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Term:Jak-Stat signaling pathway
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Accession:PW:0000209 term browser browse the term
Definition:The Jak-Stat pathway is a main intracellular cascade initiated primarily in response to cytokine and also other ligand signaling. Four Janus kinases (Jak) and seven signal transducers and activators of transcription (Stat) families of proteins mediate the action of almost 40 cytokine receptors, including the receptor for leptin. Combinations between four Jak(s) and seven Stat(s) shape the outcome of ligand triggered signaling through the various receptors.
Synonyms:related_synonym: KEGG:04630

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Jak-Stat signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 thymoma viral proto-oncogene 1 JBrowse link 12 112,653,821 112,674,884 RGD:6907045
G Akt2 thymoma viral proto-oncogene 2 JBrowse link 7 27,591,552 27,640,826 RGD:6907045
G Akt3 thymoma viral proto-oncogene 3 JBrowse link 1 177,020,076 177,261,781 RGD:6907045
G Bcl2l1 BCL2-like 1 JBrowse link 2 152,758,732 152,833,803 RGD:6907045
G Cbl Casitas B-lineage lymphoma JBrowse link 9 44,142,976 44,234,259 RGD:6907045
G Cblb Casitas B-lineage lymphoma b JBrowse link 16 52,031,230 52,208,047 RGD:6907045
G Cblc Casitas B-lineage lymphoma c JBrowse link 7 19,779,718 19,796,809 RGD:6907045
G Ccnd1 cyclin D1 JBrowse link 7 144,929,931 144,939,937 RGD:6907045
G Ccnd2 cyclin D2 JBrowse link 6 127,125,162 127,152,188 RGD:6907045
G Ccnd3 cyclin D3 JBrowse link 17 47,505,051 47,599,689 RGD:6907045
G Cish cytokine inducible SH2-containing protein JBrowse link 9 107,296,659 107,302,784 RGD:6907045
G Clcf1 cardiotrophin-like cytokine factor 1 JBrowse link 19 4,214,238 4,223,505 RGD:6907045
G Cntf ciliary neurotrophic factor JBrowse link 19 12,763,528 12,765,632 RGD:6907045
G Cntfr ciliary neurotrophic factor receptor JBrowse link 4 41,657,498 41,697,091 RGD:6907045
G Crebbp CREB binding protein JBrowse link 16 4,081,334 4,213,957 RGD:6907045
G Crlf2 cytokine receptor-like factor 2 JBrowse link 5 109,554,709 109,559,128 RGD:6907045
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) JBrowse link 11 54,247,270 54,249,899 RGD:6907045
G Csf2ra colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) JBrowse link 19 61,217,191 61,228,461 RGD:6907045
G Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) JBrowse link 15 78,325,800 78,351,001 RGD:6907045
G Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) JBrowse link 15 78,282,507 78,305,721 RGD:6907045
G Csf3 colony stimulating factor 3 (granulocyte) JBrowse link 11 98,700,183 98,703,631 RGD:6907045
G Csf3r colony stimulating factor 3 receptor (granulocyte) JBrowse link 4 126,023,441 126,044,975 RGD:6907045
G Ctf1 cardiotrophin 1 JBrowse link 7 127,712,676 127,718,188 RGD:6907045
G Ep300 E1A binding protein p300 JBrowse link 15 81,586,209 81,652,077 RGD:6907045
G Epo erythropoietin JBrowse link 5 137,483,020 137,485,816 RGD:6907045
G Epor erythropoietin receptor JBrowse link 9 21,958,897 21,963,576 RGD:6907045
G Gh growth hormone JBrowse link 11 106,300,261 106,303,703 RGD:6907045
G Ghr growth hormone receptor JBrowse link 15 3,317,755 3,583,352 RGD:6907045
G Grb2 growth factor receptor bound protein 2 JBrowse link 11 115,644,045 115,708,597 RGD:6907045
G Ifna1 interferon alpha 1 JBrowse link 4 88,850,087 88,850,656 RGD:6907045
G Ifna11 interferon alpha 11 JBrowse link 4 88,819,919 88,820,565 RGD:6907045
G Ifna12 interferon alpha 12 JBrowse link 4 88,602,580 88,603,376 RGD:6907045
G Ifna13 interferon alpha 13 JBrowse link 4 88,643,641 88,644,459 RGD:6907045
G Ifna14 interferon alpha 14 JBrowse link 4 88,571,229 88,571,798 RGD:6907045
G Ifna15 interferon alpha 15 JBrowse link 4 88,557,673 88,558,245 RGD:6907045
