PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: mTOR signaling pathway
Accession: PW:0000180
browse the term
Definition: The mTOR signaling pathway regulates cellular processes such as translation, ribosome biogenesis, cell growth and autophagy and is regulated by or responds to growth factors, energy metabolites and/or levels of nutrients.
Synonyms: related_synonym: MTOR signalling; TOR signaling
View Interactive Diagram
GViewer not supported for the selected species.
G
Akt1
AKT serine/threonine kinase 1
ISO
PID
PID:200096
NCBI chrNW_004624734:507,880...525,295
Ensembl chrNW_004624734:509,368...525,295
G
Akt1s1
AKT1 substrate 1
ISO
PID RGD
PMID:19339977 PMID:22500797
PID:200096 RGD:11535033 RGD:2308795
NCBI chrNW_004624832:4,454,257...4,461,603
Ensembl chrNW_004624832:4,454,309...4,461,603
G
Atg13
autophagy related 13
ISO
PID
PID:200096
NCBI chrNW_004624767:1,924,672...1,953,868
G
Bnip3
BCL2 interacting protein 3
ISO
PID
PID:200096
NCBI chrNW_004624737:14,848,355...14,863,731
Ensembl chrNW_004624737:14,848,350...14,862,965
G
Braf
B-Raf proto-oncogene, serine/threonine kinase
ISO
PID
PID:200096
NCBI chrNW_004624765:20,766,368...20,951,560
Ensembl chrNW_004624765:20,773,885...20,951,736
G
Castor1
cytosolic arginine sensor for mTORC1 subunit 1
ISO
RGD
PMID:27015302
RGD:11535047
NCBI chrNW_004624747:6,592,962...6,604,811
Ensembl chrNW_004624747:6,600,335...6,604,890
G
Castor2
cytosolic arginine sensor for mTORC1 subunit 2
ISO
RGD
PMID:27015302
RGD:11535047
NCBI chrNW_004624740:13,324,798...13,363,640
Ensembl chrNW_004624740:13,324,809...13,360,179
G
Ccne1
cyclin E1
ISO
PID
PID:200096
NCBI chrNW_004624794:4,957,156...4,967,058
Ensembl chrNW_004624794:4,957,178...4,967,140
G
Cdk2
cyclin dependent kinase 2
ISO
PID
PID:200096
NCBI chrNW_004624802:12,076,443...12,082,608
Ensembl chrNW_004624802:12,076,443...12,082,630
G
Clip1
CAP-Gly domain containing linker protein 1
ISO
PID
PID:200096
NCBI chrNW_004624747:22,481,304...22,596,779
Ensembl chrNW_004624747:22,481,196...22,598,038
G
Cxcl8
C-X-C motif chemokine ligand 8
ISO
RGD
PMID:26078356
RGD:11526468
NCBI chrNW_004624730:1,744,097...1,747,206
Ensembl chrNW_004624730:1,743,916...1,747,293
G
Ddit4
DNA damage inducible transcript 4
ISO
PID
PID:200096
NCBI chrNW_004624754:6,091,914...6,094,035
Ensembl chrNW_004624754:6,091,809...6,094,525
G
Depdc5
DEP domain containing 5, GATOR1 subcomplex subunit
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chrNW_004624747:8,169,035...8,310,945
Ensembl chrNW_004624747:8,168,321...8,310,457
G
Deptor
DEP domain containing MTOR interacting protein
ISO
RGD PID
PMID:22500797
PID:200096 RGD:11535033
NCBI chrNW_004624763:17,935,171...17,956,858
Ensembl chrNW_004624763:17,935,108...17,956,909
G
Eef2
eukaryotic translation elongation factor 2
ISO
PID
PID:200096
NCBI chrNW_004624828:5,601,906...5,609,978
Ensembl chrNW_004624828:5,601,444...5,611,405
G
Eef2k
eukaryotic elongation factor 2 kinase
ISO
PID
PID:200096
NCBI chrNW_004624782:7,606,576...7,668,771
Ensembl chrNW_004624782:7,606,655...7,666,206
G
Eif4a1
