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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:transforming growth factor-beta superfamily mediated signaling pathway
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Accession:PW:0000329 term browser browse the term
Definition:The TGF-beta superfamily of growth factors regulates a broad spectrum of processes such as angiogenesis, embryonic development, cell differentiation, proliferation and wound healing. Binding to two types of serine/threonine receptors and activation of Smad proteins is a common theme. However, ligand-receptor interaction and the identity of the activated Smad protein(s) appear to be member-specific.
Synonyms:related_synonym: Signaling by TGF-beta family members;   TGF-beta superfamily mediated signaling pathway


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transforming growth factor-beta superfamily mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVR1 activin A receptor type 1 IEA KEGG hsa:04350 NCBI chr 2:157,736,446...157,876,330
Ensembl chr 2:157,736,251...157,876,330 		JBrowse link
G ACVR1C activin A receptor type 1C IEA KEGG hsa:04350 NCBI chr 2:157,526,767...157,628,864
Ensembl chr 2:157,526,767...157,628,864 		JBrowse link
G ACVR2A activin A receptor type 2A IEA KEGG hsa:04350 NCBI chr 2:147,844,517...147,930,822
Ensembl chr 2:147,844,517...147,930,826 		JBrowse link
G ACVR2B activin A receptor type 2B IEA KEGG hsa:04350 NCBI chr 3:38,453,890...38,493,142
Ensembl chr 3:38,453,890...38,493,142 		JBrowse link
G AMH anti-Mullerian hormone IEA KEGG hsa:04350 NCBI chr19:2,249,323...2,252,073
Ensembl chr19:2,249,309...2,252,073 		JBrowse link
G AMHR2 anti-Mullerian hormone receptor type 2 IEA KEGG hsa:04350 NCBI chr12:53,423,855...53,431,672
Ensembl chr12:53,423,855...53,431,672 		JBrowse link
G BMP2 bone morphogenetic protein 2 IEA KEGG hsa:04350 NCBI chr20:6,767,686...6,780,246
Ensembl chr20:6,767,686...6,780,246 		JBrowse link
G BMP4 bone morphogenetic protein 4 IEA KEGG hsa:04350 NCBI chr14:53,949,736...53,956,891
Ensembl chr14:53,949,736...53,958,761 		JBrowse link
G BMP5 bone morphogenetic protein 5 IEA KEGG hsa:04350 NCBI chr 6:55,753,653...55,875,590
Ensembl chr 6:55,753,653...55,875,590 		JBrowse link
G BMP6 bone morphogenetic protein 6 IEA KEGG hsa:04350 NCBI chr 6:7,726,099...7,881,728
Ensembl chr 6:7,726,099...7,881,728 		JBrowse link
G BMP7 bone morphogenetic protein 7 IEA KEGG hsa:04350 NCBI chr20:57,168,753...57,266,641
Ensembl chr20:57,168,753...57,266,641 		JBrowse link
G BMP8A bone morphogenetic protein 8a IEA KEGG hsa:04350 NCBI chr 1:39,491,636...39,529,869
Ensembl chr 1:39,491,636...39,529,869 		JBrowse link
G BMP8B bone morphogenetic protein 8b IEA KEGG hsa:04350 NCBI chr 1:39,757,182...39,788,865
Ensembl chr 1:39,757,182...39,788,865 		JBrowse link
G BMPR1A bone morphogenetic protein receptor type 1A IEA KEGG hsa:04350 NCBI chr10:86,755,763...86,932,844
Ensembl chr10:86,755,786...86,932,825 		JBrowse link
G BMPR1B bone morphogenetic protein receptor type 1B IEA KEGG hsa:04350 NCBI chr 4:94,757,955...95,158,450
Ensembl chr 4:94,757,955...95,158,448 		JBrowse link
G BMPR2 bone morphogenetic protein receptor type 2 IEA KEGG hsa:04350 NCBI chr 2:202,376,327...202,567,749
Ensembl chr 2:202,376,327...202,567,751 		JBrowse link
G CDKN2B cyclin dependent kinase inhibitor 2B IEA KEGG hsa:04350 NCBI chr 9:22,002,903...22,009,313
Ensembl chr 9:22,002,903...22,009,305 		JBrowse link
G CHRD chordin IEA KEGG hsa:04350 NCBI chr 3:184,380,054...184,390,739
Ensembl chr 3:184,380,054...184,390,736 		JBrowse link
G COMP cartilage oligomeric matrix protein IEA KEGG hsa:04350 NCBI chr19:18,782,773...18,791,305
Ensembl chr19:18,782,773...18,791,305 		JBrowse link
G CREBBP CREB binding protein IEA KEGG hsa:04350 NCBI chr16:3,725,054...3,880,713
Ensembl chr16:3,725,054...3,880,713 		JBrowse link
G CUL1 cullin 1 IEA KEGG hsa:04350 NCBI chr 7:148,697,756...148,801,110
Ensembl chr 7:148,697,914...148,801,110 		JBrowse link
G DCN decorin IEA KEGG hsa:04350 NCBI chr12:91,140,484...91,182,817
Ensembl chr12:91,140,484...91,183,217 		JBrowse link
G E2F4 E2F transcription factor 4 IEA KEGG hsa:04350 NCBI chr16:67,192,155...67,198,918
Ensembl chr16:67,192,155...67,198,918 		JBrowse link
