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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:stress response pathway
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Accession:PW:0000237 term browser browse the term
Definition:The pathway(s) elicited as a physiological response to various types of insults, injuries, shocks and other situations the organism perceives as threatening.

show annotations for term's descendants           Sort by:
 
altered p53 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ets1 ETS proto-oncogene 1, transcription factor ISO RGD PMID:22713868 RGD:8663430 NCBI chr 8:33,756,634...33,879,625
Ensembl chr 8:33,816,386...33,879,625 		JBrowse link
G Mdm2 MDM2 proto-oncogene ISO RGD PMID:19165225, PMID:23262034 RGD:2316186, RGD:8663434 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328 		JBrowse link
G Mdm4 MDM4 regulator of p53 ISO RGD PMID:23262034 RGD:8663434 NCBI chr13:49,786,776...49,828,780
Ensembl chr13:49,792,794...49,828,720 		JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease ISO RGD PMID:23263379 RGD:8663431 NCBI chr 8:13,304,355...13,350,329
Ensembl chr 8:13,305,152...13,352,489 		JBrowse link
G Nfya nuclear transcription factor Y subunit alpha ISO RGD PMID:23263379, PMID:22713868 RGD:8663431, RGD:8663430 NCBI chr 9:14,551,752...14,577,002
Ensembl chr 9:14,551,758...14,576,967 		JBrowse link
G Nfyb nuclear transcription factor Y subunit beta ISO RGD PMID:23263379, PMID:22713868 RGD:8663431, RGD:8663430 NCBI chr 7:27,081,667...27,097,481
Ensembl chr 7:27,081,667...27,097,479 		JBrowse link
G Nfyc nuclear transcription factor Y subunit gamma ISO RGD PMID:23263379, PMID:22713868 RGD:8663431, RGD:8663430 NCBI chr 5:139,687,442...139,760,154
Ensembl chr 5:139,687,448...139,749,050 		JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 ISO RGD PMID:22713868 RGD:8663430 NCBI chr 8:21,669,236...21,680,615
Ensembl chr 8:21,669,236...21,680,615 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 ISO RGD PMID:23263379, PMID:22713868 RGD:8663431, RGD:8663430 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603 		JBrowse link
G Tp53 tumor protein p53 ISO DNA:mutations:exon RGD PMID:19165225, PMID:23759327, PMID:22713868, PMID:23263379, PMID:18772397, PMID:20951313, PMID:19078924 RGD:2316186, RGD:8693397, RGD:8663430, RGD:8663431, RGD:5490966, RGD:5133242, RGD:4143515 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Tp63 tumor protein p63 ISO RGD PMID:23263379, PMID:22713868 RGD:8663431, RGD:8663430 NCBI chr11:78,234,853...78,456,559
Ensembl chr11:78,234,800...78,456,501 		JBrowse link
G Tp73 tumor protein p73 ISO RGD PMID:23263379, PMID:22713868 RGD:8663431, RGD:8663430 NCBI chr 5:171,355,876...171,415,354
Ensembl chr 5:171,355,876...171,415,354 		JBrowse link
G Vdr vitamin D receptor ISO RGD PMID:22713868 RGD:8663430 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166 		JBrowse link
endoplasmic reticulum stress - the unfolded protein response pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 ISO RGD PMID:22733998 RGD:10450872 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772 		JBrowse link
G Atf6 activating transcription factor 6 ISO RGD PMID:22733998 RGD:10450872 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443 		JBrowse link
G Creb3 cAMP responsive element binding protein 3 ISO RGD PMID:22733998 RGD:10450872 NCBI chr 5:59,063,532...59,068,196
Ensembl chr 5:59,063,531...59,068,188 		JBrowse link
G Creb3l1 cAMP responsive element binding protein 3-like 1 ISO RGD PMID:22733998 RGD:10450872 NCBI chr 3:80,892,433...80,933,283
Ensembl chr 3:80,892,435...80,933,283 		JBrowse link
G Creb3l2 cAMP responsive element binding protein 3-like 2 ISO RGD PMID:22733998 RGD:10450872 NCBI chr 4:64,869,285...64,981,519
Ensembl chr 4:64,869,026...64,981,384 		JBrowse link
G Creb3l3 cAMP responsive element binding protein 3-like 3 ISO RGD PMID:22733998 RGD:10450872 NCBI chr 7:11,490,852...11,499,287
Ensembl chr 7:11,490,852...11,499,282 		JBrowse link
G Creb3l4 cAMP responsive element binding protein 3-like 4 ISO RGD PMID:22733998 RGD:10450872 NCBI chr 2:189,596,657...189,602,243
