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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:transforming growth factor-beta superfamily mediated signaling pathway
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Accession:PW:0000329 term browser browse the term
Definition:The TGF-beta superfamily of growth factors regulates a broad spectrum of processes such as angiogenesis, embryonic development, cell differentiation, proliferation and wound healing. Binding to two types of serine/threonine receptors and activation of Smad proteins is a common theme. However, ligand-receptor interaction and the identity of the activated Smad protein(s) appear to be member-specific.
Synonyms:related_synonym: Signaling by TGF-beta family members;   TGF-beta superfamily mediated signaling pathway



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transforming growth factor-beta superfamily mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 IEA KEGG rno:04350 NCBI chr 3:63,387,378...63,506,980
Ensembl chr 3:42,978,561...43,098,241
JBrowse link
G Acvr1c activin A receptor type 1C IEA KEGG rno:04350 NCBI chr 3:63,224,322...63,301,252
Ensembl chr 3:42,822,610...42,892,327
JBrowse link
G Acvr2a activin A receptor type 2A IEA KEGG rno:04350 NCBI chr 3:53,614,143...53,701,933
Ensembl chr 3:33,205,523...33,289,968
JBrowse link
G Acvr2b activin A receptor type 2B IEA KEGG rno:04350 NCBI chr 8:128,016,589...128,056,193
Ensembl chr 8:119,138,812...119,170,458
JBrowse link
G Amh anti-Mullerian hormone IEA KEGG rno:04350 NCBI chr 7:9,557,451...9,559,867
Ensembl chr 7:8,906,836...8,909,282
JBrowse link
G Amhr2 anti-Mullerian hormone receptor type 2 IEA KEGG rno:04350 NCBI chr 7:135,454,517...135,470,183
Ensembl chr 7:133,579,393...133,588,258
JBrowse link
G Bmp2 bone morphogenetic protein 2 IEA KEGG rno:04350 NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Bmp4 bone morphogenetic protein 4 IEA KEGG rno:04350 NCBI chr15:22,098,191...22,113,145
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Bmp5 bone morphogenetic protein 5 IEA KEGG rno:04350 NCBI chr 8:85,397,629...85,520,374
Ensembl chr 8:76,517,164...76,639,925
JBrowse link
G Bmp6 bone morphogenetic protein 6 IEA KEGG rno:04350 NCBI chr17:26,523,704...26,785,558
Ensembl chr17:26,318,569...26,470,365
JBrowse link
G Bmp7 bone morphogenetic protein 7 IEA KEGG rno:04350 NCBI chr 3:182,059,318...182,135,273
Ensembl chr 3:161,516,462...161,716,788
JBrowse link
G Bmp8a bone morphogenetic protein 8a IEA KEGG rno:04350 NCBI chr 5:135,589,839...135,617,785
Ensembl chr 5:135,591,716...135,617,785
JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A IEA KEGG rno:04350 NCBI chr16:9,740,751...9,786,861
Ensembl chr16:9,736,630...9,780,616
JBrowse link
G Bmpr1b bone morphogenetic protein receptor type 1B IEA KEGG rno:04350 NCBI chr 2:233,211,525...233,544,344
Ensembl chr 2:230,541,558...230,871,368
JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 IEA KEGG rno:04350 NCBI chr 9:68,685,942...68,801,353
Ensembl chr 9:61,190,566...61,301,809
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B IEA KEGG rno:04350 NCBI chr 5:109,123,308...109,134,906
Ensembl chr 5:104,010,680...104,019,050
JBrowse link
G Chrd chordin IEA KEGG rno:04350 NCBI chr11:93,676,400...93,685,584
Ensembl chr11:80,171,994...80,180,673
JBrowse link
G Comp cartilage oligomeric matrix protein IEA KEGG rno:04350 NCBI chr16:19,047,206...19,055,584
Ensembl chr16:19,047,207...19,055,845
JBrowse link
G Crebbp CREB binding protein IEA KEGG rno:04350 NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,335,953...11,461,888
JBrowse link
G Cul1 cullin 1 IEA KEGG rno:04350 NCBI chr 4:77,551,781...77,634,210
Ensembl chr 4:76,551,983...76,627,980
JBrowse link
G Dcn decorin IEA KEGG rno:04350 NCBI chr 7:34,167,973...34,208,004
Ensembl chr 7:32,281,252...32,321,270
JBrowse link
G E2f5 E2F transcription factor 5 IEA KEGG rno:04350 NCBI chr 2:88,718,567...88,734,143
Ensembl chr 2:86,997,332...87,012,990
JBrowse link
