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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:stress-regulated MAPK signaling pathway
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Accession:PW:0000312 term browser browse the term
Definition:MAPK signaling pathways that are responding to stress or injury as well as inflammatory cytokines.
Synonyms:related_synonym: SAPK signaling pathway;   stress-activated MAPK cascade


show annotations for term's descendants           Sort by:
c-Jun N-terminal kinases MAPK signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc42 cell division cycle 42 ISO RGD PMID:8910292 PMID:9305638 RGD:2293876, RGD:2293879 NCBI chr 5:154,838,478...154,876,629
Ensembl chr 5:154,839,631...154,876,627 		JBrowse link
G Dusp1 dual specificity phosphatase 1 ISO RGD PMID:17208316 RGD:2293881 NCBI chr10:17,184,853...17,187,646
Ensembl chr10:17,184,823...17,187,644 		JBrowse link
G Dusp10 dual specificity phosphatase 10 ISO RGD PMID:17208316 RGD:2293881 NCBI chr13:98,145,317...98,183,304
Ensembl chr13:98,145,893...98,183,304 		JBrowse link
G Dusp16 dual specificity phosphatase 16 ISO RGD PMID:17208316 RGD:2293881 NCBI chr 4:169,278,118...169,361,508
Ensembl chr 4:169,278,118...169,361,508 		JBrowse link
G Dusp19 dual specificity phosphatase 19 ISO RGD PMID:11959862 RGD:2314491 NCBI chr 3:85,945,289...86,081,289 JBrowse link
G Dusp8 dual specificity phosphatase 8 ISO RGD PMID:17208316 RGD:2293881 NCBI chr 1:206,596,912...206,613,728
Ensembl chr 1:206,598,942...206,612,441 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 ISO
IDA 		RGD PMID:17306896 PMID:10051439 PMID:17064355 RGD:2293875, RGD:2298561, RGD:2298577 NCBI chr10:50,842,348...50,947,063
Ensembl chr10:50,844,034...50,947,185 		JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 ISO
IDA 		RGD PMID:17306896 PMID:10051439 PMID:15680699 PMID:17064355 RGD:2293875, RGD:2298561, RGD:2298567, RGD:2298577 NCBI chr12:7,389,032...7,398,377
Ensembl chr12:7,389,155...7,398,377 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 ISO RGD PMID:9305638 PMID:17306896 RGD:2293879, RGD:2293875 NCBI chr 2:45,081,889...45,150,555
Ensembl chr 2:45,081,889...45,149,897 		JBrowse link
G Map3k10 mitogen activated protein kinase kinase kinase 10 ISO RGD PMID:17306896 RGD:2293875 NCBI chr 1:92,083,376...92,101,676
Ensembl chr 1:92,083,376...92,101,676 		JBrowse link
G Map3k11 mitogen-activated protein kinase kinase kinase 11 ISO
IDA 		RGD PMID:8910292 PMID:17306896 PMID:15680699 PMID:17064355 RGD:2293876, RGD:2293875, RGD:2298567, RGD:2298577 NCBI chr 1:212,404,685...212,417,986
Ensembl chr 1:212,403,680...212,417,983 		JBrowse link
G Map3k12 mitogen activated protein kinase kinase kinase 12 ISO RGD PMID:17306896 RGD:2293875 NCBI chr 7:133,630,267...133,648,464
Ensembl chr 7:135,508,790...135,515,137 		JBrowse link
G Map3k13 mitogen-activated protein kinase kinase kinase 13 ISO RGD PMID:17306896 RGD:2293875 NCBI chr11:92,596,436...92,741,717
Ensembl chr11:92,601,738...92,739,663 		JBrowse link
G Map3k2 mitogen activated protein kinase kinase kinase 2 ISO RGD PMID:9305638 PMID:17306896 RGD:2293879, RGD:2293875 NCBI chr18:23,807,218...23,879,722
Ensembl chr18:24,081,444...24,147,323 		JBrowse link
