PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: mTOR signaling pathway
Accession: PW:0000180
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Definition: The mTOR signaling pathway regulates cellular processes such as translation, ribosome biogenesis, cell growth and autophagy and is regulated by or responds to growth factors, energy metabolites and/or levels of nutrients.
Synonyms: related_synonym: MTOR signalling; TOR signaling
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Akt1
AKT serine/threonine kinase 1
ISO
PID
PID:200096
NCBI chrNW_004936621:620,163...639,115
Ensembl chrNW_004936621:620,074...639,093
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Akt1s1
AKT1 substrate 1
ISO
PID RGD
PMID:19339977 PMID:22500797
PID:200096 RGD:11535033 RGD:2308795
NCBI chrNW_004936664:3,657,170...3,664,375
Ensembl chrNW_004936664:3,657,207...3,664,024
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Atg13
autophagy related 13
ISO
PID
PID:200096
NCBI chrNW_004936562:2,424,398...2,473,103
Ensembl chrNW_004936562:2,423,001...2,473,232
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Bnip3
BCL2 interacting protein 3
ISO
PID
PID:200096
NCBI chrNW_004936486:18,449,371...18,460,435
Ensembl chrNW_004936486:18,448,494...18,455,927
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Braf
B-Raf proto-oncogene, serine/threonine kinase
ISO
PID
PID:200096
NCBI chrNW_004936592:4,728,371...4,833,830
Ensembl chrNW_004936592:4,737,011...4,834,664
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Castor1
cytosolic arginine sensor for mTORC1 subunit 1
ISO
RGD
PMID:27015302
RGD:11535047
NCBI chrNW_004936904:372,609...376,878
Ensembl chrNW_004936904:373,198...376,370
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Castor2
cytosolic arginine sensor for mTORC1 subunit 2
ISO
RGD
PMID:27015302
RGD:11535047
NCBI chrNW_004936543:3,692,040...3,709,658
Ensembl chrNW_004936543:3,692,040...3,709,653
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Ccne1
cyclin E1
ISO
PID
PID:200096
NCBI chrNW_004936570:5,536,817...5,547,880
Ensembl chrNW_004936570:5,536,672...5,548,008
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Cdk2
cyclin dependent kinase 2
ISO
PID
PID:200096
NCBI chrNW_004936646:379,849...385,648
Ensembl chrNW_004936646:379,842...385,877
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Clip1
CAP-Gly domain containing linker protein 1
ISO
PID
PID:200096
NCBI chrNW_004936558:2,109,569...2,224,907
Ensembl chrNW_004936558:2,137,392...2,224,878
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Ddit4
DNA damage inducible transcript 4
ISO
PID
PID:200096
NCBI chrNW_004936521:6,646,864...6,648,982
Ensembl chrNW_004936521:6,646,797...6,648,983
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Depdc5
DEP domain containing 5, GATOR1 subcomplex subunit
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chrNW_004936755:871,935...1,024,538
Ensembl chrNW_004936755:872,815...1,024,057
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Deptor
DEP domain containing MTOR interacting protein
ISO
PID RGD
PMID:22500797
PID:200096 RGD:11535033
NCBI chrNW_004936470:26,698,707...26,837,470
Ensembl chrNW_004936470:26,704,021...26,837,470
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Eef2
eukaryotic translation elongation factor 2
ISO
PID
PID:200096
NCBI chrNW_004936588:2,259,236...2,267,692
Ensembl chrNW_004936588:2,258,309...2,266,609
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Eef2k
eukaryotic elongation factor 2 kinase
ISO
PID
PID:200096
NCBI chrNW_004936501:7,160,134...7,205,231
Ensembl chrNW_004936501:7,160,134...7,207,377
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Eif4a1
eukaryotic translation initiation factor 4A1
ISO
PID
PID:200096
NCBI chrNW_004936595:851,731...858,225
Ensembl chrNW_004936595:851,731...858,898
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Eif4b
eukaryotic translation initiation factor 4B
ISO
PID
PID:200096
NCBI chrNW_004936512:10,341,443...10,369,385
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Eif4e