Ensembl chr 2:189,595,415...189,602,143 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A ISO RGD PMID:22733998 RGD:10450872 NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO RGD PMID:22733998 RGD:10450872 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 ISO RGD PMID:22733998 RGD:10450872 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914 		JBrowse link
G Xbp1 X-box binding protein 1 ISO RGD PMID:22733998 RGD:10450872 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145 		JBrowse link
glutathione conjugation pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsta1 glutathione S-transferase alpha 1 ISS
IDA		 RGD PMID:10720752, PMID:17197701 RGD:1358120, RGD:1641938 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 ISS
IDA		 RGD PMID:10720752, PMID:17197701 RGD:1358120, RGD:1641938 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta4 glutathione S-transferase alpha 4 ISO
IDA		 RGD PMID:10720752, PMID:11018474 RGD:1358120, RGD:1641942 NCBI chr 8:85,497,557...85,514,732
Ensembl chr 8:85,497,557...85,518,879 		JBrowse link
G Gstk1 glutathione S-transferase kappa 1 ISS RGD PMID:10720752 RGD:1358120 NCBI chr 4:71,621,777...71,626,096
Ensembl chr 4:71,621,729...71,626,107 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 ISS RGD PMID:10720752 RGD:1358120 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 IAGP RGD PMID:12624007 RGD:631154 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856 		JBrowse link
G Gstm3 glutathione S-transferase mu 3 ISS RGD PMID:10720752 RGD:1358120 NCBI chr 2:210,685,204...210,688,273
Ensembl chr 2:210,685,197...210,688,272 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 ISS RGD PMID:10720752 RGD:1358120 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272 		JBrowse link
G Gstm6l glutathione S-transferase, mu 6-like ISS RGD PMID:14576844 RGD:1358122 NCBI chr 2:210,698,155...210,703,265
Ensembl chr 2:210,698,155...210,703,606 		JBrowse link
G Gstm7 glutathione S-transferase, mu 7 TAS RGD PMID:10720752 RGD:1358120 NCBI chr 2:210,720,719...210,726,179
Ensembl chr 2:210,720,704...210,782,856 		JBrowse link
G Gsto1 glutathione S-transferase omega 1 ISS RGD PMID:10720752 RGD:1358120 NCBI chr 1:267,607,437...267,617,387
Ensembl chr 1:267,607,418...267,617,387 		JBrowse link
G Gsto2 glutathione S-transferase omega 2 ISO RGD PMID:10720752 RGD:1358120 NCBI chr 1:267,617,517...267,640,455
Ensembl chr 1:271,229,036...271,243,517
Ensembl chr 1:271,229,036...271,243,517 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 IDA RGD PMID:15110098, PMID:11018474 RGD:1357965, RGD:1641942 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 ISS RGD PMID:10720752 RGD:1358120 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526 		JBrowse link
G Gstt2 glutathione S-transferase, theta 2 ISS RGD PMID:10720752 RGD:1358120 NCBI chr20:13,760,810...13,764,481
Ensembl chr20:13,760,810...13,764,475 		JBrowse link
multidrug resistance protein mediated transport pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 ISS RGD PMID:12433976 RGD:1358123 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
multidrug resistance-associated protein mediated transport pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 ISS RGD PMID:12433976 RGD:1358123 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196 		JBrowse link
G Abcc10 ATP binding cassette subfamily C member 10 ISO RGD PMID:12433976 RGD:1358123 NCBI chr 9:17,041,351...17,061,263
Ensembl chr 9:17,041,389...17,063,780 		JBrowse link
G Abcc12 ATP binding cassette subfamily C member 12 ISS RGD PMID:12801629 RGD:1302885 NCBI chr19:21,541,324...21,612,757
Ensembl chr19:21,541,742...21,612,527 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 TAS RGD PMID:11557524 RGD:70559 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 ISS RGD PMID:12433976 RGD:1358123 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 ISS RGD PMID:12433976 RGD:1358123 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592 		JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 IDA RGD PMID:10893247 RGD:632215 NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211 		JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 ISS RGD PMID:12433976 RGD:1358123 NCBI chr 1:101,954,786...102,013,252
