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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:tumor necrosis factor mediated signaling pathway
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Accession:PW:0000233 term browser browse the term
Definition:Tumor necrosis factor (Tnf) signaling plays pivotal roles in immunity, cell proliferation, differentiation and apoptosis by activating several pathways. NF-kB is a major pathway activated by Tnf; others include JNK and P38 MAPK. Through receptor-associated adapters, Tnf elicits apoptosis via the extrinsic pathway. Deregulation of Tnf signaling has been implicated in a great number of human diseases - cerebral malaria, cancer and multiple sclerosis are a few examples.
Synonyms:related_synonym: TNF signaling;   TNF signaling pathway;   TNFalpha signaling pathway;   tumor necrosis factor-mediated signaling pathway
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tumor necrosis factor mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM17 ADAM metallopeptidase domain 17 ISO PID
RGD		 PMID:12655295 PID:200102 RGD:2292150 NCBI chr2A:9,478,080...9,545,363
Ensembl chr2A:9,641,201...9,708,054 		JBrowse link
G BAG4 BAG cochaperone 4 ISO PID
RGD		 PMID:12655295 PID:200102 RGD:2292150 NCBI chr 8:37,479,231...37,515,303
Ensembl chr 8:34,656,000...34,692,666 		JBrowse link
G BIRC2 baculoviral IAP repeat containing 2 ISO PID
RGD		 PMID:23085193 PID:200102 RGD:7800730 NCBI chr11:97,298,736...97,324,966
Ensembl chr11:100,793,036...100,822,421 		JBrowse link
G BIRC3 baculoviral IAP repeat containing 3 ISO PID
RGD		 PMID:23085193 PID:200102 RGD:7800730 NCBI chr11:97,269,778...97,290,112
Ensembl chr11:100,763,274...100,785,194 		JBrowse link
G CASP8 caspase 8 ISO PID PID:200102 NCBI chr2B:88,490,611...88,542,132
Ensembl chr2B:206,669,544...206,696,468 		JBrowse link
G CAV1 caveolin 1 ISO PID PID:200102 NCBI chr 7:108,497,125...108,533,090
Ensembl chr 7:121,193,424...121,229,655 		JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex ISO PID
RGD		 PMID:12655295 PID:200102 RGD:2292150 NCBI chr10:96,794,228...96,835,449
Ensembl chr10:100,280,490...100,316,918 		JBrowse link
G CYLD CYLD lysine 63 deubiquitinase ISO PID
RGD		 PMID:21119682 PMID:23312890 PID:200102 RGD:7800734 RGD:7800735 NCBI chr16:31,004,393...31,064,546
Ensembl chr16:49,882,751...49,942,629 		JBrowse link
G FADD Fas associated via death domain ISO PID
RGD		 PMID:12655295 PID:200102 RGD:2292150 NCBI chr11:65,300,889...65,305,020 JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta ISO PID
RGD		 PMID:12655295 PID:200102 RGD:2292150 NCBI chr 8:41,515,613...41,576,229
Ensembl chr 8:38,960,594...39,020,971 		JBrowse link
G IKBKG inhibitor of nuclear factor kappa B kinase regulatory subunit gamma ISO PID
RGD		 PMID:12655295 PID:200102 RGD:2292150 NCBI chr  X:143,988,720...144,010,078
Ensembl chr  X:153,854,493...153,876,092 		JBrowse link
G ITCH itchy E3 ubiquitin protein ligase ISO RGD PMID:21119682 PMID:23312890 RGD:7800734 RGD:7800735 NCBI chr20:30,690,172...30,840,504
Ensembl chr20:31,852,203...31,971,945 		JBrowse link
G MADD MAP kinase activating death domain ISO PID PID:200102 NCBI chr11:47,216,006...47,276,422
Ensembl chr11:47,773,733...47,828,360 		JBrowse link
G MAP2K7 mitogen-activated protein kinase kinase 7 ISO PID PID:200102 NCBI chr19:7,205,124...7,215,776
Ensembl chr19:8,057,598...8,066,512 		JBrowse link
G MAP3K1 mitogen-activated protein kinase kinase kinase 1 ISO PID PID:200102 NCBI chr 5:57,116,405...57,197,017
Ensembl chr 5:58,745,579...58,826,959 		JBrowse link