eukaryotic translation initiation factor 4E
ISO
PID
PID:200096
NCBI chrNW_004936520:3,922,457...3,964,721
Ensembl chrNW_004936520:3,922,339...3,960,359
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Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
ISO
PID RGD
PMID:16885148 PMID:19339977
PID:200096 RGD:1625616 RGD:2308795
NCBI chrNW_004936710:1,446,030...1,461,945
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Fbxw11
F-box and WD repeat domain containing 11
ISO
PID
PID:200096
NCBI chrNW_004936609:3,256,658...3,341,918
Ensembl chrNW_004936609:3,256,657...3,341,994
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Fkbp1a
FKBP prolyl isomerase 1A
ISO
RGD
PMID:22500797
RGD:11535033
NCBI chrNW_004936485:17,305,376...17,311,797
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Flcn
folliculin
ISO
RGD
PMID:27076075
RGD:11535042
NCBI chrNW_004936741:881,150...901,296
Ensembl chrNW_004936741:880,736...901,468
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Fnip1
folliculin interacting protein 1
ISO
RGD
PMID:27076075
RGD:11535042
NCBI chrNW_004936647:3,329,097...3,428,170
Ensembl chrNW_004936647:3,329,103...3,428,242
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Fnip2
folliculin interacting protein 2
ISO
RGD
PMID:27076075
RGD:11535042
NCBI chrNW_004936576:5,221,619...5,335,133
Ensembl chrNW_004936576:5,221,613...5,335,191
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Hras
HRas proto-oncogene, GTPase
ISO
PID
PID:200096
NCBI chrNW_004936888:375,372...378,125
Ensembl chrNW_004936888:375,377...377,958
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Ikbkb
inhibitor of nuclear factor kappa B kinase subunit beta
ISO
PID
PID:200096
NCBI chrNW_004936785:358,128...406,751
Ensembl chrNW_004936785:356,168...406,773
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Irs1
insulin receptor substrate 1
ISO
PID
PID:200096
NCBI chrNW_004936525:9,064,442...9,125,972
Ensembl chrNW_004936525:9,064,466...9,122,635
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Lamtor1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chrNW_004936498:1,446,794...1,459,590
Ensembl chrNW_004936498:1,442,754...1,459,673
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Lamtor2
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chrNW_004936580:5,316,748...5,320,364
Ensembl chrNW_004936580:5,316,616...5,322,158
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Lamtor3
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chrNW_004936520:3,113,178...3,128,333
Ensembl chrNW_004936520:3,113,235...3,128,333
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Lamtor4
late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chrNW_004936543:408,345...411,723
Ensembl chrNW_004936543:408,363...411,723
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Lamtor5
late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chrNW_004936704:1,830,470...1,835,966
Ensembl chrNW_004936704:1,830,470...1,835,994
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LOC101964975
interleukin-8
ISO
RGD
PMID:26078356
RGD:11526468
NCBI chrNW_004936598:1,779,471...1,781,353
Ensembl chrNW_004936598:1,779,471...1,781,353
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LOC101966958
GATOR complex protein WDR59
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chrNW_004936475:23,754,525...23,803,942
Ensembl chrNW_004936475:23,726,314...23,803,854
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LOC101972385
SCO-spondin
ISO
PID
PID:200096
NCBI chrNW_004936527:5,821,533...5,874,995
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Lpin1
lipin 1
ISO
RGD
PMID:11792863
RGD:1641823
NCBI chrNW_004936532:7,596,279...7,654,139
Ensembl chrNW_004936532:7,605,965...7,652,573
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Map2k1
mitogen-activated protein kinase kinase 1
ISO
PID
PID:200096
NCBI chrNW_004936471:26,589,251...26,628,302
Ensembl chrNW_004936471:26,589,161...26,628,302
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Map2k2
mitogen-activated protein kinase kinase 2
ISO
PID
PID:200096
