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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:altered Hedgehog signaling pathway
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Accession:PW:0000321 term browser browse the term
Definition:A Hedgehog signaling pathway that deviates from what its normal course should be. Aberrant Hedgehog signaling pathway has been involved in a number of human cancers.


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altered Hedgehog signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BOC BOC cell adhesion associated, oncogene regulated TAS RGD PMID:18772397 RGD:5490966 NCBI chr 3:113,210,926...113,287,459
Ensembl chr 3:113,211,003...113,287,459 		JBrowse link
G DHH desert hedgehog signaling molecule ISO RGD PMID:11118005 RGD:634737 NCBI chr12:49,086,656...49,094,801
Ensembl chr12:49,086,656...49,094,801 		JBrowse link
G GLI1 GLI family zinc finger 1 TAS RGD PMID:21186299 PMID:18772397 RGD:5491005, RGD:5490966 NCBI chr12:57,459,785...57,472,268
Ensembl chr12:57,459,785...57,472,268 		JBrowse link
G GLI3 GLI family zinc finger 3 TAS RGD PMID:18772397 RGD:5490966 NCBI chr 7:41,960,949...42,264,268
Ensembl chr 7:41,960,949...42,264,100 		JBrowse link
G LRP2 LDL receptor related protein 2 TAS RGD PMID:18772397 RGD:5490966 NCBI chr 2:169,127,109...169,362,534
Ensembl chr 2:169,127,109...169,362,534 		JBrowse link
G SHH sonic hedgehog signaling molecule TAS RGD PMID:19506583 RGD:5490965 NCBI chr 7:155,799,980...155,812,463
Ensembl chr 7:155,799,980...155,812,463 		JBrowse link
G SMO smoothened, frizzled class receptor IMP RGD PMID:9422511 RGD:704355 NCBI chr 7:129,188,633...129,213,545
Ensembl chr 7:129,188,633...129,213,545 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5958
    signaling pathway 2506
      signaling pathway pertinent to development 534
        Hedgehog signaling pathway 104
          altered Hedgehog signaling pathway 7
Path 2
Term Annotations click to browse term
  pathway 5958
    regulatory pathway 3604
      homeostasis pathway 1667
        cardiovascular system homeostasis pathway 423
          hematopoiesis pathway 104
            Hedgehog signaling pathway 104
              altered Hedgehog signaling pathway 7
paths to the root