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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:hypoxia inducible factor pathway
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Accession:PW:0000360 term browser browse the term
Definition:The hypoxia inducible transcription factor is activated in response to hypoxic conditions to promote the expression of many genes that play important roles in glucose and energy metabolism, angiogenesis and erythropoiesis.
Synonyms:related_synonym: HIF pathway;   Regulation of gene expression by Hypoxia-inducible Factor
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hypoxia inducible factor pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1 ATP binding cassette subfamily B member 1 ISO PID PID:200202 NCBI chrNW_004936763:1,225,355...1,308,257
Ensembl chrNW_004936763:1,226,482...1,297,427 		JBrowse link
G Adm adrenomedullin ISO PID PID:200202 NCBI chrNW_004936528:8,005,223...8,007,586
Ensembl chrNW_004936528:8,005,189...8,007,643 		JBrowse link
G Adora2a adenosine A2a receptor ISO PID PID:200036 NCBI chrNW_004936619:597,970...618,564
Ensembl chrNW_004936619:608,441...616,779 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO PID PID:200202 NCBI chrNW_004936621:620,163...639,115
Ensembl chrNW_004936621:620,074...639,093 		JBrowse link
G Aldoa aldolase, fructose-bisphosphate A ISO PID PID:200202 NCBI chrNW_004936501:12,418,090...12,423,959
Ensembl chrNW_004936501:12,418,090...12,422,689 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 ISO PID PID:200036 NCBI chrNW_004936877:666,545...669,351
Ensembl chrNW_004936877:666,523...669,338 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator ISO PID
RGD		 PMID:22169972 PID:200036 PID:200202 RGD:6483352 NCBI chrNW_004936580:1,038,420...1,093,319
Ensembl chrNW_004936580:1,036,973...1,082,984 		JBrowse link
G Arnt2 aryl hydrocarbon receptor nuclear translocator 2 ISO RGD PMID:22169972 RGD:6483352 NCBI chrNW_004936483:20,041,712...20,218,853
Ensembl chrNW_004936483:20,041,657...20,218,965 		JBrowse link
G Bhlhe40 basic helix-loop-helix family member e40 ISO PID PID:200036 PID:200202 NCBI chrNW_004936577:4,316,099...4,321,193
Ensembl chrNW_004936577:4,315,977...4,322,032 		JBrowse link
G Bhlhe41 basic helix-loop-helix family member e41 ISO PID PID:200202 NCBI chrNW_004936548:1,306,939...1,314,678 JBrowse link
G Bnip3 BCL2 interacting protein 3 ISO PID PID:200202 NCBI chrNW_004936486:18,449,371...18,460,435
Ensembl chrNW_004936486:18,448,494...18,455,927 		JBrowse link
G Ca9 carbonic anhydrase 9 ISO PID PID:200202 NCBI chrNW_004936524:3,672,393...3,678,630
Ensembl chrNW_004936524:3,672,541...3,678,433 		JBrowse link
G Cited2 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 ISO PID PID:200036 PID:200202 NCBI chrNW_004936560:6,353,901...6,356,749
Ensembl chrNW_004936560:6,354,338...6,356,735 		JBrowse link
G Cops5 COP9 signalosome subunit 5 ISO PID PID:200202 NCBI chrNW_004936496:7,035,973...7,050,538
Ensembl chrNW_004936496:7,035,924...7,050,786 		JBrowse link
G Cp ceruloplasmin ISO PID PID:200202 NCBI chrNW_004936519:6,431,156...6,473,183
Ensembl chrNW_004936519:6,431,144...6,481,858 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 ISO PID PID:200202 NCBI chrNW_004936631:3,721,307...3,785,346
