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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:nicotinamide adenine dinucleotide biosynthetic pathway
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Accession:PW:0000219 term browser browse the term
Definition:Those metabolic reactions involved in the synthesis of nicotinamide adenine dinucleotide (NAD). NAD can be synthesized de novo downstream of kynurenine metabolism of tryptophan degradation, or from precursors such as nicotinamide, nicotinic acid or nicotinamide riboside, collectively known as vitamin B3 or niacin.
Synonyms:exact_synonym: NAD biosynthetic pathway
 related_synonym: NAD biosynthetic process
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de novo nicotinamide adenine dinucleotide biosynthetic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NADSYN1 NAD synthetase 1 ISO RGD PMID:20007326 RGD:11099972 NCBI chr11:66,464,320...66,537,649
Ensembl chr11:69,735,871...69,788,953 		JBrowse link
G NMNAT1 nicotinamide nucleotide adenylyltransferase 1 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 1:8,712,798...8,753,027
Ensembl chr 1:9,942,491...9,982,364 		JBrowse link
G NMNAT2 nicotinamide nucleotide adenylyltransferase 2 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 1:158,768,949...158,948,711
Ensembl chr 1:162,929,609...163,105,524 		JBrowse link
G NMNAT3 nicotinamide nucleotide adenylyltransferase 3 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 3:136,594,825...136,715,437 JBrowse link
G QPRT quinolinate phosphoribosyltransferase ISO RGD PMID:20007326 RGD:11099972 Ensembl chr16:30,049,806...30,070,469 JBrowse link
nicotinamide adenine dinucleotide biosynthesis, the salvage pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NADSYN1 NAD synthetase 1 ISO RGD PMID:20007326 RGD:11099972 NCBI chr11:66,464,320...66,537,649
Ensembl chr11:69,735,871...69,788,953 		JBrowse link
G NAMPT nicotinamide phosphoribosyltransferase ISO RGD PMID:20007326 RGD:11099972 NCBI chr 7:98,227,071...98,262,254
Ensembl chr 7:110,952,876...110,981,967 		JBrowse link
G NAPRT nicotinate phosphoribosyltransferase ISO RGD PMID:20007326 RGD:11099972 NCBI chr 8:140,328,119...140,331,972
Ensembl chr 8:143,340,928...143,362,971 		JBrowse link
G NMNAT1 nicotinamide nucleotide adenylyltransferase 1 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 1:8,712,798...8,753,027
Ensembl chr 1:9,942,491...9,982,364 		JBrowse link
G NMNAT2 nicotinamide nucleotide adenylyltransferase 2 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 1:158,768,949...158,948,711
Ensembl chr 1:162,929,609...163,105,524 		JBrowse link
G NMNAT3 nicotinamide nucleotide adenylyltransferase 3 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 3:136,594,825...136,715,437 JBrowse link
G NMRK1 nicotinamide riboside kinase 1 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 9:49,746,075...49,773,245
Ensembl chr 9:73,917,674...73,945,304 		JBrowse link
G NMRK2 nicotinamide riboside kinase 2 ISO RGD PMID:20007326 RGD:11099972 NCBI chr19:2,958,503...2,967,246 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4064
    classic metabolic pathway 1015
      metabolic pathway of cofactors, vitamins, nutrients 239
        nicotinamide adenine dinucleotide metabolic pathway 59
          nicotinamide adenine dinucleotide biosynthetic pathway 9
            de novo nicotinamide adenine dinucleotide biosynthetic pathway 5
            nicotinamide adenine dinucleotide biosynthesis, the salvage pathway 8
paths to the root