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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:angiotensin signaling pathway
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Accession:PW:0000245 term browser browse the term
Definition:Angiotensin peptides Ang II, Ang III, Ang IV and Ang (1-7) generated from a single precursor protein - angiotensinogen - regulate an array of physiological and pathophysiological processes.

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show annotations for term's descendants           Sort by:
angiotensin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen ISO RGD PMID:12676165 RGD:1566511 NCBI chrNW_004936484:19,713,299...19,721,144
Ensembl chrNW_004936484:19,716,165...19,721,261 		JBrowse link
angiotensin (1-7) signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 ISO RGD PMID:15638741 RGD:1581742 NCBI chrNW_004936470:4,964,526...5,011,808
Ensembl chrNW_004936470:4,965,332...5,011,702 		JBrowse link
G Agt angiotensinogen ISO RGD PMID:15951342 RGD:1581938 NCBI chrNW_004936484:19,713,299...19,721,144
Ensembl chrNW_004936484:19,716,165...19,721,261 		JBrowse link
G LOC101968921 angiotensin-converting enzyme ISO RGD PMID:10642323 PMID:15283675 RGD:1581953 RGD:1598433 NCBI chrNW_004936541:4,157,847...4,178,156
Ensembl chrNW_004936541:4,157,393...4,178,177 		JBrowse link
G Mme membrane metalloendopeptidase ISO RGD PMID:10642323 PMID:15638741 PMID:16520407 RGD:1581742 RGD:1581931 RGD:1581953 NCBI chrNW_004936519:2,513,896...2,595,896
Ensembl chrNW_004936519:2,513,704...2,595,971 		JBrowse link
angiotensin II signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen ISO RGD PMID:16141358 RGD:1581847 NCBI chrNW_004936484:19,713,299...19,721,144
Ensembl chrNW_004936484:19,716,165...19,721,261 		JBrowse link
G Agtr1 angiotensin II receptor type 1 ISO RGD PMID:15590154 RGD:1579760 NCBI chrNW_004936519:6,831,096...6,873,977
Ensembl chrNW_004936519:6,831,096...6,873,985 		JBrowse link
G Agtr2 angiotensin II receptor type 2 ISO RGD PMID:14657020 RGD:1566502 NCBI chrNW_004936479:13,252,678...13,255,570
Ensembl chrNW_004936479:13,252,678...13,255,570 		JBrowse link
G Jak2 Janus kinase 2 ISO RGD PMID:16269269 RGD:1600094 NCBI chrNW_004936503:111,722...243,627
Ensembl chrNW_004936503:110,963...241,867 		JBrowse link
G LOC101968921 angiotensin-converting enzyme ISO RGD PMID:15638741 RGD:1581742 NCBI chrNW_004936541:4,157,847...4,178,156
Ensembl chrNW_004936541:4,157,393...4,178,177 		JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 ISO RGD PMID:12661921 RGD:1580992 NCBI chrNW_004936902:405,536...416,393
Ensembl chrNW_004936902:409,704...416,401 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase 1 ISO RGD PMID:14585963 RGD:1581775 NCBI chrNW_004936694:1,444,819...1,487,628
Ensembl chrNW_004936694:1,444,880...1,488,265
Ensembl chrNW_004936694:1,444,880...1,488,265 		JBrowse link
G Pla2g6 phospholipase A2 group VI ISO RGD PMID:17613534 RGD:12910844 NCBI chrNW_004936492:3,011,752...3,060,962
Ensembl chrNW_004936492:3,011,772...3,060,986 		JBrowse link
G Prkcz protein kinase C zeta ISO RGD PMID:16113073 RGD:1642674 NCBI chrNW_004936737:1,303,502...1,383,135
Ensembl chrNW_004936737:1,303,887...1,321,944 		JBrowse link
angiotensin II signaling pathway via AT1 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen ISO RGD PMID:16141358 RGD:1581847 NCBI chrNW_004936484:19,713,299...19,721,144
Ensembl chrNW_004936484:19,716,165...19,721,261 		JBrowse link
G Agtr1 angiotensin II receptor type 1 ISO RGD PMID:9287353 PMID:10977869 PMID:12446719 PMID:14559250 RGD:1581825 RGD:2316188 RGD:5133683 RGD:629553 NCBI chrNW_004936519:6,831,096...6,873,977
Ensembl chrNW_004936519:6,831,096...6,873,985 		JBrowse link
G Agtrap angiotensin II receptor associated protein ISO RGD PMID:17875818 RGD:2314353 NCBI chrNW_004936474:585,440...597,493
Ensembl chrNW_004936474:585,440...597,257 		JBrowse link