Ensembl chrNW_004936631:3,721,313...3,780,892 		JBrowse link
G Crebbp CREB binding protein ISO PID
RGD		 PMID:19364912 PMID:20396958 PID:200036 PID:200202 RGD:6483358 RGD:6483503 NCBI chrNW_004936694:552,447...663,237
Ensembl chrNW_004936694:553,753...663,617 		JBrowse link
G Cul2 cullin 2 ISO RGD PMID:19364912 RGD:6483358 NCBI chrNW_004936574:3,310,304...3,408,389
Ensembl chrNW_004936574:3,309,941...3,408,370 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 ISO PID PID:200202 NCBI chrNW_004936617:4,224,131...4,239,080
Ensembl chrNW_004936617:4,224,131...4,238,796 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 ISO PID PID:200202 NCBI chrNW_004936469:39,794,613...39,798,448
Ensembl chrNW_004936469:39,794,584...39,798,459 		JBrowse link
G Edn1 endothelin 1 ISO PID PID:200202 NCBI chrNW_004936534:885,489...892,292
Ensembl chrNW_004936534:885,287...891,772 		JBrowse link
G Efna1 ephrin A1 ISO PID PID:200036 NCBI chrNW_004936580:4,654,503...4,660,950
Ensembl chrNW_004936580:4,654,503...4,660,966 		JBrowse link
G Egln1 egl-9 family hypoxia inducible factor 1 ISO PID
RGD		 PMID:12876291 PMID:14597660 PMID:19364912 PMID:20396958 PID:200036 PID:200202 RGD:1334466 RGD:6483358 RGD:6483503 RGD:727754 NCBI chrNW_004936484:19,343,770...19,386,087 JBrowse link
G Egln2 egl-9 family hypoxia inducible factor 2 ISO PID
RGD		 PMID:14597660 PMID:20396958 PID:200036 RGD:1334466 RGD:6483503 NCBI chrNW_004936661:3,061,391...3,070,219
Ensembl chrNW_004936661:3,061,308...3,070,192 		JBrowse link
G Egln3 egl-9 family hypoxia inducible factor 3 ISO PID
RGD		 PMID:14597660 PMID:20396958 PID:200036 PID:200202 RGD:1334466 RGD:6483503 NCBI chrNW_004936494:8,240,272...8,267,487
Ensembl chrNW_004936494:8,238,858...8,267,606 		JBrowse link
G Eif3e eukaryotic translation initiation factor 3 subunit E ISO PID PID:200036 NCBI chrNW_004936470:36,556,666...36,599,075
Ensembl chrNW_004936470:36,556,599...36,599,264 		JBrowse link
G Elk1 ETS transcription factor ELK1 ISO PID PID:200036 NCBI chrNW_004936502:13,402,726...13,418,214
Ensembl chrNW_004936502:13,402,728...13,418,214 		JBrowse link
G Elob elongin B ISO PID
RGD		 PMID:19364912 PID:200036 RGD:6483358 NCBI chrNW_004936694:1,296,304...1,301,183
Ensembl chrNW_004936694:1,296,782...1,300,149 		JBrowse link
G Eloc elongin C ISO PID
RGD		 PMID:19364912 PID:200036 RGD:6483358 NCBI chrNW_004936648:2,606,075...2,629,997
Ensembl chrNW_004936648:2,604,283...2,630,035 		JBrowse link
G Eng endoglin ISO PID PID:200202 NCBI chrNW_004936487:15,467,165...15,499,180
Ensembl chrNW_004936487:15,467,835...15,477,488 		JBrowse link
G Eno1 enolase 1 ISO PID PID:200202 NCBI chrNW_004936623:3,115,357...3,130,289
Ensembl chrNW_004936623:3,115,081...3,128,183 		JBrowse link
G Ep300 E1A binding protein p300 ISO PID
RGD		 PMID:19364912 PMID:20396958 PID:200036 PID:200202 RGD:6483358 RGD:6483503 NCBI chrNW_004936492:696,982...778,132
Ensembl chrNW_004936492:696,960...778,138 		JBrowse link
G Epas1 endothelial PAS domain protein 1 ISO PID
RGD		 PMID:20396958 PMID:22169972 PID:200036 RGD:6483352 RGD:6483503 NCBI chrNW_004936508:5,855,748...5,938,879
Ensembl chrNW_004936508:5,855,732...5,938,856 		JBrowse link
G Epo erythropoietin ISO PID PID:200036 PID:200202 NCBI chrNW_004936543:742,722...745,332