G E2F5 E2F transcription factor 5 IEA KEGG hsa:04350 NCBI chr 8:85,177,154...85,214,518
Ensembl chr 8:85,177,154...85,217,158 		JBrowse link
G EP300 E1A binding protein p300 IEA KEGG hsa:04350 NCBI chr22:41,092,592...41,180,077
Ensembl chr22:41,092,510...41,180,077 		JBrowse link
G FST follistatin IEA KEGG hsa:04350 NCBI chr 5:53,480,629...53,487,134
Ensembl chr 5:53,480,626...53,487,134 		JBrowse link
G GDF5 growth differentiation factor 5 IEA KEGG hsa:04350 NCBI chr20:35,433,347...35,454,749
Ensembl chr20:35,433,347...35,454,746 		JBrowse link
G GDF6 growth differentiation factor 6 IEA KEGG hsa:04350 NCBI chr 8:96,142,333...96,160,806
Ensembl chr 8:96,142,333...96,160,806 		JBrowse link
G GDF7 growth differentiation factor 7 IEA KEGG hsa:04350 NCBI chr 2:20,667,144...20,679,243
Ensembl chr 2:20,667,144...20,679,243 		JBrowse link
G ID1 inhibitor of DNA binding 1 IEA KEGG hsa:04350 NCBI chr20:31,605,289...31,606,510
Ensembl chr20:31,573,014...31,606,515 		JBrowse link
G ID2 inhibitor of DNA binding 2 IEA KEGG hsa:04350 NCBI chr 2:8,682,056...8,684,461
Ensembl chr 2:8,678,845...8,684,461 		JBrowse link
G ID3 inhibitor of DNA binding 3 IEA KEGG hsa:04350 NCBI chr 1:23,557,926...23,559,501
Ensembl chr 1:23,557,926...23,559,501 		JBrowse link
G ID4 inhibitor of DNA binding 4 IEA KEGG hsa:04350 NCBI chr 6:19,837,370...19,842,197
Ensembl chr 6:19,837,370...19,842,197 		JBrowse link
G IFNG interferon gamma IEA KEGG hsa:04350 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G INHBA inhibin subunit beta A IEA KEGG hsa:04350 NCBI chr 7:41,685,114...41,705,406
Ensembl chr 7:41,667,168...41,705,834 		JBrowse link
G INHBB inhibin subunit beta B IEA KEGG hsa:04350 NCBI chr 2:120,346,136...120,351,803
Ensembl chr 2:120,346,136...120,351,803 		JBrowse link
G INHBC inhibin subunit beta C IEA KEGG hsa:04350 NCBI chr12:57,434,784...57,452,062
Ensembl chr12:57,434,784...57,452,062 		JBrowse link
G INHBE inhibin subunit beta E IEA KEGG hsa:04350 NCBI chr12:57,455,307...57,458,025
Ensembl chr12:57,452,323...57,459,280 		JBrowse link
G LEFTY1 left-right determination factor 1 IEA KEGG hsa:04350 NCBI chr 1:225,886,282...225,889,146
Ensembl chr 1:225,886,282...225,911,382 		JBrowse link
G LEFTY2 left-right determination factor 2 IEA KEGG hsa:04350 NCBI chr 1:225,936,603...225,941,220
Ensembl chr 1:225,936,598...225,941,383 		JBrowse link
G LTBP1 latent transforming growth factor beta binding protein 1 IEA KEGG hsa:04350 NCBI chr 2:32,946,953...33,399,509
Ensembl chr 2:32,946,953...33,399,509 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 IEA KEGG hsa:04350 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 IEA KEGG hsa:04350 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor IEA KEGG hsa:04350 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951 		JBrowse link
G NODAL nodal growth differentiation factor IEA KEGG hsa:04350 NCBI chr10:70,431,936...70,447,951
Ensembl chr10:70,431,936...70,447,951 		JBrowse link
G NOG noggin IEA KEGG hsa:04350 NCBI chr17:56,593,699...56,595,611
Ensembl chr17:56,593,699...56,595,611 		JBrowse link
G PITX2 paired like homeodomain 2 IEA KEGG hsa:04350 NCBI chr 4:110,617,423...110,642,123
Ensembl chr 4:110,617,423...110,642,123 		JBrowse link
G PPP2CA protein phosphatase 2 catalytic subunit alpha IEA KEGG hsa:04350 NCBI chr 5:134,194,332...134,226,073
Ensembl chr 5:134,193,978...134,226,073 		JBrowse link
G PPP2CB protein phosphatase 2 catalytic subunit beta IEA KEGG hsa:04350 NCBI chr 8:30,785,616...30,812,818
Ensembl chr 8:30,774,457...30,814,314 		JBrowse link
G PPP2R1A protein phosphatase 2 scaffold subunit Aalpha IEA KEGG hsa:04350 NCBI chr19:52,190,052...52,229,518
Ensembl chr19:52,170,936...52,229,518 		JBrowse link
G PPP2R1B protein phosphatase 2 scaffold subunit Abeta IEA KEGG hsa:04350 NCBI chr11:111,688,000...111,766,389
Ensembl chr11:111,726,908...111,766,389 		JBrowse link
G RBL1 RB transcriptional corepressor like 1 IEA KEGG hsa:04350 NCBI chr20:36,996,349...37,095,997
Ensembl chr20:36,996,349...37,095,997 		JBrowse link
G RBL2 RB transcriptional corepressor like 2 IEA KEGG hsa:04350 NCBI chr16:53,434,471...53,491,648
Ensembl chr16:53,433,977...53,491,648 		JBrowse link
G RBX1 ring-box 1 IEA KEGG hsa:04350 NCBI chr22:40,951,378...40,973,309
Ensembl chr22:40,951,347...40,973,309 		JBrowse link