G Ifna2 interferon alpha 2 JBrowse link 4 88,683,207 88,683,779 RGD:6907045
G Ifna4 interferon alpha 4 JBrowse link 4 88,841,816 88,842,459 RGD:6907045
G Ifna5 interferon alpha 5 JBrowse link 4 88,835,525 88,836,094 RGD:6907045
G Ifna6 interferon alpha 6 JBrowse link 4 88,827,276 88,828,032 RGD:6907045
G Ifna7 interferon alpha 7 JBrowse link 4 88,816,225 88,816,800 RGD:6907045
G Ifna9 interferon alpha 9 JBrowse link 4 88,591,813 88,592,385 RGD:6907045
G Ifnab interferon alpha B JBrowse link 4 88,690,599 88,691,268 RGD:6907045
G Ifnar1 interferon (alpha and beta) receptor 1 JBrowse link 16 91,485,032 91,510,523 RGD:6907045
G Ifnar2 interferon (alpha and beta) receptor 2 JBrowse link 16 91,372,783 91,405,589 RGD:6907045
G Ifnb1 interferon beta 1, fibroblast JBrowse link 4 88,522,025 88,522,794 RGD:6907045
G Ifne interferon epsilon JBrowse link 4 88,879,538 88,880,201 RGD:6907045
G Ifng interferon gamma JBrowse link 10 118,441,046 118,445,894 RGD:6907045
G Ifngr1 interferon gamma receptor 1 JBrowse link 10 19,591,949 19,610,229 RGD:6907045
G Ifngr2 interferon gamma receptor 2 JBrowse link 16 91,547,059 91,564,007 RGD:6907045
G Ifnk interferon kappa JBrowse link 4 35,152,055 35,154,019 RGD:6907045
G Ifnl2 interferon lambda 2 JBrowse link 7 28,508,784 28,510,532 RGD:6907045
G Ifnl3 interferon lambda 3 JBrowse link 7 28,522,833 28,524,401 RGD:6907045
G Ifnlr1 interferon lambda receptor 1 JBrowse link 4 135,686,457 135,708,181 RGD:6907045
G Il10 interleukin 10 JBrowse link 1 131,019,845 131,024,970 RGD:6907045
G Il10ra interleukin 10 receptor, alpha JBrowse link 9 45,253,837 45,269,149 RGD:6907045
G Il10rb interleukin 10 receptor, beta JBrowse link 16 91,406,157 91,425,834 RGD:6907045
G Il11 interleukin 11 JBrowse link 7 4,772,373 4,782,907 RGD:6907045
G Il11ra1 interleukin 11 receptor, alpha chain 1 JBrowse link 4 41,760,443 41,769,473 RGD:6907045
G Il11ra2 interleukin 11 receptor, alpha chain 2 JBrowse link 4 42,655,275 42,665,763 RGD:6907045
G Il12a interleukin 12a JBrowse link 3 68,690,644 68,698,550 RGD:6907045
G Il12b interleukin 12b JBrowse link 11 44,400,063 44,414,677 RGD:6907045
G Il12rb1 interleukin 12 receptor, beta 1 JBrowse link 8 70,808,360 70,823,542 RGD:6907045
G Il12rb2 interleukin 12 receptor, beta 2 JBrowse link 6 67,285,986 67,376,293 RGD:6907045
G Il13 interleukin 13 JBrowse link 11 53,631,323 53,634,702 RGD:6907045
G Il13ra1 interleukin 13 receptor, alpha 1 JBrowse link X 36,112,108 36,171,262 RGD:6907045
G Il13ra2 interleukin 13 receptor, alpha 2 JBrowse link X 147,383,478 147,429,192 RGD:6907045
G Il15 interleukin 15 JBrowse link 8 82,331,624 82,403,252 RGD:5024920
RGD:6907045
G Il15ra interleukin 15 receptor, alpha chain JBrowse link 2 11,705,172 11,733,985 RGD:5001122
RGD:6907045
G Il19 interleukin 19 JBrowse link 1 130,932,656 130,945,457 RGD:6907045
G Il2 interleukin 2 JBrowse link 3 37,120,713 37,125,954 RGD:6907045
G Il20 interleukin 20 JBrowse link 1 130,906,985 130,911,296 RGD:6907045
G Il20ra interleukin 20 receptor, alpha JBrowse link 10 19,711,673 19,760,053 RGD:6907045
G Il20rb interleukin 20 receptor beta JBrowse link 9 100,457,719 100,486,473 RGD:6907045
G Il21 interleukin 21 JBrowse link 3 37,222,759 37,232,636 RGD:6907045
G Il21r interleukin 21 receptor JBrowse link 7 125,603,252 125,634,397 RGD:6907045
G Il22 interleukin 22 JBrowse link 10 118,204,584 118,210,047 RGD:6907045
G Il22ra1 interleukin 22 receptor, alpha 1 JBrowse link 4 135,728,159 135,755,383 RGD:6907045
G Il22ra2 interleukin 22 receptor, alpha 2 JBrowse link 10 19,622,028 19,634,681 RGD:6907045
G Il23a interleukin 23, alpha subunit p19 JBrowse link 10 128,296,140 128,298,084 RGD:6907045
G Il23r interleukin 23 receptor JBrowse link 6 67,422,932 67,491,855 RGD:6907045
