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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:biogenic amines and polyamines metabolic pathway
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Accession:PW:0000211 term browser browse the term
Definition:Those metabolic reactions involved in the synthesis, utilization and/or degradation of biogenic amines and polyamines. Important biogenic amines are histamine, serotonin and the catecholamines. Spermidine and spermine are examples of important polyamines.


show annotations for term's descendants           Sort by:
acetylcholine metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase IDA rostral-caudal differences in Ache and Chat enzyme activities in the superior colliculus
activities of Ache and Chat varied considerably between different layers of the cerebellar vermis		 RGD PMID:126256 PMID:4008917 PMID:6854006 PMID:334962 RGD:2301195, RGD:2301203, RGD:2301199, RGD:2301197 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Chat choline O-acetyltransferase IDA rostral-caudal differences in Ache and Chat enzyme activities in the superior colliculus
activities of Ache and Chat varied considerably between different layers of the cerebellar vermis		 RGD PMID:126256 PMID:4008917 PMID:6854006 PMID:334962 RGD:2301195, RGD:2301203, RGD:2301199, RGD:2301197 NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093 		JBrowse link
catecholamine biosynthetic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dbh dopamine beta-hydroxylase ISO SMPDB SMP:00012 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248 		JBrowse link
G Ddc dopa decarboxylase ISO SMPDB SMP:00012 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208 		JBrowse link
G Pnmt phenylethanolamine-N-methyltransferase ISO SMPDB SMP:00012 NCBI chr10:83,383,019...83,386,557
Ensembl chr10:83,384,923...83,386,556 		JBrowse link
G Th tyrosine hydroxylase ISO SMPDB SMP:00012 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
choline metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahcy adenosylhomocysteinase ISO SMPDB SMP:00123 NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393 		JBrowse link
G Aldh7a1 aldehyde dehydrogenase 7 family, member A1 ISO SMPDB SMP:00123 NCBI chr18:50,003,242...50,042,193
Ensembl chr18:50,009,934...50,042,193 		JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase ISO SMPDB SMP:00123 NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742 		JBrowse link
G Chdh choline dehydrogenase ISO SMPDB SMP:00123 NCBI chr16:5,194,269...5,225,541
Ensembl chr16:5,194,269...5,225,537 		JBrowse link
G Mat2a methionine adenosyltransferase 2A ISO SMPDB SMP:00123 NCBI chr 4:104,489,877...104,495,447
Ensembl chr 4:104,488,466...104,495,493 		JBrowse link
G Mat2b methionine adenosyltransferase 2 non-catalytic beta subunit ISO SMPDB SMP:00123 NCBI chr10:25,106,928...25,122,982
Ensembl chr10:25,106,930...25,122,777 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase ISO SMPDB SMP:00123 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822 		JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase ISO SMPDB SMP:00123 NCBI chr10:44,775,910...44,849,990
Ensembl chr10:44,775,911...44,850,013 		JBrowse link
G Sardh sarcosine dehydrogenase IDA RGD PMID:9839943 RGD:634034 NCBI chr 3:10,510,553...10,575,342
Ensembl chr 3:10,510,553...10,573,874 		JBrowse link
dopamine biosynthetic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddc dopa decarboxylase ISO RGD PMID:19342614 RGD:4139904 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208 		JBrowse link
G Qdpr quinoid dihydropteridine reductase ISO RGD PMID:19342614 RGD:4139904 NCBI chr14:65,670,251...65,683,853