G Ep300 E1A binding protein p300 IEA KEGG rno:04350 NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088
JBrowse link
G Fst follistatin IEA KEGG rno:04350 NCBI chr 2:47,856,345...47,863,670
Ensembl chr 2:46,123,439...46,130,571
JBrowse link
G Gdf5 growth differentiation factor 5 IEA KEGG rno:04350 NCBI chr 3:164,914,401...164,918,593
Ensembl chr 3:144,454,338...144,458,612
JBrowse link
G Gdf6 growth differentiation factor 6 IEA KEGG rno:04350 NCBI chr 5:27,793,561...27,809,884
Ensembl chr 5:22,996,246...23,012,567
JBrowse link
G Gdf7 growth differentiation factor 7 IEA KEGG rno:04350 NCBI chr 6:31,171,495...31,182,484
Ensembl chr 6:31,178,119...31,182,447
JBrowse link
G Id1 inhibitor of DNA binding 1 IEA KEGG rno:04350 NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:141,211,267...141,212,419
JBrowse link
G Id2 inhibitor of DNA binding 2 IEA KEGG rno:04350 NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:41,728,946...41,744,400
JBrowse link
G Id3 inhibitor of DNA binding 3 IEA KEGG rno:04350 NCBI chr 5:153,656,253...153,657,860
Ensembl chr 5:148,372,762...148,374,349
JBrowse link
G Id4 inhibitor of DNA binding 4 IEA KEGG rno:04350 NCBI chr17:16,595,724...16,598,293
Ensembl chr17:16,389,387...16,392,470
JBrowse link
G Ifng interferon gamma IEA KEGG rno:04350 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Inhba inhibin subunit beta A IEA KEGG rno:04350 NCBI chr17:53,787,159...53,810,942
Ensembl chr17:49,095,920...49,108,982
JBrowse link
G Inhbb inhibin subunit beta B IEA KEGG rno:04350 NCBI chr13:33,083,671...33,089,373
Ensembl chr13:30,530,860...30,537,832
JBrowse link
G Inhbc inhibin subunit beta C IEA KEGG rno:04350 NCBI chr 7:65,069,450...65,082,919
Ensembl chr 7:63,184,142...63,197,630
JBrowse link
G Inhbe inhibin subunit beta E IEA KEGG rno:04350 NCBI chr 7:65,061,531...65,064,519
Ensembl chr 7:63,176,219...63,179,172
JBrowse link
G Lefty1 left right determination factor 1 IEA KEGG rno:04350 NCBI chr13:95,188,091...95,191,488
Ensembl chr13:92,656,323...92,659,720
JBrowse link
G Lefty2 Left-right determination factor 2 IEA KEGG rno:04350 NCBI chr13:92,610,185...92,620,918
Ensembl chr13:92,615,360...92,619,880
JBrowse link
G Ltbp1 latent transforming growth factor beta binding protein 1 IEA KEGG rno:04350 NCBI chr 6:25,781,625...26,177,346
Ensembl chr 6:20,029,629...20,425,349
JBrowse link
G Mapk1 mitogen activated protein kinase 1 IEA KEGG rno:04350 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 IEA KEGG rno:04350 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor IEA KEGG rno:04350 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nodal nodal growth differentiation factor IEA KEGG rno:04350 NCBI chr20:29,911,258...29,919,659
Ensembl chr20:29,368,436...29,376,837
JBrowse link
G Nog noggin IEA KEGG rno:04350 NCBI chr10:74,625,874...74,627,501
Ensembl chr10:74,128,712...74,130,339
JBrowse link
G Pitx2 paired-like homeodomain 2 IEA KEGG rno:04350 NCBI chr 2:220,391,417...220,411,588
Ensembl chr 2:217,717,693...217,737,293
JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha IEA KEGG rno:04350 NCBI chr10:36,856,534...36,878,789
Ensembl chr10:36,358,101...36,377,862
JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta IEA KEGG rno:04350 NCBI chr16:65,261,178...65,282,658
Ensembl chr16:58,558,122...58,579,576
JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha IEA KEGG rno:04350 NCBI chr 1:69,213,198...69,232,441
Ensembl chr 1:60,540,194...60,560,129
JBrowse link
G Ppp2r1b protein phosphatase 2 scaffold subunit A beta IEA KEGG rno:04350 NCBI chr 8:60,092,540...60,125,512
Ensembl chr 8:51,186,717...51,228,485
JBrowse link
G Rbl1 RB transcriptional corepressor like 1 IEA KEGG rno:04350 NCBI chr 3:166,226,187...166,289,862
Ensembl chr 3:145,807,095...145,869,330
JBrowse link
G Rbl2 RB transcriptional corepressor like 2 IEA KEGG rno:04350 NCBI chr19:32,049,690...32,096,467
Ensembl chr19:15,876,853...15,923,572
JBrowse link
G Rbx1 ring-box 1 IEA KEGG rno:04350 NCBI chr 7:114,870,893...114,881,194
Ensembl chr 7:112,990,835...113,001,051
JBrowse link