eukaryotic translation initiation factor 4A1
ISO
PID
PID:200096
NCBI chrNW_004624786:10,188,326...10,194,466
Ensembl chrNW_004624786:10,188,406...10,194,464
G
Eif4b
eukaryotic translation initiation factor 4B
ISO
PID
PID:200096
NCBI chrNW_004624904:1,074,091...1,106,465
G
Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
ISO
PID RGD
PMID:16885148 PMID:19339977
PID:200096 RGD:1625616 RGD:2308795
NCBI chrNW_004624780:5,543,117...5,561,285
Ensembl chrNW_004624780:5,543,117...5,561,261
G
Fbxw11
F-box and WD repeat domain containing 11
ISO
PID
PID:200096
NCBI chrNW_004624733:17,985,546...18,121,398
G
Fkbp1a
FKBP prolyl isomerase 1A
ISO
RGD
PMID:22500797
RGD:11535033
NCBI chrNW_004624741:2,669,909...2,692,959
Ensembl chrNW_004624741:2,666,636...2,692,938
G
Flcn
folliculin
ISO
RGD
PMID:27076075
RGD:11535042
NCBI chrNW_004624849:4,157,683...4,179,724
G
Fnip1
folliculin interacting protein 1
ISO
RGD
PMID:27076075
RGD:11535042
NCBI chrNW_004624733:40,263,760...40,396,183
Ensembl chrNW_004624733:40,263,898...40,393,690
G
Fnip2
folliculin interacting protein 2
ISO
RGD
PMID:27076075
RGD:11535042
NCBI chrNW_004624848:3,739,677...3,826,931
Ensembl chrNW_004624848:3,756,247...3,827,288
G
Hras
HRas proto-oncogene, GTPase
ISO
PID
PID:200096
NCBI chrNW_004624766:21,907,423...21,913,414
Ensembl chrNW_004624766:21,911,241...21,913,653
G
Ikbkb
inhibitor of nuclear factor kappa B kinase subunit beta
ISO
PID
PID:200096
NCBI chrNW_004624780:922,524...978,687
Ensembl chrNW_004624780:923,744...970,519
G
Irs1
insulin receptor substrate 1
ISO
PID
PID:200096
NCBI chrNW_004624843:1,113,075...1,178,859
Ensembl chrNW_004624843:1,120,974...1,178,859
G
Lamtor1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chrNW_004624817:4,872,630...4,879,217
Ensembl chrNW_004624817:4,872,672...4,890,791
G
Lamtor2
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chrNW_004624885:1,399,235...1,403,669
Ensembl chrNW_004624885:1,398,505...1,403,789
G
Lamtor3
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chrNW_004624830:7,296,133...7,311,907
Ensembl chrNW_004624830:7,296,458...7,312,186
G
Lamtor4
late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chrNW_004624740:16,752,834...16,756,119
Ensembl chrNW_004624740:16,752,834...16,756,069
G
Lamtor5
late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chrNW_004624772:6,132,459...6,137,182
G
LOC101718508
cytochrome c, somatic
ISO
PID
PID:200096
NCBI chrNW_004624739:5,411,192...5,413,995
Ensembl chrNW_004624739:5,411,273...5,413,995
G
Lpin1
lipin 1
ISO
RGD
PMID:11792863
RGD:1641823
NCBI chrNW_004624865:4,220,047...4,258,014
Ensembl chrNW_004624865:4,219,081...4,258,448
G
Map2k1
mitogen-activated protein kinase kinase 1
ISO
PID
PID:200096
NCBI chrNW_004624781:6,222,365...6,285,398
Ensembl chrNW_004624781:6,222,365...6,285,531
G
Map2k2
mitogen-activated protein kinase kinase 2
ISO
PID
PID:200096
NCBI chrNW_004624828:5,489,085...5,511,166
Ensembl chrNW_004624828:5,488,814...5,511,445
G
Mapk1
mitogen-activated protein kinase 1
ISO
PID
PID:200096
NCBI chrNW_004624747:1,296,062...1,389,674
Ensembl chrNW_004624747:1,296,221...1,389,757
