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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:mTOR signaling pathway
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Accession:PW:0000180 term browser browse the term
Definition:The mTOR signaling pathway regulates cellular processes such as translation, ribosome biogenesis, cell growth and autophagy and is regulated by or responds to growth factors, energy metabolites and/or levels of nutrients.
Synonyms:related_synonym: MTOR signalling;   TOR signaling

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mTOR signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO PID PID:200096 NCBI chrNW_004624734:507,880...525,295
Ensembl chrNW_004624734:509,368...525,295
JBrowse link
G Akt1s1 AKT1 substrate 1 ISO PID
RGD
PMID:19339977 PMID:22500797 PID:200096 RGD:11535033 RGD:2308795 NCBI chrNW_004624832:4,454,257...4,461,603
Ensembl chrNW_004624832:4,454,309...4,461,603
JBrowse link
G Atg13 autophagy related 13 ISO PID PID:200096 NCBI chrNW_004624767:1,924,672...1,953,868 JBrowse link
G Bnip3 BCL2 interacting protein 3 ISO PID PID:200096 NCBI chrNW_004624737:14,848,355...14,863,731
Ensembl chrNW_004624737:14,848,350...14,862,965
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO PID PID:200096 NCBI chrNW_004624765:20,766,368...20,951,560
Ensembl chrNW_004624765:20,773,885...20,951,736
JBrowse link
G Castor1 cytosolic arginine sensor for mTORC1 subunit 1 ISO RGD PMID:27015302 RGD:11535047 NCBI chrNW_004624747:6,592,962...6,604,811
Ensembl chrNW_004624747:6,600,335...6,604,890
JBrowse link
G Castor2 cytosolic arginine sensor for mTORC1 subunit 2 ISO RGD PMID:27015302 RGD:11535047 NCBI chrNW_004624740:13,324,798...13,363,640
Ensembl chrNW_004624740:13,324,809...13,360,179
JBrowse link
G Ccne1 cyclin E1 ISO PID PID:200096 NCBI chrNW_004624794:4,957,156...4,967,058
Ensembl chrNW_004624794:4,957,178...4,967,140
JBrowse link
G Cdk2 cyclin dependent kinase 2 ISO PID PID:200096 NCBI chrNW_004624802:12,076,443...12,082,608
Ensembl chrNW_004624802:12,076,443...12,082,630
JBrowse link
G Clip1 CAP-Gly domain containing linker protein 1 ISO PID PID:200096 NCBI chrNW_004624747:22,481,304...22,596,779
Ensembl chrNW_004624747:22,481,196...22,598,038
JBrowse link
G Cxcl8 C-X-C motif chemokine ligand 8 ISO RGD PMID:26078356 RGD:11526468 NCBI chrNW_004624730:1,744,097...1,747,206
Ensembl chrNW_004624730:1,743,916...1,747,293
JBrowse link
G Ddit4 DNA damage inducible transcript 4 ISO PID PID:200096 NCBI chrNW_004624754:6,091,914...6,094,035
Ensembl chrNW_004624754:6,091,809...6,094,525
JBrowse link
G Depdc5 DEP domain containing 5, GATOR1 subcomplex subunit ISO RGD PMID:24698685 RGD:11535043 NCBI chrNW_004624747:8,169,035...8,310,945
Ensembl chrNW_004624747:8,168,321...8,310,457
JBrowse link
G Deptor DEP domain containing MTOR interacting protein ISO RGD
PID
PMID:22500797 PID:200096 RGD:11535033 NCBI chrNW_004624763:17,935,171...17,956,858
Ensembl chrNW_004624763:17,935,108...17,956,909
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 ISO PID PID:200096 NCBI chrNW_004624828:5,601,906...5,609,978
Ensembl chrNW_004624828:5,601,444...5,611,405
JBrowse link
G Eef2k eukaryotic elongation factor 2 kinase ISO PID PID:200096 NCBI chrNW_004624782:7,606,576...7,668,771
Ensembl chrNW_004624782:7,606,655...7,666,206
JBrowse link
G Eif4a1 eukaryotic translation initiation factor 4A1 ISO PID PID:200096 NCBI chrNW_004624786:10,188,326...10,194,466