G Rhoa ras homolog family member A IEA KEGG rno:04350 NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 IEA KEGG rno:04350 NCBI chr18:1,387,360...1,509,218
Ensembl chr18:1,115,905...1,235,571
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 IEA KEGG rno:04350 NCBI chr 6:45,407,823...45,502,773
Ensembl chr 6:39,679,082...39,774,031
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 IEA KEGG rno:04350 NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 IEA KEGG rno:04350 NCBI chr 1:210,880,824...210,887,556
Ensembl chr 1:201,451,265...201,458,078
JBrowse link
G RSA-14-44 RSA-14-44 protein IEA KEGG rno:04350 NCBI chr 4:95,251,657...95,253,029
Ensembl chr 4:95,251,610...95,253,088
JBrowse link
G Skp1 S-phase kinase-associated protein 1 IEA KEGG rno:04350 NCBI chr10:36,898,670...36,917,828
Ensembl chr10:36,402,153...36,417,388
JBrowse link
G Smad1 SMAD family member 1 IEA KEGG rno:04350 NCBI chr19:45,417,430...45,477,962
Ensembl chr19:28,513,131...28,573,651
JBrowse link
G Smad2 SMAD family member 2 IEA KEGG rno:04350 NCBI chr18:72,124,792...72,193,345
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Smad3 SMAD family member 3 IEA KEGG rno:04350 NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Smad4 SMAD family member 4 IEA KEGG rno:04350 NCBI chr18:69,518,988...69,549,684
Ensembl chr18:67,243,742...67,274,438
JBrowse link
G Smad5 SMAD family member 5 IEA KEGG rno:04350 NCBI chr17:7,862,332...7,891,678
Ensembl chr17:7,864,720...7,891,634
JBrowse link
G Smad6 SMAD family member 6 IEA KEGG rno:04350 NCBI chr 8:73,345,457...73,414,985
Ensembl chr 8:64,450,114...64,519,763
JBrowse link
G Smad7 SMAD family member 7 IEA KEGG rno:04350 NCBI chr18:71,263,508...71,291,849
Ensembl chr18:68,988,429...69,016,765
JBrowse link
G Smad9 SMAD family member 9 IEA KEGG rno:04350 NCBI chr 2:141,106,668...141,156,477
Ensembl chr 2:138,986,471...139,006,307
JBrowse link
G Smurf2 SMAD specific E3 ubiquitin protein ligase 2 IEA KEGG rno:04350 NCBI chr10:91,761,798...91,862,485
Ensembl chr10:91,761,807...91,862,488
JBrowse link
G Sp1 Sp1 transcription factor IEA KEGG rno:04350 NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Tfdp1 transcription factor Dp-1 IEA KEGG rno:04350 NCBI chr16:82,864,220...82,903,166
Ensembl chr16:76,162,043...76,200,817
JBrowse link
G Tgfb1 transforming growth factor, beta 1 IEA KEGG rno:04350 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfb2 transforming growth factor, beta 2 IEA KEGG rno:04350 NCBI chr13:100,691,540...100,793,227
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Tgfb3 transforming growth factor, beta 3 IEA KEGG rno:04350 NCBI chr 6:111,435,170...111,457,646
Ensembl chr 6:105,704,236...105,726,564
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 IEA KEGG rno:04350 NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:61,653,233...61,710,777
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 IEA KEGG rno:04350 NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:115,794,537...115,883,228
JBrowse link
G Thbs1 thrombospondin 1 IEA KEGG rno:04350 NCBI chr 3:125,510,250...125,525,402
Ensembl chr 3:105,056,292...105,071,440
JBrowse link
G Thbs2 thrombospondin 2 IEA KEGG rno:04350 NCBI chr 1:64,343,523...64,372,918
Ensembl chr 1:55,670,394...55,699,789
JBrowse link
G Thbs4 thrombospondin 4 IEA KEGG rno:04350 NCBI chr 2:25,718,219...25,760,345
Ensembl chr 2:23,983,158...24,026,313
JBrowse link
G Tnf tumor necrosis factor IEA KEGG rno:04350 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Zfyve16 zinc finger FYVE-type containing 16 IEA KEGG rno:04350 NCBI chr 2:25,448,264...25,495,180
Ensembl chr 2:23,713,766...23,756,990
JBrowse link
G Zfyve9 zinc finger FYVE-type containing 9 IEA KEGG rno:04350 NCBI chr 5:123,370,677...123,529,699
Ensembl chr 5:123,370,677...123,529,699
JBrowse link
activin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 TAS
ISO
PID
RGD
PMID:12770730 PID:200029, RGD:1559169 NCBI chr 3:63,387,378...63,506,980
Ensembl chr 3:42,978,561...43,098,241
JBrowse link
G Acvr1b activin A receptor type 1B TAS
IMP
