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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:autophagy pathway
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Accession:PW:0000278 term browser browse the term
Definition:The autophagic pathway involves the sequestration of misfolded or long-lived proteins and of defective organelles within double membrane vesicles, and delivery of the cargo to lysosomes for degradation and recycling. It is also known as macroautophagy, or bulk autophagy.
Synonyms:related_synonym: Macroautophagy
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autophagy pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACP2 acid phosphatase 2, lysosomal ISO RGD PMID:18690537 RGD:4892631 NCBI chr 1:18,061,094...18,070,929
Ensembl chr 1:18,060,994...18,072,208 		JBrowse link
G ATG10 autophagy related 10 ISO RGD PMID:15325588 PMID:20034776 RGD:1643329 RGD:4889529 NCBI chr 4:76,092,887...76,378,175
Ensembl chr 4:76,092,832...76,377,403 		JBrowse link
G ATG12 autophagy related 12 ISO RGD PMID:15325588 PMID:18059433 PMID:20034776 RGD:1643329 RGD:2301217 RGD:4889529 NCBI chr23:19,073,545...19,087,603
Ensembl chr23:19,072,401...19,087,625 		JBrowse link
G ATG13 autophagy related 13 ISO RGD PMID:20034776 RGD:4889529 NCBI chr 1:18,651,872...18,712,395
Ensembl chr 1:18,652,998...18,712,482 		JBrowse link
G ATG14 autophagy related 14 ISO RGD PMID:20034776 RGD:4889529 NCBI chr24:32,560,580...32,605,336
Ensembl chr24:32,559,955...32,605,282 		JBrowse link
G ATG16L1 autophagy related 16 like 1 ISO RGD PMID:15325588 PMID:20034776 RGD:1643329 RGD:4889529 NCBI chr10:119,286,609...119,331,226
Ensembl chr10:119,286,751...119,333,267 		JBrowse link
G ATG16L2 autophagy related 16 like 2 ISO RGD PMID:15325588 PMID:20034776 RGD:1643329 RGD:4889529 NCBI chr 1:64,051,793...64,066,204
Ensembl chr 1:64,052,390...64,065,972 		JBrowse link
G ATG3 autophagy related 3 ISO RGD PMID:15325588 PMID:17110912 PMID:20034776 RGD:1643237 RGD:1643329 RGD:4889529 NCBI chr22:68,227,772...68,256,555
Ensembl chr22:68,228,203...68,257,503 		JBrowse link
G ATG4A autophagy related 4A cysteine peptidase ISO RGD PMID:15325588 RGD:1643329 NCBI chr  X:95,936,385...96,011,541
Ensembl chr  X:95,983,662...96,010,578 		JBrowse link
G ATG4B autophagy related 4B cysteine peptidase ISO RGD PMID:15325588 RGD:1643329 NCBI chr10:127,689,577...127,720,232 JBrowse link
G ATG4C autophagy related 4C cysteine peptidase ISO RGD PMID:15325588 RGD:1643329 NCBI chr20:70,209,536...70,291,750
Ensembl chr20:70,208,716...70,291,718 		JBrowse link
G ATG4D autophagy related 4D cysteine peptidase ISO RGD PMID:15325588 RGD:1643329 NCBI chr 6:9,555,792...9,565,295
Ensembl chr 6:9,555,780...9,568,814 		JBrowse link
G ATG5 autophagy related 5 ISO RGD PMID:18059433 PMID:20034776 RGD:2301217 RGD:4889529 NCBI chr13:67,482,538...67,619,201
Ensembl chr13:67,482,595...67,617,902 		JBrowse link
G ATG7 autophagy related 7 ISO RGD PMID:15325588 PMID:17665967 PMID:20034776 RGD:1643198 RGD:1643329 RGD:4889529 NCBI chr22:47,187,305...47,571,309
Ensembl chr22:47,325,614...47,571,070 		JBrowse link
G ATG9A autophagy related 9A ISO RGD PMID:20034776 RGD:4889529 NCBI chr10:105,123,039...105,133,057
Ensembl chr10:105,124,412...105,131,409 		JBrowse link
G ATG9B autophagy related 9B ISO RGD PMID:20034776 RGD:4889529 NCBI chr21:119,197,387...119,209,578
Ensembl chr21:119,198,125...119,206,599 		JBrowse link
G BECN1 beclin 1 ISO RGD PMID:15325588 PMID:16697404 PMID:20034776 RGD:1643194 RGD:1643329 RGD:4889529 NCBI chr16:63,469,187...63,482,627
Ensembl chr16:63,469,192...63,485,322 		JBrowse link
G CHMP2B charged multivesicular body protein 2B ISO RGD PMID:19535733 RGD:4892619 NCBI chr22:89,672,043...89,701,801
Ensembl chr22:89,672,022...89,701,897 		JBrowse link
G CHMP3 charged multivesicular body protein 3 ISO RGD PMID:19535733 RGD:4892619 NCBI chr14:20,536,490...20,654,761
Ensembl chr14:20,594,817...20,654,404 		JBrowse link
G GABARAP GABA type A receptor-associated protein ISO RGD PMID:15325588 PMID:20562859 RGD:1643329 RGD:4890444 NCBI chr16:6,614,478...6,616,516
Ensembl chr16:6,614,688...6,616,443 		JBrowse link
G GABARAPL1 GABA type A receptor associated protein like 1 ISO RGD PMID:20562859 RGD:4890444 NCBI chr11:10,087,582...10,099,125
Ensembl chr11:10,087,604...10,096,612 		JBrowse link