G RHOA ras homolog family member A IEA KEGG hsa:04350 NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,139...49,412,998 		JBrowse link
G ROCK1 Rho associated coiled-coil containing protein kinase 1 IEA KEGG hsa:04350 NCBI chr18:20,946,906...21,111,813
Ensembl chr18:20,944,612...21,111,813 		JBrowse link
G ROCK2 Rho associated coiled-coil containing protein kinase 2 IEA KEGG hsa:04350 NCBI chr 2:11,179,759...11,345,437
Ensembl chr 2:11,179,759...11,348,330 		JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 IEA KEGG hsa:04350 NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574 		JBrowse link
G RPS6KB2 ribosomal protein S6 kinase B2 IEA KEGG hsa:04350 NCBI chr11:67,428,494...67,435,401
Ensembl chr11:67,428,460...67,435,401 		JBrowse link
G SKP1 S-phase kinase associated protein 1 IEA KEGG hsa:04350 NCBI chr 5:134,148,935...134,176,950
Ensembl chr 5:134,148,935...134,176,964 		JBrowse link
G SMAD1 SMAD family member 1 IEA KEGG hsa:04350 NCBI chr 4:145,480,770...145,559,176
Ensembl chr 4:145,481,194...145,559,176 		JBrowse link
G SMAD2 SMAD family member 2 IEA KEGG hsa:04350 NCBI chr18:47,808,957...47,930,872
Ensembl chr18:47,808,957...47,931,146 		JBrowse link
G SMAD3 SMAD family member 3 IEA KEGG hsa:04350 NCBI chr15:67,065,602...67,195,169
Ensembl chr15:67,063,763...67,195,173 		JBrowse link
G SMAD4 SMAD family member 4 IEA KEGG hsa:04350 NCBI chr18:51,030,213...51,085,042
Ensembl chr18:51,028,528...51,085,045 		JBrowse link
G SMAD5 SMAD family member 5 IEA KEGG hsa:04350 NCBI chr 5:136,132,845...136,182,733
Ensembl chr 5:136,132,845...136,188,747 		JBrowse link
G SMAD6 SMAD family member 6 IEA KEGG hsa:04350 NCBI chr15:66,702,236...66,782,849
Ensembl chr15:66,702,236...66,782,849 		JBrowse link
G SMAD7 SMAD family member 7 IEA KEGG hsa:04350 NCBI chr18:48,919,853...48,950,965
Ensembl chr18:48,919,853...48,950,965 		JBrowse link
G SMAD9 SMAD family member 9 IEA KEGG hsa:04350 NCBI chr13:36,844,831...36,920,854
Ensembl chr13:36,844,831...36,920,887 		JBrowse link
G SMURF1 SMAD specific E3 ubiquitin protein ligase 1 IEA KEGG hsa:04350 NCBI chr 7:99,027,440...99,144,108
Ensembl chr 7:99,027,440...99,144,108 		JBrowse link
G SMURF2 SMAD specific E3 ubiquitin protein ligase 2 IEA KEGG hsa:04350 NCBI chr17:64,542,282...64,662,307
Ensembl chr17:64,542,282...64,662,307 		JBrowse link
G SP1 Sp1 transcription factor IEA KEGG hsa:04350 NCBI chr12:53,380,176...53,416,446
Ensembl chr12:53,380,176...53,416,446 		JBrowse link
G TFDP1 transcription factor Dp-1 IEA KEGG hsa:04350 NCBI chr13:113,584,688...113,641,473
Ensembl chr13:113,584,721...113,641,473 		JBrowse link
G TGFB1 transforming growth factor beta 1 IEA KEGG hsa:04350 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TGFB2 transforming growth factor beta 2 IEA KEGG hsa:04350 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619 		JBrowse link
G TGFB3 transforming growth factor beta 3 IEA KEGG hsa:04350 NCBI chr14:75,958,097...75,983,011
Ensembl chr14:75,958,097...75,983,011 		JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 IEA KEGG hsa:04350 NCBI chr 9:99,103,647...99,154,192
Ensembl chr 9:99,104,038...99,154,192 		JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 IEA KEGG hsa:04350 NCBI chr 3:30,606,356...30,694,142
Ensembl chr 3:30,606,478...30,694,249 		JBrowse link
G THBS1 thrombospondin 1 IEA KEGG hsa:04350 NCBI chr15:39,581,079...39,599,466
Ensembl chr15:39,581,079...39,599,466 		JBrowse link
G THBS2 thrombospondin 2 IEA KEGG hsa:04350 NCBI chr 6:169,215,785...169,253,846
Ensembl chr 6:169,215,780...169,254,050 		JBrowse link
G THBS3 thrombospondin 3 IEA KEGG hsa:04350 NCBI chr 1:155,195,588...155,209,178
Ensembl chr 1:155,195,588...155,209,051 		JBrowse link
G THBS4 thrombospondin 4 IEA KEGG hsa:04350 NCBI chr 5:79,991,332...80,083,287
Ensembl chr 5:79,991,311...80,083,287 		JBrowse link
G TNF tumor necrosis factor IEA KEGG hsa:04350 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G ZFYVE16 zinc finger FYVE-type containing 16 IEA KEGG hsa:04350 NCBI chr 5:80,407,610...80,483,379
Ensembl chr 5:80,408,013...80,483,379 		JBrowse link
G ZFYVE9 zinc finger FYVE-type containing 9 IEA KEGG hsa:04350 NCBI chr 1:52,142,089...52,346,634
Ensembl chr 1:52,142,089...52,348,671 		JBrowse link
activin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVR1 activin A receptor type 1 ISS