RGD PMID:12770730 PMID:17040568 RGD:1559169, RGD:2315948 NCBI chr 7:134,164,987...134,208,389
Ensembl chr 7:132,286,275...132,329,673
JBrowse link
G Acvr2a activin A receptor type 2A TAS RGD PMID:12770730 RGD:1559169 NCBI chr 3:53,614,143...53,701,933
Ensembl chr 3:33,205,523...33,289,968
JBrowse link
G Acvr2b activin A receptor type 2B TAS RGD PMID:12770730 RGD:1559169 NCBI chr 8:128,016,589...128,056,193
Ensembl chr 8:119,138,812...119,170,458
JBrowse link
G Acvrl1 activin A receptor like type 1 TAS
ISO
PID
RGD
PMID:12770730 PID:200029, RGD:1559169 NCBI chr 7:134,117,917...134,135,306
Ensembl chr 7:132,239,729...132,256,591
JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A ISO PID PID:200029 NCBI chr 3:160,500,748...160,520,492
Ensembl chr 3:140,040,278...140,060,743
JBrowse link
G Smad2 SMAD family member 2 TAS RGD PMID:12770730 RGD:1559169 NCBI chr18:72,124,792...72,193,345
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Smad3 SMAD family member 3 TAS RGD PMID:12770730 RGD:1559169 NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
altered transforming growth factor-beta Smad dependent signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smad2 SMAD family member 2 ISO RGD PMID:17613544 PMID:18662538 RGD:2306282, RGD:2308865 NCBI chr18:72,124,792...72,193,345
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Smad3 SMAD family member 3 ISO RGD PMID:17613544 PMID:18772397 RGD:2306282, RGD:5490966 NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Smad4 SMAD family member 4 ISO RGD PMID:17613544 PMID:18662538 PMID:18772397 PMID:19506583 RGD:2306282, RGD:2308865, RGD:5490966, RGD:5490965 NCBI chr18:69,518,988...69,549,684
Ensembl chr18:67,243,742...67,274,438
JBrowse link
G Smad7 SMAD family member 7 ISO RGD PMID:18662538 RGD:2308865 NCBI chr18:71,263,508...71,291,849
Ensembl chr18:68,988,429...69,016,765
JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO RGD PMID:18313409 PMID:17613544 RGD:2299005, RGD:2306282 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 ISO RGD PMID:18313409 PMID:17613544 RGD:2299005, RGD:2306282 NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:61,653,233...61,710,777
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 ISO RGD PMID:18313409 PMID:17613544 PMID:18662538 PMID:18772397 PMID:19506583 RGD:2299005, RGD:2306282, RGD:2308865, RGD:5490966, RGD:5490965 NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:115,794,537...115,883,228
JBrowse link
Bone morphogenetic proteins signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahsg alpha-2-HS-glycoprotein ISO PID PID:200144 NCBI chr11:91,625,975...91,632,583
Ensembl chr11:78,117,918...78,145,999
JBrowse link
G Bambi BMP and activin membrane-bound inhibitor ISO PID PID:200144 NCBI chr17:58,816,438...58,821,003
Ensembl chr17:54,121,255...54,126,060
JBrowse link
G Bmp2 bone morphogenetic protein 2 IMP
ISO
PID
RGD
PMID:16361357 PID:200144, RGD:1580077 NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Bmp4 bone morphogenetic protein 4 ISO PID
RGD
PMID:18985159 PID:200144, RGD:11553861 NCBI chr15:22,098,191...22,113,145
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Bmp6 bone morphogenetic protein 6 ISO PID PID:200144 NCBI chr17:26,523,704...26,785,558
Ensembl chr17:26,318,569...26,470,365
JBrowse link
G Bmp7 bone morphogenetic protein 7 ISO PID PID:200144 NCBI chr 3:182,059,318...182,135,273
Ensembl chr 3:161,516,462...161,716,788
JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A ISO PID PID:200144 NCBI chr16:9,740,751...9,786,861
Ensembl chr16:9,736,630...9,780,616
JBrowse link
G Bmpr1b bone morphogenetic protein receptor type 1B ISO PID PID:200144 NCBI chr 2:233,211,525...233,544,344
Ensembl chr 2:230,541,558...230,871,368
JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 IMP
ISO
PID
RGD
PMID:16361357 PID:200144, RGD:1580077 NCBI chr 9:68,685,942...68,801,353
Ensembl chr 9:61,190,566...61,301,809
JBrowse link
G Cer1 cerberus 1, DAN family BMP antagonist ISO PID PID:200144 NCBI chr 5:102,352,364...102,355,720
Ensembl chr 5:97,306,431...97,309,783
