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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:angiotensin signaling pathway
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Accession:PW:0000245 term browser browse the term
Definition:Angiotensin peptides Ang II, Ang III, Ang IV and Ang (1-7) generated from a single precursor protein - angiotensinogen - regulate an array of physiological and pathophysiological processes.


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angiotensin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen ISO RGD PMID:12676165 RGD:1566511 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833 		JBrowse link
angiotensin (1-7) signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 ISO RGD PMID:10642323 PMID:15283675 RGD:1581953 RGD:1598433 NCBI chr12:15,394,487...15,414,609
Ensembl chr12:15,394,487...15,414,703 		JBrowse link
G ACE2 angiotensin converting enzyme 2 ISO RGD PMID:15638741 RGD:1581742 NCBI chr  X:12,099,849...12,152,204
Ensembl chr  X:12,093,242...12,151,286 		JBrowse link
G AGT angiotensinogen ISO RGD PMID:15951342 RGD:1581938 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833 		JBrowse link
G MAS1 MAS1 proto-oncogene, G protein-coupled receptor ISO RGD PMID:15951342 PMID:16520407 RGD:1581931 RGD:1581938 NCBI chr 1:7,527,566...7,542,110
Ensembl chr 1:7,527,861...7,528,838 		JBrowse link
G MME membrane metalloendopeptidase ISO RGD PMID:10642323 PMID:15638741 PMID:16520407 RGD:1581742 RGD:1581931 RGD:1581953 NCBI chr13:95,018,395...95,122,977
Ensembl chr13:95,019,081...95,126,045 		JBrowse link
angiotensin II signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 ISO RGD PMID:15638741 RGD:1581742 NCBI chr12:15,394,487...15,414,609
Ensembl chr12:15,394,487...15,414,703 		JBrowse link
G AGT angiotensinogen ISO RGD PMID:16141358 RGD:1581847 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833 		JBrowse link
G AGTR1 angiotensin II receptor type 1 ISO RGD PMID:15590154 RGD:1579760 NCBI chr13:88,934,873...88,980,317
Ensembl chr13:88,934,868...88,983,105 		JBrowse link
G AGTR2 angiotensin II receptor type 2 ISO RGD PMID:14657020 RGD:1566502 NCBI chr  X:95,267,709...95,272,237
Ensembl chr  X:95,269,300...95,270,388 		JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 ISO RGD PMID:14684844 RGD:1582323 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026 		JBrowse link
G JAK2 Janus kinase 2 ISO RGD PMID:16269269 RGD:1600094 NCBI chr 1:216,849,744...217,002,310
Ensembl chr 1:216,848,689...217,002,148 		JBrowse link
G OLR1 oxidized low density lipoprotein receptor 1 ISO RGD PMID:12661921 RGD:1580992 NCBI chr 5:61,799,356...61,809,691
Ensembl chr 5:61,799,286...61,810,624 		JBrowse link
G PDPK1 3-phosphoinositide dependent protein kinase 1 ISO RGD PMID:14585963 RGD:1581775 NCBI chr 3:39,429,928...39,512,623
Ensembl chr 3:39,432,058...39,512,601 		JBrowse link
G PLA2G6 phospholipase A2 group VI ISO RGD PMID:17613534 RGD:12910844 NCBI chr 5:9,713,809...9,777,921
Ensembl chr 5:9,713,873...9,777,918 		JBrowse link
G PRKCZ protein kinase C zeta ISO RGD PMID:16113073 RGD:1642674 NCBI chr 6:64,073,343...64,159,187
Ensembl chr 6:64,068,577...64,163,472 		JBrowse link
angiotensin II signaling pathway via AT1 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen ISO RGD PMID:16141358 RGD:1581847 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833 		JBrowse link
G AGTR1 angiotensin II receptor type 1 ISO RGD PMID:9287353 PMID:10977869 PMID:12446719 PMID:14559250 RGD:1581825 RGD:2316188 RGD:5133683 RGD:629553 NCBI chr13:88,934,873...88,980,317
Ensembl chr13:88,934,868...88,983,105 		JBrowse link