Ensembl chr 1:101,959,540...102,013,243 		JBrowse link
multispecific organic anion transporter mediated transport pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a6 solute carrier family 22 member 6 IDA RGD PMID:9228014 RGD:68822 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 IDA RGD PMID:9650585 RGD:70525 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766 		JBrowse link
G Slco1a1 solute carrier organic anion transporter family, member 1a1 IDA RGD PMID:12006354 RGD:625763 NCBI chr 4:176,158,174...176,231,331
Ensembl chr 4:176,158,640...176,231,344 		JBrowse link
G Slco1a3 solute carrier organic anion transporter family member 1A3 IDA RGD PMID:8702823 RGD:729732 NCBI chr 4:176,255,603...176,299,119
Ensembl chr 4:176,255,603...176,295,195 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 ISS RGD PMID:9294213 RGD:729806 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163 		JBrowse link
G Slco1a5 solute carrier organic anion transporter family, member 1A5 TAS RGD PMID:11867608 RGD:70527 NCBI chr 4:176,445,856...176,528,117
Ensembl chr 4:176,445,858...176,528,110 		JBrowse link
G Slco1a6 solute carrier organic anion transporter family, member 1a6 ISS RGD PMID:12433976 RGD:1358123 NCBI chr 4:176,345,671...176,390,729
Ensembl chr 4:176,345,671...176,381,477 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 IDA RGD PMID:10838093 RGD:68850 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768 		JBrowse link
G Slco1c1 solute carrier organic anion transporter family, member 1c1 IDA RGD PMID:11981753 RGD:634158 NCBI chr 4:175,729,709...175,776,749
Ensembl chr 4:175,729,726...175,776,808 		JBrowse link
G Slco4a1 solute carrier organic anion transporter family, member 4a1 TAS RGD PMID:11316767 RGD:727314 NCBI chr 3:175,838,994...175,857,985
Ensembl chr 3:175,838,994...175,857,983 		JBrowse link
G Slco4c1 solute carrier organic anion transporter family, member 4C1 IDA RGD PMID:14993604 RGD:1303977 NCBI chr 9:104,301,935...104,350,262
Ensembl chr 9:104,299,277...104,350,308 		JBrowse link
G test test1 ISS RGD PMID:11981753, PMID:9650585 RGD:634158, RGD:70525
nuclear factor, erythroid 2 like 2 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca1 BRCA1, DNA repair associated ISO RGD PMID:24647116 RGD:11535066 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681 		JBrowse link
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase ISO RGD PMID:24647116, PMID:25937177 RGD:11535066, RGD:11535070 NCBI chr 1:265,100,094...265,270,263
Ensembl chr 1:265,157,379...265,269,837 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A ISO RGD PMID:24647116 RGD:11535066 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Chd6 chromodomain helicase DNA binding protein 6 ISO RGD PMID:24647116 RGD:11535066 NCBI chr 3:156,937,746...157,099,328
Ensembl chr 3:156,937,733...157,099,306 		JBrowse link
G Crebbp CREB binding protein ISO RGD PMID:24647116 RGD:11535066 NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039 		JBrowse link
G Cul1 cullin 1 ISO RGD PMID:24647116 RGD:11535066 NCBI chr 4:77,211,814...77,283,369
Ensembl chr 4:77,211,692...77,280,250 		JBrowse link
G Cul3 cullin 3 ISO RGD PMID:24647116 RGD:11535066 NCBI chr 9:86,044,485...86,129,066
Ensembl chr 9:86,044,485...86,129,329 		JBrowse link
G Dpp3 dipeptidylpeptidase 3 ISO RGD PMID:24647116 RGD:11535066 NCBI chr 1:220,166,124...220,189,762
Ensembl chr 1:220,166,127...220,188,541 		JBrowse link
G Gadd45gip1 GADD45G interacting protein 1 ISO RGD PMID:24647116 RGD:11535066 NCBI chr19:25,946,979...25,949,528
Ensembl chr19:25,946,979...25,949,528 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha ISO RGD PMID:25937177 RGD:11535070 NCBI chr 1:82,097,244...82,108,238
Ensembl chr 1:82,097,247...82,108,203 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta ISO RGD PMID:25937177 RGD:11535070 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta ISO RGD PMID:24647116 RGD:11535066 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 IMP
