PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: folate mediated one-carbon metabolic pathway
Accession: PW:0000189
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Definition: Folate mediated one-carbon metabolism represents the one-carbon transfer reactions important for de novo purine and thymidylate biosynthesis and for the remethylation of methionine in the methionine cycle and homocysteine metabolism. The methionine cycle also produces the major methyl donor for proteins, nucleic acids, lipids and other small molecules. The folate mediated one-carbon transfer and the folate cycle pathways are part of folate metabolism.
Synonyms: related_synonym: KEGG:00670
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Aldh1l1
aldehyde dehydrogenase 1 family member L1
ISO
RGD
PMID:14729668
RGD:1547843
NCBI chrNW_004936898:456,299...484,681
Ensembl chrNW_004936898:456,521...484,282
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Atic
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
ISO
RGD
PMID:9332377 PMID:22332074
RGD:70804 RGD:7242561
NCBI chrNW_004936586:1,782,581...1,809,458
Ensembl chrNW_004936586:1,782,528...1,810,010
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Dhfr
dihydrofolate reductase
ISO
RGD
PMID:11502523 PMID:22332074
RGD:1298877 RGD:7242561
NCBI chrNW_004936469:67,962...83,116
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Dmgdh
dimethylglycine dehydrogenase
ISO
RGD
PMID:15358367
RGD:1547831
NCBI chrNW_004936549:6,838,773...6,899,961
Ensembl chrNW_004936549:6,839,295...6,899,911
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Gart
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
ISO
RGD
PMID:12450384 PMID:22332074
RGD:1547842 RGD:7242561
NCBI chrNW_004936500:8,750,928...8,782,303
Ensembl chrNW_004936500:8,753,463...8,786,236
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Gnmt
glycine N-methyltransferase
ISO
RGD
PMID:8278367
RGD:1545057
NCBI chrNW_004936476:16,961,734...16,965,487
Ensembl chrNW_004936476:16,957,270...16,965,346
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Mthfd1
methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
ISO
RGD
PMID:2186031 PMID:22332074
RGD:1299513 RGD:7242561
NCBI chrNW_004936495:8,100,977...8,170,244
Ensembl chrNW_004936495:8,100,912...8,171,800
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Mthfd2
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
ISO
RGD
PMID:9454603
RGD:1540378
NCBI chrNW_004936556:462,998...475,092
Ensembl chrNW_004936556:462,974...475,159
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Mthfr
methylenetetrahydrofolate reductase
ISO
RGD
PMID:11933257 PMID:22332074
RGD:1535021 RGD:7242561
NCBI chrNW_004936474:623,438...637,849
Ensembl chrNW_004936474:623,291...638,193
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Mtr
5-methyltetrahydrofolate-homocysteine methyltransferase
ISO
RGD
PMID:15845641 PMID:20814827
RGD:1359026 RGD:7242426
NCBI chrNW_004936484:16,087,924...16,180,089
Ensembl chrNW_004936484:16,087,923...16,180,148
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Mtrr
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
ISO
RGD
PMID:20814827
RGD:7242426
NCBI chrNW_004936643:379,790...410,034
Ensembl chrNW_004936643:380,968...409,464
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Shmt1
serine hydroxymethyltransferase 1
ISO
RGD
PMID:3110140 PMID:15671219 PMID:22332074
RGD:1359815 RGD:2300383 RGD:7242561
NCBI chrNW_004936741:1,849,239...1,877,724
Ensembl chrNW_004936741:1,849,609...1,877,727
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Shmt2
serine hydroxymethyltransferase 2
ISO
RGD
PMID:3110140 PMID:15671219 PMID:22332074
RGD:1359815 RGD:2300383 RGD:7242561
NCBI chrNW_004936646:1,422,844...1,427,929
Ensembl chrNW_004936646:1,422,817...1,429,037
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Tyms
thymidylate synthetase
ISO
RGD
PMID:9894005 PMID:22332074
RGD:1545055 RGD:7242561
NCBI chrNW_004936550:33,797...42,233
Ensembl chrNW_004936550:34,048...41,840
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Mthfd1
methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
ISO
RGD
PMID:22353665
RGD:7242562
NCBI chrNW_004936495:8,100,977...8,170,244
Ensembl chrNW_004936495:8,100,912...8,171,800
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Mthfr
methylenetetrahydrofolate reductase
ISO
RGD
PMID:22353665
RGD:7242562
NCBI chrNW_004936474:623,438...637,849
Ensembl chrNW_004936474:623,291...638,193
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Mtr
5-methyltetrahydrofolate-homocysteine methyltransferase
ISO
RGD
PMID:22353665
RGD:7242562
NCBI chrNW_004936484:16,087,924...16,180,089
Ensembl chrNW_004936484:16,087,923...16,180,148
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