G Il24 interleukin 24 JBrowse link 1 130,882,074 130,887,411 RGD:6907045
G Il2ra interleukin 2 receptor, alpha chain JBrowse link 2 11,642,792 11,693,194 RGD:6907045
G Il2rb interleukin 2 receptor, beta chain JBrowse link 15 78,479,256 78,511,621 RGD:6907045
G Il2rg interleukin 2 receptor, gamma chain JBrowse link X 101,264,385 101,268,255 RGD:6907045
G Il3 interleukin 3 JBrowse link 11 54,265,085 54,267,279 RGD:6907045
G Il3ra interleukin 3 receptor, alpha chain JBrowse link 14 14,345,912 14,355,493 RGD:6907045
G Il4 interleukin 4 JBrowse link 11 53,612,460 53,618,665 RGD:6907045
G Il4ra interleukin 4 receptor, alpha JBrowse link 7 125,552,271 125,579,474 RGD:6907045
G Il5 interleukin 5 JBrowse link 11 53,720,794 53,725,103 RGD:6907045
G Il5ra interleukin 5 receptor, alpha JBrowse link 6 106,710,375 106,749,037 RGD:6907045
G Il6 interleukin 6 JBrowse link 5 30,013,114 30,019,975 RGD:6907045
G Il6ra interleukin 6 receptor, alpha JBrowse link 3 89,869,324 89,913,196 RGD:6907045
G Il6st interleukin 6 signal transducer JBrowse link 13 112,464,070 112,506,860 RGD:6907045
G Il7 interleukin 7 JBrowse link 3 7,572,028 7,613,760 RGD:6907045
G Il7r interleukin 7 receptor JBrowse link 15 9,506,159 9,529,941 RGD:6907045
G Il9 interleukin 9 JBrowse link 13 56,479,277 56,482,257 RGD:6907045
G Il9r interleukin 9 receptor JBrowse link 11 32,187,544 32,205,283 RGD:6907045
G Irf1 interferon regulatory factor 1 JBrowse link 11 53,769,854 53,778,374 RGD:5128774
G Irf9 interferon regulatory factor 9 JBrowse link 14 55,603,985 55,610,030 RGD:6907045
G Jak1 Janus kinase 1 JBrowse link 4 101,151,974 101,265,282 RGD:1625126
RGD:6907045
G Jak2 Janus kinase 2 JBrowse link 19 29,251,803 29,313,095 RGD:1624963
RGD:6907045
RGD:1625126
G Jak3 Janus kinase 3 JBrowse link 8 71,676,383 71,690,577 RGD:1625126
RGD:6907045
G Lep leptin JBrowse link 6 29,060,221 29,073,876 RGD:6907045
G Lepr leptin receptor JBrowse link 4 101,717,137 101,815,352 RGD:6907045
G Lif leukemia inhibitory factor JBrowse link 11 4,257,568 4,272,514 RGD:6907045
G Lifr LIF receptor alpha JBrowse link 15 7,090,610 7,197,489 RGD:6907045
G Mpl myeloproliferative leukemia virus oncogene JBrowse link 4 118,442,412 118,457,688 RGD:6907045
G Myc myelocytomatosis oncogene JBrowse link 15 61,985,341 61,990,361 RGD:6907045
G Osm oncostatin M JBrowse link 11 4,236,785 4,241,026 RGD:6907045
G Osmr oncostatin M receptor JBrowse link 15 6,813,568 6,874,968 RGD:6907045
G Pias1 protein inhibitor of activated STAT 1 JBrowse link 9 62,878,366 62,980,879 RGD:2290530
RGD:6907045
G Pias2 protein inhibitor of activated STAT 2 JBrowse link 18 77,065,176 77,155,710 RGD:2290530
RGD:6907045
G Pias3 protein inhibitor of activated STAT 3 JBrowse link 3 96,696,361 96,706,070 RGD:2290530
RGD:6907045
G Pias4 protein inhibitor of activated STAT 4 JBrowse link 10 81,153,961 81,167,720 RGD:2290530
RGD:6907045
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha JBrowse link 3 32,397,059 32,468,486 RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta JBrowse link 9 99,038,402 99,140,235 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta JBrowse link 4 149,649,168 149,702,566 RGD:6907045
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma JBrowse link 12 32,173,397 32,208,677 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 13 101,680,761 101,768,217 RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 8 70,768,176 70,776,712 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 4 116,221,400 116,303,056 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase regulatory subunit 5 JBrowse link 11 68,432,125 68,497,849 RGD:6907045
G Pim1 proviral integration site 1 JBrowse link 17 29,490,785 29,496,111 RGD:6907045
G Prl prolactin JBrowse link 13 27,057,570 27,065,204 RGD:6907045