Ensembl chrNW_004624786:10,188,406...10,194,464
JBrowse link
G Eif4b eukaryotic translation initiation factor 4B ISO PID PID:200096 NCBI chrNW_004624904:1,074,091...1,106,465 JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 ISO PID
RGD
PMID:16885148 PMID:19339977 PID:200096 RGD:1625616 RGD:2308795 NCBI chrNW_004624780:5,543,117...5,561,285
Ensembl chrNW_004624780:5,543,117...5,561,261
JBrowse link
G Fbxw11 F-box and WD repeat domain containing 11 ISO PID PID:200096 NCBI chrNW_004624733:17,985,546...18,121,398 JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A ISO RGD PMID:22500797 RGD:11535033 NCBI chrNW_004624741:2,669,909...2,692,959
Ensembl chrNW_004624741:2,666,636...2,692,938
JBrowse link
G Flcn folliculin ISO RGD PMID:27076075 RGD:11535042 NCBI chrNW_004624849:4,157,683...4,179,724 JBrowse link
G Fnip1 folliculin interacting protein 1 ISO RGD PMID:27076075 RGD:11535042 NCBI chrNW_004624733:40,263,760...40,396,183
Ensembl chrNW_004624733:40,263,898...40,393,690
JBrowse link
G Fnip2 folliculin interacting protein 2 ISO RGD PMID:27076075 RGD:11535042 NCBI chrNW_004624848:3,739,677...3,826,931
Ensembl chrNW_004624848:3,756,247...3,827,288
JBrowse link
G Hras HRas proto-oncogene, GTPase ISO PID PID:200096 NCBI chrNW_004624766:21,907,423...21,913,414
Ensembl chrNW_004624766:21,911,241...21,913,653
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta ISO PID PID:200096 NCBI chrNW_004624780:922,524...978,687
Ensembl chrNW_004624780:923,744...970,519
JBrowse link
G Irs1 insulin receptor substrate 1 ISO PID PID:200096 NCBI chrNW_004624843:1,113,075...1,178,859
Ensembl chrNW_004624843:1,120,974...1,178,859
JBrowse link
G Lamtor1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 ISO RGD PMID:24698685 RGD:11535043 NCBI chrNW_004624817:4,872,630...4,879,217
Ensembl chrNW_004624817:4,872,672...4,890,791
JBrowse link
G Lamtor2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 ISO RGD PMID:24698685 RGD:11535043 NCBI chrNW_004624885:1,399,235...1,403,669
Ensembl chrNW_004624885:1,398,505...1,403,789
JBrowse link
G Lamtor3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 ISO RGD PMID:24698685 RGD:11535043 NCBI chrNW_004624830:7,296,133...7,311,907
Ensembl chrNW_004624830:7,296,458...7,312,186
JBrowse link
G Lamtor4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 ISO RGD PMID:24698685 RGD:11535043 NCBI chrNW_004624740:16,752,834...16,756,119
Ensembl chrNW_004624740:16,752,834...16,756,069
JBrowse link
G Lamtor5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 ISO RGD PMID:24698685 RGD:11535043 NCBI chrNW_004624772:6,132,459...6,137,182 JBrowse link
G LOC101718508 cytochrome c, somatic ISO PID PID:200096 NCBI chrNW_004624739:5,411,192...5,413,995
Ensembl chrNW_004624739:5,411,273...5,413,995
JBrowse link
G Lpin1 lipin 1 ISO RGD PMID:11792863 RGD:1641823 NCBI chrNW_004624865:4,220,047...4,258,014
Ensembl chrNW_004624865:4,219,081...4,258,448
JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 ISO PID PID:200096 NCBI chrNW_004624781:6,222,365...6,285,398
Ensembl chrNW_004624781:6,222,365...6,285,531
JBrowse link
G Map2k2 mitogen-activated protein kinase kinase 2 ISO PID PID:200096 NCBI chrNW_004624828:5,489,085...5,511,166
Ensembl chrNW_004624828:5,488,814...5,511,445
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 ISO PID PID:200096 NCBI chrNW_004624747:1,296,062...1,389,674