JBrowse link
G Chrd chordin ISO PID PID:200144 NCBI chr11:93,676,400...93,685,584
Ensembl chr11:80,171,994...80,180,673
JBrowse link
G Chrdl1 chordin-like 1 ISO PID PID:200144 NCBI chr  X:111,685,864...111,789,684
Ensembl chr  X:106,889,125...106,992,921
JBrowse link
G Ctdsp1 CTD small phosphatase 1 ISO PID PID:200144 NCBI chr 9:83,422,755...83,428,411
Ensembl chr 9:75,973,962...75,979,297
JBrowse link
G Ctdsp2 CTD small phosphatase 2 ISO PID PID:200144 NCBI chr 7:62,805,398...62,825,306
Ensembl chr 7:62,805,658...62,825,302
JBrowse link
G Ctdspl CTD small phosphatase like ISO PID PID:200144 NCBI chr 8:118,642,729...118,767,238
Ensembl chr 8:118,642,672...118,767,117
JBrowse link
G Fst follistatin ISO PID PID:200144 NCBI chr 2:47,856,345...47,863,670
Ensembl chr 2:46,123,439...46,130,571
JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist ISO PID PID:200144 NCBI chr 3:120,966,639...120,978,319
Ensembl chr 3:100,512,313...100,524,082
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta ISO PID PID:200144 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hjv hemojuvelin BMP co-receptor ISO PID PID:200144 NCBI chr 2:186,754,801...186,758,708
Ensembl chr 2:184,065,970...184,069,850
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 ISO PID PID:200144 NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:46,357,931...46,415,597
JBrowse link
G Mapk1 mitogen activated protein kinase 1 ISO PID PID:200144 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Nog noggin ISO PID PID:200144 NCBI chr10:74,625,874...74,627,501
Ensembl chr10:74,128,712...74,130,339
JBrowse link
G Nup214 nucleoporin 214 ISO PID PID:200144 NCBI chr 3:35,652,841...35,738,323
Ensembl chr 3:15,255,119...15,340,568
JBrowse link
G Ppm1a protein phosphatase, Mg2+/Mn2+ dependent, 1A ISO PID PID:200144 NCBI chr 6:97,174,955...97,216,585
Ensembl chr 6:91,438,834...91,480,697
JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha ISO PID PID:200144 NCBI chr 1:210,914,576...210,918,193
Ensembl chr 1:201,485,085...201,497,327
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A ISO PID PID:200144 NCBI chr 1:105,136,521...105,139,596
Ensembl chr 1:96,000,058...96,003,171
JBrowse link
G Rgma repulsive guidance molecule BMP co-receptor a ISO PID PID:200144 NCBI chr 1:127,128,934...127,172,918
Ensembl chr 1:127,128,934...127,172,918
JBrowse link
G Rgmb repulsive guidance molecule BMP co-receptor b ISO PID PID:200144 NCBI chr 1:56,766,598...56,792,396
Ensembl chr 1:56,767,850...56,792,425
JBrowse link
G Ski Ski proto-oncogene ISO PID PID:200144 NCBI chr 5:170,995,851...171,064,957
Ensembl chr 5:165,714,093...165,782,733
JBrowse link
G Slc39a13 solute carrier family 39 member 13 ISO RGD PMID:18985159 RGD:11553861 NCBI chr 3:97,495,229...97,504,279
Ensembl chr 3:77,037,565...77,049,226
JBrowse link
G Smad1 SMAD family member 1 IMP
ISO
PID
RGD
PMID:16361357 PMID:18985159 PID:200144, RGD:1580077, RGD:11553861 NCBI chr19:45,417,430...45,477,962
Ensembl chr19:28,513,131...28,573,651
JBrowse link
G Smad4 SMAD family member 4 ISO PID PID:200144 NCBI chr18:69,518,988...69,549,684
Ensembl chr18:67,243,742...67,274,438
JBrowse link
G Smad5 SMAD family member 5 IMP
ISO
PID
RGD
PMID:16361357 PMID:18985159 PID:200144, RGD:1580077, RGD:11553861 NCBI chr17:7,862,332...7,891,678
Ensembl chr17:7,864,720...7,891,634
JBrowse link
G Smad6 SMAD family member 6 ISO PID PID:200144 NCBI chr 8:73,345,457...73,414,985
Ensembl chr 8:64,450,114...64,519,763
JBrowse link
G Smad7 SMAD family member 7 ISO PID PID:200144 NCBI chr18:71,263,508...71,291,849
Ensembl chr18:68,988,429...69,016,765
JBrowse link
G Smad9 SMAD family member 9 IMP
ISO
PID
RGD
PMID:16361357 PID:200144, RGD:1580077 NCBI chr 2:141,106,668...141,156,477
Ensembl chr 2:138,986,471...139,006,307
JBrowse link
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 ISO PID PID:200144 NCBI chr12:14,748,717...14,840,273
Ensembl chr12:9,635,025...9,726,519
JBrowse link
G Smurf2 SMAD specific E3 ubiquitin protein ligase 2 ISO PID PID:200144 NCBI chr10:91,761,798...91,862,485