EXP		 PID
RGD		 PMID:12770730 PID:200029, RGD:1559169 NCBI chr 2:157,736,446...157,876,330
Ensembl chr 2:157,736,251...157,876,330 		JBrowse link
G ACVR1B activin A receptor type 1B ISS
ISO		 RGD PMID:12770730 PMID:17040568 RGD:1559169, RGD:2315948 NCBI chr12:51,951,699...51,997,078
Ensembl chr12:51,951,699...51,997,078 		JBrowse link
G ACVR2A activin A receptor type 2A ISS RGD PMID:12770730 RGD:1559169 NCBI chr 2:147,844,517...147,930,822
Ensembl chr 2:147,844,517...147,930,826 		JBrowse link
G ACVR2B activin A receptor type 2B ISS RGD PMID:12770730 RGD:1559169 NCBI chr 3:38,453,890...38,493,142
Ensembl chr 3:38,453,890...38,493,142 		JBrowse link
G ACVRL1 activin A receptor like type 1 ISS
EXP		 PID
RGD		 PMID:12770730 PID:200029, RGD:1559169 NCBI chr12:51,906,944...51,923,361
Ensembl chr12:51,906,908...51,923,361 		JBrowse link
G FKBP1A FKBP prolyl isomerase 1A EXP PID PID:200029 NCBI chr20:1,368,978...1,393,054
Ensembl chr20:1,368,977...1,393,164 		JBrowse link
G SMAD2 SMAD family member 2 ISS RGD PMID:12770730 RGD:1559169 NCBI chr18:47,808,957...47,930,872
Ensembl chr18:47,808,957...47,931,146 		JBrowse link
G SMAD3 SMAD family member 3 ISS RGD PMID:12770730 RGD:1559169 NCBI chr15:67,065,602...67,195,169
Ensembl chr15:67,063,763...67,195,173 		JBrowse link
altered transforming growth factor-beta Smad dependent signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SMAD2 SMAD family member 2 TAS RGD PMID:17613544 PMID:18662538 RGD:2306282, RGD:2308865 NCBI chr18:47,808,957...47,930,872
Ensembl chr18:47,808,957...47,931,146 		JBrowse link
G SMAD3 SMAD family member 3 TAS
IMP		 RGD PMID:17613544 PMID:18772397 RGD:2306282, RGD:5490966 NCBI chr15:67,065,602...67,195,169
Ensembl chr15:67,063,763...67,195,173 		JBrowse link
G SMAD4 SMAD family member 4 TAS
IMP		 RGD PMID:17613544 PMID:18662538 PMID:18772397 PMID:19506583 RGD:2306282, RGD:2308865, RGD:5490966, RGD:5490965 NCBI chr18:51,030,213...51,085,042
Ensembl chr18:51,028,528...51,085,045 		JBrowse link
G SMAD7 SMAD family member 7 TAS RGD PMID:18662538 RGD:2308865 NCBI chr18:48,919,853...48,950,965
Ensembl chr18:48,919,853...48,950,965 		JBrowse link
G TGFB1 transforming growth factor beta 1 TAS RGD PMID:18313409 PMID:17613544 RGD:2299005, RGD:2306282 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 TAS RGD PMID:18313409 PMID:17613544 RGD:2299005, RGD:2306282 NCBI chr 9:99,103,647...99,154,192
Ensembl chr 9:99,104,038...99,154,192 		JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 TAS
IMP		 RGD PMID:18313409 PMID:17613544 PMID:18662538 PMID:18772397 PMID:19506583 RGD:2299005, RGD:2306282, RGD:2308865, RGD:5490966, RGD:5490965 NCBI chr 3:30,606,356...30,694,142
Ensembl chr 3:30,606,478...30,694,249 		JBrowse link
Bone morphogenetic proteins signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHSG alpha 2-HS glycoprotein EXP PID PID:200144 NCBI chr 3:186,613,060...186,621,318
Ensembl chr 3:186,613,060...186,621,318 		JBrowse link
G BAMBI BMP and activin membrane bound inhibitor EXP PID PID:200144 NCBI chr10:28,677,521...28,682,932
Ensembl chr10:28,677,510...28,682,932 		JBrowse link
G BMP2 bone morphogenetic protein 2 ISO
EXP		 PID
RGD		 PMID:16361357 PID:200144, RGD:1580077 NCBI chr20:6,767,686...6,780,246
Ensembl chr20:6,767,686...6,780,246 		JBrowse link
G BMP4 bone morphogenetic protein 4 EXP
ISO		 PID
RGD		 PMID:18985159 PID:200144, RGD:11553861 NCBI chr14:53,949,736...53,956,891
Ensembl chr14:53,949,736...53,958,761 		JBrowse link
G BMP6 bone morphogenetic protein 6 EXP PID PID:200144 NCBI chr 6:7,726,099...7,881,728
Ensembl chr 6:7,726,099...7,881,728 		JBrowse link
G BMP7 bone morphogenetic protein 7 EXP PID PID:200144 NCBI chr20:57,168,753...57,266,641
Ensembl chr20:57,168,753...57,266,641 		JBrowse link
G BMPR1A bone morphogenetic protein receptor type 1A EXP PID PID:200144 NCBI chr10:86,755,763...86,932,844
Ensembl chr10:86,755,786...86,932,825 		JBrowse link
G BMPR1B bone morphogenetic protein receptor type 1B EXP PID PID:200144 NCBI chr 4:94,757,955...95,158,450
Ensembl chr 4:94,757,955...95,158,448 		JBrowse link
G BMPR2 bone morphogenetic protein receptor type 2 ISO
EXP		 PID
RGD		 PMID:16361357 PID:200144, RGD:1580077 NCBI chr 2:202,376,327...202,567,749
Ensembl chr 2:202,376,327...202,567,751 		JBrowse link