ISO
IDA		 RGD PMID:11439354, PMID:24647116, PMID:26419687, PMID:20026152 RGD:727319, RGD:11535066, RGD:11530066, RGD:6902900 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779 		JBrowse link
G Maff MAF bZIP transcription factor F ISO RGD PMID:24647116 RGD:11535066 NCBI chr 7:120,580,743...120,592,095
Ensembl chr 7:120,580,743...120,592,095 		JBrowse link
G Mafg MAF bZIP transcription factor G ISO RGD PMID:24647116 RGD:11535066 NCBI chr10:109,802,877...109,811,476
Ensembl chr10:109,806,159...109,811,323 		JBrowse link
G Mafk MAF bZIP transcription factor K ISO RGD PMID:24647116 RGD:11535066 NCBI chr12:16,923,989...16,934,706
Ensembl chr12:16,923,990...16,934,706 		JBrowse link
G Ncoa3 nuclear receptor coactivator 3 ISO RGD PMID:24647116 RGD:11535066 NCBI chr 3:162,692,176...162,788,582
Ensembl chr 3:162,692,185...162,787,548 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 ISO RGD PMID:26419687, PMID:25937177, PMID:24647116 RGD:11530066, RGD:11535070, RGD:11535066 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 IEP RGD PMID:31889292, PMID:31432116 RGD:21201308, RGD:25823187 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Palb2 partner and localizer of BRCA2 ISO RGD PMID:24647116 RGD:11535066 NCBI chr 1:192,064,586...192,088,547
Ensembl chr 1:192,064,589...192,088,520 		JBrowse link
G Pgam5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase ISO RGD PMID:24647116 RGD:11535066 NCBI chr12:52,467,417...52,474,533
Ensembl chr12:52,467,450...52,474,511 		JBrowse link
G Pten phosphatase and tensin homolog ISO RGD PMID:25937177 RGD:11535070 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832 		JBrowse link
G Rbx1 ring-box 1 ISO RGD PMID:24647116 RGD:11535066 NCBI chr 7:122,700,849...122,710,907
Ensembl chr 7:122,700,854...122,709,935 		JBrowse link
G Rnf4 ring finger protein 4 ISO RGD PMID:24647116 RGD:11535066 NCBI chr14:81,658,400...81,679,756
Ensembl chr14:81,660,354...81,679,082 		JBrowse link
G Siah2 siah E3 ubiquitin protein ligase 2 ISO RGD PMID:24647116 RGD:11535066 NCBI chr 2:148,874,151...148,891,900
Ensembl chr 2:148,874,151...148,891,900 		JBrowse link
G Skp1 S-phase kinase-associated protein 1 ISO RGD PMID:24647116 RGD:11535066 NCBI chr10:37,594,578...37,609,498
Ensembl chr10:37,594,578...37,609,498 		JBrowse link
G Sqstm1 sequestosome 1 ISO RGD PMID:24647116 RGD:11535066 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294 		JBrowse link
oxidative stress response pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmox1 heme oxygenase 1 IDA blood protein analysis (MMO:0000166), western blot assay (MMO:0000669) RGD PMID:29091898 RGD:15090820 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 IDA blood protein analysis (MMO:0000166), western blot assay (MMO:0000669) RGD PMID:29091898 RGD:15090820 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 IDA blood protein analysis (MMO:0000166), western blot assay (MMO:0000669) RGD PMID:12603827, PMID:29091898 RGD:727509, RGD:15090820 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G test test1 ISS RGD PMID:12603827 RGD:727509
p53 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase ISO PID PMID:20679336 PID:200206, RGD:8662965 NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388
Ensembl chr 3:10,041,826...10,144,388 		JBrowse link
G Adgrb1 adhesion G protein-coupled receptor B1 IEA KEGG rno:04115 NCBI chr 7:115,766,484...115,828,514 JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO PID PID:200206 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 IEA KEGG rno:04115 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192 		JBrowse link
G Atm ATM serine/threonine kinase ISO
IEA		 KEGG
PID		 PMID:19450511, PMID:16601750 PID:200206 rno:04115, RGD:2316155, RGD:2316156 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045 		JBrowse link
