembl chr 4:155,575,818...155,643,726 		JBrowse link
G Gng12 guanine nucleotide binding protein (G protein), gamma 12 ISO SMPDB SMP:00308 NCBI chr 6:66,873,381...66,998,345
Ensembl chr 6:66,873,381...66,998,334 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO RGD PMID:21303898 RGD:11041134 NCBI chr19:4,336,029...4,356,356
Ensembl chr19:4,336,029...4,356,250 		JBrowse link
G Grk3 G protein-coupled receptor kinase 3 ISO RGD PMID:21303898 RGD:11041134 NCBI chr 5:113,058,344...113,163,518
Ensembl chr 5:113,058,348...113,163,657 		JBrowse link
G Grk5 G protein-coupled receptor kinase 5 ISO RGD PMID:21303898 RGD:11041134 NCBI chr19:60,877,995...61,084,406
Ensembl chr19:60,878,187...61,084,406 		JBrowse link
G Grk6 G protein-coupled receptor kinase 6 ISO RGD PMID:21303898 RGD:11041134 NCBI chr13:55,592,865...55,608,740
Ensembl chr13:55,592,885...55,608,740 		JBrowse link
G Prkacb protein kinase, cAMP dependent, catalytic, beta ISO SMPDB SMP:00308 NCBI chr 3:146,435,334...146,518,691
Ensembl chr 3:146,435,329...146,518,745 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 ISO RGD PMID:21303898 RGD:11041134 NCBI chr 1:143,875,076...143,879,887
Ensembl chr 1:143,875,076...143,879,899 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 ISO RGD PMID:21303898 RGD:11041134 NCBI chr 1:169,569,046...169,575,211
Ensembl chr 1:169,569,046...169,575,211 		JBrowse link
G Rgs7 regulator of G protein signaling 7 ISO RGD PMID:21303898 RGD:11041134 NCBI chr 1:174,886,642...175,320,287
Ensembl chr 1:174,886,653...175,320,066 		JBrowse link
G Rgs7bp regulator of G-protein signalling 7 binding protein ISO RGD PMID:21303898 RGD:11041134 NCBI chr13:105,082,412...105,191,438
Ensembl chr13:105,082,412...105,191,438 		JBrowse link
G Rgs9 regulator of G-protein signaling 9 ISO RGD PMID:21303898 RGD:11041134 NCBI chr11:109,116,174...109,189,013
Ensembl chr11:109,116,181...109,188,955 		JBrowse link
dopamine signaling pathway via D2 family of receptors term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy5 adenylate cyclase 5 ISO RGD PMID:26468202 RGD:11041137 NCBI chr16:34,974,933...35,126,108
Ensembl chr16:34,975,247...35,126,108 		JBrowse link
G Arrb1 arrestin, beta 1 ISO RGD PMID:21303898 PMID:21303898 RGD:11041134, RGD:11041134 NCBI chr 7:99,184,356...99,255,979
Ensembl chr 7:99,184,673...99,255,978 		JBrowse link
G Arrb2 arrestin, beta 2 ISO RGD PMID:21303898 RGD:11041134 NCBI chr11:70,323,051...70,331,654
Ensembl chr11:70,323,461...70,331,654 		JBrowse link
G Drd2 dopamine receptor D2 ISO RGD PMID:21303898 RGD:11041134 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477 		JBrowse link
G Drd3 dopamine receptor D3 ISO RGD PMID:21303898 RGD:11041134 NCBI chr16:43,574,285...43,646,353
Ensembl chr16:43,574,389...43,643,295 		JBrowse link
G Drd4 dopamine receptor D4 ISO RGD PMID:21303898 RGD:11041134 NCBI chr 7:140,871,931...140,874,868
Ensembl chr 7:140,871,919...140,876,377 		JBrowse link
G Gnai2 G protein subunit alpha i2 ISO RGD PMID:24831693 RGD:11041136 NCBI chr 9:107,491,324...107,512,542
Ensembl chr 9:107,491,324...107,512,566 		JBrowse link
G Gnao1 guanine nucleotide binding protein, alpha O ISO RGD PMID:24831693 RGD:11041136 NCBI chr 8:94,537,213...94,696,016
Ensembl chr 8:94,536,594...94,696,016 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO RGD PMID:21303898 PMID:23940634 RGD:11041134, RGD:13792715 NCBI chr19:4,336,029...4,356,356
Ensembl chr19:4,336,029...4,356,250 		JBrowse link
G Grk3 G protein-coupled receptor kinase 3 ISO RGD PMID:21303898 RGD:11041134 NCBI chr 5:113,058,344...113,163,518
Ensembl chr 5:113,058,348...113,163,657 		JBrowse link
G Grk5 G protein-coupled receptor kinase 5 ISO RGD PMID:21303898 RGD:11041134 NCBI chr19:60,877,995...61,084,406
Ensembl chr19:60,878,187...61,084,406 		JBrowse link
G Grk6 G protein-coupled receptor kinase 6 ISO RGD PMID:21303898 RGD:11041134 NCBI chr13:55,592,865...55,608,740
Ensembl chr13:55,592,885...55,608,740 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 ISO RGD PMID:21303898 RGD:11041134 NCBI chr 1:143,875,076...143,879,887
Ensembl chr 1:143,875,076...143,879,899 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 ISO RGD PMID:21303898 RGD:11041134 NCBI chr 1:169,569,046...169,575,211
Ensembl chr 1:169,569,046...169,575,211 		JBrowse link
G Rgs7 regulator of G protein signaling 7 ISO RGD PMID:21303898 RGD:11041134 NCBI chr 1:174,886,642...175,320,287
Ensembl chr 1:174,886,653...175,320,066 		JBrowse link
G Rgs7bp regulator of G-protein signalling 7 binding protein ISO RGD PMID:21303898 RGD:11041134 NCBI chr13:105,082,412...105,191,438
Ensembl chr13:105,082,412...105,191,438 		JBrowse link
G Rgs9 regulator of G-protein signaling 9 ISO RGD PMID:21303898 RGD:11041134 NCBI chr11:109,116,174...109,189,013
Ensembl chr11:109,116,181...109,188,955 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6072
    signaling pathway 2512
      chemical compound signaling pathway 86
        dopamine signaling pathway 41
          altered dopamine signaling pathway 0
          dopamine signaling pathway via D1 family of receptors 20
          dopamine signaling pathway via D2 family of receptors 17
Path 2
Term Annotations click to browse term
  pathway 6072
    signaling pathway 2512
      signaling pathway pertinent to the brain and nervous system 474
        neuron-to-neuron signaling pathways 288
          neuron-to-neuron signaling pathway via the chemical synapse 286
            dopamine signaling pathway 41
              altered dopamine signaling pathway 0
              dopamine signaling pathway via D1 family of receptors 20
              dopamine signaling pathway via D2 family of receptors 17
paths to the root