Ensembl chr10:91,761,807...91,862,488
JBrowse link
G Sostdc1 sclerostin domain containing 1 ISO PID PID:200144 NCBI chr 6:58,778,623...58,782,797
Ensembl chr 6:53,051,354...53,055,579
JBrowse link
G Stambp Stam binding protein ISS RGD PMID:11483516 RGD:1549422 NCBI chr 4:116,055,563...116,083,563
Ensembl chr 4:116,056,057...116,080,543
JBrowse link
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 ISO PID PID:200144 NCBI chr 7:113,556,157...113,587,351
Ensembl chr 7:111,686,371...111,707,058
JBrowse link
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 ISO PID PID:200144 NCBI chr 1:4,195,400...4,245,485
Ensembl chr 1:2,375,490...2,424,756
JBrowse link
G Xiap X-linked inhibitor of apoptosis ISO PID PID:200144 NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
G Zfyve16 zinc finger FYVE-type containing 16 ISO PID PID:200144 NCBI chr 2:25,448,264...25,495,180
Ensembl chr 2:23,713,766...23,756,990
JBrowse link
transforming growth factor-beta signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav1 caveolin 1 IMP RGD PMID:29069575 RGD:151347449 NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Park7 Parkinsonism associated deglycase IDA RGD PMID:29069575 RGD:151347449 NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:161,353,719...161,376,970
JBrowse link
G Tsc2 TSC complex subunit 2 ISO RGD PMID:15066998 RGD:1580519 NCBI chr10:14,125,679...14,160,317
Ensembl chr10:13,621,136...13,655,951
JBrowse link
transforming growth factor-beta Smad dependent signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin IMP RGD PMID:12809600 RGD:2298922 NCBI chr 4:156,570,163...156,619,870
Ensembl chr 4:154,897,877...154,947,786
JBrowse link
G Arrb2 arrestin, beta 2 ISO PID PID:200227 NCBI chr10:55,645,539...55,653,485
Ensembl chr10:55,146,818...55,154,850
JBrowse link
G Atf3 activating transcription factor 3 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr13:105,274,103...105,331,653
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Axin1 axin 1 ISO PID PID:200227 NCBI chr10:15,667,894...15,720,092
Ensembl chr10:15,163,684...15,215,615
JBrowse link
G Bambi BMP and activin membrane-bound inhibitor ISO PID PID:200227 NCBI chr17:58,816,438...58,821,003
Ensembl chr17:54,121,255...54,126,060
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha ISO PID PID:200227 NCBI chr18:56,648,779...56,711,505
Ensembl chr18:54,378,784...54,438,994
JBrowse link
G Cav1 caveolin 1 ISO PID PID:200227 NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Ccn2 cellular communication network factor 2 ISO PID PID:200227 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Creb1 cAMP responsive element binding protein 1 IMP RGD PMID:16891311 RGD:1625706 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Crebbp CREB binding protein ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,335,953...11,461,888
JBrowse link
G Ctnnb1 catenin beta 1 ISO PID PID:200227 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Dact2 dishevelled-binding antagonist of beta-catenin 2 ISO PID PID:200227 NCBI chr 1:63,854,182...63,864,153
Ensembl chr 1:55,181,024...55,191,096
JBrowse link
G Daxx death-domain associated protein ISO PID PID:200227 NCBI chr20:4,971,973...4,978,062
Ensembl chr20:4,970,092...4,975,843
JBrowse link
G Dcn decorin ISO RGD PMID:12809600 RGD:2298922 NCBI chr 7:34,167,973...34,208,004
Ensembl chr 7:32,281,252...32,321,270
JBrowse link
G Dynlrb1 dynein light chain roadblock-type 1 ISO PID PID:200227 NCBI chr 3:143,742,427...143,764,227
Ensembl chr 3:143,742,586...143,764,227
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A ISO PID PID:200227 NCBI chr 2:144,911,247...144,944,705
Ensembl chr 2:142,761,416...142,795,068
JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A ISO PID
RGD
PMID:12809600 PID:200227, RGD:2298922 NCBI chr 3:160,500,748...160,520,492
Ensembl chr 3:140,040,278...140,060,743
JBrowse link
G Foxh1 forkhead box H1 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr 7:110,268,608...110,272,105
Ensembl chr 7:108,387,969...108,390,049