G
Mapk3
mitogen-activated protein kinase 3
ISO
PID
PID:200096
NCBI chrNW_004624782:13,150,824...13,158,327
Ensembl chrNW_004624782:13,152,039...13,159,113
G
Mapkap1
MAPK associated protein 1
ISO
RGD PID
PMID:19339977 PMID:22500797
PID:200096 RGD:11535033 RGD:2308795
NCBI chrNW_004624760:9,588,021...9,828,045
Ensembl chrNW_004624760:9,587,926...9,829,680
G
Mios
meiosis regulator for oocyte development
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chrNW_004624813:5,179,650...5,219,683
Ensembl chrNW_004624813:5,179,555...5,217,688
G
Mlst8
MTOR associated protein, LST8 homolog
ISO
PID RGD
PMID:12718876 PMID:19339977 PMID:22500797
PID:200096 RGD:11535033 RGD:1626104 RGD:2308795
NCBI chrNW_004624913:50,622...54,643
Ensembl chrNW_004624913:47,962...55,048
G
Mtor
mechanistic target of rapamycin kinase
ISO
RGD PID
PMID:16885148 PMID:17110594 PMID:17142137 PMID:19339977 PMID:22500797
PID:200096 RGD:11535033 RGD:1625611 RGD:1625616 RGD:2307383 RGD:2308795
NCBI chrNW_004624818:1,570,155...1,698,264
Ensembl chrNW_004624818:1,570,276...1,698,259
G
Nprl2
NPR2 like, GATOR1 complex subunit
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chrNW_004624730:4,196,154...4,200,100
Ensembl chrNW_004624730:4,196,154...4,200,102
G
Nprl3
NPR3 like, GATOR1 complex subunit
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chrNW_004624913:968,093...1,013,990
Ensembl chrNW_004624913:968,093...1,014,035
G
Nras
NRAS proto-oncogene, GTPase
ISO
PID
PID:200096
NCBI chrNW_004624772:10,358,554...10,369,371
G
Pdcd4
programmed cell death 4
ISO
PID
PID:200096
NCBI chrNW_004624737:35,414,078...35,451,023
G
Pdpk1
3-phosphoinositide dependent protein kinase 1
ISO
PID
PID:200096
NCBI chrNW_004624824:279,893...383,220
Ensembl chrNW_004624824:293,374...383,156
G
Pld1
phospholipase D1
ISO
PID
PID:200096
NCBI chrNW_004624730:49,665,432...49,885,242
Ensembl chrNW_004624730:49,665,432...49,885,184
G
Pld2
phospholipase D2
ISO
PID
PID:200096
NCBI chrNW_004624786:8,690,968...8,702,213
Ensembl chrNW_004624786:8,690,461...8,702,771
G
Pml
PML nuclear body scaffold
ISO
PID
PID:200096
NCBI chrNW_004624781:464,858...498,146
Ensembl chrNW_004624781:464,658...497,775
G
Poldip3
DNA polymerase delta interacting protein 3
ISO
PID
PID:200096
NCBI chrNW_004624752:6,200,864...6,228,472
Ensembl chrNW_004624752:6,200,888...6,228,471
G
Ppargc1a
PPARG coactivator 1 alpha
ISO
PID
PID:200096
NCBI chrNW_004624755:7,826,219...8,460,746
Ensembl chrNW_004624755:8,375,596...8,465,297
G
Prkca
protein kinase C alpha
ISO
PID
PID:200096
NCBI chrNW_004624870:1,589,775...2,023,160
Ensembl chrNW_004624870:1,596,102...2,023,172
G
Prr5
proline rich 5
ISO
PID RGD
PMID:22500797
PID:200096 RGD:11535033
NCBI chrNW_004624752:4,684,145...4,726,608
Ensembl chrNW_004624752:4,683,851...4,707,995
G
Prr5l
proline rich 5 like
ISO
RGD
PMID:22500797
RGD:11535033
NCBI chrNW_004624767:10,781,954...10,950,142
Ensembl chrNW_004624767:10,781,954...10,950,243
G
Pxn
paxillin
ISO
PID
PID:200096
NCBI chrNW_004624747:13,371,128...13,435,619
Ensembl chrNW_004624747:13,370,243...13,435,714
