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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:mTOR signaling pathway
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Accession:PW:0000180 term browser browse the term
Definition:The mTOR signaling pathway regulates cellular processes such as translation, ribosome biogenesis, cell growth and autophagy and is regulated by or responds to growth factors, energy metabolites and/or levels of nutrients.
Synonyms:related_synonym: MTOR signalling;   TOR signaling

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mTOR signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO PID PID:200096 NCBI chrNW_004936621:620,163...639,115
Ensembl chrNW_004936621:620,074...639,093
JBrowse link
G Akt1s1 AKT1 substrate 1 ISO PID
RGD
PMID:19339977 PMID:22500797 PID:200096 RGD:11535033 RGD:2308795 NCBI chrNW_004936664:3,657,170...3,664,375
Ensembl chrNW_004936664:3,657,207...3,664,024
JBrowse link
G Atg13 autophagy related 13 ISO PID PID:200096 NCBI chrNW_004936562:2,424,398...2,473,103
Ensembl chrNW_004936562:2,423,001...2,473,232
JBrowse link
G Bnip3 BCL2 interacting protein 3 ISO PID PID:200096 NCBI chrNW_004936486:18,449,371...18,460,435
Ensembl chrNW_004936486:18,448,494...18,455,927
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO PID PID:200096 NCBI chrNW_004936592:4,728,371...4,833,830
Ensembl chrNW_004936592:4,737,011...4,834,664
JBrowse link
G Castor1 cytosolic arginine sensor for mTORC1 subunit 1 ISO RGD PMID:27015302 RGD:11535047 NCBI chrNW_004936904:372,609...376,878
Ensembl chrNW_004936904:373,198...376,370
JBrowse link
G Castor2 cytosolic arginine sensor for mTORC1 subunit 2 ISO RGD PMID:27015302 RGD:11535047 NCBI chrNW_004936543:3,692,040...3,709,658
Ensembl chrNW_004936543:3,692,040...3,709,653
JBrowse link
G Ccne1 cyclin E1 ISO PID PID:200096 NCBI chrNW_004936570:5,536,817...5,547,880
Ensembl chrNW_004936570:5,536,672...5,548,008
JBrowse link
G Cdk2 cyclin dependent kinase 2 ISO PID PID:200096 NCBI chrNW_004936646:379,849...385,648
Ensembl chrNW_004936646:379,842...385,877
JBrowse link
G Clip1 CAP-Gly domain containing linker protein 1 ISO PID PID:200096 NCBI chrNW_004936558:2,109,569...2,224,907
Ensembl chrNW_004936558:2,137,392...2,224,878
JBrowse link
G Ddit4 DNA damage inducible transcript 4 ISO PID PID:200096 NCBI chrNW_004936521:6,646,864...6,648,982
Ensembl chrNW_004936521:6,646,797...6,648,983
JBrowse link
G Depdc5 DEP domain containing 5, GATOR1 subcomplex subunit ISO RGD PMID:24698685 RGD:11535043 NCBI chrNW_004936755:871,935...1,024,538
Ensembl chrNW_004936755:872,815...1,024,057
JBrowse link
G Deptor DEP domain containing MTOR interacting protein ISO PID
RGD
PMID:22500797 PID:200096 RGD:11535033 NCBI chrNW_004936470:26,698,707...26,837,470
Ensembl chrNW_004936470:26,704,021...26,837,470
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 ISO PID PID:200096 NCBI chrNW_004936588:2,259,236...2,267,692
Ensembl chrNW_004936588:2,258,309...2,266,609
JBrowse link
G Eef2k eukaryotic elongation factor 2 kinase ISO PID PID:200096 NCBI chrNW_004936501:7,160,134...7,205,231
Ensembl chrNW_004936501:7,160,134...7,207,377
JBrowse link
G Eif4a1 eukaryotic translation initiation factor 4A1 ISO PID PID:200096 NCBI chrNW_004936595:851,731...858,225
Ensembl chrNW_004936595:851,731...858,898
JBrowse link
G Eif4b eukaryotic translation initiation factor 4B ISO PID PID:200096 NCBI chrNW_004936512:10,341,443...10,369,385 JBrowse link
