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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:nicotinamide adenine dinucleotide biosynthetic pathway
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Accession:PW:0000219 term browser browse the term
Definition:Those metabolic reactions involved in the synthesis of nicotinamide adenine dinucleotide (NAD). NAD can be synthesized de novo downstream of kynurenine metabolism of tryptophan degradation, or from precursors such as nicotinamide, nicotinic acid or nicotinamide riboside, collectively known as vitamin B3 or niacin.
Synonyms:exact_synonym: NAD biosynthetic pathway
 related_synonym: NAD biosynthetic process
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de novo nicotinamide adenine dinucleotide biosynthetic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nadsyn1 NAD synthetase 1 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 1:198,981,559...199,009,853
Ensembl chr 1:198,981,604...199,009,869 		JBrowse link
G Nmnat1 nicotinamide nucleotide adenylyltransferase 1 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 5:159,910,242...159,928,201
Ensembl chr 5:159,910,242...159,928,180 		JBrowse link
G Nmnat2 nicotinamide nucleotide adenylyltransferase 2 ISO RGD PMID:20007326 RGD:11099972 NCBI chr13:65,105,950...65,277,350
Ensembl chr13:65,105,950...65,278,484 		JBrowse link
G Nmnat3 nicotinamide nucleotide adenylyltransferase 3 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 8:98,892,168...99,003,912
Ensembl chr 8:98,873,398...99,020,645 		JBrowse link
G Qprt quinolinate phosphoribosyltransferase ISO RGD PMID:20007326 RGD:11099972 NCBI chr 1:181,718,189...181,733,486
Ensembl chr 1:181,718,190...181,733,486 		JBrowse link
nicotinamide adenine dinucleotide biosynthesis, the salvage pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nadsyn1 NAD synthetase 1 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 1:198,981,559...199,009,853
Ensembl chr 1:198,981,604...199,009,869 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase ISO RGD PMID:20007326 RGD:11099972 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100 		JBrowse link
G Naprt nicotinate phosphoribosyltransferase ISO RGD PMID:20007326 RGD:11099972 NCBI chr 7:107,576,645...107,580,102
Ensembl chr 7:107,576,627...107,580,102 		JBrowse link
G Nmnat1 nicotinamide nucleotide adenylyltransferase 1 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 5:159,910,242...159,928,201
Ensembl chr 5:159,910,242...159,928,180 		JBrowse link
G Nmnat2 nicotinamide nucleotide adenylyltransferase 2 ISO RGD PMID:20007326 RGD:11099972 NCBI chr13:65,105,950...65,277,350
Ensembl chr13:65,105,950...65,278,484 		JBrowse link
G Nmnat3 nicotinamide nucleotide adenylyltransferase 3 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 8:98,892,168...99,003,912
Ensembl chr 8:98,873,398...99,020,645 		JBrowse link
G Nmrk1 nicotinamide riboside kinase 1 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 1:216,049,350...216,076,792
Ensembl chr 1:216,049,437...216,076,791 		JBrowse link
G Nmrk2 nicotinamide riboside kinase 2 ISO RGD PMID:20007326 RGD:11099972 NCBI chr 7:8,514,855...8,517,916
Ensembl chr 7:8,514,927...8,517,922 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    classic metabolic pathway 1854
      metabolic pathway of cofactors, vitamins, nutrients 367
        nicotinamide adenine dinucleotide metabolic pathway 59
          nicotinamide adenine dinucleotide biosynthetic pathway 9
            de novo nicotinamide adenine dinucleotide biosynthetic pathway 5
            nicotinamide adenine dinucleotide biosynthesis, the salvage pathway 8
paths to the root