G MAP3K3 mitogen-activated protein kinase kinase kinase 3 ISO PID PID:200102 NCBI chr17:57,702,242...57,776,601
Ensembl chr17:62,858,635...62,922,874 		JBrowse link
G MAP3K5 mitogen-activated protein kinase kinase kinase 5 ISO PID PID:200102 NCBI chr 6:134,316,841...134,582,843
Ensembl chr 6:138,406,398...138,641,727 		JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 ISO PID
RGD		 PMID:21135871 PID:200102 RGD:5490225 NCBI chr 6:88,398,329...88,470,926
Ensembl chr 6:91,664,263...91,737,468 		JBrowse link
G MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 ISO PID PID:200102 NCBI chr11:60,142,445...60,158,728
Ensembl chr11:63,486,827...63,499,746 		JBrowse link
G MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 ISO PID PID:200102 NCBI chr2A:39,286,787...39,474,780
Ensembl chr2A:40,040,497...40,228,109 		JBrowse link
G MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 ISO PID PID:200102 Ensembl chr2A:102,750,221...102,945,263 JBrowse link
G MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 ISO PID PID:200102 NCBI chr14:31,008,177...31,122,127
Ensembl chr14:49,311,733...49,425,520 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 ISO PID PID:200102 NCBI chr 4:94,925,048...95,040,849
Ensembl chr 4:105,589,062...105,704,098 		JBrowse link
G NRK Nik related kinase ISO PID PID:200102 NCBI chr  X:94,957,923...95,094,749
Ensembl chr  X:105,337,327...105,470,331 		JBrowse link
G NSMAF neutral sphingomyelinase activation associated factor ISO PID PID:200102 NCBI chr 8:55,023,206...55,099,816
Ensembl chr 8:56,674,483...56,751,585 		JBrowse link
G PRKCI protein kinase C iota ISO PID PID:200102 NCBI chr 3:167,237,093...167,320,522
Ensembl chr 3:175,426,774...175,510,072 		JBrowse link
G PRKCZ protein kinase C zeta ISO PID PID:200102 NCBI chr 1:763,942...901,531
Ensembl chr 1:1,920,219...2,045,855 		JBrowse link
G RACK1 receptor for activated C kinase 1 ISO PID PID:200102 NCBI chr 5:176,462,991...176,470,153
Ensembl chr 5:183,712,665...183,720,128 		JBrowse link
G RBCK1 RANBP2-type and C3HC4-type zinc finger containing 1 ISO RGD PMID:23085193 RGD:7800730 NCBI chr20:615,987...639,366
Ensembl chr20:386,569...409,580 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit ISO PID PID:200102 NCBI chr11:61,012,839...61,022,225
Ensembl chr11:64,347,859...64,356,868 		JBrowse link
G RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase ISO PID PID:200102 NCBI chr17:21,696,808...21,779,878
Ensembl chr17:22,035,643...22,069,546 		JBrowse link
G RIPK1 receptor interacting serine/threonine kinase 1 ISO PID
RGD		 PMID:12655295 PMID:23085193 PID:200102 RGD:2292150 RGD:7800730 NCBI chr 6:2,893,802...2,943,162
Ensembl chr 6:2,997,343...3,045,078 		JBrowse link
G RNF11 ring finger protein 11 ISO RGD PMID:21119682 PMID:23312890 RGD:7800734 RGD:7800735 NCBI chr 1:50,480,862...50,517,676
Ensembl chr 1:51,980,420...52,016,730 		JBrowse link
G RNF31 ring finger protein 31 ISO RGD PMID:23085193 RGD:7800730 NCBI chr14:4,923,391...4,936,959
Ensembl chr14:23,047,893...23,061,923 		JBrowse link
G SHARPIN SHANK associated RH domain interactor ISO RGD PMID:23085193 RGD:7800730 NCBI chr 8:140,865,009...140,870,580
Ensembl chr 8:143,854,902...143,862,888 		JBrowse link
G SMPD1 sphingomyelin phosphodiesterase 1 ISO PID PID:200102 NCBI chr11:6,521,812...6,526,349 JBrowse link
G SMPD2 sphingomyelin phosphodiesterase 2 ISO PID PID:200102 NCBI chr 6:107,243,751...107,246,941
Ensembl chr 6:111,292,130...111,295,408 		JBrowse link
G SQSTM1 sequestosome 1 ISO PID PID:200102 NCBI chr 5:174,960,727...174,989,946