Ensembl chr14:65,670,131...65,683,854 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 IDA RGD PMID:19903816 RGD:5128868 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325 		JBrowse link
G Th tyrosine hydroxylase ISO RGD PMID:19342614 RGD:4139904 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
epinephrine biosynthetic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dbh dopamine beta-hydroxylase ISO RGD PMID:19342614 RGD:4139904 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248 		JBrowse link
G Ddc dopa decarboxylase ISO RGD PMID:19342614 RGD:4139904 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208 		JBrowse link
G Pnmt phenylethanolamine-N-methyltransferase IDA
ISO		 RGD PMID:7914070 PMID:19342614 RGD:4139902, RGD:4139904 NCBI chr10:83,383,019...83,386,557
Ensembl chr10:83,384,923...83,386,556 		JBrowse link
G Qdpr quinoid dihydropteridine reductase ISO RGD PMID:19342614 RGD:4139904 NCBI chr14:65,670,251...65,683,853
Ensembl chr14:65,670,131...65,683,854 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 IDA RGD PMID:19903816 RGD:5128868 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325 		JBrowse link
G Th tyrosine hydroxylase ISO RGD PMID:19342614 RGD:4139904 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
norepinephrine biosynthetic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dbh dopamine beta-hydroxylase ISO RGD PMID:19342614 RGD:4139904 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248 		JBrowse link
G Ddc dopa decarboxylase ISO RGD PMID:19342614 RGD:4139904 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208 		JBrowse link
G Qdpr quinoid dihydropteridine reductase ISO RGD PMID:19342614 RGD:4139904 NCBI chr14:65,670,251...65,683,853
Ensembl chr14:65,670,131...65,683,854 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 IDA RGD PMID:19903816 RGD:5128868 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325 		JBrowse link
G Th tyrosine hydroxylase ISO RGD PMID:19342614 RGD:4139904 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
polyamine metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amd1 adenosylmethionine decarboxylase 1 IDA
ISO		 RGD PMID:10430362 PMID:13678416 RGD:1578320, RGD:7244193 NCBI chr20:43,695,783...43,711,476
Ensembl chr20:43,697,237...43,711,476 		JBrowse link
G Azin1 antizyme inhibitor 1 ISO RGD PMID:21849468 RGD:7244195 NCBI chr 7:69,654,773...69,681,578
Ensembl chr 7:69,654,663...69,681,578 		JBrowse link
G Oaz1 ornithine decarboxylase antizyme 1 ISO RGD PMID:21849468 RGD:7244195 NCBI chr 7:8,883,855...8,886,315
Ensembl chr 7:8,883,851...8,886,310 		JBrowse link
G Oaz2 ornithine decarboxylase antizyme 2 ISO RGD PMID:21849468 RGD:7244195 NCBI chr 8:66,199,694...66,213,513
Ensembl chr 8:66,199,706...66,231,453 		JBrowse link
G Oaz3 ornithine decarboxylase antizyme 3 ISO RGD PMID:21849468 RGD:7244195 NCBI chr 2:182,073,212...182,076,147
Ensembl chr 2:182,073,215...182,082,399 		JBrowse link
G Odc1 ornithine decarboxylase 1 IDA
ISO		 RGD PMID:10430362 PMID:13678416 RGD:1578320, RGD:7244193 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Paox polyamine oxidase IDA
ISO		 RGD PMID:15541750 PMID:13678416 RGD:7244190, RGD:7244193 NCBI chr 1:194,903,267...194,928,504
Ensembl chr 1:194,903,273...194,928,504 		JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 IDA
ISO
TAS		 RGD PMID:15541750 PMID:13678416 PMID:13678416 RGD:7244190, RGD:7244193, RGD:7244193 NCBI chr  X:40,158,354...40,161,641
Ensembl chr  X:40,157,046...40,196,813 		JBrowse link
G Smox spermine oxidase IDA
ISO		 RGD PMID:15541750 PMID:13678416 RGD:7244190, RGD:7244193 NCBI chr 3:118,731,814...118,767,242
Ensembl chr 3:118,731,900...118,765,710 		JBrowse link
