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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:glycerophospholipid metabolic pathway
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Accession:PW:0000354 term browser browse the term
Definition:Those metabolic reactions involved in the synthesis, utilization and/or degradation of glycerophospholipids, also known as phospholipids. They are key components of membranes and some are also involved in signaling.
Synonyms:related_synonym: KEGG:00564;   SMP:00025;   phospholipid metabolic pathway


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glycerophospholipid metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase ISO SMPDB SMP:00025 NCBI chr 3:8,732,451...8,738,274
Ensembl chr 3:8,732,324...8,739,149
JBrowse link
G AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 ISO SMPDB SMP:00025 NCBI chr 7:24,205,930...24,208,430
Ensembl chr 7:24,204,902...24,213,193
JBrowse link
G CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase ISO SMPDB SMP:00025 NCBI chr 3:18,087,497...18,095,015
Ensembl chr 3:18,084,549...18,091,798
JBrowse link
G CDS1 CDP-diacylglycerol synthase 1 ISO SMPDB SMP:00025 NCBI chr 8:133,959,250...134,041,258
Ensembl chr 8:133,959,245...134,040,759
JBrowse link
G CHAT choline O-acetyltransferase ISO SMPDB SMP:00025 NCBI chr14:90,117,464...90,167,611
Ensembl chr14:90,117,464...90,167,611
JBrowse link
G CHKA choline kinase alpha ISO SMPDB SMP:00025 NCBI chr 2:4,788,508...4,846,667
Ensembl chr 2:4,788,412...4,846,667
JBrowse link
G CHPT1 choline phosphotransferase 1 ISO SMPDB SMP:00025 NCBI chr 5:82,500,925...82,544,390
Ensembl chr 5:82,497,645...82,544,264
JBrowse link
G CRLS1 cardiolipin synthase 1 ISO SMPDB SMP:00025 NCBI chr17:14,860,319...14,892,436
Ensembl chr17:14,860,320...14,892,436
JBrowse link
G DGKA diacylglycerol kinase alpha ISO SMPDB SMP:00025 NCBI chr 5:21,331,473...21,355,614
Ensembl chr 5:21,331,473...21,355,535
JBrowse link
G GDE1 glycerophosphodiester phosphodiesterase 1 ISO SMPDB SMP:00025 NCBI chr 3:26,190,261...26,205,851
Ensembl chr 3:26,190,287...26,206,222
JBrowse link
G GPAM glycerol-3-phosphate acyltransferase, mitochondrial ISO SMPDB SMP:00025 NCBI chr14:122,538,600...122,582,390
Ensembl chr14:122,538,600...122,724,131
JBrowse link
G GPD1 glycerol-3-phosphate dehydrogenase 1 ISO SMPDB SMP:00025 NCBI chr 5:16,008,179...16,021,676
Ensembl chr 5:16,007,448...16,017,825
JBrowse link
G GPD2 glycerol-3-phosphate dehydrogenase 2 ISO SMPDB SMP:00025 NCBI chr15:63,592,723...63,728,636
Ensembl chr15:63,592,698...63,728,634
JBrowse link
G LYPLA1 lysophospholipase 1 ISO SMPDB SMP:00025 NCBI chr 4:77,083,624...77,102,407
Ensembl chr 4:77,083,585...77,102,408
JBrowse link
G PCYT1A phosphate cytidylyltransferase 1, choline, alpha ISO SMPDB SMP:00025 NCBI chr13:133,794,337...133,851,004
Ensembl chr13:133,774,574...133,850,999
JBrowse link
G PEMT phosphatidylethanolamine N-methyltransferase ISO SMPDB SMP:00025 NCBI chr12:60,880,367...60,919,279 JBrowse link
G PGS1 phosphatidylglycerophosphate synthase 1 ISO SMPDB SMP:00025 NCBI chr12:3,589,539...3,628,964
Ensembl chr12:3,589,539...3,628,961
JBrowse link
G PHOSPHO1 phosphoethanolamine/phosphocholine phosphatase 1 ISO SMPDB SMP:00025 NCBI chr12:25,441,564...25,449,267 JBrowse link
G PISD phosphatidylserine decarboxylase ISO SMPDB SMP:00025 NCBI chr14:48,303,459...48,341,820
Ensembl chr14:48,303,458...48,341,796
JBrowse link
G PLA2G2D phospholipase A2 group IID ISO SMPDB SMP:00025 NCBI chr 6:78,391,063...78,397,394
Ensembl chr 6:78,391,062...78,397,514
JBrowse link
G PLA2G4B phospholipase A2 group IVB ISO SMPDB SMP:00025 NCBI chr 1:129,514,801...129,524,365
Ensembl chr 1:129,514,341...129,533,398
JBrowse link
G PLD2 phospholipase D2 ISO SMPDB SMP:00025 NCBI chr12:52,073,913...52,087,804