G Atr ATR serine/threonine kinase ISO PID PID:200206 NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator IEA KEGG rno:04115 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bbc3 Bcl-2 binding component 3 IEA KEGG rno:04115 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bid BH3 interacting domain death agonist IEA KEGG rno:04115 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203 		JBrowse link
G Brca1 BRCA1, DNA repair associated ISO RGD PMID:20679336 RGD:8662965 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681 		JBrowse link
G Casp3 caspase 3 IEA KEGG rno:04115 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 IEA KEGG rno:04115 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 IEA KEGG rno:04115 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Ccna2 cyclin A2 ISO PID PID:200206 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214 		JBrowse link
G Ccnb1 cyclin B1 IEA KEGG rno:04115 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221 		JBrowse link
G Ccnb2 cyclin B2 IEA KEGG rno:04115 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Ccnb3 cyclin B3 IEA KEGG rno:04115 NCBI chr  X:16,300,752...16,402,206
Ensembl chr  X:16,337,102...16,402,202 		JBrowse link
G Ccnd1 cyclin D1 IEA KEGG rno:04115 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Ccnd2 cyclin D2 IEA KEGG rno:04115 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207 		JBrowse link
G Ccnd3 cyclin D3 IEA KEGG rno:04115 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943 		JBrowse link
G Ccne1 cyclin E1 IEA KEGG rno:04115 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980 		JBrowse link
G Ccne2 cyclin E2 IEA KEGG rno:04115 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406 		JBrowse link
G Ccng1 cyclin G1 ISO
IEA		 PID
KEGG		 PID:200206 rno:04115 NCBI chr10:25,903,925...25,910,298
Ensembl chr10:25,903,911...25,910,325 		JBrowse link
G Ccng2 cyclin G2 IEA KEGG rno:04115 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068 		JBrowse link
G Cd82 Cd82 molecule IEA KEGG rno:04115 NCBI chr 3:82,324,344...82,368,846
Ensembl chr 3:82,324,354...82,368,357 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 IEA KEGG rno:04115 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549 		JBrowse link
G Cdk2 cyclin dependent kinase 2 ISO
IEA		 PID
KEGG		 PID:200206 rno:04115 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 IEA KEGG rno:04115 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 IEA KEGG rno:04115 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A IEA KEGG rno:04115 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A IEA KEGG rno:04115 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175 		JBrowse link
G Chek1 checkpoint kinase 1 ISO
IEA		 KEGG
PID		 PMID:19450511, PMID:16601750 PID:200206 rno:04115, RGD:2316155, RGD:2316156 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882 		JBrowse link
G Chek2 checkpoint kinase 2 ISO
IEA		 KEGG
PID		 PMID:19450511, PMID:16601750 PID:200206 rno:04115, RGD:2316155, RGD:2316156 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624 		JBrowse link
G Cop1 COP1, E3 ubiquitin ligase IEA KEGG rno:04115 NCBI chr13:76,942,883...77,076,015
Ensembl chr13:76,942,928...77,075,723 		JBrowse link
G Crebbp CREB binding protein ISO PID PMID:19450511, PMID:20679336 PID:200206, RGD:2316155, RGD:8662965 NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039 		JBrowse link
G Cse1l chromosome segregation 1 like ISO PID PID:200206 NCBI chr 3:163,664,074...163,702,074
Ensembl chr 3:163,664,136...163,702,060 		JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 ISO PID PID:200206 NCBI chr18:56,887,722...56,910,610
Ensembl chr18:56,887,354...56,918,345 		JBrowse link
G Csnk1d casein kinase 1, delta ISO PID PID:200206 NCBI chr10:110,147,786...110,182,413
Ensembl chr10:110,148,600...110,182,408 		JBrowse link
G Csnk1e casein kinase 1, epsilon ISO PID PID:200206 NCBI chr 7:120,651,976...120,675,559
Ensembl chr 7:120,651,881...120,672,359 		JBrowse link
G Csnk1g1 casein kinase 1, gamma 1 ISO PID PID:200206 NCBI chr 8:71,533,372...71,688,483
Ensembl chr 8:71,547,468...71,679,666 		JBrowse link
G Csnk1g2 casein kinase 1, gamma 2 ISO PID PID:200206 NCBI chr 7:11,944,957...11,963,268