G Map3k20 mitogen-activated protein kinase kinase kinase 20 ISO RGD PMID:17306896 RGD:2293875 NCBI chr 3:77,538,146...77,697,540
Ensembl chr 3:77,537,956...77,697,538 		JBrowse link
G Map3k21 mitogen-activated protein kinase kinase kinase 21 ISO RGD PMID:17306896 RGD:2293875 NCBI chr19:53,880,032...53,913,560
Ensembl chr19:70,777,472...70,810,882 		JBrowse link
G Map3k3 mitogen activated protein kinase kinase kinase 3 ISO RGD PMID:9305638 PMID:17306896 RGD:2293879, RGD:2293875 NCBI chr10:91,519,976...91,588,651
Ensembl chr10:91,519,888...91,588,651 		JBrowse link
G Map3k4 mitogen activated protein kinase kinase kinase 4 ISO RGD PMID:9305638 PMID:17306896 RGD:2293879, RGD:2293875 NCBI chr 1:50,977,870...51,067,117
Ensembl chr 1:50,979,586...51,067,117 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 ISO RGD PMID:12215209 PMID:17306896 RGD:2293875 RGD:2296020 NCBI chr 1:16,505,387...16,723,899
Ensembl chr 1:16,505,596...16,723,898 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 ISO RGD PMID:17306896 RGD:2293875 NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:51,154,352...51,212,012 		JBrowse link
G Map3k9 mitogen-activated protein kinase kinase kinase 9 ISO RGD PMID:17306896 RGD:2293875 NCBI chr 6:101,423,754...101,488,822
Ensembl chr 6:107,161,534...107,220,061 		JBrowse link
G Mapk10 mitogen activated protein kinase 10 ISO
IDA 		RGD PMID:17306896 PMID:10051439 PMID:15680699 RGD:2293875, RGD:2298561, RGD:2298567 NCBI chr14:6,802,247...7,094,103
Ensembl chr14:6,802,295...7,094,100 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO
IDA 		RGD PMID:17306896 PMID:10051439 PMID:17064355 RGD:2293875, RGD:2298561, RGD:2298577 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 ISO
IDA 		RGD PMID:17726577 PMID:15816852 RGD:2293880, RGD:1579811 NCBI chr 3:98,810,540...98,829,302
Ensembl chr 3:98,810,541...98,828,368 		JBrowse link
G Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 ISO RGD PMID:17726577 RGD:2293880 NCBI chr 7:122,406,350...122,416,602
Ensembl chr 7:122,406,350...122,416,602 		JBrowse link
G Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 ISO RGD PMID:17726577 RGD:2293880 NCBI chr10:14,422,936...14,463,387
Ensembl chr10:14,422,936...14,462,812 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 ISO
IDA 		RGD PMID:17306896 PMID:10051439 PMID:17064355 RGD:2293875, RGD:2298561, RGD:2298577 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228 		JBrowse link
G Rac1 Rac family small GTPase 1 ISO RGD PMID:8910292 PMID:9305638 RGD:2293876, RGD:2293879 NCBI chr12:16,150,411...16,170,864
Ensembl chr12:16,128,649...16,172,109 		JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 IMP RGD PMID:10811109 RGD:11534984 NCBI chr 3:33,296,211...33,414,119
Ensembl chr 3:33,296,230...33,414,119 		JBrowse link
G Spp1 secreted phosphoprotein 1 ISO RGD PMID:15757900 RGD:1581337 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 ISO RGD PMID:12215209 RGD:2296020 NCBI chr 3:28,740,098...28,764,752
Ensembl chr 3:28,740,098...28,764,691 		JBrowse link
p38 MAPK signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin IMP RGD PMID:16157033 RGD:1625329 NCBI chr 1:174,164,178...174,182,372
Ensembl chr 1:174,178,773...174,182,371 		JBrowse link
