altered vascular endothelial growth factor signaling pathway - Ontology Report - Rat Genome Database

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The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:	altered vascular endothelial growth factor signaling pathway	go back to main search page
Accession:	PW:0000350	browse the term
Definition:	A VEGF mediated pathway that deviates from what its normal course should be. Aberrant VEGF mediated pathways have been implicated in a number of human cancers. Upregulation of VEGF expression is associated with cancer and tumor growth.
Synonyms:	related_synonym:	altered VEGF signaling pathways

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Genes (3)

altered vascular endothelial growth factor signaling pathway

term browser

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

FMS-like tyrosine kinase 4

NCBI chr11:49,500,506...49,543,566
Ensembl chr11:49,500,090...49,543,566

altered vascular endothelial growth factor signaling pathway involving proteins affecting its expression

term browser

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

kinase insert domain protein receptor

RGD

NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118

G

vascular endothelial growth factor A

RGD

NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295

altered vascular endothelial growth factor signaling pathway involving the main players

term browser

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

FMS-like tyrosine kinase 4

NCBI chr11:49,500,506...49,543,566
Ensembl chr11:49,500,090...49,543,566

G

kinase insert domain protein receptor

RGD

NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118

G

vascular endothelial growth factor A

RGD

NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295

Term paths to the root

Path 1
Term	Annotations
pathway	6072
signaling pathway	2512
growth factor signaling pathway	529
vascular endothelial growth factor signaling pathway	137
altered vascular endothelial growth factor signaling pathway	3
altered vascular endothelial growth factor signaling pathway involving proteins affecting its expression	2
altered vascular endothelial growth factor signaling pathway involving the macromolecules modifying the main players	0
altered vascular endothelial growth factor signaling pathway involving the main players	3
Path 2
Term	Annotations
pathway	6072
regulatory pathway	3689
homeostasis pathway	1721
altered homeostasis pathway	29
altered cardiovascular system homeostasis pathway	3
altered vascular endothelial growth factor signaling pathway	3
altered vascular endothelial growth factor signaling pathway involving proteins affecting its expression	2
altered vascular endothelial growth factor signaling pathway involving the macromolecules modifying the main players	0
altered vascular endothelial growth factor signaling pathway involving the main players	3

paths to the root