Ensembl chr 7:11,944,958...11,963,268 		JBrowse link
G Csnk1g3 casein kinase 1, gamma 3 ISO PID PID:200206 NCBI chr18:48,831,209...48,913,341
Ensembl chr18:48,853,418...48,911,122 		JBrowse link
G Cycs cytochrome c, somatic IEA KEGG rno:04115 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326 		JBrowse link
G Cyct cytochrome c, testis IEA KEGG rno:04115 NCBI chr 3:63,204,779...63,211,847
Ensembl chr 3:62,818,502...63,211,845 		JBrowse link
G Daxx death-domain associated protein ISO PID PID:200206 NCBI chr20:5,480,103...5,485,962
Ensembl chr20:5,480,103...5,485,926 		JBrowse link
G Dyrk2 dual specificity tyrosine phosphorylation regulated kinase 2 ISO PID PID:200206 NCBI chr 7:61,785,423...61,816,775
Ensembl chr 7:61,786,309...61,798,729 		JBrowse link
G E4f1 E4F transcription factor 1 ISO PID PID:200206 NCBI chr10:13,812,335...13,835,847
Ensembl chr10:13,815,293...13,826,945 		JBrowse link
G Ei24 EI24, autophagy associated transmembrane protein IEA KEGG rno:04115 NCBI chr 8:39,254,883...39,271,238
Ensembl chr 8:39,254,889...39,266,959 		JBrowse link
G Ep300 E1A binding protein p300 ISO PID PID:200206 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296 		JBrowse link
G Fas Fas cell surface death receptor IEA KEGG rno:04115 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Fbxo11 F-box protein 11 ISO PID PID:200206 NCBI chr 6:11,662,356...11,737,427
Ensembl chr 6:11,662,356...11,686,682 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha IEA KEGG rno:04115 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842 		JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta IEA KEGG rno:04115 NCBI chr 7:11,646,283...11,648,338
Ensembl chr 7:11,646,269...11,648,322 		JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma IEA KEGG rno:04115 NCBI chr17:13,391,474...13,393,219
Ensembl chr17:13,391,467...13,393,243 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta ISO PID PID:200206 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268 		JBrowse link
G Gtse1 G-2 and S-phase expressed 1 IEA KEGG rno:04115 NCBI chr 7:126,736,416...126,753,221
Ensembl chr 7:126,736,732...126,753,220 		JBrowse link
G Hdac1 histone deacetylase 1 ISO RGD PMID:19450511 RGD:2316155 NCBI chr 5:147,716,664...147,743,723
Ensembl chr 5:147,716,664...147,743,723 		JBrowse link
G Hipk2 homeodomain interacting protein kinase 2 ISO PID PID:200206 NCBI chr 4:66,438,390...66,625,183
Ensembl chr 4:66,445,266...66,624,912 		JBrowse link
G Huwe1 HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 ISO PID PID:200206 NCBI chr  X:21,474,627...21,603,348
Ensembl chr  X:21,499,934...21,598,876 		JBrowse link
G Igf1 insulin-like growth factor 1 IEA KEGG rno:04115 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 IEA KEGG rno:04115 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374 		JBrowse link
G Kat2a lysine acetyltransferase 2A ISO RGD PMID:20679336 RGD:8662965 NCBI chr10:88,611,586...88,619,558
Ensembl chr10:88,611,586...88,619,537 		JBrowse link
G Kat2b lysine acetyltransferase 2B ISO RGD PMID:20679336 RGD:8662965 NCBI chr 9:4,440,982...4,492,949 JBrowse link
G Kat5 lysine acetyltransferase 5 ISO PID PMID:19450511, PMID:20679336 PID:200206, RGD:2316155, RGD:8662965 NCBI chr 1:220,967,795...220,974,596
Ensembl chr 1:220,967,796...220,974,597 		JBrowse link
G Kat8 lysine acetyltransferase 8 ISO PID PMID:19450511 PID:200206, RGD:2316155 NCBI chr 1:199,360,645...199,372,925
Ensembl chr 1:199,360,645...199,372,923 		JBrowse link
G Kmt5a lysine methyltransferase 5A ISO PID PID:200206 NCBI chr12:37,558,150...37,581,183
Ensembl chr12:37,559,770...37,574,750 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 ISO PID PID:200206 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO PID PID:200206 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 ISO PID PID:200206 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355 		JBrowse link
G Mdm2 MDM2 proto-oncogene ISO
IEA		 KEGG
PID		 PMID:19450511, PMID:16601750 PID:200206 rno:04115, RGD:2316155, RGD:2316156 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328 		JBrowse link
