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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:heme biosynthetic pathway
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Accession:PW:0000218 term browser browse the term
Definition:Those metabolic reactions involved in the biosynthesis of heme - an iron-containing compound where the iron is complexed within a porphyrin heterocyclic ring. There are several kinds of heme depending on the composition of their side chain. Heme serves as a prosthetic group for several classes of proteins that include hemoglobin and myoglobin, cytochromes, peroxidases, catalases and others.
Synonyms:related_synonym: Heme biosynthesis;   heme biosynthetic process
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heme biosynthetic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase IEA
ISO		 RGD PMID: PMID:16839620 PMID:26785297 RGD:1578396, RGD:4144542, RGD:11554188 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474 		JBrowse link
G Alas1 5'-aminolevulinate synthase 1 IEA
IDA
ISO		 RGD PMID: PMID:16125296 PMID:16839620 PMID:26785297 RGD:1578396, RGD:1601233, RGD:4144542, RGD:11554188 NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917 		JBrowse link
G Alas2 5'-aminolevulinate synthase 2 IEA
ISO		 RGD PMID: PMID:16839620 PMID:26785297 RGD:1578396, RGD:4144542, RGD:11554188 NCBI chr  X:19,463,146...19,486,526
Ensembl chr  X:19,463,171...19,486,519 		JBrowse link
G Cpox coproporphyrinogen oxidase IEA
ISO		 RGD PMID: PMID:16839620 PMID:26785297 RGD:1578396, RGD:4144542, RGD:11554188 NCBI chr11:41,936,585...41,946,568
Ensembl chr11:41,936,591...41,946,746 		JBrowse link
G Fech ferrochelatase IEA
ISO		 RGD PMID: PMID:16839620 PMID:26785297 RGD:1578396, RGD:4144542, RGD:11554188 NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348 		JBrowse link
G Hmbs hydroxymethylbilane synthase IEA
IDA
ISO
IMP		 RGD PMID: PMID:6712591 PMID:16839620 PMID:26785297 PMID:6893114 More... RGD:1578396, RGD:2301704, RGD:4144542, RGD:11554188, RGD:26923963, RGD:25440495, RGD:25330343, RGD:26884337 NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957 		JBrowse link
G Ppox protoporphyrinogen oxidase IEA
IDA
ISO		 RGD PMID: PMID:3663105 PMID:16839620 PMID:26785297 RGD:1578396, RGD:1599180, RGD:4144542, RGD:11554188 NCBI chr13:83,697,661...83,701,998
Ensembl chr13:83,664,891...83,701,805 		JBrowse link
G Slc25a38 solute carrier family 25, member 38 ISO RGD PMID:26785297 PMID:27476175 RGD:11554188, RGD:11556278 NCBI chr 8:119,835,546...119,848,334
Ensembl chr 8:119,835,634...119,848,332 		JBrowse link
G Tspo translocator protein ISO RGD PMID:26785297 RGD:11554188 NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450 		JBrowse link
G Urod uroporphyrinogen decarboxylase IEA
IDA
ISO		 RGD PMID: PMID:10416273 PMID:16839620 PMID:26785297 RGD:1578396, RGD:2303399, RGD:4144542, RGD:11554188 NCBI chr 5:130,464,695...130,468,783
Ensembl chr 5:130,455,217...130,468,808 		JBrowse link
G Uros uroporphyrinogen III synthase IEA
ISO
TAS		 RGD PMID: PMID:16839620 PMID:3327431 PMID:26785297 RGD:1578396, RGD:4144542, RGD:4144823, RGD:11554188 NCBI chr 1:188,490,832...188,513,659
Ensembl chr 1:188,490,323...188,512,249 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    classic metabolic pathway 1854
      metabolic pathway of cofactors, vitamins, nutrients 367
        porphyrin and chlorophyll metabolic pathway 38
          porphyrin metabolic pathway 17
            heme metabolic pathway 12
              heme biosynthetic pathway 11
Path 2
Term Annotations click to browse term
  pathway 6092
    regulatory pathway 3867
      homeostasis pathway 1773
        inorganic chemical homeostasis pathway 430
          metal homeostasis pathway 339
            iron homeostasis pathway 62
              iron utilization pathway 37
                heme biosynthetic pathway 11
paths to the root