G Arap1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 ISO RGD PMID:14559250 RGD:2316188 NCBI chrNW_004936498:1,953,770...2,016,875
Ensembl chrNW_004936498:1,953,762...2,003,367 		JBrowse link
G Arrb1 arrestin beta 1 ISO RGD PMID:16304060 RGD:5133417 NCBI chrNW_004936498:4,089,621...4,172,749
Ensembl chrNW_004936498:4,094,893...4,172,755 		JBrowse link
G Arrb2 arrestin beta 2 ISO RGD PMID:16304060 RGD:5133417 NCBI chrNW_004936677:3,173,054...3,181,475
Ensembl chrNW_004936677:3,172,925...3,181,520 		JBrowse link
G Gna11 G protein subunit alpha 11 ISO RGD PMID:16141358 RGD:1581847 NCBI chrNW_004936588:1,770,777...1,789,143
Ensembl chrNW_004936588:1,770,771...1,789,170 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO RGD PMID:16304060 RGD:5133417 NCBI chrNW_004936599:2,437,061...2,456,141
Ensembl chrNW_004936599:2,437,032...2,456,147 		JBrowse link
G Grk3 G protein-coupled receptor kinase 3 ISO RGD PMID:16304060 RGD:5133417 NCBI chrNW_004936657:425,902...522,331
Ensembl chrNW_004936657:426,787...521,198 		JBrowse link
G Grk5 G protein-coupled receptor kinase 5 ISO RGD PMID:16304060 RGD:5133417 NCBI chrNW_004936486:8,720,036...8,830,472
Ensembl chrNW_004936486:8,720,036...8,831,075 		JBrowse link
G Grk6 G protein-coupled receptor kinase 6 ISO RGD PMID:16304060 RGD:5133417 NCBI chrNW_004936597:1,706,671...1,722,370
Ensembl chrNW_004936597:1,706,665...1,722,370 		JBrowse link
G Jak2 Janus kinase 2 ISO RGD PMID:9287353 PMID:9314843 RGD:5133683 RGD:6478796 NCBI chrNW_004936503:111,722...243,627
Ensembl chrNW_004936503:110,963...241,867 		JBrowse link
G LOC101971998 guanine nucleotide-binding protein G(q) subunit alpha ISO RGD PMID:16141358 RGD:1581847 NCBI chrNW_004936503:13,098,517...13,276,106
Ensembl chrNW_004936503:13,099,558...13,276,152 		JBrowse link
G Rgs2 regulator of G protein signaling 2 ISO RGD PMID:12588881 RGD:5133418 NCBI chrNW_004936638:1,065,866...1,068,649
Ensembl chrNW_004936638:1,065,832...1,069,247 		JBrowse link
G Tyk2 tyrosine kinase 2 ISO RGD PMID:9314843 RGD:6478796 NCBI chrNW_004936659:681,463...704,484
Ensembl chrNW_004936659:681,310...702,962 		JBrowse link
angiotensin II signaling pathway via AT2 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen ISO RGD PMID:16286564 PMID:16286568 PMID:22949090 RGD:1582434 RGD:1582435 RGD:7401256 NCBI chrNW_004936484:19,713,299...19,721,144
Ensembl chrNW_004936484:19,716,165...19,721,261 		JBrowse link
G Agtr2 angiotensin II receptor type 2 ISO RGD PMID:10977869 PMID:22949090 RGD:1581825 RGD:7401256 NCBI chrNW_004936479:13,252,678...13,255,570
Ensembl chrNW_004936479:13,252,678...13,255,570 		JBrowse link
G Cnksr1 connector enhancer of kinase suppressor of Ras 1 ISO RGD PMID:20889352 RGD:5133679 NCBI chrNW_004936474:10,697,777...10,706,988
Ensembl chrNW_004936474:10,699,819...10,706,591 		JBrowse link
G Dusp1 dual specificity phosphatase 1 ISO RGD PMID:18804122 RGD:5133675 NCBI chrNW_004936609:2,688,170...2,691,057
Ensembl chrNW_004936609:2,688,181...2,690,408 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 ISO RGD PMID:20889352 RGD:5133679 NCBI chrNW_004936646:497,783...515,247
Ensembl chrNW_004936646:498,749...513,297 		JBrowse link
G Gnai2 G protein subunit alpha i2 ISO RGD PMID:22949090 RGD:7401256 NCBI chrNW_004936529:1,779,582...1,801,251
Ensembl chrNW_004936529:1,779,571...1,801,255 		JBrowse link
G Gnai3 G protein subunit alpha i3 ISO RGD PMID:22949090 RGD:7401256 NCBI chrNW_004936704:1,031,476...1,075,662
Ensembl chrNW_004936704:1,032,708...1,074,384 		JBrowse link
G Mtus1 microtubule associated scaffold protein 1 ISO RGD PMID:20889352 RGD:5133679 NCBI chrNW_004936614:242,710...387,541
Ensembl chrNW_004936614:240,113...387,730 		JBrowse link
G Ptpn6 protein tyrosine phosphatase non-receptor type 6 ISO RGD PMID:18804122 RGD:5133675 NCBI chrNW_004936709:864,206...884,630
