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ONTOLOGY REPORT - ANNOTATIONS


Term:hypertrophic cardiomyopathy pathway
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Accession:PW:0000296 term browser browse the term
Definition:Hypertrophic cardiomyopathy, or HCM, is a disease of the myocardium (the muscle of the heart) in which a portion of the myocardium is thickened. Many physiological and pathological conditions as well as many pathways underlie the hypertrophic response.
Synonyms:exact_synonym: HCM pathway
 related_synonym: KEGG:05410


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hypertrophic cardiomyopathy pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:6907045
G Actb actin, beta JBrowse link 12 13,715,843 13,718,813 RGD:6907045
G Actc1 actin, alpha, cardiac muscle 1 JBrowse link 3 105,507,403 105,512,939 RGD:6907045
G Actg1 actin, gamma 1 JBrowse link 10 109,518,429 109,521,288 RGD:6907045
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 JBrowse link 12 39,553,903 39,603,326 RGD:6907045
G Cacna1c calcium voltage-gated channel subunit alpha1 C JBrowse link 4 150,635,808 151,270,790 RGD:6907045
G Cacna1d calcium voltage-gated channel subunit alpha1 D JBrowse link 16 6,110,294 6,405,022 RGD:6907045
G Cacna1f calcium voltage-gated channel subunit alpha1 F JBrowse link X 15,712,709 15,741,135 RGD:6907045
G Cacna1s calcium voltage-gated channel subunit alpha1 S JBrowse link 13 52,889,570 52,964,558 RGD:6907045
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 JBrowse link 4 15,706,974 16,130,848 RGD:6907045
G Cacna2d2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 JBrowse link 8 116,154,661 116,285,643 RGD:6907045
G Cacna2d3 calcium voltage-gated channel auxiliary subunit alpha2delta 3 JBrowse link 16 4,871,348 5,795,825 RGD:6907045
G Cacna2d4 calcium voltage-gated channel auxiliary subunit alpha2delta 4 JBrowse link 4 151,298,548 151,409,263 RGD:6907045
G Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 JBrowse link 10 85,954,138 85,974,764 RGD:6907045
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 JBrowse link 17 81,673,862 82,019,219 RGD:6907045
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 JBrowse link 7 140,311,120 140,324,902 RGD:6907045
G Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 JBrowse link 3 37,950,846 38,211,478 RGD:6907045
G Cacng1 calcium voltage-gated channel auxiliary subunit gamma 1 JBrowse link 10 95,921,479 95,934,170 RGD:6907045
G Cacng2 calcium voltage-gated channel auxiliary subunit gamma 2 JBrowse link 7 119,228,112 119,353,332 RGD:6907045
G Cacng3 calcium voltage-gated channel auxiliary subunit gamma 3 JBrowse link 1 192,613,766 192,708,371 RGD:6907045
G Cacng4 calcium voltage-gated channel auxiliary subunit gamma 4 JBrowse link 10 95,954,160 96,015,484 RGD:6907045
G Cacng5 calcium voltage-gated channel auxiliary subunit gamma 5 JBrowse link 10 96,122,240 96,166,606 RGD:6907045
G Cacng6 calcium voltage-gated channel auxiliary subunit gamma 6 JBrowse link 1 64,307,684 64,322,124 RGD:6907045
G Cacng7 calcium voltage-gated channel auxiliary subunit gamma 7 JBrowse link 1 64,374,547 64,405,380 RGD:6907045
G Cacng8 calcium voltage-gated channel auxiliary subunit gamma 8 JBrowse link 1 64,330,106 64,350,338 RGD:6907045
G Dag1 dystroglycan 1 JBrowse link 8 116,980,501 116,993,182 RGD:6907045
G Des desmin JBrowse link 9 82,556,574 82,564,288 RGD:6907045
G Emd emerin JBrowse link X 156,452,847 156,455,858 RGD:6907045
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:6907045
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6907045
G Itga1 integrin subunit alpha 1 JBrowse link 2 47,127,403 47,281,387 RGD:6907045
G Itga10 integrin subunit alpha 10 JBrowse link 2 198,772,937 198,792,253 RGD:6907045
G Itga11 integrin subunit alpha 11 JBrowse link 8 67,566,874 67,683,973 RGD:6907045
G Itga2 integrin subunit alpha 2 JBrowse link 2 46,996,904 47,097,011 RGD:6907045
G Itga2b integrin subunit alpha 2b JBrowse link 10 90,397,960 90,416,550 RGD:6907045