G Atm ATM serine/threonine kinase ISO PID PID:200018 NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629 		JBrowse link
G Bnip2 BCL2 interacting protein 2 ISO RGD PMID:20626350 RGD:7240533 NCBI chr 8:79,521,375...79,539,148
Ensembl chr 8:79,521,363...79,547,368 		JBrowse link
G Calm1 calmodulin 1 ISO PID PID:200018 NCBI chr 6:125,217,191...125,227,855
Ensembl chr 6:125,217,246...125,225,381 		JBrowse link
G Calm2 calmodulin 2 ISO PID PID:200018 NCBI chr 6:12,845,170...12,857,830
Ensembl chr15:64,519,554...64,520,657
Ensembl chr 6:64,519,554...64,520,657 		JBrowse link
G Calm3 calmodulin 3 ISO PID PID:200018 NCBI chr 1:86,718,761...86,725,869
Ensembl chr 1:86,717,321...86,725,960 		JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta ISO PID PID:200018 NCBI chr14:85,059,166...85,148,121
Ensembl chr14:85,059,191...85,148,485 		JBrowse link
G Ccm2 CCM2 scaffold protein ISO PID
RGD		 PMID:17481747 PMID:20626350 PID:200018, RGD:2293891, RGD:7240533 NCBI chr14:85,632,338...85,678,016
Ensembl chr14:85,632,001...85,678,028 		JBrowse link
G Cdc42 cell division cycle 42 ISO RGD PMID:20626350 RGD:7240533 NCBI chr 5:154,838,478...154,876,629
Ensembl chr 5:154,839,631...154,876,627 		JBrowse link
G Cdon cell adhesion associated, oncogene regulated ISO RGD PMID:20626350 RGD:7240533 NCBI chr 8:42,032,921...42,119,451
Ensembl chr 8:42,033,042...42,119,345 		JBrowse link
G Dlk1 delta like non-canonical Notch ligand 1 ISO RGD PMID:20626350 RGD:7240533 NCBI chr 6:134,192,491...134,199,779
Ensembl chr 6:134,192,518...134,200,529 		JBrowse link
G Dusp1 dual specificity phosphatase 1 ISO RGD PMID:20626350 RGD:7240533 NCBI chr10:17,184,853...17,187,646
Ensembl chr10:17,184,823...17,187,644 		JBrowse link
G Dusp10 dual specificity phosphatase 10 ISO RGD PMID:20626350 RGD:7240533 NCBI chr13:98,145,317...98,183,304
Ensembl chr13:98,145,893...98,183,304 		JBrowse link
G Dusp16 dual specificity phosphatase 16 ISO RGD PMID:20626350 RGD:7240533 NCBI chr 4:169,278,118...169,361,508
Ensembl chr 4:169,278,118...169,361,508 		JBrowse link
G Dusp9 dual specificity phosphatase 9 ISO RGD PMID:20626350 RGD:7240533 NCBI chr  X:156,503,237...156,507,162
Ensembl chr  X:156,503,190...156,507,161 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha ISO PID PID:200018 NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807 		JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta ISO PID PID:200018 NCBI chr 7:9,428,689...9,430,991
Ensembl chr 7:9,428,689...9,430,718 		JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma ISO PID PID:200018 NCBI chr17:13,528,606...13,530,351
Ensembl chr17:13,528,610...13,530,369 		JBrowse link
G Irf1 interferon regulatory factor 1 IMP RGD PMID:15141302 RGD:5128786 NCBI chr10:38,417,935...38,424,946
Ensembl chr10:38,417,148...38,424,947 		JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 ISO
IDA 		PID
RGD		 PMID:17481747 PMID:16183734 PID:200018, RGD:2293891, RGD:2298758 NCBI chr10:46,107,639...46,128,986
Ensembl chr10:46,106,548...46,129,004 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 ISO
IDA 		PID
RGD		 PMID:17481747 PMID:16183734 PID:200018, RGD:2293891, RGD:2298758 NCBI chr10:95,872,747...95,987,747
Ensembl chr10:95,872,546...95,987,721 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 ISO PID PID:200018 NCBI chr 2:45,081,889...45,150,555