G Prlr prolactin receptor JBrowse link 15 10,177,238 10,349,190 RGD:6907045
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 JBrowse link 2 167,930,750 167,979,385 RGD:2290530
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 5 121,130,533 121,191,397 RGD:2290530
RGD:6907045
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 67,665,501 67,724,632 RGD:2290530
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 JBrowse link 6 124,720,707 124,738,709 RGD:2290530
RGD:6907045
G Socs1 suppressor of cytokine signaling 1 JBrowse link 16 10,783,808 10,785,536 RGD:6907045
G Socs2 suppressor of cytokine signaling 2 JBrowse link 10 95,383,903 95,417,321 RGD:6907045
G Socs3 suppressor of cytokine signaling 3 JBrowse link 11 117,966,079 117,970,336 RGD:6907045
G Socs4 suppressor of cytokine signaling 4 JBrowse link 14 47,277,143 47,291,591 RGD:6907045
G Socs5 suppressor of cytokine signaling 5 JBrowse link 17 87,107,278 87,137,647 RGD:1357941
RGD:6907045
G Socs7 suppressor of cytokine signaling 7 JBrowse link 11 97,362,292 97,398,542 RGD:6907045
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 17 80,393,752 80,480,453 RGD:6907045
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 12 69,583,761 69,681,852 RGD:6907045
G Spred1 sprouty protein with EVH-1 domain 1, related sequence JBrowse link 2 117,121,071 117,182,279 RGD:6907045
G Spred2 sprouty-related EVH1 domain containing 2 JBrowse link 11 19,924,442 20,024,026 RGD:6907045
G Spred3 sprouty-related EVH1 domain containing 3 JBrowse link 7 29,157,783 29,170,070 RGD:6907045
G Spry1 sprouty RTK signaling antagonist 1 JBrowse link 3 37,639,291 37,644,599 RGD:6907045
G Spry2 sprouty RTK signaling antagonist 2 JBrowse link 14 105,891,947 105,896,819 RGD:6907045
G Spry3 sprouty RTK signaling antagonist 3 RGD:6907045
G Spry4 sprouty RTK signaling antagonist 4 JBrowse link 18 38,586,247 38,601,347 RGD:6907045
G Stam signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 JBrowse link 2 14,073,962 14,148,338 RGD:6907045
G Stam2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 JBrowse link 2 52,692,206 52,742,149 RGD:6907045
G Stat1 signal transducer and activator of transcription 1 JBrowse link 1 52,119,438 52,161,865 RGD:1625126
RGD:6907045
G Stat2 signal transducer and activator of transcription 2 JBrowse link 10 128,270,498 128,292,853 RGD:1625126
RGD:6907045
G Stat3 signal transducer and activator of transcription 3 JBrowse link 11 100,886,806 100,939,594 RGD:1625126
RGD:6907045
G Stat4 signal transducer and activator of transcription 4 JBrowse link 1 51,987,106 52,107,189 RGD:1625126
RGD:6907045
G Stat5a signal transducer and activator of transcription 5A JBrowse link 11 100,859,351 100,885,169 RGD:1624963
RGD:6907045
RGD:1625126
G Stat5b signal transducer and activator of transcription 5B JBrowse link 11 100,780,731 100,859,004 RGD:1624963
RGD:6907045
RGD:1625126
G Stat6 signal transducer and activator of transcription 6 JBrowse link 10 127,642,955 127,660,987 RGD:1625126
RGD:6907045
G Tpo thyroid peroxidase JBrowse link 12 30,054,659 30,132,984 RGD:6907045
G Tslp thymic stromal lymphopoietin JBrowse link 18 32,815,383 32,819,799 RGD:6907045
G Tyk2 tyrosine kinase 2 JBrowse link 9 21,104,068 21,131,393 RGD:1625126
RGD:6907045

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6011
    signaling pathway 2476
      signaling pathway pertinent to immunity 591
        Jak-Stat signaling pathway 156
          altered Jak-Stat signaling pathway 0
Path 2
Term Annotations click to browse term
  pathway 6011
    signaling pathway 2476
      kinase mediated signaling pathway 604
        tyrosine-specific protein kinase mediated signaling pathway 156
          Jak-Stat signaling pathway 156
            altered Jak-Stat signaling pathway 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.