Ensembl chrNW_004936543:743,537...745,343 		JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor ISO PID PID:200036 PID:200202 NCBI chrNW_004936572:3,728,971...3,795,612
Ensembl chrNW_004936572:3,730,327...3,795,625 		JBrowse link
G Fech ferrochelatase ISO PID PID:200202 NCBI chrNW_004936497:6,755,626...6,788,568
Ensembl chrNW_004936497:6,755,553...6,790,944 		JBrowse link
G Flt1 fms related receptor tyrosine kinase 1 ISO PID PID:200036 NCBI chrNW_004936472:23,442,946...23,617,523
Ensembl chrNW_004936472:23,440,088...23,617,041 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit ISO PID PID:200202 NCBI chrNW_004936488:4,384,710...4,388,118
Ensembl chrNW_004936488:4,384,705...4,388,122 		JBrowse link
G Furin furin, paired basic amino acid cleaving enzyme ISO PID PID:200202 NCBI chrNW_004936483:16,136,099...16,147,945
Ensembl chrNW_004936483:16,136,099...16,144,635 		JBrowse link
G Fxn frataxin ISO PID PID:200036 NCBI chrNW_004936503:5,323,206...5,343,228 JBrowse link
G Gata2 GATA binding protein 2 ISO PID PID:200202 NCBI chrNW_004936798:406,258...414,785
Ensembl chrNW_004936798:406,258...414,931 		JBrowse link
G Gck glucokinase ISO PID PID:200202 NCBI chrNW_004936478:19,104,477...19,118,915
Ensembl chrNW_004936478:19,105,361...19,158,733 		JBrowse link
G Hdac7 histone deacetylase 7 ISO PID PID:200202 NCBI chrNW_004936512:5,680,564...5,701,182
Ensembl chrNW_004936512:5,682,490...5,697,869 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO RGD
PID		 PMID:12388599 PMID:14597660 PMID:15063765 PMID:18614764 PMID:20396958 More... PID:200202 RGD:1334466 RGD:1580561 RGD:2301848 RGD:628389 RGD:6483352 RGD:6483503 NCBI chrNW_004936495:5,770,988...5,816,157
Ensembl chrNW_004936495:5,770,669...5,816,157 		JBrowse link
G Hif1an hypoxia inducible factor 1 subunit alpha inhibitor ISO PID
RGD		 PMID:14597660 PMID:19364912 PMID:22169972 PID:200036 RGD:1334466 RGD:6483352 RGD:6483358 NCBI chrNW_004936600:5,106,166...5,116,865 JBrowse link
G Hif3a hypoxia inducible factor 3 subunit alpha ISO RGD PMID:11237857 PMID:22169972 RGD:6483352 RGD:68201 NCBI chrNW_004936664:296,288...323,143
Ensembl chrNW_004936664:294,975...323,149 		JBrowse link
G Hk1 hexokinase 1 ISO PID PID:200202 NCBI chrNW_004936521:9,067,062...9,139,112
Ensembl chrNW_004936521:9,066,999...9,159,793 		JBrowse link
G Hk2 hexokinase 2 ISO PID PID:200202 NCBI chrNW_004936556:1,054,143...1,113,425
Ensembl chrNW_004936556:1,054,021...1,113,450 		JBrowse link
G Hmox1 heme oxygenase 1 ISO PID PID:200202 NCBI chrNW_004936492:5,042,353...5,049,216
Ensembl chrNW_004936492:5,042,330...5,049,311 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4 alpha ISO PID PID:200202 NCBI chrNW_004936530:2,401,053...2,425,989
Ensembl chrNW_004936530:2,401,043...2,454,466 		JBrowse link
G Id2 inhibitor of DNA binding 2 ISO PID PID:200202 NCBI chrNW_004936532:5,236,175...5,238,689
Ensembl chrNW_004936532:5,236,037...5,238,881 		JBrowse link
G Igfbp1 insulin like growth factor binding protein 1 ISO PID PID:200202 NCBI chrNW_004936478:20,494,190...20,499,001
Ensembl chrNW_004936478:20,494,203...20,499,001 		JBrowse link
G Itgb2 integrin subunit beta 2 ISO PID PID:200202 NCBI chrNW_004936778:1,286,475...1,311,184
Ensembl chrNW_004936778:1,286,341...1,311,194 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO PID PID:200202 NCBI chrNW_004936522:3,034,364...3,037,632