Ensembl chrNW_004936709:864,197...884,610 		JBrowse link
G Slc9a6 solute carrier family 9 member A6 ISO RGD PMID:20889352 RGD:5133679 NCBI chrNW_004936513:11,158,609...11,215,477
Ensembl chrNW_004936513:11,158,730...11,215,568 		JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 ISO RGD PMID:20889352 RGD:5133679 NCBI chrNW_004936492:6,996,627...7,046,137
Ensembl chrNW_004936492:6,996,613...7,046,190 		JBrowse link
G Zbtb16 zinc finger and BTB domain containing 16 ISO RGD PMID:20889352 RGD:5133679 NCBI chrNW_004936612:389,877...570,595
Ensembl chrNW_004936612:395,177...570,595 		JBrowse link
angiotensin III signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen ISO RGD PMID:11295571 RGD:1582124 NCBI chrNW_004936484:19,713,299...19,721,144
Ensembl chrNW_004936484:19,716,165...19,721,261 		JBrowse link
G Agtr1 angiotensin II receptor type 1 ISO RGD PMID:11295571 RGD:1582124 NCBI chrNW_004936519:6,831,096...6,873,977
Ensembl chrNW_004936519:6,831,096...6,873,985 		JBrowse link
G Agtr2 angiotensin II receptor type 2 ISO RGD PMID:11295571 RGD:1582124 NCBI chrNW_004936479:13,252,678...13,255,570
Ensembl chrNW_004936479:13,252,678...13,255,570 		JBrowse link
G Enpep glutamyl aminopeptidase ISO RGD PMID:15638741 PMID:16537183 RGD:1581649 RGD:1581742 NCBI chrNW_004936563:1,585,450...1,665,663
Ensembl chrNW_004936563:1,585,471...1,665,677 		JBrowse link
angiotensin III signaling pathway via AT1 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen ISO RGD PMID:11100981 RGD:1582152 NCBI chrNW_004936484:19,713,299...19,721,144
Ensembl chrNW_004936484:19,716,165...19,721,261 		JBrowse link
G Agtr1 angiotensin II receptor type 1 ISO RGD PMID:11100981 RGD:1582152 NCBI chrNW_004936519:6,831,096...6,873,977
Ensembl chrNW_004936519:6,831,096...6,873,985 		JBrowse link
angiotensin III signaling pathway via AT2 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen ISO RGD PMID:16380540 RGD:1582118 NCBI chrNW_004936484:19,713,299...19,721,144
Ensembl chrNW_004936484:19,716,165...19,721,261 		JBrowse link
G Agtr2 angiotensin II receptor type 2 ISO RGD PMID:16380540 RGD:1582118 NCBI chrNW_004936479:13,252,678...13,255,570
Ensembl chrNW_004936479:13,252,678...13,255,570 		JBrowse link
angiotensin IV signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen ISO RGD PMID:11282364 RGD:1582105 NCBI chrNW_004936484:19,713,299...19,721,144
Ensembl chrNW_004936484:19,716,165...19,721,261 		JBrowse link
G Anpep alanyl aminopeptidase, membrane ISO RGD PMID:15638741 PMID:16537183 RGD:1581649 RGD:1581742 NCBI chrNW_004936483:15,563,540...15,582,521
Ensembl chrNW_004936483:15,563,528...15,589,601 		JBrowse link
G Lnpep leucyl and cystinyl aminopeptidase ISO RGD PMID:11282364 PMID:12591177 RGD:1581864 RGD:1582105 NCBI chrNW_004936523:6,443,571...6,533,122
Ensembl chrNW_004936523:6,445,939...6,532,566 		JBrowse link
G Rnpep arginyl aminopeptidase ISO RGD PMID:16537183 RGD:1581649 NCBI chrNW_004936567:2,504,544...2,524,977
Ensembl chrNW_004936567:2,504,537...2,525,018 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3948
    signaling pathway 1893
      hormone signaling pathway 368
        peptide and protein hormone signaling pathway 263
          angiotensin signaling pathway 37
            angiotensin (1-7) signaling pathway 4
            angiotensin II signaling pathway + 31
            angiotensin III signaling pathway + 4
            angiotensin IV signaling pathway 4
Path 2
Term Annotations click to browse term
  pathway 3948
    regulatory pathway 2450
      homeostasis pathway 1274
        cardiovascular system homeostasis pathway 256
          renin-angiotensin cascade pathway 41
            angiotensin signaling pathway 37
              angiotensin (1-7) signaling pathway 4
              angiotensin II signaling pathway + 31
              angiotensin III signaling pathway + 4
              angiotensin IV signaling pathway 4
paths to the root