G Eif4e eukaryotic translation initiation factor 4E ISO PID PID:200096 NCBI chrNW_004936520:3,922,457...3,964,721
Ensembl chrNW_004936520:3,922,339...3,960,359
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 ISO PID
RGD
PMID:16885148 PMID:19339977 PID:200096 RGD:1625616 RGD:2308795 NCBI chrNW_004936710:1,446,030...1,461,945 JBrowse link
G Fbxw11 F-box and WD repeat domain containing 11 ISO PID PID:200096 NCBI chrNW_004936609:3,256,658...3,341,918
Ensembl chrNW_004936609:3,256,657...3,341,994
JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A ISO RGD PMID:22500797 RGD:11535033 NCBI chrNW_004936485:17,305,376...17,311,797 JBrowse link
G Flcn folliculin ISO RGD PMID:27076075 RGD:11535042 NCBI chrNW_004936741:881,150...901,296
Ensembl chrNW_004936741:880,736...901,468
JBrowse link
G Fnip1 folliculin interacting protein 1 ISO RGD PMID:27076075 RGD:11535042 NCBI chrNW_004936647:3,329,097...3,428,170
Ensembl chrNW_004936647:3,329,103...3,428,242
JBrowse link
G Fnip2 folliculin interacting protein 2 ISO RGD PMID:27076075 RGD:11535042 NCBI chrNW_004936576:5,221,619...5,335,133
Ensembl chrNW_004936576:5,221,613...5,335,191
JBrowse link
G Hras HRas proto-oncogene, GTPase ISO PID PID:200096 NCBI chrNW_004936888:375,372...378,125
Ensembl chrNW_004936888:375,377...377,958
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta ISO PID PID:200096 NCBI chrNW_004936785:358,128...406,751
Ensembl chrNW_004936785:356,168...406,773
JBrowse link
G Irs1 insulin receptor substrate 1 ISO PID PID:200096 NCBI chrNW_004936525:9,064,442...9,125,972
Ensembl chrNW_004936525:9,064,466...9,122,635
JBrowse link
G Lamtor1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 ISO RGD PMID:24698685 RGD:11535043 NCBI chrNW_004936498:1,446,794...1,459,590
Ensembl chrNW_004936498:1,442,754...1,459,673
JBrowse link
G Lamtor2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 ISO RGD PMID:24698685 RGD:11535043 NCBI chrNW_004936580:5,316,748...5,320,364
Ensembl chrNW_004936580:5,316,616...5,322,158
JBrowse link
G Lamtor3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 ISO RGD PMID:24698685 RGD:11535043 NCBI chrNW_004936520:3,113,178...3,128,333
Ensembl chrNW_004936520:3,113,235...3,128,333
JBrowse link
G Lamtor4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 ISO RGD PMID:24698685 RGD:11535043 NCBI chrNW_004936543:408,345...411,723
Ensembl chrNW_004936543:408,363...411,723
JBrowse link
G Lamtor5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 ISO RGD PMID:24698685 RGD:11535043 NCBI chrNW_004936704:1,830,470...1,835,966
Ensembl chrNW_004936704:1,830,470...1,835,994
JBrowse link
G LOC101964975 interleukin-8 ISO RGD PMID:26078356 RGD:11526468 NCBI chrNW_004936598:1,779,471...1,781,353
Ensembl chrNW_004936598:1,779,471...1,781,353
JBrowse link
G LOC101966958 GATOR complex protein WDR59 ISO RGD PMID:24698685 RGD:11535043 NCBI chrNW_004936475:23,754,525...23,803,942
Ensembl chrNW_004936475:23,726,314...23,803,854
JBrowse link
G LOC101972385 SCO-spondin ISO PID PID:200096 NCBI chrNW_004936527:5,821,533...5,874,995 JBrowse link
G Lpin1 lipin 1 ISO RGD PMID:11792863 RGD:1641823 NCBI chrNW_004936532:7,596,279...7,654,139
Ensembl chrNW_004936532:7,605,965...7,652,573
JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 ISO PID PID:200096 NCBI chrNW_004936471:26,589,251...26,628,302
Ensembl chrNW_004936471:26,589,161...26,628,302
JBrowse link
G Map2k2 mitogen-activated protein kinase kinase 2 ISO PID PID:200096 NCBI chrNW_004936588:2,338,127...2,377,090