G GABARAPL2 GABA type A receptor associated protein like 2 ISO RGD PMID:15325588 PMID:20562859 RGD:1643329 RGD:4890444 NCBI chr 5:61,053,283...61,078,675
Ensembl chr 5:61,053,262...61,066,083 		JBrowse link
G HGS hepatocyte growth factor-regulated tyrosine kinase substrate ISO RGD PMID:19535733 RGD:4892619 NCBI chr16:73,613,711...73,632,527
Ensembl chr16:73,613,786...73,632,016 		JBrowse link
G LAMP1 lysosomal associated membrane protein 1 ISO RGD PMID:18690537 PMID:20548331 RGD:4892310 RGD:4892631 NCBI chr 3:91,295,758...91,319,881
Ensembl chr 3:91,295,681...91,321,333 		JBrowse link
G LAMP2 lysosomal associated membrane protein 2 ISO RGD PMID:20548331 RGD:4892310
G MAP1LC3A microtubule associated protein 1 light chain 3 alpha ISO RGD PMID:15325588 PMID:17665967 PMID:20562859 RGD:1643198 RGD:1643329 RGD:4890444 NCBI chr 2:38,857,235...38,858,955
Ensembl chr 2:38,857,299...38,858,505 		JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta ISO RGD PMID:15325588 PMID:20562859 RGD:1643329 RGD:4890444 NCBI chr 5:72,762,428...72,774,204
Ensembl chr 5:72,763,050...72,772,770 		JBrowse link
G MAP1LC3C microtubule associated protein 1 light chain 3 gamma ISO RGD PMID:20562859 RGD:4890444 NCBI chr25:79,079,750...79,084,248
Ensembl chr25:79,080,728...79,083,762 		JBrowse link
G PIK3C3 phosphatidylinositol 3-kinase catalytic subunit type 3 ISO RGD PMID:20034776 RGD:4889529 NCBI chr18:38,785,476...38,914,279
Ensembl chr18:38,787,717...38,914,185 		JBrowse link
G PIK3R4 phosphoinositide-3-kinase regulatory subunit 4 ISO RGD PMID:20034776 RGD:4889529 NCBI chr15:59,444,570...59,515,619
Ensembl chr15:59,444,616...59,515,240 		JBrowse link
G RAB11A RAB11A, member RAS oncogene family ISO RGD PMID:20548331 RGD:4892310 NCBI chr26:17,682,629...17,702,325
Ensembl chr26:17,682,874...17,702,309 		JBrowse link
G RAB33B RAB33B, member RAS oncogene family ISO RGD PMID:20548331 RGD:4892310 NCBI chr 7:86,422,234...86,446,341
Ensembl chr 7:86,422,612...86,446,338 		JBrowse link
G RAB5A RAB5A, member RAS oncogene family ISO RGD PMID:20548331 RGD:4892310 NCBI chr15:64,678,910...64,715,228
Ensembl chr15:64,682,723...64,713,928 		JBrowse link
G RAB7A RAB7A, member RAS oncogene family ISO RGD PMID:20548331 RGD:4892310 NCBI chr22:52,231,481...52,309,276
Ensembl chr22:52,230,835...52,309,306 		JBrowse link
G RB1CC1 RB1 inducible coiled-coil 1 ISO RGD PMID:20034776 RGD:4889529 NCBI chr 8:48,726,551...48,818,027
Ensembl chr 8:48,724,393...48,817,928 		JBrowse link
G RUBCN rubicon autophagy regulator ISO RGD PMID:20034776 RGD:4889529 NCBI chr15:91,401,565...91,468,837
Ensembl chr15:91,400,031...91,457,933 		JBrowse link
G SNF8 SNF8 subunit of ESCRT-II ISO RGD PMID:19535733 RGD:4892619 NCBI chr16:69,343,260...69,357,843
Ensembl chr16:69,339,804...69,357,860 		JBrowse link
G TSG101 tumor susceptibility 101 ISO RGD PMID:19535733 RGD:4892619 NCBI chr 1:46,401,889...46,451,122
Ensembl chr 1:46,402,024...46,450,916 		JBrowse link
G ULK1 unc-51 like autophagy activating kinase 1 ISO RGD PMID:15325588 PMID:20034776 RGD:1643329 RGD:4889529 NCBI chr11:127,276,172...127,304,270
Ensembl chr11:127,276,210...127,304,497 		JBrowse link
G ULK2 unc-51 like autophagy activating kinase 2 ISO RGD PMID:20034776 RGD:4889529 NCBI chr16:18,335,095...18,434,031
Ensembl chr16:18,335,235...18,433,578 		JBrowse link
G UVRAG UV radiation resistance associated ISO RGD PMID:20034776 RGD:4889529 NCBI chr 1:67,032,575...67,353,207
Ensembl chr 1:67,032,436...67,353,166 		JBrowse link
G VAMP3 vesicle associated membrane protein 3 ISO RGD PMID:20548331 RGD:4892310 NCBI chr20:123,973,672...123,984,230
Ensembl chr20:123,971,992...123,984,187 		JBrowse link
G VAMP7 vesicle associated membrane protein 7 ISO RGD PMID:20548331 RGD:4892310 NCBI chr  X:129,937,026...129,984,071
Ensembl chr  X:129,937,046...129,984,119 		JBrowse link
G VPS4A vacuolar protein sorting 4 homolog A ISO RGD PMID:19535733 RGD:4892619 NCBI chr 5:58,081,800...58,095,115
Ensembl chr 5:58,082,521...58,095,173 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4034
    regulatory pathway 2500
      cell death pathway 185
        programmed cell death pathway 185
          non-apoptotic cell death pathway 75
            cellular autophagy pathway 75
              autophagy pathway 44
                altered autophagy pathway 0
paths to the root