NCBI chrNW_004936588:2,338,127...2,377,090
Ensembl chrNW_004936588:2,336,858...2,377,090
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Mapk1
mitogen-activated protein kinase 1
ISO
PID
PID:200096
NCBI chrNW_004936619:1,889,841...1,932,646
Ensembl chrNW_004936619:1,889,708...1,932,646
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Mapk3
mitogen-activated protein kinase 3
ISO
PID
PID:200096
NCBI chrNW_004936501:12,342,670...12,390,650
Ensembl chrNW_004936501:12,384,804...12,392,180
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Mapkap1
MAPK associated protein 1
ISO
PID RGD
PMID:19339977 PMID:22500797
PID:200096 RGD:11535033 RGD:2308795
NCBI chrNW_004936487:13,511,632...13,743,022
Ensembl chrNW_004936487:13,510,592...13,743,069
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Mios
meiosis regulator for oocyte development
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chrNW_004936585:2,296,713...2,331,737
Ensembl chrNW_004936585:2,296,830...2,331,601
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Mlst8
MTOR associated protein, LST8 homolog
ISO
PID RGD
PMID:12718876 PMID:19339977 PMID:22500797
PID:200096 RGD:11535033 RGD:1626104 RGD:2308795
NCBI chrNW_004936694:1,839,135...1,849,307
Ensembl chrNW_004936694:1,834,701...1,842,719
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Mtor
mechanistic target of rapamycin kinase
ISO
PID RGD
PMID:16885148 PMID:17110594 PMID:17142137 PMID:19339977 PMID:22500797
PID:200096 RGD:11535033 RGD:1625611 RGD:1625616 RGD:2307383 RGD:2308795
NCBI chrNW_004936474:158,376...282,310
Ensembl chrNW_004936474:157,590...282,342
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Nprl2
NPR2 like, GATOR1 complex subunit
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chrNW_004939530:1,745...5,100
Ensembl chrNW_004939530:1,769...5,100
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Nprl3
NPR3 like, GATOR1 complex subunit
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chrNW_004936501:747,806...783,479
Ensembl chrNW_004936501:747,736...787,244
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Nras
NRAS proto-oncogene, GTPase
ISO
PID
PID:200096
NCBI chrNW_004936627:73,413...82,590
Ensembl chrNW_004936627:73,413...82,590
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Pdcd4
programmed cell death 4
ISO
PID
PID:200096
NCBI chrNW_004936486:1,684,167...1,705,387
Ensembl chrNW_004936486:1,684,135...1,705,715
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Pdpk1
3-phosphoinositide dependent protein kinase 1
ISO
PID
PID:200096
NCBI chrNW_004936694:1,444,819...1,487,628
Ensembl chrNW_004936694:1,444,880...1,488,265 Ensembl chrNW_004936694:1,444,880...1,488,265
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Pld1
phospholipase D1
ISO
PID
PID:200096
NCBI chrNW_004936593:844,634...1,049,478
Ensembl chrNW_004936593:930,637...1,046,821
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Pld2
phospholipase D2
ISO
PID
PID:200096
NCBI chrNW_004936677:2,870,664...2,883,545
Ensembl chrNW_004936677:2,870,660...2,883,567
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Pml
PML nuclear body scaffold
ISO
PID
PID:200096
NCBI chrNW_004936471:33,135,186...33,173,218
Ensembl chrNW_004936471:33,135,164...33,177,666
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Poldip3
DNA polymerase delta interacting protein 3
ISO
PID
PID:200096
NCBI chrNW_004936718:516,609...538,275
Ensembl chrNW_004936718:515,200...536,802
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Ppargc1a
PPARG coactivator 1 alpha
ISO
PID
PID:200096
NCBI chrNW_004936477:4,881,230...5,488,208
Ensembl chrNW_004936477:5,199,881...5,488,226
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Prkca
protein kinase C alpha
ISO
PID
PID:200096
NCBI chrNW_004936541:6,231,604...6,488,201
Ensembl chrNW_004936541:6,233,110...6,488,052
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Prr5
proline rich 5
ISO
PID RGD
PMID:22500797
PID:200096 RGD:11535033
NCBI chrNW_004936718:2,094,802...2,170,916
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Prr5l