G CER1 cerberus 1, DAN family BMP antagonist EXP PID PID:200144 NCBI chr 9:14,717,326...14,722,733
Ensembl chr 9:14,719,724...14,722,733 		JBrowse link
G CHRD chordin EXP PID PID:200144 NCBI chr 3:184,380,054...184,390,739
Ensembl chr 3:184,380,054...184,390,736 		JBrowse link
G CHRDL1 chordin like 1 EXP PID PID:200144 NCBI chr  X:110,673,856...110,795,817
Ensembl chr  X:110,673,856...110,795,819 		JBrowse link
G CTDSP1 CTD small phosphatase 1 EXP PID PID:200144 NCBI chr 2:218,396,351...218,405,941
Ensembl chr 2:218,397,136...218,405,941 		JBrowse link
G CTDSP2 CTD small phosphatase 2 EXP PID PID:200144 NCBI chr12:57,819,927...57,846,729
Ensembl chr12:57,819,927...57,846,729 		JBrowse link
G CTDSPL CTD small phosphatase like EXP PID PID:200144 NCBI chr 3:37,861,880...37,984,469
Ensembl chr 3:37,861,880...37,984,469 		JBrowse link
G FST follistatin EXP PID PID:200144 NCBI chr 5:53,480,629...53,487,134
Ensembl chr 5:53,480,626...53,487,134 		JBrowse link
G GREM1 gremlin 1, DAN family BMP antagonist EXP PID PID:200144 NCBI chr15:32,718,004...32,745,106
Ensembl chr15:32,718,004...32,745,106 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta EXP PID PID:200144 NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994 		JBrowse link
G HJV hemojuvelin BMP co-receptor EXP PID PID:200144 NCBI chr 1:146,017,470...146,021,735
Ensembl chr 1:146,017,468...146,036,746 		JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 EXP PID PID:200144 NCBI chr 6:90,513,579...90,587,072
Ensembl chr 6:90,513,573...90,587,086 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 EXP PID PID:200144 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G NOG noggin EXP PID PID:200144 NCBI chr17:56,593,699...56,595,611
Ensembl chr17:56,593,699...56,595,611 		JBrowse link
G NUP214 nucleoporin 214 EXP PID PID:200144 NCBI chr 9:131,125,586...131,234,663
Ensembl chr 9:131,125,573...131,234,663 		JBrowse link
G PPM1A protein phosphatase, Mg2+/Mn2+ dependent 1A EXP PID PID:200144 NCBI chr14:60,245,750...60,299,087
Ensembl chr14:60,245,752...60,299,087 		JBrowse link
G PPP1CA protein phosphatase 1 catalytic subunit alpha EXP PID PID:200144 NCBI chr11:67,398,183...67,401,858
Ensembl chr11:67,398,181...67,421,183 		JBrowse link
G PPP1R15A protein phosphatase 1 regulatory subunit 15A EXP PID PID:200144 NCBI chr19:48,872,421...48,876,058
Ensembl chr19:48,872,212...48,876,059 		JBrowse link
G RGMA repulsive guidance molecule BMP co-receptor a EXP PID PID:200144 NCBI chr15:93,035,271...93,089,211
Ensembl chr15:93,035,271...93,089,211 		JBrowse link
G RGMB repulsive guidance molecule BMP co-receptor b EXP PID PID:200144 NCBI chr 5:98,768,632...98,796,494
Ensembl chr 5:98,768,650...98,798,643 		JBrowse link
G SKI SKI proto-oncogene EXP PID PID:200144 NCBI chr 1:2,228,319...2,310,213
Ensembl chr 1:2,227,388...2,310,213 		JBrowse link
G SLC39A13 solute carrier family 39 member 13 ISO RGD PMID:18985159 RGD:11553861 NCBI chr11:47,407,276...47,416,500
Ensembl chr11:47,407,132...47,416,496 		JBrowse link
G SMAD1 SMAD family member 1 ISO
EXP		 PID
RGD		 PMID:16361357 PMID:18985159 PID:200144, RGD:1580077, RGD:11553861 NCBI chr 4:145,480,770...145,559,176
Ensembl chr 4:145,481,194...145,559,176 		JBrowse link
G SMAD4 SMAD family member 4 EXP PID PID:200144 NCBI chr18:51,030,213...51,085,042
Ensembl chr18:51,028,528...51,085,045 		JBrowse link
G SMAD5 SMAD family member 5 ISO
EXP		 PID
RGD		 PMID:16361357 PMID:18985159 PID:200144, RGD:1580077, RGD:11553861 NCBI chr 5:136,132,845...136,182,733
Ensembl chr 5:136,132,845...136,188,747 		JBrowse link
G SMAD6 SMAD family member 6 EXP PID PID:200144 NCBI chr15:66,702,236...66,782,849
Ensembl chr15:66,702,236...66,782,849 		JBrowse link
G SMAD7 SMAD family member 7 EXP PID PID:200144 NCBI chr18:48,919,853...48,950,965
Ensembl chr18:48,919,853...48,950,965 		JBrowse link
G SMAD9 SMAD family member 9 ISO
EXP		 PID
RGD		 PMID:16361357 PID:200144, RGD:1580077 NCBI chr13:36,844,831...36,920,854
Ensembl chr13:36,844,831...36,920,887 		JBrowse link
G SMURF1 SMAD specific E3 ubiquitin protein ligase 1 EXP PID PID:200144 NCBI chr 7:99,027,440...99,144,108
Ensembl chr 7:99,027,440...99,144,108 		JBrowse link
G SMURF2 SMAD specific E3 ubiquitin protein ligase 2 EXP PID PID:200144 NCBI chr17:64,542,282...64,662,307
