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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:nicotinamide adenine dinucleotide biosynthetic pathway
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Accession:PW:0000219 term browser browse the term
Definition:Those metabolic reactions involved in the synthesis of nicotinamide adenine dinucleotide (NAD). NAD can be synthesized de novo downstream of kynurenine metabolism of tryptophan degradation, or from precursors such as nicotinamide, nicotinic acid or nicotinamide riboside, collectively known as vitamin B3 or niacin.
Synonyms:exact_synonym: NAD biosynthetic pathway
 related_synonym: NAD biosynthetic process

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de novo nicotinamide adenine dinucleotide biosynthetic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NADSYN1 NAD synthetase 1 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 1:3,189,054...3,243,087
Ensembl chr 1:3,188,348...3,238,435
JBrowse link
G NMNAT1 nicotinamide nucleotide adenylyltransferase 1 ISO RGD PMID:20007326 RGD:11099972 NCBI chr20:121,790,836...121,797,043 JBrowse link
G NMNAT2 nicotinamide nucleotide adenylyltransferase 2 ISO RGD PMID:20007326 RGD:11099972 NCBI chr25:45,954,934...46,130,106
Ensembl chr25:45,954,862...46,125,378
JBrowse link
G NMNAT3 nicotinamide nucleotide adenylyltransferase 3 ISO RGD PMID:20007326 RGD:11099972 NCBI chr15:50,880,146...50,990,958
Ensembl chr15:50,880,235...50,991,281
JBrowse link
G QPRT quinolinate phosphoribosyltransferase ISO RGD PMID:20007326 RGD:11099972 NCBI chr 5:26,953,980...26,970,120
Ensembl chr 5:26,950,391...26,970,079
JBrowse link
nicotinamide adenine dinucleotide biosynthesis, the salvage pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NADSYN1 NAD synthetase 1 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 1:3,189,054...3,243,087
Ensembl chr 1:3,188,348...3,238,435
JBrowse link
G NAMPT nicotinamide phosphoribosyltransferase ISO RGD PMID:20007326 RGD:11099972 NCBI chr21:75,160,748...75,195,781
Ensembl chr21:75,158,596...75,196,025
JBrowse link
G NAPRT nicotinate phosphoribosyltransferase ISO RGD PMID:20007326 RGD:11099972 NCBI chr 8:137,794,933...137,799,145
Ensembl chr 8:137,792,993...137,798,658
JBrowse link
G NMNAT1 nicotinamide nucleotide adenylyltransferase 1 ISO RGD PMID:20007326 RGD:11099972 NCBI chr20:121,790,836...121,797,043 JBrowse link
G NMNAT2 nicotinamide nucleotide adenylyltransferase 2 ISO RGD PMID:20007326 RGD:11099972 NCBI chr25:45,954,934...46,130,106
Ensembl chr25:45,954,862...46,125,378
JBrowse link
G NMNAT3 nicotinamide nucleotide adenylyltransferase 3 ISO RGD PMID:20007326 RGD:11099972 NCBI chr15:50,880,146...50,990,958
Ensembl chr15:50,880,235...50,991,281
JBrowse link
G NMRK1 nicotinamide riboside kinase 1 ISO RGD PMID:20007326 RGD:11099972 NCBI chr12:86,112,583...86,140,457
Ensembl chr12:86,112,271...86,140,449
JBrowse link
G NMRK2 nicotinamide riboside kinase 2 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 6:3,685,337...3,697,868
Ensembl chr 6:3,688,166...3,697,960
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4028
    classic metabolic pathway 1003
      metabolic pathway of cofactors, vitamins, nutrients 233
        nicotinamide adenine dinucleotide metabolic pathway 60
          nicotinamide adenine dinucleotide biosynthetic pathway 9
            de novo nicotinamide adenine dinucleotide biosynthetic pathway 5
            nicotinamide adenine dinucleotide biosynthesis, the salvage pathway 8
paths to the root