Ensembl chrNW_004936522:3,035,346...3,036,350 		JBrowse link
G Kdr kinase insert domain receptor ISO PID PID:200036 NCBI chrNW_004936482:17,537,697...17,581,320
Ensembl chrNW_004936482:17,538,864...17,581,002 		JBrowse link
G Ldha lactate dehydrogenase A ISO PID PID:200202 NCBI chrNW_004936528:866,607...879,977 JBrowse link
G Lep leptin ISO PID PID:200202 NCBI chrNW_004936479:15,394,966...15,411,334
Ensembl chrNW_004936479:15,394,966...15,411,334 		JBrowse link
G LOC101970831 serotransferrin ISO PID PID:200202 NCBI chrNW_004936529:6,917,762...6,947,512
Ensembl chrNW_004936529:6,855,958...6,947,394 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member ISO PID PID:200202 NCBI chrNW_004936580:803,452...806,966
Ensembl chrNW_004936580:804,903...806,796 		JBrowse link
G Mmp14 matrix metallopeptidase 14 ISO PID PID:200036 NCBI chrNW_004936722:1,447,189...1,457,632
Ensembl chrNW_004936722:1,447,335...1,457,611 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 ISO PID PID:200202 NCBI chrNW_004936493:7,368,393...7,605,754
Ensembl chrNW_004936493:7,368,462...7,465,615 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 ISO PID PID:200202 NCBI chrNW_004936496:14,844,923...15,102,922
Ensembl chrNW_004936496:14,844,855...15,016,454 		JBrowse link
G Ndrg1 N-myc downstream regulated 1 ISO PID PID:200202 NCBI chrNW_004936470:16,051,291...16,102,563
Ensembl chrNW_004936470:16,051,015...16,102,585 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO PID PID:200202 NCBI chrNW_004936538:4,052,277...4,097,051
Ensembl chrNW_004936538:4,052,448...4,097,051 		JBrowse link
G Npm1 nucleophosmin 1 ISO PID PID:200202 NCBI chrNW_004936609:3,712,628...3,725,635 JBrowse link
G Nt5e 5'-nucleotidase ecto ISO PID PID:200202 NCBI chrNW_004936510:5,797,218...5,846,118
Ensembl chrNW_004936510:5,797,212...5,846,124 		JBrowse link
G Os9 OS9 endoplasmic reticulum lectin ISO RGD PMID:19364912 RGD:6483358 NCBI chrNW_004936646:1,832,434...1,860,200
Ensembl chrNW_004936646:1,832,015...1,859,576 		JBrowse link
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 ISO PID PID:200202 NCBI chrNW_004936484:8,356,523...8,434,529
Ensembl chrNW_004936484:8,356,487...8,434,925 		JBrowse link
G Pfkl phosphofructokinase, liver type ISO PID PID:200202 NCBI chrNW_004936500:94,016...117,598
Ensembl chrNW_004936500:93,854...117,653 		JBrowse link
G Pgk1 phosphoglycerate kinase 1 ISO PID PID:200036 PID:200202 NCBI chrNW_004936547:286,267...310,062
Ensembl chrNW_004936547:286,267...310,062 		JBrowse link
G Pgm1 phosphoglucomutase 1 ISO PID PID:200202 NCBI chrNW_004936692:1,160,836...1,221,270
Ensembl chrNW_004936692:1,160,623...1,221,746 		JBrowse link
G Pkm pyruvate kinase M1/2 ISO PID PID:200202 NCBI chrNW_004936471:31,589,322...31,617,891
Ensembl chrNW_004936471:31,589,324...31,617,873 		JBrowse link
G Plin2 perilipin 2 ISO PID PID:200202 NCBI chrNW_004936652:1,039,248...1,059,983
Ensembl chrNW_004936652:1,039,259...1,060,122 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 ISO PID PID:200036 NCBI chrNW_004936837:827,568...838,933 JBrowse link
G Rack1 receptor for activated C kinase 1 ISO RGD PMID:19364912 RGD:6483358 NCBI chrNW_004936826:748,256...753,460
Ensembl chrNW_004936826:747,291...753,442 		JBrowse link