Ensembl chr 5:182,284,436...182,299,093 		JBrowse link
G STAT1 signal transducer and activator of transcription 1 ISO PID PID:200102 NCBI chr2B:78,270,642...78,316,074
Ensembl chr2B:196,186,906...196,232,280 		JBrowse link
G TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 ISO PID
RGD		 PMID:21135871 PID:200102 RGD:5490225 NCBI chr22:20,303,547...20,343,314
Ensembl chr22:38,122,835...38,162,705 		JBrowse link
G TAB2 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 ISO PID
RGD		 PMID:21135871 PID:200102 RGD:5490225 NCBI chr 6:147,138,553...147,231,559
Ensembl chr 6:151,868,513...151,936,841 		JBrowse link
G TAB3 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 ISO RGD PMID:21135871 RGD:5490225 NCBI chr  X:23,428,343...23,489,688
Ensembl chr  X:30,980,841...31,012,994 		JBrowse link
G TAX1BP1 Tax1 binding protein 1 ISO RGD PMID:21119682 PMID:23312890 RGD:7800734 RGD:7800735 NCBI chr 7:28,379,135...28,476,179
Ensembl chr 7:27,975,026...28,074,513 		JBrowse link
G TNF tumor necrosis factor ISO PID
RGD		 PMID:12655295 PID:200102 RGD:2292150 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
G TNFAIP3 TNF alpha induced protein 3 ISO PID
RGD		 PMID:21119682 PMID:23312890 PID:200102 RGD:7800734 RGD:7800735 NCBI chr 6:135,617,465...135,634,085
Ensembl chr 6:139,705,255...139,720,819 		JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A ISO PID
RGD		 PMID:12655295 PMID:20967881 PID:200102 RGD:2292150 RGD:5130945 NCBI chr12:6,457,617...6,470,969
Ensembl chr12:6,374,257...6,387,613 		JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B ISO PID
RGD		 PMID:12655295 PID:200102 RGD:2292150 NCBI chr 1:10,915,743...10,957,765
Ensembl chr 1:12,130,663...12,172,646 		JBrowse link
G TNIK TRAF2 and NCK interacting kinase ISO PID PID:200102 NCBI chr 3:168,067,839...168,466,290
Ensembl chr 3:176,255,547...176,650,795 		JBrowse link
G TRADD TNFRSF1A associated via death domain ISO PID
RGD		 PMID:12655295 PID:200102 RGD:2292150 NCBI chr16:47,499,881...47,506,220
Ensembl chr16:66,889,006...66,891,016 		JBrowse link
G TRAF1 TNF receptor associated factor 1 ISO PID PID:200102 NCBI chr 9:92,030,205...92,056,776
Ensembl chr 9:120,376,592...120,402,948 		JBrowse link
G TRAF2 TNF receptor associated factor 2 ISO RGD
PID		 PMID:12655295 PMID:20967881 PMID:23085193 PID:200102 RGD:2292150 RGD:5130945 RGD:7800730 NCBI chr 9:107,938,935...107,984,797
Ensembl chr 9:136,917,358...136,955,331 		JBrowse link
G TRAF5 TNF receptor associated factor 5 ISO RGD PMID:23085193 RGD:7800730 NCBI chr 1:186,889,615...186,938,416
Ensembl chr 1:191,754,652...191,802,075 		JBrowse link
G TXN thioredoxin ISO PID PID:200102 NCBI chr 9:81,399,056...81,411,607
Ensembl chr 9:109,565,557...109,578,311 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4069
    signaling pathway 1942
      cytokine and chemokine mediated signaling pathway 340
        cytokine mediated signaling pathway 339
          tumor necrosis factor superfamily mediated signaling pathway 90
            tumor necrosis factor mediated signaling pathway 53
              altered tumor necrosis factor mediated signaling pathway 0
Path 2
Term Annotations click to browse term
  pathway 4069
    regulatory pathway 2518
      cell death pathway 186
        programmed cell death pathway 186
          apoptotic cell death pathway 115
            extrinsic apoptotic pathway 90
              tumor necrosis factor mediated signaling pathway 53
                altered tumor necrosis factor mediated signaling pathway 0
paths to the root