Ensembl chr17:64,542,282...64,662,307 		JBrowse link
G SOSTDC1 sclerostin domain containing 1 EXP PID PID:200144 NCBI chr 7:16,461,481...16,465,738
Ensembl chr 7:16,461,481...16,530,580 		JBrowse link
G TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 EXP PID PID:200144 NCBI chr22:39,399,780...39,437,132
Ensembl chr22:39,399,778...39,437,060 		JBrowse link
G TAB2 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 EXP PID PID:200144 NCBI chr 6:149,217,926...149,411,607
Ensembl chr 6:149,218,641...149,411,613 		JBrowse link
G XIAP X-linked inhibitor of apoptosis EXP PID PID:200144 NCBI chr  X:123,859,708...123,913,972
Ensembl chr  X:123,859,712...123,913,972 		JBrowse link
G ZFYVE16 zinc finger FYVE-type containing 16 EXP PID PID:200144 NCBI chr 5:80,407,610...80,483,379
Ensembl chr 5:80,408,013...80,483,379 		JBrowse link
transforming growth factor-beta signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAV1 caveolin 1 ISO RGD PMID:29069575 RGD:151347449 NCBI chr 7:116,525,009...116,561,185
Ensembl chr 7:116,524,994...116,561,179 		JBrowse link
G PARK7 Parkinsonism associated deglycase ISO RGD PMID:29069575 RGD:151347449 NCBI chr 1:7,961,711...7,985,505
Ensembl chr 1:7,954,291...7,985,505 		JBrowse link
G TSC2 TSC complex subunit 2 IMP RGD PMID:15066998 RGD:1580519 NCBI chr16:2,047,985...2,089,491
Ensembl chr16:2,047,967...2,089,491 		JBrowse link
transforming growth factor-beta Smad dependent signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2M alpha-2-macroglobulin TAS RGD PMID:12809600 RGD:2298922 NCBI chr12:9,067,708...9,116,229
Ensembl chr12:9,067,664...9,116,229 		JBrowse link
G ARRB2 arrestin beta 2 EXP PID PID:200227 NCBI chr17:4,710,632...4,721,497
Ensembl chr17:4,710,596...4,721,499 		JBrowse link
G ATF3 activating transcription factor 3 TAS RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777 		JBrowse link
G AXIN1 axin 1 EXP PID PID:200227 NCBI chr16:287,440...352,723
Ensembl chr16:287,440...352,723 		JBrowse link
G BAMBI BMP and activin membrane bound inhibitor EXP PID PID:200227 NCBI chr10:28,677,521...28,682,932
Ensembl chr10:28,677,510...28,682,932 		JBrowse link
G CAMK2A calcium/calmodulin dependent protein kinase II alpha EXP PID PID:200227 NCBI chr 5:150,219,491...150,290,130
Ensembl chr 5:150,219,491...150,290,093 		JBrowse link
G CAV1 caveolin 1 EXP PID PID:200227 NCBI chr 7:116,525,009...116,561,185
Ensembl chr 7:116,524,994...116,561,179 		JBrowse link
G CCN2 cellular communication network factor 2 EXP PID PID:200227 NCBI chr 6:131,948,176...131,951,372
Ensembl chr 6:131,948,176...131,951,372 		JBrowse link
G CREB1 cAMP responsive element binding protein 1 ISO RGD PMID:16891311 RGD:1625706 NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988 		JBrowse link
G CREBBP CREB binding protein TAS RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr16:3,725,054...3,880,713
Ensembl chr16:3,725,054...3,880,713 		JBrowse link
G CTNNB1 catenin beta 1 EXP PID PID:200227 NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096 		JBrowse link
G DACT2 dishevelled binding antagonist of beta catenin 2 EXP PID PID:200227 NCBI chr 6:168,292,830...168,319,777
Ensembl chr 6:168,292,830...168,319,777 		JBrowse link
G DAXX death domain associated protein EXP PID PID:200227 NCBI chr 6:33,318,558...33,322,959
Ensembl chr 6:33,318,558...33,323,016 		JBrowse link
G DCN decorin TAS RGD PMID:12809600 RGD:2298922 NCBI chr12:91,140,484...91,182,817
Ensembl chr12:91,140,484...91,183,217 		JBrowse link
G DYNLRB1 dynein light chain roadblock-type 1 EXP PID PID:200227 NCBI chr20:34,515,602...34,540,958
Ensembl chr20:34,516,395...34,540,958 		JBrowse link
G EIF2A eukaryotic translation initiation factor 2A EXP PID PID:200227 NCBI chr 3:150,546,787...150,586,016
Ensembl chr 3:150,546,678...150,586,016 		JBrowse link
G FKBP1A FKBP prolyl isomerase 1A TAS
EXP		 PID
RGD		 PMID:12809600 PID:200227, RGD:2298922 NCBI chr20:1,368,978...1,393,054
Ensembl chr20:1,368,977...1,393,164 		JBrowse link
G FOXH1 forkhead box H1 TAS RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr 8:144,473,412...144,475,849
Ensembl chr 8:144,473,412...144,475,849 		JBrowse link
G FOXO1 forkhead box O1 TAS RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641 		JBrowse link
G FOXO3 forkhead box O3 TAS RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr 6:108,559,825...108,684,774