G Mdm4 MDM4 regulator of p53 ISO
IEA		 KEGG
PID		 PMID:19450511, PMID:16601750 PID:200206 rno:04115, RGD:2316155, RGD:2316156 NCBI chr13:49,786,776...49,828,780
Ensembl chr13:49,792,794...49,828,720 		JBrowse link
G Muc1 mucin 1, cell surface associated ISO RGD PMID:20679336 RGD:8662965 NCBI chr 2:188,543,137...188,547,874
Ensembl chr 2:188,543,137...188,547,874 		JBrowse link
G Nedd8 NEDD8 ubiquitin like modifier ISO PID PID:200206 NCBI chr15:34,340,607...34,352,673
Ensembl chr15:34,340,607...34,352,673 		JBrowse link
G Perp p53 apoptosis effector related to PMP22 IEA KEGG rno:04115 NCBI chr 1:14,224,392...14,236,838
Ensembl chr 1:14,224,393...14,236,846 		JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 ISO PID PMID:20679336 PID:200206, RGD:8662965 NCBI chr 8:21,669,236...21,680,615
Ensembl chr 8:21,669,236...21,680,615 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 IEA KEGG rno:04115 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102 		JBrowse link
G Pou4f1 POU class 4 homeobox 1 ISO RGD PMID:20679336 RGD:8662965 NCBI chr15:88,618,255...88,622,712
Ensembl chr15:88,620,470...88,622,413 		JBrowse link
G Pou4f2 POU class 4 homeobox 2 ISO RGD PMID:20679336 RGD:8662965 NCBI chr19:33,160,180...33,163,821
Ensembl chr19:33,160,180...33,163,821 		JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D ISO
IEA		 PID
KEGG		 PID:200206 rno:04115 NCBI chr10:72,909,550...72,945,884
Ensembl chr10:72,909,550...72,945,884 		JBrowse link
G Ppp1r13b protein phosphatase 1, regulatory subunit 13B ISO RGD PMID:20679336 RGD:8662965 NCBI chr 6:136,397,658...136,469,757
Ensembl chr 6:136,398,518...136,436,818 		JBrowse link
G Ppp1r13l protein phosphatase 1, regulatory subunit 13 like ISO PID PMID:20679336 PID:200206, RGD:8662965 NCBI chr 1:80,271,288...80,290,946
Ensembl chr 1:80,279,706...80,290,408 		JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha ISO PID PID:200206 NCBI chr10:37,534,449...37,554,861
Ensembl chr10:37,535,871...37,554,664 		JBrowse link
G Prkcd protein kinase C, delta ISO PID PID:200206 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746 		JBrowse link
G Prmt5 protein arginine methyltransferase 5 ISO PID PID:200206 NCBI chr15:33,156,508...33,165,893
Ensembl chr15:33,156,492...33,165,895 		JBrowse link
G Pten phosphatase and tensin homolog IEA KEGG rno:04115 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832 		JBrowse link
G Ptpa protein phosphatase 2 phosphatase activator ISO PID PID:200206 NCBI chr 3:8,982,122...9,012,585
Ensembl chr 3:8,982,122...9,012,585 		JBrowse link
G Rassf1 Ras association domain family member 1 ISO PID PID:200206 NCBI chr 8:116,307,149...116,318,289
Ensembl chr 8:116,307,141...116,318,289 		JBrowse link
G Rchy1 ring finger and CHY zinc finger domain containing 1 ISO
IEA		 KEGG
PID		 PMID:19450511 PID:200206 rno:04115, RGD:2316155 NCBI chr14:17,615,968...17,631,715
Ensembl chr14:17,615,968...17,631,714 		JBrowse link
G Rpl11 ribosomal protein L11 ISO PID PID:200206 NCBI chr 5:154,390,809...154,394,412
Ensembl chr 5:154,388,140...154,394,328 		JBrowse link
G Rpl23 ribosomal protein L23 ISO PID PID:200206 NCBI chr10:85,721,398...85,725,359
Ensembl chr10:85,721,394...85,725,429 		JBrowse link
G Rpl5 ribosomal protein L5 ISO PID PID:200206 NCBI chr14:2,860,963...2,867,397
Ensembl chr14:2,860,965...2,867,397 		JBrowse link
G Rpl5l1 ribosomal protein L5-like 1 ISO PID PID:200206 NCBI chr10:112,564,193...112,565,170 JBrowse link
G Rprm reprimo, TP53 dependent G2 arrest mediator homolog IEA KEGG rno:04115 NCBI chr 3:39,595,301...39,596,718
Ensembl chr 3:39,595,301...39,596,718 		JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 IEA KEGG rno:04115 NCBI chr 6:43,884,627...43,890,818
Ensembl chr 6:43,884,678...43,889,515 		JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B IEA KEGG rno:04115 NCBI chr 7:76,750,045...76,780,817
Ensembl chr 7:76,750,050...76,780,817 		JBrowse link
G Serpinb5 serpin family B member 5 IEA KEGG rno:04115 NCBI chr13:26,903,052...26,923,250
Ensembl chr13:26,903,052...26,923,250 		JBrowse link