proline rich 5 like
ISO
RGD
PMID:22500797
RGD:11535033
NCBI chrNW_004936533:1,895,594...1,975,442
Ensembl chrNW_004936533:1,895,380...1,975,824
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Pxn
paxillin
ISO
PID
PID:200096
NCBI chrNW_004936668:660,415...709,282
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Rac1
Rac family small GTPase 1
ISO
PID
PID:200096
NCBI chrNW_004936750:107,689...122,679
Ensembl chrNW_004936750:107,689...122,676
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Raf1
Raf-1 proto-oncogene, serine/threonine kinase
ISO
PID
PID:200096
NCBI chrNW_004936602:1,089,979...1,114,376
Ensembl chrNW_004936602:1,051,205...1,117,096
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Rb1cc1
RB1 inducible coiled-coil 1
ISO
PID
PID:200096
NCBI chrNW_004936590:260,685...335,143
Ensembl chrNW_004936590:260,685...334,721
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Rheb
Ras homolog, mTORC1 binding
ISO
RGD PID
PMID:16354680 PMID:16885148 PMID:19339977 PMID:26159692
PID:200096 RGD:11535034 RGD:1625606 RGD:1625616 RGD:2308795
NCBI chrNW_004936527:6,832,286...6,877,938
Ensembl chrNW_004936527:6,832,169...6,878,164
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Rhoa
ras homolog family member A
ISO
PID
PID:200096
NCBI chrNW_004936529:1,000,050...1,045,655
Ensembl chrNW_004936529:999,935...1,045,681
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Rictor
RPTOR independent companion of MTOR complex 2
ISO
RGD PID
PMID:16885148 PMID:17110594 PMID:19339977 PMID:22500797
PID:200096 RGD:11535033 RGD:1625616 RGD:2307383 RGD:2308795
NCBI chrNW_004936518:3,198,312...3,314,393
Ensembl chrNW_004936518:3,198,337...3,310,000
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Rps6ka1
ribosomal protein S6 kinase A1
ISO
PID
PID:200096
NCBI chrNW_004936474:10,996,867...11,030,504
Ensembl chrNW_004936474:10,996,813...11,030,557
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Rps6kb1
ribosomal protein S6 kinase B1
ISO
PID RGD
PMID:11574531 PMID:16885148 PMID:19339977
PID:200096 RGD:1625616 RGD:1626103 RGD:2308795
NCBI chrNW_004936490:3,441,046...3,492,917
Ensembl chrNW_004936490:3,441,055...3,492,917
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Rps6kb2
ribosomal protein S6 kinase B2
ISO
RGD
PMID:11574531 PMID:16885148 PMID:19339977
RGD:1625616 RGD:1626103 RGD:2308795
NCBI chrNW_004936599:2,315,146...2,321,127
Ensembl chrNW_004936599:2,315,146...2,321,152
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Rptor
regulatory associated protein of MTOR complex 1
ISO
RGD PID
PMID:16885148 PMID:17110594 PMID:19339977 PMID:22500797
PID:200096 RGD:11535033 RGD:1625616 RGD:2307383 RGD:2308795
NCBI chrNW_004936594:4,427,225...4,758,081
Ensembl chrNW_004936594:4,427,169...4,760,120
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Rraga
Ras related GTP binding A
ISO
PID RGD
PMID:19339977 PMID:24698685
PID:200096 RGD:11535043 RGD:2308795
NCBI chrNW_004936652:991,832...993,439
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Rragb
Ras related GTP binding B
ISO
PID RGD
PMID:19339977 PMID:24698685
PID:200096 RGD:11535043 RGD:2308795
NCBI chrNW_004936819:946,874...988,531
Ensembl chrNW_004936819:955,527...988,644
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Rragc
Ras related GTP binding C
ISO
PID RGD
PMID:19339977 PMID:24698685
PID:200096 RGD:11535043 RGD:2308795
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Rragd
Ras related GTP binding D
ISO
PID RGD
PMID:19339977 PMID:24698685
PID:200096 RGD:11535043 RGD:2308795
NCBI chrNW_004936510:2,810,028...2,849,792
Ensembl chrNW_004936510:2,810,022...2,853,306
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Rrn3
RRN3 homolog, RNA polymerase I transcription factor
ISO
PID
PID:200096
NCBI chrNW_004936501:2,893,304...2,926,795
Ensembl chrNW_004936501:2,893,298...2,926,804
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Sesn2
sestrin 2
ISO
RGD
PMID:27076075
RGD:11535042
NCBI chrNW_004936474:12,416,652...12,436,799
Ensembl chrNW_004936474:12,416,652...12,436,814
