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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:spermine metabolic pathway
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Accession:PW:0000216 term browser browse the term
Definition:Polyamine metabolism plays important roles in a number of cellular processes. Spermidine and spermine are formed in two consecutive reactions carried out by distinct enzymes that employ the decarboxylated form of AdoMet as an aminopropyl donor.
Synonyms:related_synonym: spermine metabolic process


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spermine metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amd1 S-adenosylmethionine decarboxylase 1 ISS
ISO		 SMPDB
RGD		 PMID:10430362 PMID:10712236 PMID:1415709 SMP:00445, RGD:1578320, RGD:7242911, RGD:7242912 NCBI chr10:40,163,454...40,178,184
Ensembl chr10:40,163,454...40,178,184 		JBrowse link
G Mat2a methionine adenosyltransferase 2A ISO SMPDB SMP:00445 NCBI chr 6:72,409,779...72,416,539
Ensembl chr 6:72,409,782...72,416,541 		JBrowse link
G Mat2b methionine adenosyltransferase 2 non-catalytic beta subunit methionine ISO SMPDB SMP:00445 NCBI chr11:40,570,141...40,586,030
Ensembl chr11:40,570,141...40,586,030 		JBrowse link
G Odc1 ornithine decarboxylase, structural 1 ISS
ISO		 SMPDB
RGD		 PMID:10430362 PMID:1415709 PMID:2292587 SMP:00445, RGD:1578320, RGD:7242912, RGD:7242932 NCBI chr12:17,594,906...17,601,503
Ensembl chr12:17,594,795...17,601,506 		JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 ISO RGD PMID:2292587 RGD:7242932 NCBI chr  X:153,996,128...153,999,345
Ensembl chr  X:153,996,128...153,999,445 		JBrowse link
G Sms spermine synthase ISO SMPDB
RGD		 PMID:23073625 PMID:2292587 SMP:00445, RGD:7242425, RGD:7242932 NCBI chr  X:156,226,847...156,275,283
Ensembl chr  X:156,226,851...156,275,283 		JBrowse link
G Srm spermidine synthase ISO SMPDB SMP:00445 NCBI chr 4:148,675,970...148,679,076
Ensembl chr 4:148,675,960...148,679,450 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6071
    classic metabolic pathway 1858
      biogenic amines and polyamines metabolic pathway 28
        polyamine metabolic pathway 13
          spermine metabolic pathway 7
Path 2
Term Annotations click to browse term
  pathway 6071
    regulatory pathway 3685
      homeostasis pathway 1721
        organic chemical homeostasis pathway 454
          S-adenosylmethionine homeostasis pathway 286
            polyamine metabolic pathway 13
              spermine metabolic pathway 7
paths to the root