G AGTRAP angiotensin II receptor associated protein ISO RGD PMID:17875818 RGD:2314353 NCBI chr 6:71,825,319...71,836,812 JBrowse link
G ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 ISO RGD PMID:14559250 RGD:2316188 NCBI chr 9:7,238,043...7,301,085
Ensembl chr 9:7,233,911...7,301,073 		JBrowse link
G ARRB1 arrestin beta 1 ISO RGD PMID:16304060 RGD:5133417 NCBI chr 9:9,516,944...9,597,446
Ensembl chr 9:9,516,947...9,597,976 		JBrowse link
G ARRB2 arrestin beta 2 ISO RGD PMID:16304060 RGD:5133417 NCBI chr12:52,161,776...52,170,362
Ensembl chr12:52,161,778...52,170,342 		JBrowse link
G GNA11 G protein subunit alpha 11 ISO RGD PMID:16141358 RGD:1581847 NCBI chr 2:75,439,405...75,456,855
Ensembl chr 2:75,437,201...75,457,092 		JBrowse link
G GNAQ G protein subunit alpha q ISO RGD PMID:16141358 RGD:1581847 NCBI chr 1:230,607,469...230,906,988
Ensembl chr 1:230,605,265...230,907,674 		JBrowse link
G GRK2 G protein-coupled receptor kinase 2 ISO RGD PMID:16304060 RGD:5133417 NCBI chr 2:5,209,435...5,227,543
Ensembl chr 2:5,209,439...5,227,758 		JBrowse link
G GRK3 G protein-coupled receptor kinase 3 ISO RGD PMID:16304060 RGD:5133417 NCBI chr14:43,305,255...43,445,626
Ensembl chr14:43,224,930...43,442,965 		JBrowse link
G GRK5 G protein-coupled receptor kinase 5 ISO RGD PMID:16304060 RGD:5133417 NCBI chr14:129,113,933...129,351,135
Ensembl chr14:129,113,603...129,347,152 		JBrowse link
G GRK6 G protein-coupled receptor kinase 6 ISO RGD PMID:16304060 RGD:5133417 NCBI chr 2:80,496,105...80,527,208
Ensembl chr 2:80,508,979...80,527,210 		JBrowse link
G JAK2 Janus kinase 2 ISO RGD PMID:9287353 PMID:9314843 RGD:5133683 RGD:6478796 NCBI chr 1:216,849,744...217,002,310
Ensembl chr 1:216,848,689...217,002,148 		JBrowse link
G RGS2 regulator of G protein signaling 2 ISO RGD PMID:12588881 RGD:5133418 NCBI chr10:936,836...940,083
Ensembl chr10:936,789...940,098 		JBrowse link
G TYK2 tyrosine kinase 2 ISO RGD PMID:9314843 RGD:6478796 NCBI chr 2:69,157,774...69,183,555
Ensembl chr 2:69,157,811...69,183,456 		JBrowse link
angiotensin II signaling pathway via AT2 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen ISO RGD PMID:16286564 PMID:16286568 PMID:22949090 RGD:1582434 RGD:1582435 RGD:7401256 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833 		JBrowse link
G AGTR2 angiotensin II receptor type 2 ISO RGD PMID:10977869 PMID:22949090 RGD:1581825 RGD:7401256 NCBI chr  X:95,267,709...95,272,237
Ensembl chr  X:95,269,300...95,270,388 		JBrowse link
G CNKSR1 connector enhancer of kinase suppressor of Ras 1 ISO RGD PMID:20889352 RGD:5133679 NCBI chr 6:83,598,363...83,608,617
Ensembl chr 6:83,598,372...83,608,607 		JBrowse link
G DUSP1 dual specificity phosphatase 1 ISO RGD PMID:18804122 RGD:5133675 NCBI chr16:51,457,924...51,461,095
Ensembl chr16:51,458,020...51,461,086 		JBrowse link
G ERBB3 erb-b2 receptor tyrosine kinase 3 ISO RGD PMID:20889352 RGD:5133679 NCBI chr 5:21,474,218...21,495,040
Ensembl chr 5:21,474,475...21,495,038 		JBrowse link
G GNAI2 G protein subunit alpha i2 ISO RGD PMID:22949090 RGD:7401256 NCBI chr13:32,705,326...32,733,804
Ensembl chr13:32,705,321...32,733,794 		JBrowse link
G GNAI3 G protein subunit alpha i3 ISO RGD PMID:22949090 RGD:7401256 NCBI chr 4:110,527,363...110,579,331
Ensembl chr 4:110,525,546...110,579,053 		JBrowse link
G MTUS1 microtubule associated scaffold protein 1 ISO RGD PMID:20889352 RGD:5133679 NCBI chr17:5,331,668...5,507,212
Ensembl chr17:5,329,750...5,507,119 		JBrowse link
G PTPN6 protein tyrosine phosphatase non-receptor type 6 ISO RGD PMID:18804122 RGD:5133675 NCBI chr 5:63,762,109...63,779,086