G Rbx1 ring-box 1 ISO RGD PMID:19364912 RGD:6483358 NCBI chrNW_004936492:872,316...890,860
Ensembl chrNW_004936492:873,576...890,835 		JBrowse link
G Sat1 spermidine/spermine N1-acetyltransferase 1 ISO RGD PMID:19364912 RGD:6483358 NCBI chrNW_004936624:756,761...759,979
Ensembl chrNW_004936624:756,712...759,983 		JBrowse link
G Sat2 spermidine/spermine N1-acetyltransferase family member 2 ISO RGD PMID:19364912 RGD:6483358 NCBI chrNW_004936595:891,380...892,937
Ensembl chrNW_004936595:889,617...893,067 		JBrowse link
G Serpine1 serpin family E member 1 ISO PID PID:200036 PID:200202 NCBI chrNW_004936543:1,032,543...1,040,956
Ensembl chrNW_004936543:1,032,794...1,039,123 		JBrowse link
G Sirt1 sirtuin 1 ISO PID PID:200036 NCBI chrNW_004936521:10,296,097...10,316,673
Ensembl chrNW_004936521:10,296,097...10,322,215 		JBrowse link
G Slc11a2 solute carrier family 11 member 2 ISO PID PID:200036 NCBI chrNW_004936512:8,590,302...8,622,121
Ensembl chrNW_004936512:8,586,262...8,623,597 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 ISO PID PID:200036 PID:200202 NCBI chrNW_004936474:24,205,878...24,236,611
Ensembl chrNW_004936474:24,206,644...24,236,713 		JBrowse link
G Smad3 SMAD family member 3 ISO PID PID:200202 NCBI chrNW_004936471:27,080,662...27,185,861
Ensembl chrNW_004936471:27,080,575...27,189,793 		JBrowse link
G Smad4 SMAD family member 4 ISO PID PID:200202 NCBI chrNW_004936497:12,242,869...12,278,012
Ensembl chrNW_004936497:12,249,140...12,278,123 		JBrowse link
G Sp1 Sp1 transcription factor ISO PID PID:200036 PID:200202 NCBI chrNW_004936512:10,655,116...10,693,025
Ensembl chrNW_004936512:10,655,349...10,693,042 		JBrowse link
G Tert telomerase reverse transcriptase ISO PID PID:200202 NCBI chrNW_004936815:468,987...492,666
Ensembl chrNW_004936815:469,020...491,697 		JBrowse link
G Tfrc transferrin receptor ISO PID PID:200202 NCBI chrNW_004936784:696,738...728,385
Ensembl chrNW_004936784:696,713...728,543 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 ISO PID PID:200036 NCBI chrNW_004936546:5,331,220...5,332,669
Ensembl chrNW_004936546:5,331,863...5,332,555 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO PID PID:200036 PID:200202 NCBI chrNW_004936476:16,245,134...16,261,180
Ensembl chrNW_004936476:16,247,100...16,260,673 		JBrowse link
G Vhl von Hippel-Lindau tumor suppressor ISO RGD
PID		 PMID:15063765 PMID:15611513 PMID:19364912 PID:200036 RGD:1358257 RGD:1580561 RGD:6483358 NCBI chrNW_004936602:3,135,790...3,140,622 JBrowse link
altered hypoxia inducible factor pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vhl von Hippel-Lindau tumor suppressor ISO RGD PMID:22035299 RGD:6907133 NCBI chrNW_004936602:3,135,790...3,140,622 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3951
    signaling pathway 1895
      transcription factor mediated signaling pathway 365
        hypoxia inducible factor pathway 90
          altered hypoxia inducible factor pathway 1
Path 2
Term Annotations click to browse term
  pathway 3951
    regulatory pathway 2451
      homeostasis pathway 1275
        inorganic chemical homeostasis pathway 288
          oxygen homeostasis pathway 90
            hypoxia inducible factor pathway 90
              altered hypoxia inducible factor pathway 1
paths to the root