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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:nicotinamide adenine dinucleotide biosynthetic pathway
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Accession:PW:0000219 term browser browse the term
Definition:Those metabolic reactions involved in the synthesis of nicotinamide adenine dinucleotide (NAD). NAD can be synthesized de novo downstream of kynurenine metabolism of tryptophan degradation, or from precursors such as nicotinamide, nicotinic acid or nicotinamide riboside, collectively known as vitamin B3 or niacin.
Synonyms:exact_synonym: NAD biosynthetic pathway
 related_synonym: NAD biosynthetic process

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de novo nicotinamide adenine dinucleotide biosynthetic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NADSYN1 NAD synthetase 1 TAS RGD PMID:20007326 RGD:11099972 NCBI chr11:71,453,203...71,501,816
Ensembl chr11:71,453,109...71,524,107
JBrowse link
G NMNAT1 nicotinamide nucleotide adenylyltransferase 1 TAS RGD PMID:20007326 RGD:11099972 NCBI chr 1:9,942,923...9,996,892
Ensembl chr 1:9,943,428...9,985,501
JBrowse link
G NMNAT2 nicotinamide nucleotide adenylyltransferase 2 TAS RGD PMID:20007326 RGD:11099972 NCBI chr 1:183,248,237...183,418,380
Ensembl chr 1:183,248,237...183,418,380
JBrowse link
G NMNAT3 nicotinamide nucleotide adenylyltransferase 3 TAS RGD PMID:20007326 RGD:11099972 NCBI chr 3:139,560,180...139,678,050
Ensembl chr 3:139,560,180...139,678,017
JBrowse link
G QPRT quinolinate phosphoribosyltransferase TAS RGD PMID:20007326 RGD:11099972 NCBI chr16:29,679,008...29,698,699
Ensembl chr16:29,663,279...29,698,699
JBrowse link
nicotinamide adenine dinucleotide biosynthesis, the salvage pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NADSYN1 NAD synthetase 1 TAS RGD PMID:20007326 RGD:11099972 NCBI chr11:71,453,203...71,501,816
Ensembl chr11:71,453,109...71,524,107
JBrowse link
G NAMPT nicotinamide phosphoribosyltransferase TAS RGD PMID:20007326 RGD:11099972 NCBI chr 7:106,248,298...106,285,888
Ensembl chr 7:106,248,298...106,285,966
JBrowse link
G NAPRT nicotinate phosphoribosyltransferase TAS RGD PMID:20007326 RGD:11099972 NCBI chr 8:143,572,874...143,578,330
Ensembl chr 8:143,574,785...143,578,649
JBrowse link
G NMNAT1 nicotinamide nucleotide adenylyltransferase 1 TAS RGD PMID:20007326 RGD:11099972 NCBI chr 1:9,942,923...9,996,892
Ensembl chr 1:9,943,428...9,985,501
JBrowse link
G NMNAT2 nicotinamide nucleotide adenylyltransferase 2 TAS RGD PMID:20007326 RGD:11099972 NCBI chr 1:183,248,237...183,418,380
Ensembl chr 1:183,248,237...183,418,380
JBrowse link
G NMNAT3 nicotinamide nucleotide adenylyltransferase 3 TAS RGD PMID:20007326 RGD:11099972 NCBI chr 3:139,560,180...139,678,050
Ensembl chr 3:139,560,180...139,678,017
JBrowse link
G NMRK1 nicotinamide riboside kinase 1 TAS RGD PMID:20007326 RGD:11099972 NCBI chr 9:75,060,577...75,088,155
Ensembl chr 9:75,060,573...75,088,217
JBrowse link
G NMRK2 nicotinamide riboside kinase 2 TAS RGD PMID:20007326 RGD:11099972 NCBI chr19:3,933,069...3,942,416
Ensembl chr19:3,933,069...3,942,416
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5957
    classic metabolic pathway 1802
      metabolic pathway of cofactors, vitamins, nutrients 370
        nicotinamide adenine dinucleotide metabolic pathway 60
          nicotinamide adenine dinucleotide biosynthetic pathway 9
            de novo nicotinamide adenine dinucleotide biosynthetic pathway 5
            nicotinamide adenine dinucleotide biosynthesis, the salvage pathway 8
paths to the root