Ensembl chr 6:108,559,835...108,684,774 		JBrowse link
G FOXO4 forkhead box O4 TAS RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr  X:71,095,851...71,103,532
Ensembl chr  X:71,095,851...71,103,535 		JBrowse link
G GRB2 growth factor receptor bound protein 2 EXP PID PID:200227 NCBI chr17:75,318,076...75,405,678
Ensembl chr17:75,318,076...75,405,709 		JBrowse link
G ITCH itchy E3 ubiquitin protein ligase EXP PID PID:200227 NCBI chr20:34,363,273...34,511,773
Ensembl chr20:34,363,235...34,511,773 		JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 EXP PID PID:200227 NCBI chr 6:90,513,579...90,587,072
Ensembl chr 6:90,513,573...90,587,086 		JBrowse link
G NEDD4L NEDD4 like E3 ubiquitin protein ligase EXP PID PID:200227 NCBI chr18:58,044,226...58,401,540
Ensembl chr18:58,044,226...58,401,540 		JBrowse link
G OCLN occludin EXP PID PID:200227 NCBI chr 5:69,492,547...69,558,104
Ensembl chr 5:69,492,292...69,558,104 		JBrowse link
G PARD6A par-6 family cell polarity regulator alpha EXP PID PID:200227 NCBI chr16:67,660,960...67,662,774
Ensembl chr16:67,660,946...67,662,774 		JBrowse link
G PDPK1 3-phosphoinositide dependent protein kinase 1 EXP PID PID:200227 NCBI chr16:2,538,021...2,603,188
Ensembl chr16:2,537,979...2,603,190 		JBrowse link
G PML PML nuclear body scaffold EXP PID PID:200227 NCBI chr15:73,994,716...74,047,827
Ensembl chr15:73,994,673...74,047,827 		JBrowse link
G PPP1CA protein phosphatase 1 catalytic subunit alpha EXP PID PID:200227 NCBI chr11:67,398,183...67,401,858
Ensembl chr11:67,398,181...67,421,183 		JBrowse link
G PPP1R15A protein phosphatase 1 regulatory subunit 15A EXP PID PID:200227 NCBI chr19:48,872,421...48,876,058
Ensembl chr19:48,872,212...48,876,059 		JBrowse link
G PPP2CA protein phosphatase 2 catalytic subunit alpha EXP PID PID:200227 NCBI chr 5:134,194,332...134,226,073
Ensembl chr 5:134,193,978...134,226,073 		JBrowse link
G PPP2CB protein phosphatase 2 catalytic subunit beta EXP PID PID:200227 NCBI chr 8:30,785,616...30,812,818
Ensembl chr 8:30,774,457...30,814,314 		JBrowse link
G PPP2R2A protein phosphatase 2 regulatory subunit Balpha EXP PID PID:200227 NCBI chr 8:26,291,508...26,372,680
Ensembl chr 8:26,291,508...26,372,680 		JBrowse link
G RHOA ras homolog family member A EXP PID PID:200227 NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,139...49,412,998 		JBrowse link
G RNF111 ring finger protein 111 EXP PID PID:200227 NCBI chr15:58,987,663...59,097,419
Ensembl chr15:58,865,175...59,097,419 		JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 EXP PID PID:200227 NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574 		JBrowse link
G RUNX1 RUNX family transcription factor 1 TAS RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr21:35,372,507...35,580,764
Ensembl chr21:34,787,801...36,004,667 		JBrowse link
G RUNX1 RUNX family transcription factor 1 ISO RGD PMID:16322555 PMID:18061509 RGD:2302137 RGD:5143919 NCBI chr21:34,787,801...35,049,302
Ensembl chr21:34,787,801...36,004,667 		JBrowse link
G RUNX2 RUNX family transcription factor 2 TAS RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr 6:45,328,330...45,551,082
Ensembl chr 6:45,328,157...45,664,349 		JBrowse link
G RUNX3 RUNX family transcription factor 3 TAS RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr 1:24,899,511...24,965,138
Ensembl chr 1:24,899,511...24,965,121 		JBrowse link
G SHC1 SHC adaptor protein 1 EXP PID PID:200227 NCBI chr 1:154,962,298...154,974,376
Ensembl chr 1:154,962,298...154,974,395 		JBrowse link
G SKIL SKI like proto-oncogene EXP PID PID:200227 NCBI chr 3:170,357,715...170,396,849
Ensembl chr 3:170,357,342...170,396,835 		JBrowse link
G SMAD2 SMAD family member 2 ISO
EXP
TAS		 PID
RGD		 PMID:16959941 PMID:18684975 PMID:12809600 PID:200227, RGD:1599906, RGD:2302517, RGD:2298922 NCBI chr18:47,808,957...47,930,872
Ensembl chr18:47,808,957...47,931,146 		JBrowse link
G SMAD3 SMAD family member 3 TAS
EXP
ISO		 PID
RGD		 PMID:12809600 PMID:16891311 PID:200227, RGD:2298922, RGD:1625706 NCBI chr15:67,065,602...67,195,169
Ensembl chr15:67,063,763...67,195,173 		JBrowse link
G SMAD4 SMAD family member 4 ISO
EXP
TAS		 PID
RGD		 PMID:16959941 PMID:12809600 PID:200227, RGD:1599906, RGD:2298922 NCBI chr18:51,030,213...51,085,042