Ensembl chrNW_004936588:2,336,858...2,377,090
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 ISO PID PID:200096 NCBI chrNW_004936619:1,889,841...1,932,646
Ensembl chrNW_004936619:1,889,708...1,932,646
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 ISO PID PID:200096 NCBI chrNW_004936501:12,342,670...12,390,650
Ensembl chrNW_004936501:12,384,804...12,392,180
JBrowse link
G Mapkap1 MAPK associated protein 1 ISO PID
RGD
PMID:19339977 PMID:22500797 PID:200096 RGD:11535033 RGD:2308795 NCBI chrNW_004936487:13,511,632...13,743,022
Ensembl chrNW_004936487:13,510,592...13,743,069
JBrowse link
G Mios meiosis regulator for oocyte development ISO RGD PMID:24698685 RGD:11535043 NCBI chrNW_004936585:2,296,713...2,331,737
Ensembl chrNW_004936585:2,296,830...2,331,601
JBrowse link
G Mlst8 MTOR associated protein, LST8 homolog ISO PID
RGD
PMID:12718876 PMID:19339977 PMID:22500797 PID:200096 RGD:11535033 RGD:1626104 RGD:2308795 NCBI chrNW_004936694:1,839,135...1,849,307
Ensembl chrNW_004936694:1,834,701...1,842,719
JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO PID
RGD
PMID:16885148 PMID:17110594 PMID:17142137 PMID:19339977 PMID:22500797 PID:200096 RGD:11535033 RGD:1625611 RGD:1625616 RGD:2307383 RGD:2308795 NCBI chrNW_004936474:158,376...282,310
Ensembl chrNW_004936474:157,590...282,342
JBrowse link
G Nprl2 NPR2 like, GATOR1 complex subunit ISO RGD PMID:24698685 RGD:11535043 NCBI chrNW_004939530:1,745...5,100
Ensembl chrNW_004939530:1,769...5,100
JBrowse link
G Nprl3 NPR3 like, GATOR1 complex subunit ISO RGD PMID:24698685 RGD:11535043 NCBI chrNW_004936501:747,806...783,479
Ensembl chrNW_004936501:747,736...787,244
JBrowse link
G Nras NRAS proto-oncogene, GTPase ISO PID PID:200096 NCBI chrNW_004936627:73,413...82,590
Ensembl chrNW_004936627:73,413...82,590
JBrowse link
G Pdcd4 programmed cell death 4 ISO PID PID:200096 NCBI chrNW_004936486:1,684,167...1,705,387
Ensembl chrNW_004936486:1,684,135...1,705,715
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase 1 ISO PID PID:200096 NCBI chrNW_004936694:1,444,819...1,487,628
Ensembl chrNW_004936694:1,444,880...1,488,265
Ensembl chrNW_004936694:1,444,880...1,488,265
JBrowse link
G Pld1 phospholipase D1 ISO PID PID:200096 NCBI chrNW_004936593:844,634...1,049,478
Ensembl chrNW_004936593:930,637...1,046,821
JBrowse link
G Pld2 phospholipase D2 ISO PID PID:200096 NCBI chrNW_004936677:2,870,664...2,883,545
Ensembl chrNW_004936677:2,870,660...2,883,567
JBrowse link
G Pml PML nuclear body scaffold ISO PID PID:200096 NCBI chrNW_004936471:33,135,186...33,173,218
Ensembl chrNW_004936471:33,135,164...33,177,666
JBrowse link
G Poldip3 DNA polymerase delta interacting protein 3 ISO PID PID:200096 NCBI chrNW_004936718:516,609...538,275
Ensembl chrNW_004936718:515,200...536,802
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha ISO PID PID:200096 NCBI chrNW_004936477:4,881,230...5,488,208
Ensembl chrNW_004936477:5,199,881...5,488,226
JBrowse link
G Prkca protein kinase C alpha ISO PID PID:200096 NCBI chrNW_004936541:6,231,604...6,488,201
Ensembl chrNW_004936541:6,233,110...6,488,052
JBrowse link
G Prr5 proline rich 5 ISO PID
RGD
PMID:22500797 PID:200096 RGD:11535033 NCBI chrNW_004936718:2,094,802...2,170,916 JBrowse link
G Prr5l proline rich 5 like ISO RGD PMID:22500797 RGD:11535033 NCBI chrNW_004936533:1,895,594...1,975,442
Ensembl chrNW_004936533:1,895,380...1,975,824
JBrowse link