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Sfn
stratifin
ISO
PID
PID:200096
NCBI chrNW_004936474:11,274,927...11,279,427
Ensembl chrNW_004936474:11,246,534...11,279,433
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Sgk1
serum/glucocorticoid regulated kinase 1
ISO
PID
PID:200096
NCBI chrNW_004936560:1,979,804...2,009,167
Ensembl chrNW_004936560:1,979,808...2,088,329
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Slc7a5
solute carrier family 7 member 5
ISO
RGD
PMID:25049270
RGD:151361107
NCBI chrNW_004936641:1,513,110...1,538,955
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Srebf1
sterol regulatory element binding transcription factor 1
ISO
PID
PID:200096
NCBI chrNW_004936741:1,408,669...1,419,717
Ensembl chrNW_004936741:1,406,521...1,419,776
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Tbc1d7
TBC1 domain family member 7
ISO
RGD
PMID:26159692
RGD:11535034
NCBI chrNW_004936534:8,104...17,056
Ensembl chrNW_004936534:8,281...27,544
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Telo2
telomere maintenance 2
ISO
RGD
PMID:22500797
RGD:11535033
NCBI chrNW_004936694:2,418,223...2,433,630
Ensembl chrNW_004936694:2,419,855...2,433,767
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Tsc1
TSC complex subunit 1
ISO
PID RGD
PMID:16885148 PMID:19339977 PMID:26159692
PID:200096 RGD:11535034 RGD:1625616 RGD:2308795
NCBI chrNW_004936487:19,331,183...19,386,841
Ensembl chrNW_004936487:19,331,194...19,386,892
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Tsc2
TSC complex subunit 2
ISO
RGD PID
PMID:12869586 PMID:16885148 PMID:19339977 PMID:26159692
PID:200096 RGD:11535034 RGD:1580520 RGD:1625616 RGD:2308795
NCBI chrNW_004936694:1,958,152...1,993,373
Ensembl chrNW_004936694:1,958,154...1,993,363
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Tti1
TELO2 interacting protein 1
ISO
RGD
PMID:22500797
RGD:11535033
NCBI chrNW_004936561:3,303,258...3,353,487
Ensembl chrNW_004936561:3,303,212...3,354,294
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Ulk1
unc-51 like autophagy activating kinase 1
ISO
PID
PID:200096
NCBI chrNW_004936660:2,160,394...2,188,848
Ensembl chrNW_004936660:2,163,844...2,187,080
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Ulk2
unc-51 like autophagy activating kinase 2
ISO
PID
PID:200096
NCBI chrNW_004936821:1,051,247...1,162,500
Ensembl chrNW_004936821:1,051,053...1,162,735
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Wdr24
WD repeat domain 24
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chrNW_004936501:321,877...326,984
Ensembl chrNW_004936501:321,924...327,253
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Ywhab
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
ISO
PID
PID:200096
NCBI chrNW_004936514:7,832,094...7,853,170
Ensembl chrNW_004936514:7,830,387...7,853,262
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Ywhae
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
ISO
PID
PID:200096
NCBI chrNW_004936538:7,518,283...7,558,458
Ensembl chrNW_004936538:7,517,271...7,558,854
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Ywhag
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
ISO
PID
PID:200096
NCBI chrNW_004936543:2,062,137...2,096,207
Ensembl chrNW_004936543:2,061,794...2,096,525
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Ywhah
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
ISO
PID
PID:200096
NCBI chrNW_004936755:1,597,487...1,608,915
Ensembl chrNW_004936755:1,597,445...1,609,003
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Ywhaq
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
ISO
PID
PID:200096
NCBI chrNW_004936532:5,931,677...5,938,569
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Ywhaz
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
ISO
PID
PID:200096
NCBI chrNW_004936470:42,444,671...42,470,548
Ensembl chrNW_004936470:42,445,412...42,470,900
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Yy1
YY1 transcription factor
ISO
PID
PID:200096
NCBI chrNW_004936604:3,911,407...3,945,405
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all