Ensembl chr18:51,028,528...51,085,045 		JBrowse link
G SMAD7 SMAD family member 7 TAS
EXP		 PID
RGD		 PMID:12809600 PID:200227, RGD:2298922 NCBI chr18:48,919,853...48,950,965
Ensembl chr18:48,919,853...48,950,965 		JBrowse link
G SMURF1 SMAD specific E3 ubiquitin protein ligase 1 TAS
EXP		 PID
RGD		 PMID:12809600 PID:200227, RGD:2298922 NCBI chr 7:99,027,440...99,144,108
Ensembl chr 7:99,027,440...99,144,108 		JBrowse link
G SMURF2 SMAD specific E3 ubiquitin protein ligase 2 TAS
EXP		 PID
RGD		 PMID:12809600 PID:200227, RGD:2298922 NCBI chr17:64,542,282...64,662,307
Ensembl chr17:64,542,282...64,662,307 		JBrowse link
G SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 EXP PID PID:200227 NCBI chr 2:38,981,549...39,124,868
Ensembl chr 2:38,962,206...39,124,345 		JBrowse link
G SPTBN1 spectrin beta, non-erythrocytic 1 EXP PID PID:200227 NCBI chr 2:54,456,327...54,671,446
Ensembl chr 2:54,456,327...54,671,446 		JBrowse link
G STRAP serine/threonine kinase receptor associated protein EXP PID PID:200227 NCBI chr12:15,882,387...15,903,478
Ensembl chr12:15,882,387...15,903,478 		JBrowse link
G TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 EXP PID PID:200227 NCBI chr22:39,399,780...39,437,132
Ensembl chr22:39,399,778...39,437,060 		JBrowse link
G TAB2 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 EXP PID PID:200227 NCBI chr 6:149,217,926...149,411,607
Ensembl chr 6:149,218,641...149,411,613 		JBrowse link
G TGFB1 transforming growth factor beta 1 ISO
EXP		 PID
RGD		 PMID:15109563 PID:200227, RGD:2298921 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TGFB2 transforming growth factor beta 2 ISO
EXP		 PID
RGD		 PMID:15109563 PID:200227, RGD:2298921 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619 		JBrowse link
G TGFB3 transforming growth factor beta 3 TAS
EXP		 PID
RGD		 PMID:12809600 PID:200227, RGD:2298922 NCBI chr14:75,958,097...75,983,011
Ensembl chr14:75,958,097...75,983,011 		JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 TAS
EXP
ISO		 PID
RGD		 PMID:12809600 PMID:18684975 PID:200227, RGD:2298922, RGD:2302517 NCBI chr 9:99,103,647...99,154,192
Ensembl chr 9:99,104,038...99,154,192 		JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 TAS
IMP
EXP
ISO		 PID
RGD		 PMID:12809600 PMID:14729511 PMID:18684975 PID:200227, RGD:2298922, RGD:1579921, RGD:2302517 NCBI chr 3:30,606,356...30,694,142
Ensembl chr 3:30,606,478...30,694,249 		JBrowse link
G TGFBR3 transforming growth factor beta receptor 3 TAS
EXP		 PID
RGD		 PMID:12809600 PID:200227, RGD:2298922 NCBI chr 1:91,680,343...91,906,002
Ensembl chr 1:91,680,343...91,906,335 		JBrowse link
G TGFBRAP1 transforming growth factor beta receptor associated protein 1 EXP PID PID:200227 NCBI chr 2:105,249,404...105,329,735
Ensembl chr 2:105,264,391...105,329,735 		JBrowse link
G WWP1 WW domain containing E3 ubiquitin protein ligase 1 EXP PID PID:200227 NCBI chr 8:86,342,547...86,468,503
Ensembl chr 8:86,342,547...86,478,420 		JBrowse link
G XIAP X-linked inhibitor of apoptosis EXP PID PID:200227 NCBI chr  X:123,859,708...123,913,972
Ensembl chr  X:123,859,712...123,913,972 		JBrowse link
G YAP1 Yes1 associated transcriptional regulator EXP PID PID:200227 NCBI chr11:102,110,447...102,233,424
Ensembl chr11:102,110,447...102,233,424 		JBrowse link
G YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon EXP PID PID:200227 NCBI chr17:1,344,275...1,400,222
Ensembl chr17:1,344,275...1,400,222 		JBrowse link
G ZFYVE16 zinc finger FYVE-type containing 16 EXP PID PID:200227 NCBI chr 5:80,407,610...80,483,379
Ensembl chr 5:80,408,013...80,483,379 		JBrowse link
G ZFYVE9 zinc finger FYVE-type containing 9 TAS
EXP		 PID
RGD		 PMID:12809600 PID:200227, RGD:2298922 NCBI chr 1:52,142,089...52,346,634
Ensembl chr 1:52,142,089...52,348,671 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5957
    signaling pathway 2493
      growth factor signaling pathway 524
        transforming growth factor-beta superfamily mediated signaling pathway 152
          Bone morphogenetic proteins signaling pathway + 43
          Nodal signaling pathway 0
          activin signaling pathway 8
          altered transforming growth factor-beta superfamily mediated signaling pathway + 7
          transforming growth factor-beta signaling pathway + 69
paths to the root