Ensembl chr12:52,073,896...52,087,809
JBrowse link
G PLPP1 phospholipid phosphatase 1 ISO SMPDB SMP:00025 NCBI chr16:34,604,367...34,741,524
Ensembl chr16:34,600,719...34,744,437
JBrowse link
G PTDSS1 phosphatidylserine synthase 1 ISO SMPDB SMP:00025 NCBI chr 4:40,297,876...40,376,099
Ensembl chr 4:40,297,885...40,376,076
JBrowse link
G PTDSS2 phosphatidylserine synthase 2 ISO SMPDB SMP:00025 NCBI chr 2:256,753...280,803
Ensembl chr 2:256,793...280,802
JBrowse link
G PTPMT1 protein tyrosine phosphatase mitochondrial 1 ISO SMPDB SMP:00025 NCBI chr 2:15,044,432...15,052,815
Ensembl chr 2:15,044,081...15,052,839
JBrowse link
cardiolipin biosynthetic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRLS1 cardiolipin synthase 1 ISO RGD PMID:24769127 RGD:10400850 NCBI chr17:14,860,319...14,892,436
Ensembl chr17:14,860,320...14,892,436
JBrowse link
G PGS1 phosphatidylglycerophosphate synthase 1 ISO RGD PMID:24769127 RGD:10400850 NCBI chr12:3,589,539...3,628,964
Ensembl chr12:3,589,539...3,628,961
JBrowse link
G PTPMT1 protein tyrosine phosphatase mitochondrial 1 ISO RGD PMID:24769127 RGD:10400850 NCBI chr 2:15,044,432...15,052,815
Ensembl chr 2:15,044,081...15,052,839
JBrowse link
G TAMM41 TAM41 mitochondrial translocator assembly and maintenance homolog ISO RGD PMID:24769127 RGD:10400850 NCBI chr13:67,922,476...67,983,526
Ensembl chr13:67,922,480...67,983,526
JBrowse link
cardiolipin metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CKMT1A creatine kinase, mitochondrial 1A ISO RGD PMID:24769127 RGD:10400850 NCBI chr 1:127,852,533...127,859,066 JBrowse link
G CYCS cytochrome c, somatic ISO RGD PMID:24769127 RGD:10400850 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
JBrowse link
G NME4 NME/NM23 nucleoside diphosphate kinase 4 ISO RGD PMID:24769127 RGD:10400850 NCBI chr 3:41,306,167...41,321,002
Ensembl chr 3:41,306,175...41,310,312
JBrowse link
G TAZ tafazzin ISO RGD PMID:24769127 RGD:10400850 NCBI chr  X:124,940,036...124,946,275
Ensembl chr  X:124,940,031...124,947,241
JBrowse link
phosphoinositide metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMBRA1 autophagy and beclin 1 regulator 1 ISO SMPDB SMP:00463 NCBI chr 2:15,935,354...16,119,082
Ensembl chr 2:15,917,698...16,119,082
JBrowse link
G BECN1 beclin 1 ISO SMPDB SMP:00463 NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373
JBrowse link
G CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase ISO SMPDB SMP:00463 NCBI chr 3:18,087,497...18,095,015
Ensembl chr 3:18,084,549...18,091,798
JBrowse link
G EGFR epidermal growth factor receptor ISO SMPDB SMP:00463 NCBI chr 9:139,302,410...139,474,632
Ensembl chr 9:139,300,022...139,478,882
JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 ISO SMPDB SMP:00463 NCBI chr12:22,591,621...22,621,384
Ensembl chr12:22,590,725...22,621,351
JBrowse link
G FIG4 FIG4 phosphoinositide 5-phosphatase ISO SMPDB SMP:00463 NCBI chr 1:75,694,151...75,847,021
Ensembl chr 1:75,692,932...75,847,528
JBrowse link
G INPP4B inositol polyphosphate-4-phosphatase type II B ISO SMPDB SMP:00463 NCBI chr 8:84,812,041...85,555,200
Ensembl chr 8:84,811,772...85,514,518
JBrowse link
G INPP5D inositol polyphosphate-5-phosphatase D ISO SMPDB SMP:00463 NCBI chr15:133,501,067...133,626,647
Ensembl chr15:133,501,092...133,626,647
JBrowse link
G INPP5E inositol polyphosphate-5-phosphatase E ISO SMPDB SMP:00463
G PI4KA phosphatidylinositol 4-kinase alpha ISO SMPDB SMP:00463 NCBI chr14:50,390,416...50,491,983
Ensembl chr14:50,390,408...50,491,950
JBrowse link
G PIK3C2A phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha ISO SMPDB SMP:00463 NCBI chr 2:41,829,969...42,024,062
Ensembl chr 2:41,829,916...42,024,362
JBrowse link
G PIK3C3 phosphatidylinositol 3-kinase catalytic subunit type 3 ISO SMPDB SMP:00463 NCBI chr 6:125,890,598...126,038,753