G
Rac1
Rac family small GTPase 1
ISO
PID
PID:200096
NCBI chrNW_004624740:30,912,841...30,933,882
Ensembl chrNW_004624740:30,911,598...30,934,025
G
Raf1
Raf-1 proto-oncogene, serine/threonine kinase
ISO
PID
PID:200096
NCBI chrNW_004624872:204,357...284,487
Ensembl chrNW_004624872:204,357...269,135
G
Rb1cc1
RB1 inducible coiled-coil 1
ISO
PID
PID:200096
NCBI chrNW_004624735:2,778,191...2,860,762
G
Rheb
Ras homolog, mTORC1 binding
ISO
RGD PID
PMID:16354680 PMID:16885148 PMID:19339977 PMID:26159692
PID:200096 RGD:11535034 RGD:1625606 RGD:1625616 RGD:2308795
NCBI chrNW_004624800:5,221,630...5,262,980
Ensembl chrNW_004624800:5,221,605...5,264,965
G
Rhoa
ras homolog family member A
ISO
PID
PID:200096
NCBI chrNW_004624730:3,316,122...3,361,820
G
Rictor
RPTOR independent companion of MTOR complex 2
ISO
PID RGD
PMID:16885148 PMID:17110594 PMID:19339977 PMID:22500797
PID:200096 RGD:11535033 RGD:1625616 RGD:2307383 RGD:2308795
NCBI chrNW_004624759:15,837,027...15,973,248
Ensembl chrNW_004624759:15,837,064...15,968,894
G
Rps6ka1
ribosomal protein S6 kinase A1
ISO
PID
PID:200096
NCBI chrNW_004624764:10,527,012...10,566,625
Ensembl chrNW_004624764:10,526,948...10,569,910
G
Rps6kb1
ribosomal protein S6 kinase B1
ISO
RGD PID
PMID:11574531 PMID:16885148 PMID:19339977
PID:200096 RGD:1625616 RGD:1626103 RGD:2308795
NCBI chrNW_004624871:1,667,292...1,705,550
Ensembl chrNW_004624871:1,667,291...1,702,783
G
Rps6kb2
ribosomal protein S6 kinase B2
ISO
RGD
PMID:11574531 PMID:16885148 PMID:19339977
RGD:1625616 RGD:1626103 RGD:2308795
NCBI chrNW_004624767:19,090,090...19,097,123
Ensembl chrNW_004624767:19,090,067...19,096,689
G
Rptor
regulatory associated protein of MTOR complex 1
ISO
RGD PID
PMID:16885148 PMID:17110594 PMID:19339977 PMID:22500797
PID:200096 RGD:11535033 RGD:1625616 RGD:2307383 RGD:2308795
NCBI chrNW_004624801:9,676,965...10,053,311
Ensembl chrNW_004624801:9,677,307...10,048,719
G
Rraga
Ras related GTP binding A
ISO
RGD PID
PMID:19339977 PMID:24698685
PID:200096 RGD:11535043 RGD:2308795
NCBI chrNW_004624736:23,035,836...23,049,574
G
Rragb
Ras related GTP binding B
ISO
PID RGD
PMID:19339977 PMID:24698685
PID:200096 RGD:11535043 RGD:2308795
NCBI chrNW_004624910:726,467...760,293
Ensembl chrNW_004624910:727,034...760,671
G
Rragc
Ras related GTP binding C
ISO
PID RGD
PMID:19339977 PMID:24698685
PID:200096 RGD:11535043 RGD:2308795
NCBI chrNW_004624764:21,460,669...21,475,470
Ensembl chrNW_004624764:21,460,666...21,475,439
G
Rragd
Ras related GTP binding D
ISO
RGD PID
PMID:19339977 PMID:24698685
PID:200096 RGD:11535043 RGD:2308795
NCBI chrNW_004624799:4,754,603...4,801,312
Ensembl chrNW_004624799:4,754,917...4,798,609
G
Rrn3
RRN3 homolog, RNA polymerase I transcription factor
ISO
PID
PID:200096
NCBI chrNW_004624824:8,582,754...8,615,073
Ensembl chrNW_004624824:8,582,803...8,614,313
G
Sesn2
sestrin 2
ISO
RGD
PMID:27076075
RGD:11535042
NCBI chrNW_004624764:12,087,901...12,135,145
Ensembl chrNW_004624764:12,087,858...12,120,914
G
Sfn
stratifin
ISO
PID
PID:200096
NCBI chrNW_004624764:10,859,556...10,860,876