Ensembl chr 2:45,081,889...45,149,897 		JBrowse link
G Map3k10 mitogen activated protein kinase kinase kinase 10 ISO PID PID:200018 NCBI chr 1:92,083,376...92,101,676
Ensembl chr 1:92,083,376...92,101,676 		JBrowse link
G Map3k11 mitogen-activated protein kinase kinase kinase 11 ISO RGD PMID:20626350 RGD:7240533 NCBI chr 1:212,404,685...212,417,986
Ensembl chr 1:212,403,680...212,417,983 		JBrowse link
G Map3k20 mitogen-activated protein kinase kinase kinase 20 ISO RGD PMID:20626350 RGD:7240533 NCBI chr 3:77,538,146...77,697,540
Ensembl chr 3:77,537,956...77,697,538 		JBrowse link
G Map3k3 mitogen activated protein kinase kinase kinase 3 ISO PID
RGD		 PMID:17481747 PMID:20626350 PID:200018, RGD:2293891, RGD:7240533 NCBI chr10:91,519,976...91,588,651
Ensembl chr10:91,519,888...91,588,651 		JBrowse link
G Map3k4 mitogen activated protein kinase kinase kinase 4 ISO PID
RGD		 PMID:20626350 PID:200018, RGD:7240533 NCBI chr 1:50,977,870...51,067,117
Ensembl chr 1:50,979,586...51,067,117 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 ISO PID
RGD		 PMID:20626350 PID:200018, RGD:7240533 NCBI chr 1:16,505,387...16,723,899
Ensembl chr 1:16,505,596...16,723,898 		JBrowse link
G Map3k6 mitogen-activated protein kinase kinase kinase 6 ISO PID PID:200018 NCBI chr 5:145,440,126...145,452,213
Ensembl chr 5:150,724,216...150,736,111 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 ISO
IDA 		PID
RGD		 PMID:17481747 PMID:20626350 PMID:16183734 PID:200018, RGD:2293891, RGD:7240533, RGD:2298758 NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:51,154,352...51,212,012 		JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 ISO RGD PMID:20626350 RGD:7240533 NCBI chr17:58,078,175...58,098,455
Ensembl chr17:58,078,320...58,098,452 		JBrowse link
G Mapk11 mitogen-activated protein kinase 11 ISO PID
RGD		 PMID:17481747 PID:200018, RGD:2293891 NCBI chr 7:122,098,120...122,105,023
Ensembl chr 7:122,098,121...122,105,038 		JBrowse link
G Mapk12 mitogen-activated protein kinase 12 ISO RGD PMID:17481747 RGD:2293891 NCBI chr 7:122,085,647...122,096,307
Ensembl chr 7:122,085,913...122,096,307 		JBrowse link
G Mapk13 mitogen activated protein kinase 13 ISO RGD PMID:17481747 RGD:2293891 NCBI chr20:6,836,979...6,847,197
Ensembl chr20:6,837,013...6,847,191 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 IDA
ISO 		PID
RGD		 PMID:16407200 PMID:17481747 PID:200018, RGD:1580544, RGD:2293891 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294 		JBrowse link
G Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 ISO
IMP 		RGD PMID:17481747 PMID:12024021 RGD:2293891, RGD:2302280 NCBI chr 7:122,406,350...122,416,602
Ensembl chr 7:122,406,350...122,416,602 		JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 ISO RGD PMID:16421520 RGD:2315047 NCBI chr13:45,066,027...45,112,326
Ensembl chr13:45,066,031...45,112,326 		JBrowse link
G Mapkapk3 MAPK activated protein kinase 3 ISO RGD PMID:16421520 RGD:2315047 NCBI chr 8:116,808,429...116,842,228
Ensembl chr 8:116,808,429...116,842,228 		JBrowse link
G Mapkapk5 MAPK activated protein kinase 5 ISO RGD PMID:16421520 RGD:2315047 NCBI chr12:40,654,220...40,673,740
Ensembl chr12:40,654,423...40,677,170 		JBrowse link
