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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:nicotinamide adenine dinucleotide biosynthetic pathway
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Accession:PW:0000219 term browser browse the term
Definition:Those metabolic reactions involved in the synthesis of nicotinamide adenine dinucleotide (NAD). NAD can be synthesized de novo downstream of kynurenine metabolism of tryptophan degradation, or from precursors such as nicotinamide, nicotinic acid or nicotinamide riboside, collectively known as vitamin B3 or niacin.
Synonyms:exact_synonym: NAD biosynthetic pathway
 related_synonym: NAD biosynthetic process
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de novo nicotinamide adenine dinucleotide biosynthetic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NADSYN1 NAD synthetase 1 ISO RGD PMID:20007326 RGD:11099972 NCBI chr18:47,216,547...47,254,582
Ensembl chr18:47,216,577...47,254,514 		JBrowse link
G NMNAT1 nicotinamide nucleotide adenylyltransferase 1 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 5:63,122,379...63,152,078
Ensembl chr 5:63,122,498...63,151,661 		JBrowse link
G NMNAT2 nicotinamide nucleotide adenylyltransferase 2 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 7:16,626,213...16,819,681
Ensembl chr 7:16,631,116...16,805,457 		JBrowse link
G NMNAT3 nicotinamide nucleotide adenylyltransferase 3 ISO RGD PMID:20007326 RGD:11099972 NCBI chr23:35,714,162...35,829,150
Ensembl chr23:35,714,933...35,829,049 		JBrowse link
G QPRT quinolinate phosphoribosyltransferase ISO RGD PMID:20007326 RGD:11099972 NCBI chr 6:17,778,664...17,794,110
Ensembl chr 6:17,779,439...17,794,035 		JBrowse link
nicotinamide adenine dinucleotide biosynthesis, the salvage pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NADSYN1 NAD synthetase 1 ISO RGD PMID:20007326 RGD:11099972 NCBI chr18:47,216,547...47,254,582
Ensembl chr18:47,216,577...47,254,514 		JBrowse link
G NAMPT nicotinamide phosphoribosyltransferase ISO RGD PMID:20007326 RGD:11099972 NCBI chr18:14,110,045...14,211,268
Ensembl chr18:13,993,022...14,208,657 		JBrowse link
G NAPRT nicotinate phosphoribosyltransferase ISO RGD PMID:20007326 RGD:11099972 NCBI chr13:37,235,985...37,239,261
Ensembl chr13:37,235,045...37,239,224 		JBrowse link
G NMNAT1 nicotinamide nucleotide adenylyltransferase 1 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 5:63,122,379...63,152,078
Ensembl chr 5:63,122,498...63,151,661 		JBrowse link
G NMNAT2 nicotinamide nucleotide adenylyltransferase 2 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 7:16,626,213...16,819,681
Ensembl chr 7:16,631,116...16,805,457 		JBrowse link
G NMNAT3 nicotinamide nucleotide adenylyltransferase 3 ISO RGD PMID:20007326 RGD:11099972 NCBI chr23:35,714,162...35,829,150
Ensembl chr23:35,714,933...35,829,049 		JBrowse link
G NMRK1 nicotinamide riboside kinase 1 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 1:83,140,816...83,163,292
Ensembl chr 1:83,140,554...83,162,374 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4047
    classic metabolic pathway 1009
      metabolic pathway of cofactors, vitamins, nutrients 238
        nicotinamide adenine dinucleotide metabolic pathway 57
          nicotinamide adenine dinucleotide biosynthetic pathway 8
            de novo nicotinamide adenine dinucleotide biosynthetic pathway 5
            nicotinamide adenine dinucleotide biosynthesis, the salvage pathway 7
paths to the root