Ensembl chrNW_004624764:10,859,667...10,860,413
G
Sgk1
serum/glucocorticoid regulated kinase 1
ISO
PID
PID:200096
NCBI chrNW_004624942:508,035...641,349
Ensembl chrNW_004624942:507,605...641,585
G
Slc7a5
solute carrier family 7 member 5
ISO
RGD
PMID:25049270
RGD:151361107
NCBI chrNW_004624746:1,325,368...1,349,616
G
Srebf1
sterol regulatory element binding transcription factor 1
ISO
PID
PID:200096
NCBI chrNW_004624849:3,602,103...3,623,922
Ensembl chrNW_004624849:3,602,261...3,623,465
G
Sspo
SCO-spondin
ISO
PID
PID:200096
NCBI chrNW_004624800:6,196,413...6,242,808
G
Tbc1d7
TBC1 domain family member 7
ISO
RGD
PMID:26159692
RGD:11535034
NCBI chrNW_004624756:12,902,917...12,921,805
Ensembl chrNW_004624756:12,903,359...12,921,805
G
Telo2
telomere maintenance 2
ISO
RGD
PMID:22500797
RGD:11535033
NCBI chrNW_004624913:711,588...729,209
G
Tsc1
TSC complex subunit 1
ISO
PID RGD
PMID:16885148 PMID:19339977 PMID:26159692
PID:200096 RGD:11535034 RGD:1625616 RGD:2308795
NCBI chrNW_004624760:3,479,028...3,536,612
Ensembl chrNW_004624760:3,498,692...3,532,011
G
Tsc2
TSC complex subunit 2
ISO
RGD PID
PMID:12869586 PMID:16885148 PMID:19339977 PMID:26159692
PID:200096 RGD:11535034 RGD:1580520 RGD:1625616 RGD:2308795
NCBI chrNW_004624913:166,931...203,008
Ensembl chrNW_004624913:166,931...202,953
G
Tti1
TELO2 interacting protein 1
ISO
RGD
PMID:22500797
RGD:11535033
NCBI chrNW_004624842:1,629,867...1,701,995
G
Ulk1
unc-51 like autophagy activating kinase 1
ISO
PID
PID:200096
NCBI chrNW_004624747:27,680,994...27,697,342
Ensembl chrNW_004624747:27,681,033...27,695,966
G
Wdr24
WD repeat domain 24
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chrNW_004624913:1,496,029...1,501,822
Ensembl chrNW_004624913:1,496,029...1,501,800
G
Wdr59
WD repeat domain 59
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chrNW_004624746:11,964,278...12,108,173
Ensembl chrNW_004624746:11,964,121...12,065,868
G
Ywhab
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
ISO
PID
PID:200096
NCBI chrNW_004624790:9,574,003...9,593,821
Ensembl chrNW_004624790:9,574,027...9,593,825
G
Ywhae
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
ISO
PID
PID:200096
NCBI chrNW_004624786:4,080,650...4,135,200
Ensembl chrNW_004624786:4,080,427...4,135,459
G
Ywhag
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
ISO
PID
PID:200096
NCBI chrNW_004624740:14,960,105...14,995,522
Ensembl chrNW_004624740:14,959,089...14,995,548
G
Ywhah
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
ISO
PID
PID:200096
NCBI chrNW_004624747:8,350,552...8,362,610
Ensembl chrNW_004624747:8,350,474...8,363,576
G
Ywhaq
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
ISO
PID
PID:200096
NCBI chrNW_004624969:167,635...199,963
Ensembl chrNW_004624969:167,676...199,963
G
Ywhaz
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
ISO
PID
PID:200096
NCBI chrNW_004624763:7,722,275...7,723,482
G
Yy1
YY1 transcription factor
ISO
PID
PID:200096
NCBI chrNW_004624734:3,846,753...3,875,294
Ensembl chrNW_004624734:3,846,765...3,875,294
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all