Ensembl chr 6:125,890,708...126,043,161
JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISO SMPDB SMP:00463 NCBI chr13:117,193,935...117,282,151
Ensembl chr13:117,180,544...117,277,232
JBrowse link
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta ISO SMPDB SMP:00463 NCBI chr 6:70,026,254...70,086,950
Ensembl chr 6:70,026,373...70,099,244
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 ISO SMPDB SMP:00463 NCBI chr16:46,434,757...46,523,626
Ensembl chr16:46,434,873...46,523,609
JBrowse link
G PIK3R4 phosphoinositide-3-kinase regulatory subunit 4 ISO SMPDB SMP:00463 NCBI chr13:1,730,988...1,815,555
Ensembl chr13:1,731,017...1,815,556
JBrowse link
G PIKFYVE phosphoinositide kinase, FYVE-type zinc finger containing ISO SMPDB SMP:00463 NCBI chr15:111,372,148...111,468,720
Ensembl chr15:111,372,173...111,467,919
JBrowse link
G PIP4K2A phosphatidylinositol-5-phosphate 4-kinase type 2 alpha ISO SMPDB SMP:00463 NCBI chr10:52,224,367...52,408,928
Ensembl chr10:52,223,425...52,408,922
JBrowse link
G PIP5K1A phosphatidylinositol-4-phosphate 5-kinase type 1 alpha ISO SMPDB SMP:00463 NCBI chr 4:98,012,941...98,062,166
Ensembl chr 4:98,012,944...98,056,815
JBrowse link
G PLCB1 phospholipase C beta 1 ISO SMPDB SMP:00463 NCBI chr17:17,007,197...17,745,314
Ensembl chr17:17,007,261...17,745,312
JBrowse link
G PTEN phosphatase and tensin homolog ISO SMPDB SMP:00463 NCBI chr14:99,929,590...100,021,619 JBrowse link
G SYNJ1 synaptojanin 1 ISO SMPDB SMP:00463 NCBI chr13:196,230,101...196,330,512
Ensembl chr13:196,230,089...196,330,465
JBrowse link
G VAC14 VAC14 component of PIKFYVE complex ISO SMPDB SMP:00463 NCBI chr 6:13,683,800...13,791,246
Ensembl chr 6:13,683,799...13,791,241
JBrowse link
plasmalogen biosynthetic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 ISO SMPDB SMP:00479 NCBI chr 7:24,205,930...24,208,430
Ensembl chr 7:24,204,902...24,213,193
JBrowse link
G AGPS alkylglycerone phosphate synthase ISO SMPDB SMP:00479 NCBI chr15:83,146,063...83,285,905
Ensembl chr15:83,145,573...83,391,970
JBrowse link
G CEPT1 choline/ethanolamine phosphotransferase 1 ISO SMPDB SMP:00479 NCBI chr 4:109,142,712...109,185,497
Ensembl chr 4:109,142,713...109,183,324
JBrowse link
G GNPAT glyceronephosphate O-acyltransferase ISO SMPDB SMP:00479 NCBI chr14:59,203,519...59,240,303
Ensembl chr14:59,203,090...59,241,247
JBrowse link
G PLPP1 phospholipid phosphatase 1 ISO SMPDB SMP:00479 NCBI chr16:34,604,367...34,741,524
Ensembl chr16:34,600,719...34,744,437
JBrowse link
plasmalogen metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 ISO SMPDB SMP:00479 NCBI chr 7:24,205,930...24,208,430
Ensembl chr 7:24,204,902...24,213,193
JBrowse link
G AGPS alkylglycerone phosphate synthase ISO SMPDB SMP:00479 NCBI chr15:83,146,063...83,285,905
Ensembl chr15:83,145,573...83,391,970
JBrowse link
G CEPT1 choline/ethanolamine phosphotransferase 1 ISO SMPDB SMP:00479 NCBI chr 4:109,142,712...109,185,497
Ensembl chr 4:109,142,713...109,183,324
JBrowse link
G GNPAT glyceronephosphate O-acyltransferase ISO SMPDB SMP:00479 NCBI chr14:59,203,519...59,240,303
Ensembl chr14:59,203,090...59,241,247
JBrowse link
G PLPP1 phospholipid phosphatase 1 ISO SMPDB SMP:00479 NCBI chr16:34,604,367...34,741,524
Ensembl chr16:34,600,719...34,744,437
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4026
    classic metabolic pathway 1006
      lipid metabolic pathway 254
        glycerophospholipid metabolic pathway 56
          altered glycerophospholipid metabolic pathway + 0
          phosphatidylcholine metabolic pathway + 0
          phosphatidylglycerol metabolic process + 8
          phosphatidylinositol metabolic pathway + 23
          phosphatidylserine metabolic process 0
          plasmalogen metabolic pathway + 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.