Ensembl chrNW_004624747:1,296,221...1,389,757
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 ISO PID PID:200096 NCBI chrNW_004624782:13,150,824...13,158,327
Ensembl chrNW_004624782:13,152,039...13,159,113
JBrowse link
G Mapkap1 MAPK associated protein 1 ISO RGD
PID
PMID:19339977 PMID:22500797 PID:200096 RGD:11535033 RGD:2308795 NCBI chrNW_004624760:9,588,021...9,828,045
Ensembl chrNW_004624760:9,587,926...9,829,680
JBrowse link
G Mios meiosis regulator for oocyte development ISO RGD PMID:24698685 RGD:11535043 NCBI chrNW_004624813:5,179,650...5,219,683
Ensembl chrNW_004624813:5,179,555...5,217,688
JBrowse link
G Mlst8 MTOR associated protein, LST8 homolog ISO PID
RGD
PMID:12718876 PMID:19339977 PMID:22500797 PID:200096 RGD:11535033 RGD:1626104 RGD:2308795 NCBI chrNW_004624913:50,622...54,643
Ensembl chrNW_004624913:47,962...55,048
JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO RGD
PID
PMID:16885148 PMID:17110594 PMID:17142137 PMID:19339977 PMID:22500797 PID:200096 RGD:11535033 RGD:1625611 RGD:1625616 RGD:2307383 RGD:2308795 NCBI chrNW_004624818:1,570,155...1,698,264
Ensembl chrNW_004624818:1,570,276...1,698,259
JBrowse link
G Nprl2 NPR2 like, GATOR1 complex subunit ISO RGD PMID:24698685 RGD:11535043 NCBI chrNW_004624730:4,196,154...4,200,100
Ensembl chrNW_004624730:4,196,154...4,200,102
JBrowse link
G Nprl3 NPR3 like, GATOR1 complex subunit ISO RGD PMID:24698685 RGD:11535043 NCBI chrNW_004624913:968,093...1,013,990
Ensembl chrNW_004624913:968,093...1,014,035
JBrowse link
G Nras NRAS proto-oncogene, GTPase ISO PID PID:200096 NCBI chrNW_004624772:10,358,554...10,369,371 JBrowse link
G Pdcd4 programmed cell death 4 ISO PID PID:200096 NCBI chrNW_004624737:35,414,078...35,451,023 JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase 1 ISO PID PID:200096 NCBI chrNW_004624824:279,893...383,220
Ensembl chrNW_004624824:293,374...383,156
JBrowse link
G Pld1 phospholipase D1 ISO PID PID:200096 NCBI chrNW_004624730:49,665,432...49,885,242
Ensembl chrNW_004624730:49,665,432...49,885,184
JBrowse link
G Pld2 phospholipase D2 ISO PID PID:200096 NCBI chrNW_004624786:8,690,968...8,702,213
Ensembl chrNW_004624786:8,690,461...8,702,771
JBrowse link
G Pml PML nuclear body scaffold ISO PID PID:200096 NCBI chrNW_004624781:464,858...498,146
Ensembl chrNW_004624781:464,658...497,775
JBrowse link
G Poldip3 DNA polymerase delta interacting protein 3 ISO PID PID:200096 NCBI chrNW_004624752:6,200,864...6,228,472
Ensembl chrNW_004624752:6,200,888...6,228,471
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha ISO PID PID:200096 NCBI chrNW_004624755:7,826,219...8,460,746
Ensembl chrNW_004624755:8,375,596...8,465,297
JBrowse link
G Prkca protein kinase C alpha ISO PID PID:200096 NCBI chrNW_004624870:1,589,775...2,023,160
Ensembl chrNW_004624870:1,596,102...2,023,172
JBrowse link
G Prr5 proline rich 5 ISO PID
RGD
PMID:22500797 PID:200096 RGD:11535033 NCBI chrNW_004624752:4,684,145...4,726,608
Ensembl chrNW_004624752:4,683,851...4,707,995
JBrowse link
G Prr5l proline rich 5 like ISO RGD PMID:22500797 RGD:11535033 NCBI chrNW_004624767:10,781,954...10,950,142
Ensembl chrNW_004624767:10,781,954...10,950,243
JBrowse link
G Pxn paxillin ISO PID PID:200096 NCBI chrNW_004624747:13,371,128...13,435,619
Ensembl chrNW_004624747:13,370,243...13,435,714
JBrowse link
G Rac1 Rac family small GTPase 1 ISO PID PID:200096 NCBI chrNW_004624740:30,912,841...30,933,882