G Sms spermine synthase ISO RGD PMID:13678416 RGD:7244193 NCBI chr  X:37,516,949...37,572,657
Ensembl chr  X:37,516,931...37,570,822 		JBrowse link
G Srm spermidine synthase ISO RGD PMID:13678416 RGD:7244193 NCBI chr 5:159,025,919...159,029,076
Ensembl chr 5:159,025,873...159,029,405 		JBrowse link
putrescine metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amd1 adenosylmethionine decarboxylase 1 IDA RGD PMID:10430362 RGD:1578320 NCBI chr20:43,695,783...43,711,476
Ensembl chr20:43,697,237...43,711,476 		JBrowse link
G Odc1 ornithine decarboxylase 1 IDA RGD PMID:10430362 RGD:1578320 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
spermidine metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amd1 adenosylmethionine decarboxylase 1 IDA
IMP
ISO		 SMPDB
RGD		 PMID:10430362 PMID:10712236 PMID:1415709 SMP:00445, RGD:1578320, RGD:7242911, RGD:7242912 NCBI chr20:43,695,783...43,711,476
Ensembl chr20:43,697,237...43,711,476 		JBrowse link
G Mat2a methionine adenosyltransferase 2A ISO SMPDB SMP:00445 NCBI chr 4:104,489,877...104,495,447
Ensembl chr 4:104,488,466...104,495,493 		JBrowse link
G Mat2b methionine adenosyltransferase 2 non-catalytic beta subunit ISO SMPDB SMP:00445 NCBI chr10:25,106,928...25,122,982
Ensembl chr10:25,106,930...25,122,777 		JBrowse link
G Odc1 ornithine decarboxylase 1 IDA
ISO
IMP		 SMPDB
RGD		 PMID:10430362 PMID:2292587 PMID:1415709 SMP:00445, RGD:1578320, RGD:7242932, RGD:7242912 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 IMP RGD PMID:2292587 RGD:7242932 NCBI chr  X:40,158,354...40,161,641
Ensembl chr  X:40,157,046...40,196,813 		JBrowse link
G Sms spermine synthase ISO SMPDB SMP:00445 NCBI chr  X:37,516,949...37,572,657
Ensembl chr  X:37,516,931...37,570,822 		JBrowse link
G Srm spermidine synthase ISO
IMP
IDA		 SMPDB
RGD		 PMID:23073625 PMID:2292587 PMID:16931179 SMP:00445, RGD:7242425, RGD:7242932, RGD:7242920 NCBI chr 5:159,025,919...159,029,076
Ensembl chr 5:159,025,873...159,029,405 		JBrowse link
spermine metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amd1 adenosylmethionine decarboxylase 1 IDA
ISO
IMP		 SMPDB
RGD		 PMID:10430362 PMID:1415709 PMID:10712236 SMP:00445, RGD:1578320, RGD:7242912, RGD:7242911 NCBI chr20:43,695,783...43,711,476
Ensembl chr20:43,697,237...43,711,476 		JBrowse link
G Mat2a methionine adenosyltransferase 2A ISO SMPDB SMP:00445 NCBI chr 4:104,489,877...104,495,447
Ensembl chr 4:104,488,466...104,495,493 		JBrowse link
G Mat2b methionine adenosyltransferase 2 non-catalytic beta subunit ISO SMPDB SMP:00445 NCBI chr10:25,106,928...25,122,982
Ensembl chr10:25,106,930...25,122,777 		JBrowse link
G Odc1 ornithine decarboxylase 1 IDA
ISO
IMP		 SMPDB
RGD		 PMID:10430362 PMID:2292587 PMID:1415709 SMP:00445, RGD:1578320, RGD:7242932, RGD:7242912 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 IMP RGD PMID:2292587 RGD:7242932 NCBI chr  X:40,158,354...40,161,641
Ensembl chr  X:40,157,046...40,196,813 		JBrowse link
G Sms spermine synthase ISO
IMP		 SMPDB
RGD		 PMID:23073625 PMID:2292587 SMP:00445, RGD:7242425, RGD:7242932 NCBI chr  X:37,516,949...37,572,657
Ensembl chr  X:37,516,931...37,570,822 		JBrowse link
G Srm spermidine synthase ISO SMPDB SMP:00445 NCBI chr 5:159,025,919...159,029,076
Ensembl chr 5:159,025,873...159,029,405 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6100
    classic metabolic pathway 1857
      biogenic amines and polyamines metabolic pathway 28
        biogenic amine biosynthetic pathway + 6
        catecholamine metabolic pathway + 6
        choline metabolic pathway + 11
        indoleamine and related compounds metabolic pathway + 0
        polyamine metabolic pathway + 13
paths to the root