JBrowse link
G Foxo1 forkhead box O1 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Foxo3 forkhead box O3 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr20:47,251,968...47,348,254
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Foxo4 forkhead box O4 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr  X:70,425,218...70,432,120
Ensembl chr  X:66,385,558...66,392,115
JBrowse link
G Grb2 growth factor receptor bound protein 2 ISO PID PID:200227 NCBI chr10:101,380,354...101,448,138
Ensembl chr10:100,869,718...100,949,309
JBrowse link
G Itch itchy E3 ubiquitin protein ligase ISO PID PID:200227 NCBI chr 3:164,102,490...164,193,932
Ensembl chr 3:143,645,637...143,733,543
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 ISO PID PID:200227 NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:46,357,931...46,415,597
JBrowse link
G Nedd4l NEDD4 like E3 ubiquitin protein ligase ISO PID PID:200227 NCBI chr18:60,663,918...60,996,824
Ensembl chr18:58,393,509...58,723,137
JBrowse link
G Ocln occludin ISO PID PID:200227 NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:31,657,220...31,764,150
JBrowse link
G Pard6a par-6 family cell polarity regulator alpha ISO PID PID:200227 NCBI chr19:50,499,420...50,502,301
Ensembl chr19:33,589,542...33,591,900
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 ISO PID PID:200227 NCBI chr10:13,610,000...13,687,226
Ensembl chr10:13,105,498...13,174,623
JBrowse link
G Pml PML nuclear body scaffold ISO PID PID:200227 NCBI chr 8:67,523,164...67,557,801
Ensembl chr 8:58,628,837...58,658,971
JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha ISO PID PID:200227 NCBI chr 1:210,914,576...210,918,193
Ensembl chr 1:201,485,085...201,497,327
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A ISO PID PID:200227 NCBI chr 1:105,136,521...105,139,596
Ensembl chr 1:96,000,058...96,003,171
JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha ISO PID PID:200227 NCBI chr10:36,856,534...36,878,789
Ensembl chr10:36,358,101...36,377,862
JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta ISO PID PID:200227 NCBI chr16:65,261,178...65,282,658
Ensembl chr16:58,558,122...58,579,576
JBrowse link
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha ISO PID PID:200227 NCBI chr15:45,380,142...45,439,428
Ensembl chr15:41,204,200...41,263,924
JBrowse link
G Rhoa ras homolog family member A ISO PID PID:200227 NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Rnf111 ring finger protein 111 ISO PID PID:200227 NCBI chr 8:79,984,831...80,061,022
Ensembl chr 8:71,103,973...71,145,070
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 ISO PID PID:200227 NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Runx1 RUNX family transcription factor 1 IMP RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr11:45,325,778...45,560,300
Ensembl chr11:31,843,764...32,074,542
JBrowse link
G Runx2 RUNX family transcription factor 2 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Runx3 RUNX family transcription factor 3 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr 5:152,644,270...152,702,835
Ensembl chr 5:147,360,994...147,419,156
JBrowse link
G Shc1 SHC adaptor protein 1 ISO PID PID:200227 NCBI chr 2:177,135,649...177,147,257
Ensembl chr 2:174,837,930...174,849,536
JBrowse link
G Skil SKI-like proto-oncogene ISO PID PID:200227 NCBI chr 2:114,175,534...114,203,663
Ensembl chr 2:112,247,051...112,275,080
JBrowse link
G Smad2 SMAD family member 2 IDA
ISO
IMP
PID
RGD
PMID:16959941 PMID:12809600 PMID:18684975 PID:200227, RGD:1599906, RGD:2298922, RGD:2302517 NCBI chr18:72,124,792...72,193,345
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Smad3 SMAD family member 3 ISO
IDA
IMP
PID
RGD
PMID:12809600 PMID:12702545 PMID:16891311 PID:200227, RGD:2298922, RGD:1299323, RGD:1625706 NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Smad4 SMAD family member 4 IDA
ISO
PID
RGD
PMID:16959941 PMID:12809600 PID:200227, RGD:1599906, RGD:2298922 NCBI chr18:69,518,988...69,549,684
Ensembl chr18:67,243,742...67,274,438