G Pxn paxillin ISO PID PID:200096 NCBI chrNW_004936668:660,415...709,282 JBrowse link
G Rac1 Rac family small GTPase 1 ISO PID PID:200096 NCBI chrNW_004936750:107,689...122,679
Ensembl chrNW_004936750:107,689...122,676
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO PID PID:200096 NCBI chrNW_004936602:1,089,979...1,114,376
Ensembl chrNW_004936602:1,051,205...1,117,096
JBrowse link
G Rb1cc1 RB1 inducible coiled-coil 1 ISO PID PID:200096 NCBI chrNW_004936590:260,685...335,143
Ensembl chrNW_004936590:260,685...334,721
JBrowse link
G Rheb Ras homolog, mTORC1 binding ISO RGD
PID
PMID:16354680 PMID:16885148 PMID:19339977 PMID:26159692 PID:200096 RGD:11535034 RGD:1625606 RGD:1625616 RGD:2308795 NCBI chrNW_004936527:6,832,286...6,877,938
Ensembl chrNW_004936527:6,832,169...6,878,164
JBrowse link
G Rhoa ras homolog family member A ISO PID PID:200096 NCBI chrNW_004936529:1,000,050...1,045,655
Ensembl chrNW_004936529:999,935...1,045,681
JBrowse link
G Rictor RPTOR independent companion of MTOR complex 2 ISO RGD
PID
PMID:16885148 PMID:17110594 PMID:19339977 PMID:22500797 PID:200096 RGD:11535033 RGD:1625616 RGD:2307383 RGD:2308795 NCBI chrNW_004936518:3,198,312...3,314,393
Ensembl chrNW_004936518:3,198,337...3,310,000
JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 ISO PID PID:200096 NCBI chrNW_004936474:10,996,867...11,030,504
Ensembl chrNW_004936474:10,996,813...11,030,557
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 ISO PID
RGD
PMID:11574531 PMID:16885148 PMID:19339977 PID:200096 RGD:1625616 RGD:1626103 RGD:2308795 NCBI chrNW_004936490:3,441,046...3,492,917
Ensembl chrNW_004936490:3,441,055...3,492,917
JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 ISO RGD PMID:11574531 PMID:16885148 PMID:19339977 RGD:1625616 RGD:1626103 RGD:2308795 NCBI chrNW_004936599:2,315,146...2,321,127
Ensembl chrNW_004936599:2,315,146...2,321,152
JBrowse link
G Rptor regulatory associated protein of MTOR complex 1 ISO RGD
PID
PMID:16885148 PMID:17110594 PMID:19339977 PMID:22500797 PID:200096 RGD:11535033 RGD:1625616 RGD:2307383 RGD:2308795 NCBI chrNW_004936594:4,427,225...4,758,081
Ensembl chrNW_004936594:4,427,169...4,760,120
JBrowse link
G Rraga Ras related GTP binding A ISO PID
RGD
PMID:19339977 PMID:24698685 PID:200096 RGD:11535043 RGD:2308795 NCBI chrNW_004936652:991,832...993,439 JBrowse link
G Rragb Ras related GTP binding B ISO PID
RGD
PMID:19339977 PMID:24698685 PID:200096 RGD:11535043 RGD:2308795 NCBI chrNW_004936819:946,874...988,531
Ensembl chrNW_004936819:955,527...988,644
JBrowse link
G Rragc Ras related GTP binding C ISO PID
RGD
PMID:19339977 PMID:24698685 PID:200096 RGD:11535043 RGD:2308795
G Rragd Ras related GTP binding D ISO PID
RGD
PMID:19339977 PMID:24698685 PID:200096 RGD:11535043 RGD:2308795 NCBI chrNW_004936510:2,810,028...2,849,792
Ensembl chrNW_004936510:2,810,022...2,853,306
JBrowse link
G Rrn3 RRN3 homolog, RNA polymerase I transcription factor ISO PID PID:200096 NCBI chrNW_004936501:2,893,304...2,926,795
Ensembl chrNW_004936501:2,893,298...2,926,804
JBrowse link
G Sesn2 sestrin 2 ISO RGD PMID:27076075 RGD:11535042 NCBI chrNW_004936474:12,416,652...12,436,799
Ensembl chrNW_004936474:12,416,652...12,436,814
JBrowse link
G Sfn stratifin ISO PID PID:200096 NCBI chrNW_004936474:11,274,927...11,279,427
Ensembl chrNW_004936474:11,246,534...11,279,433
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 ISO PID PID:200096 NCBI chrNW_004936560:1,979,804...2,009,167
Ensembl chrNW_004936560:1,979,808...2,088,329