Ensembl chr 5:63,762,112...63,808,350 		JBrowse link
G SLC9A6 solute carrier family 9 member A6 ISO RGD PMID:20889352 RGD:5133679 NCBI chr  X:111,176,461...111,233,108
Ensembl chr  X:111,176,495...111,233,099 		JBrowse link
G TIMP3 TIMP metallopeptidase inhibitor 3 ISO RGD PMID:20889352 RGD:5133679 NCBI chr 5:12,185,816...12,242,599
Ensembl chr 5:12,185,818...12,242,581 		JBrowse link
G ZBTB16 zinc finger and BTB domain containing 16 ISO RGD PMID:20889352 RGD:5133679 NCBI chr 9:41,639,536...41,839,254
Ensembl chr 9:41,639,701...41,836,742 		JBrowse link
angiotensin III signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen ISO RGD PMID:11295571 RGD:1582124 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833 		JBrowse link
G AGTR1 angiotensin II receptor type 1 ISO RGD PMID:11295571 RGD:1582124 NCBI chr13:88,934,873...88,980,317
Ensembl chr13:88,934,868...88,983,105 		JBrowse link
G AGTR2 angiotensin II receptor type 2 ISO RGD PMID:11295571 RGD:1582124 NCBI chr  X:95,267,709...95,272,237
Ensembl chr  X:95,269,300...95,270,388 		JBrowse link
G ENPEP glutamyl aminopeptidase ISO RGD PMID:15638741 PMID:16537183 RGD:1581649 RGD:1581742 NCBI chr 8:111,765,839...111,858,349
Ensembl chr 8:111,748,514...111,858,510 		JBrowse link
angiotensin III signaling pathway via AT1 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen ISO RGD PMID:11100981 RGD:1582152 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833 		JBrowse link
G AGTR1 angiotensin II receptor type 1 ISO RGD PMID:11100981 RGD:1582152 NCBI chr13:88,934,873...88,980,317
Ensembl chr13:88,934,868...88,983,105 		JBrowse link
angiotensin III signaling pathway via AT2 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen ISO RGD PMID:16380540 RGD:1582118 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833 		JBrowse link
G AGTR2 angiotensin II receptor type 2 ISO RGD PMID:16380540 RGD:1582118 NCBI chr  X:95,267,709...95,272,237
Ensembl chr  X:95,269,300...95,270,388 		JBrowse link
angiotensin IV signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen ISO RGD PMID:11282364 RGD:1582105 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833 		JBrowse link
G ANPEP alanyl aminopeptidase, membrane ISO RGD PMID:15638741 PMID:16537183 RGD:1581649 RGD:1581742 NCBI chr 7:55,351,081...55,373,856
Ensembl chr 7:55,351,087...55,373,881 		JBrowse link
G LNPEP leucyl and cystinyl aminopeptidase ISO RGD PMID:11282364 PMID:12591177 RGD:1581864 RGD:1582105 NCBI chr 2:103,568,366...103,659,589
Ensembl chr 2:103,567,602...103,661,070 		JBrowse link
G RNPEP arginyl aminopeptidase ISO RGD PMID:16537183 RGD:1581649 NCBI chr10:24,218,144...24,235,520
Ensembl chr10:24,218,139...24,235,518 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4045
    signaling pathway 1929
      hormone signaling pathway 378
        peptide and protein hormone signaling pathway 272
          angiotensin signaling pathway 39
            angiotensin (1-7) signaling pathway 5
            angiotensin II signaling pathway + 32
            angiotensin III signaling pathway + 4
            angiotensin IV signaling pathway 4
Path 2
Term Annotations click to browse term
  pathway 4045
    regulatory pathway 2500
      homeostasis pathway 1301
        cardiovascular system homeostasis pathway 262
          renin-angiotensin cascade pathway 43
            angiotensin signaling pathway 39
              angiotensin (1-7) signaling pathway 5
              angiotensin II signaling pathway + 32
              angiotensin III signaling pathway + 4
              angiotensin IV signaling pathway 4
paths to the root