JBrowse link
G Smad7 SMAD family member 7 ISO PID
RGD
PMID:12809600 PID:200227, RGD:2298922 NCBI chr18:71,263,508...71,291,849
Ensembl chr18:68,988,429...69,016,765
JBrowse link
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 ISO PID
RGD
PMID:12809600 PID:200227, RGD:2298922 NCBI chr12:14,748,717...14,840,273
Ensembl chr12:9,635,025...9,726,519
JBrowse link
G Smurf2 SMAD specific E3 ubiquitin protein ligase 2 ISO PID
RGD
PMID:12809600 PID:200227, RGD:2298922 NCBI chr10:91,761,798...91,862,485
Ensembl chr10:91,761,807...91,862,488
JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 ISO PID PID:200227 NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:14,533,360...14,611,107
JBrowse link
G Sptbn1 spectrin, beta, non-erythrocytic 1 ISO PID PID:200227 NCBI chr14:108,042,629...108,217,884
Ensembl chr14:103,842,684...104,008,507
JBrowse link
G Strap serine/threonine kinase receptor associated protein ISO PID PID:200227 NCBI chr 4:170,646,042...170,660,291
Ensembl chr 4:170,646,001...170,660,828
JBrowse link
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 ISO PID PID:200227 NCBI chr 7:113,556,157...113,587,351
Ensembl chr 7:111,686,371...111,707,058
JBrowse link
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 ISO PID PID:200227 NCBI chr 1:4,195,400...4,245,485
Ensembl chr 1:2,375,490...2,424,756
JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO PID
RGD
PMID:15109563 PID:200227, RGD:2298921 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfb2 transforming growth factor, beta 2 ISO PID
RGD
PMID:15109563 PID:200227, RGD:2298921 NCBI chr13:100,691,540...100,793,227
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Tgfb3 transforming growth factor, beta 3 ISO PID
RGD
PMID:12809600 PID:200227, RGD:2298922 NCBI chr 6:111,435,170...111,457,646
Ensembl chr 6:105,704,236...105,726,564
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 ISO
IMP
RGD PMID:12809600 PMID:18684975 RGD:2298922, RGD:2302517 NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:61,653,233...61,710,777
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 ISO
IMP
PID
RGD
PMID:15109563 PMID:14729511 PMID:18684975 PID:200227, RGD:2298921, RGD:1579921, RGD:2302517 NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:115,794,537...115,883,228
JBrowse link
G Tgfbr3 transforming growth factor beta receptor 3 ISO PID
RGD
PMID:12809600 PID:200227, RGD:2298922 NCBI chr14:2,634,294...2,810,269
Ensembl chr14:2,489,397...2,663,341
JBrowse link
G Tgfbrap1 transforming growth factor, beta receptor associated protein 1 ISO PID PID:200227 NCBI chr 9:45,320,975...45,371,329
Ensembl chr 9:45,320,930...45,371,311
JBrowse link
G Wwp1 WW domain containing E3 ubiquitin protein ligase 1 ISO PID PID:200227 NCBI chr 5:37,889,280...37,982,743
Ensembl chr 5:33,098,494...33,186,046
JBrowse link
G Xiap X-linked inhibitor of apoptosis ISO PID PID:200227 NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
G Yap1 Yes1 associated transcriptional regulator ISO PID PID:200227 NCBI chr 8:13,380,551...13,451,640
Ensembl chr 8:5,095,722...5,167,010
JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon ISO PID PID:200227 NCBI chr10:61,082,934...61,120,618
Ensembl chr10:60,584,652...60,671,589
JBrowse link
G Zfyve16 zinc finger FYVE-type containing 16 ISO PID PID:200227 NCBI chr 2:25,448,264...25,495,180
Ensembl chr 2:23,713,766...23,756,990
JBrowse link
G Zfyve9 zinc finger FYVE-type containing 9 ISO PID
RGD
PMID:12809600 PID:200227, RGD:2298922 NCBI chr 5:123,370,677...123,529,699
Ensembl chr 5:123,370,677...123,529,699
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2636
      growth factor signaling pathway 523
        transforming growth factor-beta superfamily mediated signaling pathway 150
          Bone morphogenetic proteins signaling pathway + 44
          Nodal signaling pathway 0
          activin signaling pathway 8
          altered transforming growth factor-beta superfamily mediated signaling pathway + 7
          transforming growth factor-beta signaling pathway + 68
paths to the root