G Itga4 integrin subunit alpha 4 JBrowse link 3 66,178,745 66,265,547 RGD:6907045
G Itga5 integrin subunit alpha 5 JBrowse link 7 144,970,444 144,993,652 RGD:6907045
G Itga6 integrin subunit alpha 6 JBrowse link 3 58,442,904 58,515,124 RGD:6907045
G Itga7 integrin subunit alpha 7 JBrowse link 7 3,355,079 3,383,886 RGD:70774
RGD:6907045
G Itga9 integrin subunit alpha 9 JBrowse link 8 127,271,029 127,576,709 RGD:6907045
G Itgb1 integrin subunit beta 1 JBrowse link 19 61,677,512 61,725,537 RGD:1302874
RGD:6907045
G Itgb3 integrin subunit beta 3 JBrowse link 10 92,667,869 92,783,413 RGD:6907045
G Itgb4 integrin subunit beta 4 JBrowse link 10 104,524,000 104,560,180 RGD:6907045
G Itgb5 integrin subunit beta 5 JBrowse link 11 70,056,500 70,172,164 RGD:6907045
G Itgb6 integrin subunit beta 6 JBrowse link 3 46,652,624 46,775,362 RGD:6907045
G Itgb7 integrin subunit beta 7 JBrowse link 7 143,820,236 143,837,802 RGD:6907045
G Itgb8 integrin subunit beta 8 JBrowse link 6 147,089,280 147,172,846 RGD:6907045
G Lama2 laminin subunit alpha 2 JBrowse link 1 18,491,264 19,143,486 RGD:6907045
G Lmna lamin A/C JBrowse link 2 187,842,884 187,863,552 RGD:6907045
G Mybpc3 myosin binding protein C3 JBrowse link 3 79,940,509 79,958,731 RGD:6907045
G Myh6 myosin heavy chain 6 JBrowse link 15 33,605,653 33,629,730 RGD:6907045
G Myh7 myosin heavy chain 7 JBrowse link 15 33,605,769 33,657,761 RGD:6907045
G Myl2 myosin light chain 2 JBrowse link 12 39,951,863 39,959,065 RGD:6907045
G Myl3 myosin light chain 3 JBrowse link 8 119,030,852 119,036,996 RGD:6907045
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 JBrowse link 2 54,857,688 54,893,404 RGD:6907045
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 JBrowse link 5 124,568,845 124,642,569 RGD:6907045
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 JBrowse link 12 46,316,298 46,326,789 RGD:6907045
G Prkab2 protein kinase AMP-activated non-catalytic subunit beta 2 JBrowse link 2 199,831,990 199,847,623 RGD:6907045
G Prkag1 protein kinase AMP-activated non-catalytic subunit gamma 1 JBrowse link 7 140,489,499 140,506,925 RGD:6907045
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 JBrowse link 4 6,559,153 6,799,888 RGD:6907045
G Prkag3 protein kinase AMP-activated non-catalytic subunit gamma 3 JBrowse link 9 81,999,368 82,008,620 RGD:6907045
G Ryr2 ryanodine receptor 2 JBrowse link 17 65,533,998 65,955,606 RGD:6907045
G Sgca sarcoglycan, alpha JBrowse link 10 82,770,905 82,785,142 RGD:6907045
G Sgcb sarcoglycan, beta JBrowse link 14 37,113,194 37,128,623 RGD:6907045
G Sgcd sarcoglycan, delta JBrowse link 10 32,062,946 32,471,454 RGD:6907045
G Sgcg sarcoglycan, gamma JBrowse link 15 41,549,330 41,595,275 RGD:6907045
G Slc8a1 solute carrier family 8 member A1 JBrowse link 6 4,244,076 4,564,262 RGD:6907045
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6907045
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:6907045
G Tgfb3 transforming growth factor, beta 3 JBrowse link 6 109,913,757 109,936,217 RGD:6907045
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6907045
G Tnnc1 troponin C1, slow skeletal and cardiac type JBrowse link 16 7,292,207 7,295,238 RGD:6907045
G Tnni3 troponin I3, cardiac type JBrowse link 1 72,882,806 72,886,490 RGD:6907045
G Tnnt2 troponin T2, cardiac type JBrowse link 13 52,662,974 52,680,992 RGD:6907045
G Tpm1 tropomyosin 1 JBrowse link 8 72,814,737 72,841,496 RGD:6907045
G Tpm2 tropomyosin 2 JBrowse link 5 59,016,616 59,025,971 RGD:6907045
G Tpm3 tropomyosin 3 JBrowse link 2 189,423,534 189,451,340 RGD:6907045
G Tpm4 tropomyosin 4 JBrowse link 16 19,385,810 19,399,851 RGD:6907045
G Ttn titin JBrowse link 3 63,565,160 63,837,815 RGD:6907045

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  pathway 6016
    disease pathway 1947
      cardiovascular system disease pathway 254
        cardiomyopathy pathway 195
          hypertrophic cardiomyopathy pathway 79
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.