Ensembl chrNW_004624740:30,911,598...30,934,025
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO PID PID:200096 NCBI chrNW_004624872:204,357...284,487
Ensembl chrNW_004624872:204,357...269,135
JBrowse link
G Rb1cc1 RB1 inducible coiled-coil 1 ISO PID PID:200096 NCBI chrNW_004624735:2,778,191...2,860,762 JBrowse link
G Rheb Ras homolog, mTORC1 binding ISO RGD
PID
PMID:16354680 PMID:16885148 PMID:19339977 PMID:26159692 PID:200096 RGD:11535034 RGD:1625606 RGD:1625616 RGD:2308795 NCBI chrNW_004624800:5,221,630...5,262,980
Ensembl chrNW_004624800:5,221,605...5,264,965
JBrowse link
G Rhoa ras homolog family member A ISO PID PID:200096 NCBI chrNW_004624730:3,316,122...3,361,820 JBrowse link
G Rictor RPTOR independent companion of MTOR complex 2 ISO PID
RGD
PMID:16885148 PMID:17110594 PMID:19339977 PMID:22500797 PID:200096 RGD:11535033 RGD:1625616 RGD:2307383 RGD:2308795 NCBI chrNW_004624759:15,837,027...15,973,248
Ensembl chrNW_004624759:15,837,064...15,968,894
JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 ISO PID PID:200096 NCBI chrNW_004624764:10,527,012...10,566,625
Ensembl chrNW_004624764:10,526,948...10,569,910
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 ISO RGD
PID
PMID:11574531 PMID:16885148 PMID:19339977 PID:200096 RGD:1625616 RGD:1626103 RGD:2308795 NCBI chrNW_004624871:1,667,292...1,705,550
Ensembl chrNW_004624871:1,667,291...1,702,783
JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 ISO RGD PMID:11574531 PMID:16885148 PMID:19339977 RGD:1625616 RGD:1626103 RGD:2308795 NCBI chrNW_004624767:19,090,090...19,097,123
Ensembl chrNW_004624767:19,090,067...19,096,689
JBrowse link
G Rptor regulatory associated protein of MTOR complex 1 ISO RGD
PID
PMID:16885148 PMID:17110594 PMID:19339977 PMID:22500797 PID:200096 RGD:11535033 RGD:1625616 RGD:2307383 RGD:2308795 NCBI chrNW_004624801:9,676,965...10,053,311
Ensembl chrNW_004624801:9,677,307...10,048,719
JBrowse link
G Rraga Ras related GTP binding A ISO RGD
PID
PMID:19339977 PMID:24698685 PID:200096 RGD:11535043 RGD:2308795 NCBI chrNW_004624736:23,035,836...23,049,574 JBrowse link
G Rragb Ras related GTP binding B ISO PID
RGD
PMID:19339977 PMID:24698685 PID:200096 RGD:11535043 RGD:2308795 NCBI chrNW_004624910:726,467...760,293
Ensembl chrNW_004624910:727,034...760,671
JBrowse link
G Rragc Ras related GTP binding C ISO PID
RGD
PMID:19339977 PMID:24698685 PID:200096 RGD:11535043 RGD:2308795 NCBI chrNW_004624764:21,460,669...21,475,470
Ensembl chrNW_004624764:21,460,666...21,475,439
JBrowse link
G Rragd Ras related GTP binding D ISO RGD
PID
PMID:19339977 PMID:24698685 PID:200096 RGD:11535043 RGD:2308795 NCBI chrNW_004624799:4,754,603...4,801,312
Ensembl chrNW_004624799:4,754,917...4,798,609
JBrowse link
G Rrn3 RRN3 homolog, RNA polymerase I transcription factor ISO PID PID:200096 NCBI chrNW_004624824:8,582,754...8,615,073
Ensembl chrNW_004624824:8,582,803...8,614,313
JBrowse link
G Sesn2 sestrin 2 ISO RGD PMID:27076075 RGD:11535042 NCBI chrNW_004624764:12,087,901...12,135,145
Ensembl chrNW_004624764:12,087,858...12,120,914
JBrowse link
G Sfn stratifin ISO PID PID:200096 NCBI chrNW_004624764:10,859,556...10,860,876
Ensembl chrNW_004624764:10,859,667...10,860,413
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 ISO PID PID:200096 NCBI chrNW_004624942:508,035...641,349
Ensembl chrNW_004624942:507,605...641,585
JBrowse link