G Serpine1 serpin family E member 1 IEA KEGG rno:04115 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482 		JBrowse link
G Sesn1 sestrin 1 IEA KEGG rno:04115 NCBI chr20:46,667,116...46,758,306
Ensembl chr20:46,667,121...46,758,305 		JBrowse link
G Sesn3 sestrin 3 IEA KEGG rno:04115 NCBI chr 8:12,823,060...12,878,749
Ensembl chr 8:12,823,155...12,872,705 		JBrowse link
G Setd7 SET domain containing 7, histone lysine methyltransferase ISO PID PMID:19450511 PID:200206, RGD:2316155 NCBI chr 2:140,576,188...140,618,405
Ensembl chr 2:140,576,188...140,618,405 		JBrowse link
G Sfn stratifin IEA KEGG rno:04115 NCBI chr 5:151,823,422...151,824,937
Ensembl chr 5:151,823,887...151,824,633 		JBrowse link
G Shisa5 shisa family member 5 IEA KEGG rno:04115 NCBI chr 8:117,780,992...117,795,923
Ensembl chr 8:117,780,891...117,795,919 		JBrowse link
G Siah1 siah E3 ubiquitin protein ligase 1 IEA KEGG rno:04115 NCBI chr19:21,372,163...21,395,773
Ensembl chr19:21,372,163...21,395,767 		JBrowse link
G Sirt1 sirtuin 1 ISO RGD PMID:19450511 RGD:2316155 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199 		JBrowse link
G Skp2 S-phase kinase associated protein 2 ISO PID PID:200206 NCBI chr 2:58,506,146...58,534,211
Ensembl chr 2:58,506,151...58,534,211 		JBrowse link
G Smyd2 SET and MYND domain containing 2 ISO PID PMID:19450511 PID:200206, RGD:2316155 NCBI chr13:108,642,156...108,686,293
Ensembl chr13:108,642,156...108,686,290 		JBrowse link
G Steap3 STEAP3 metalloreductase IEA KEGG rno:04115 NCBI chr13:36,257,220...36,274,144
Ensembl chr13:36,257,112...36,290,531 		JBrowse link
G Tp53 tumor protein p53 ISO
IEA		 KEGG
PID		 PMID:19450511, PMID:16601750 PID:200206 rno:04115, RGD:2316155, RGD:2316156 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Tp53bp2 tumor protein p53 binding protein, 2 ISO RGD PMID:20679336 RGD:8662965 NCBI chr13:100,817,206...100,873,837
Ensembl chr13:100,817,359...100,873,890 		JBrowse link
G Tp73 tumor protein p73 IEA KEGG rno:04115 NCBI chr 5:171,355,876...171,415,354
Ensembl chr 5:171,355,876...171,415,354 		JBrowse link
G Trim28 tripartite motif-containing 28 ISO PID PID:200206 NCBI chr 1:65,544,369...65,551,043
Ensembl chr 1:65,544,373...65,551,043 		JBrowse link
G Tsc2 TSC complex subunit 2 IEA KEGG rno:04115 NCBI chr10:13,962,006...13,996,684
Ensembl chr10:13,961,947...13,996,584 		JBrowse link
G Ttc5 tetratricopeptide repeat domain 5 ISO PID PID:200206 NCBI chr15:27,698,375...27,715,970
Ensembl chr15:27,698,362...27,716,008 		JBrowse link
G Ube2d1 ubiquitin-conjugating enzyme E2D 1 ISO PID PID:200206 NCBI chr20:18,547,370...18,580,291
Ensembl chr20:18,547,370...18,580,291 		JBrowse link
G Usp7 ubiquitin specific peptidase 7 ISO PID PMID:19450511 PID:200206, RGD:2316155 NCBI chr10:6,930,462...7,019,910
Ensembl chr10:6,975,244...7,018,930 		JBrowse link
G Ybx1 Y box binding protein 1 ISO RGD PMID:20679336 RGD:8662965 NCBI chr 5:138,319,754...138,336,721
Ensembl chr 5:138,319,762...138,336,475 		JBrowse link
G Yy1 YY1 transcription factor ISO PID PID:200206 NCBI chr 6:132,702,443...132,726,848
Ensembl chr 6:132,702,448...132,727,046 		JBrowse link
G Zfp385a zinc finger protein 385A ISO RGD PMID:20679336 RGD:8662965 NCBI chr 7:144,939,616...144,966,364
Ensembl chr 7:144,939,619...144,966,370 		JBrowse link
G Zfp420 zinc finger protein 420 ISO RGD PMID:20679336 RGD:8662965 NCBI chr 1:88,531,975...88,564,480
Ensembl chr 1:88,542,035...88,544,156 		JBrowse link
G Zmat3 zinc finger, matrin type 3 IEA KEGG rno:04115 NCBI chr 2:118,715,229...118,746,109
Ensembl chr 2:118,721,334...118,745,766 		JBrowse link
G Znhit1 zinc finger, HIT-type containing 1 ISO RGD PMID:20679336 RGD:8662965 NCBI chr12:22,726,643...22,732,917
Ensembl chr12:22,726,643...22,732,943 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6103
    regulatory pathway 3880
      stress response pathway 199
        altered stress response pathway + 13
        endoplasmic reticulum stress - the unfolded protein response pathway 11
        mitochondrial unfolded protein response pathway 0
        oxidative stress response pathway + 64
        p53 signaling pathway + 129
paths to the root