G Mknk1 MAPK interacting serine/threonine kinase 1 ISO RGD PMID:16421520 RGD:2315047 NCBI chr 5:134,554,881...134,594,392
Ensembl chr 5:134,554,943...134,594,393 		JBrowse link
G Mknk2 MAPK interacting serine/threonine kinase 2 ISO RGD PMID:16421520 RGD:2315047 NCBI chr 7:9,039,771...9,050,832
Ensembl chr 7:9,690,421...9,701,529 		JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D ISO RGD PMID:20626350 RGD:7240533 NCBI chr10:70,670,026...70,706,030
Ensembl chr10:70,670,020...70,706,256 		JBrowse link
G Rac1 Rac family small GTPase 1 ISO PID
RGD		 PMID:17481747 PID:200018, RGD:2293891 NCBI chr12:16,150,411...16,170,864
Ensembl chr12:16,128,649...16,172,109 		JBrowse link
G Rps6ka4 ribosomal protein S6 kinase A4 ISO RGD PMID:16421520 RGD:2315047 NCBI chr 1:213,451,026...213,461,982
Ensembl chr 1:213,451,027...213,461,982 		JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 ISO RGD PMID:16421520 RGD:2315047 NCBI chr 6:125,558,434...125,736,576
Ensembl chr 6:125,558,434...125,735,856 		JBrowse link
G Spag9 sperm associated antigen 9 ISO RGD PMID:20626350 RGD:7240533 NCBI chr10:79,440,311...79,574,709
Ensembl chr10:79,440,377...79,575,258 		JBrowse link
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 ISO PID PID:200018 NCBI chr 7:113,556,157...113,587,351
Ensembl chr 7:113,555,819...113,587,351 		JBrowse link
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 ISO PID PID:200018 NCBI chr 1:4,195,400...4,245,485
Ensembl chr 1:4,195,400...4,245,485 		JBrowse link
G Taok1 TAO kinase 1 ISO PID
RGD		 PMID:20626350 PID:200018, RGD:7240533 NCBI chr10:62,871,198...62,989,049
Ensembl chr10:62,871,198...62,957,595 		JBrowse link
G Taok2 TAO kinase 2 ISO PID
RGD		 PMID:20626350 PID:200018, RGD:7240533 NCBI chr 1:190,906,236...190,925,359
Ensembl chr 1:190,906,239...190,925,140 		JBrowse link
G Taok3 TAO kinase 3 ISO PID PID:200018 NCBI chr12:44,973,180...45,134,439
Ensembl chr12:44,973,180...45,134,439 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 ISO PID
RGD		 PMID:12215209 PID:200018, RGD:2296020 NCBI chr 3:28,740,098...28,764,752
Ensembl chr 3:28,740,098...28,764,691 		JBrowse link
G Traf6 TNF receptor associated factor 6 ISO PID
RGD		 PMID:20626350 PID:200018, RGD:7240533 NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:108,418,513...108,443,328 		JBrowse link
G Txn1 thioredoxin 1 ISO PID PID:200018 NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:77,507,321...77,520,307 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      mitogen activated protein kinase signaling pathway 299
        stress-regulated MAPK signaling pathway 70
          altered stress-regulated MAPK signaling pathway + 0
          c-Jun N-terminal kinases MAPK signaling pathway + 31
          p38 MAPK signaling pathway + 54
Path 2
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      kinase mediated signaling pathway 602
        serine/threonine-specific kinase mediated signaling pathway 476
          mitogen activated protein kinase signaling pathway 299
            stress-regulated MAPK signaling pathway 70
              altered stress-regulated MAPK signaling pathway + 0
              c-Jun N-terminal kinases MAPK signaling pathway + 31
              p38 MAPK signaling pathway + 54
paths to the root