JBrowse link
G Slc7a5 solute carrier family 7 member 5 ISO RGD PMID:25049270 RGD:151361107 NCBI chrNW_004936641:1,513,110...1,538,955 JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 ISO PID PID:200096 NCBI chrNW_004936741:1,408,669...1,419,717
Ensembl chrNW_004936741:1,406,521...1,419,776
JBrowse link
G Tbc1d7 TBC1 domain family member 7 ISO RGD PMID:26159692 RGD:11535034 NCBI chrNW_004936534:8,104...17,056
Ensembl chrNW_004936534:8,281...27,544
JBrowse link
G Telo2 telomere maintenance 2 ISO RGD PMID:22500797 RGD:11535033 NCBI chrNW_004936694:2,418,223...2,433,630
Ensembl chrNW_004936694:2,419,855...2,433,767
JBrowse link
G Tsc1 TSC complex subunit 1 ISO PID
RGD
PMID:16885148 PMID:19339977 PMID:26159692 PID:200096 RGD:11535034 RGD:1625616 RGD:2308795 NCBI chrNW_004936487:19,331,183...19,386,841
Ensembl chrNW_004936487:19,331,194...19,386,892
JBrowse link
G Tsc2 TSC complex subunit 2 ISO RGD
PID
PMID:12869586 PMID:16885148 PMID:19339977 PMID:26159692 PID:200096 RGD:11535034 RGD:1580520 RGD:1625616 RGD:2308795 NCBI chrNW_004936694:1,958,152...1,993,373
Ensembl chrNW_004936694:1,958,154...1,993,363
JBrowse link
G Tti1 TELO2 interacting protein 1 ISO RGD PMID:22500797 RGD:11535033 NCBI chrNW_004936561:3,303,258...3,353,487
Ensembl chrNW_004936561:3,303,212...3,354,294
JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 ISO PID PID:200096 NCBI chrNW_004936660:2,160,394...2,188,848
Ensembl chrNW_004936660:2,163,844...2,187,080
JBrowse link
G Ulk2 unc-51 like autophagy activating kinase 2 ISO PID PID:200096 NCBI chrNW_004936821:1,051,247...1,162,500
Ensembl chrNW_004936821:1,051,053...1,162,735
JBrowse link
G Wdr24 WD repeat domain 24 ISO RGD PMID:24698685 RGD:11535043 NCBI chrNW_004936501:321,877...326,984
Ensembl chrNW_004936501:321,924...327,253
JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta ISO PID PID:200096 NCBI chrNW_004936514:7,832,094...7,853,170
Ensembl chrNW_004936514:7,830,387...7,853,262
JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon ISO PID PID:200096 NCBI chrNW_004936538:7,518,283...7,558,458
Ensembl chrNW_004936538:7,517,271...7,558,854
JBrowse link
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma ISO PID PID:200096 NCBI chrNW_004936543:2,062,137...2,096,207
Ensembl chrNW_004936543:2,061,794...2,096,525
JBrowse link
G Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta ISO PID PID:200096 NCBI chrNW_004936755:1,597,487...1,608,915
Ensembl chrNW_004936755:1,597,445...1,609,003
JBrowse link
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta ISO PID PID:200096 NCBI chrNW_004936532:5,931,677...5,938,569 JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta ISO PID PID:200096 NCBI chrNW_004936470:42,444,671...42,470,548
Ensembl chrNW_004936470:42,445,412...42,470,900
JBrowse link
G Yy1 YY1 transcription factor ISO PID PID:200096 NCBI chrNW_004936604:3,911,407...3,945,405 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3945
    regulatory pathway 2439
      pathway pertinent to DNA replication and repair, cell cycle, maintenance of genomic integrity, RNA and protein biosynthesis 1309
        mTOR signaling pathway 93
          altered mTOR signaling pathway 0
Path 2
Term Annotations click to browse term
  pathway 3945
    regulatory pathway 2439
      homeostasis pathway 1275
        energy homeostasis pathway 232
          mTOR signaling pathway 93
            altered mTOR signaling pathway 0
paths to the root