G Slc7a5 solute carrier family 7 member 5 ISO RGD PMID:25049270 RGD:151361107 NCBI chrNW_004624746:1,325,368...1,349,616 JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 ISO PID PID:200096 NCBI chrNW_004624849:3,602,103...3,623,922
Ensembl chrNW_004624849:3,602,261...3,623,465
JBrowse link
G Sspo SCO-spondin ISO PID PID:200096 NCBI chrNW_004624800:6,196,413...6,242,808 JBrowse link
G Tbc1d7 TBC1 domain family member 7 ISO RGD PMID:26159692 RGD:11535034 NCBI chrNW_004624756:12,902,917...12,921,805
Ensembl chrNW_004624756:12,903,359...12,921,805
JBrowse link
G Telo2 telomere maintenance 2 ISO RGD PMID:22500797 RGD:11535033 NCBI chrNW_004624913:711,588...729,209 JBrowse link
G Tsc1 TSC complex subunit 1 ISO PID
RGD
PMID:16885148 PMID:19339977 PMID:26159692 PID:200096 RGD:11535034 RGD:1625616 RGD:2308795 NCBI chrNW_004624760:3,479,028...3,536,612
Ensembl chrNW_004624760:3,498,692...3,532,011
JBrowse link
G Tsc2 TSC complex subunit 2 ISO RGD
PID
PMID:12869586 PMID:16885148 PMID:19339977 PMID:26159692 PID:200096 RGD:11535034 RGD:1580520 RGD:1625616 RGD:2308795 NCBI chrNW_004624913:166,931...203,008
Ensembl chrNW_004624913:166,931...202,953
JBrowse link
G Tti1 TELO2 interacting protein 1 ISO RGD PMID:22500797 RGD:11535033 NCBI chrNW_004624842:1,629,867...1,701,995 JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 ISO PID PID:200096 NCBI chrNW_004624747:27,680,994...27,697,342
Ensembl chrNW_004624747:27,681,033...27,695,966
JBrowse link
G Wdr24 WD repeat domain 24 ISO RGD PMID:24698685 RGD:11535043 NCBI chrNW_004624913:1,496,029...1,501,822
Ensembl chrNW_004624913:1,496,029...1,501,800
JBrowse link
G Wdr59 WD repeat domain 59 ISO RGD PMID:24698685 RGD:11535043 NCBI chrNW_004624746:11,964,278...12,108,173
Ensembl chrNW_004624746:11,964,121...12,065,868
JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta ISO PID PID:200096 NCBI chrNW_004624790:9,574,003...9,593,821
Ensembl chrNW_004624790:9,574,027...9,593,825
JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon ISO PID PID:200096 NCBI chrNW_004624786:4,080,650...4,135,200
Ensembl chrNW_004624786:4,080,427...4,135,459
JBrowse link
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma ISO PID PID:200096 NCBI chrNW_004624740:14,960,105...14,995,522
Ensembl chrNW_004624740:14,959,089...14,995,548
JBrowse link
G Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta ISO PID PID:200096 NCBI chrNW_004624747:8,350,552...8,362,610
Ensembl chrNW_004624747:8,350,474...8,363,576
JBrowse link
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta ISO PID PID:200096 NCBI chrNW_004624969:167,635...199,963
Ensembl chrNW_004624969:167,676...199,963
JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta ISO PID PID:200096 NCBI chrNW_004624763:7,722,275...7,723,482 JBrowse link
G Yy1 YY1 transcription factor ISO PID PID:200096 NCBI chrNW_004624734:3,846,753...3,875,294
Ensembl chrNW_004624734:3,846,765...3,875,294
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3917
    regulatory pathway 2426
      pathway pertinent to DNA replication and repair, cell cycle, maintenance of genomic integrity, RNA and protein biosynthesis 1306
        mTOR signaling pathway 92
          altered mTOR signaling pathway 0
Path 2
Term Annotations click to browse term
  pathway 3917
    regulatory pathway 2426
      homeostasis pathway 1267
        energy homeostasis pathway 231
          mTOR signaling pathway 92
            altered mTOR signaling pathway 0
paths to the root