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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:mTOR signaling pathway
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Accession:PW:0000180 term browser browse the term
Definition:The mTOR signaling pathway regulates cellular processes such as translation, ribosome biogenesis, cell growth and autophagy and is regulated by or responds to growth factors, energy metabolites and/or levels of nutrients.
Synonyms:related_synonym: MTOR signalling;   TOR signaling
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mTOR signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 ISO PID PID:200096 NCBI chr24:82,704,087...82,730,711
Ensembl chr24:82,704,068...82,727,698 		JBrowse link
G AKT1S1 AKT1 substrate 1 ISO PID
RGD		 PMID:19339977 PMID:22500797 PID:200096 RGD:11535033 RGD:2308795 NCBI chr 6:43,026,392...43,034,896
Ensembl chr 6:43,026,286...43,035,533 		JBrowse link
G ATG13 autophagy related 13 ISO PID PID:200096 NCBI chr 1:18,651,872...18,712,395
Ensembl chr 1:18,652,998...18,712,482 		JBrowse link
G BNIP3 BCL2 interacting protein 3 ISO PID PID:200096 NCBI chr 9:124,570,958...124,586,002
Ensembl chr 9:124,568,695...124,585,980 		JBrowse link
G BRAF B-Raf proto-oncogene, serine/threonine kinase ISO PID PID:200096 NCBI chr21:109,495,525...109,690,261 JBrowse link
G CASTOR1 cytosolic arginine sensor for mTORC1 subunit 1 ISO RGD PMID:27015302 RGD:11535047 NCBI chr19:13,165,945...13,172,734
Ensembl chr19:13,165,873...13,170,465 		JBrowse link
G CASTOR2 cytosolic arginine sensor for mTORC1 subunit 2 ISO RGD PMID:27015302 RGD:11535047 NCBI chr28:8,137,339...8,205,551
Ensembl chr28:8,137,564...8,198,674 		JBrowse link
G CCNE1 cyclin E1 ISO PID PID:200096 NCBI chr 6:24,879,923...24,888,985 JBrowse link
G CDK2 cyclin dependent kinase 2 ISO PID PID:200096 NCBI chr11:51,905,085...51,910,209
Ensembl chr11:51,905,115...51,909,907 		JBrowse link
G CLIP1 CAP-Gly domain containing linker protein 1 ISO PID PID:200096 NCBI chr11:117,621,047...117,775,717
Ensembl chr11:117,620,949...117,729,506 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 ISO RGD PMID:26078356 RGD:11526468 NCBI chr 7:22,202,497...22,205,730
Ensembl chr 7:22,202,527...22,204,068 		JBrowse link
G DDIT4 DNA damage inducible transcript 4 ISO PID PID:200096 NCBI chr 9:59,033,058...59,035,157
Ensembl chr 9:59,032,755...59,035,241 		JBrowse link
G DEPDC5 DEP domain containing 5, GATOR1 subcomplex subunit ISO RGD PMID:24698685 RGD:11535043 NCBI chr19:14,634,836...14,798,050
Ensembl chr19:14,635,947...14,787,591 		JBrowse link
G DEPTOR DEP domain containing MTOR interacting protein ISO RGD
PID		 PMID:22500797 PID:200096 RGD:11535033 NCBI chr 8:114,442,212...114,626,411
Ensembl chr 8:114,442,379...114,625,171 		JBrowse link
G EEF2 eukaryotic translation elongation factor 2 ISO PID PID:200096 NCBI chr 6:3,733,056...3,742,526
Ensembl chr 6:3,732,425...3,742,826 		JBrowse link
G EEF2K eukaryotic elongation factor 2 kinase ISO PID PID:200096 NCBI chr 5:19,871,669...19,957,471
Ensembl chr 5:19,871,310...19,957,395 		JBrowse link
G EIF4A1 eukaryotic translation initiation factor 4A1 ISO PID PID:200096 NCBI chr16:6,949,574...6,956,540
Ensembl chr16:6,949,628...6,956,026 		JBrowse link
G EIF4B eukaryotic translation initiation factor 4B ISO PID PID:200096 NCBI chr11:49,125,177...49,161,027
Ensembl chr11:49,125,362...49,159,034 		JBrowse link
G EIF4E eukaryotic translation initiation factor 4E ISO PID PID:200096 NCBI chr 7:47,002,522...47,053,060
Ensembl chr 7:47,001,008...47,051,571 		JBrowse link
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 ISO RGD
PID		 PMID:16885148 PMID:19339977 PID:200096 RGD:1625616 RGD:2308795 NCBI chr 8:36,063,311...36,092,439 JBrowse link
G FBXW11 F-box and WD repeat domain containing 11 ISO PID PID:200096 NCBI chr23:74,015,964...74,154,285
Ensembl chr23:74,015,964...74,154,062 		JBrowse link
G FKBP1A FKBP prolyl isomerase 1A ISO RGD PMID:22500797 RGD:11535033 NCBI chr 2:55,170,816...55,195,380 JBrowse link
G FLCN folliculin ISO RGD PMID:27076075 RGD:11535042 NCBI chr16:16,245,840...16,271,465
Ensembl chr16:16,245,715...16,267,698 		JBrowse link
G FNIP1 folliculin interacting protein 1 ISO RGD PMID:27076075 RGD:11535042 NCBI chr23:34,443,171...34,637,797
Ensembl chr23:34,480,901...34,637,662 		JBrowse link
G FNIP2 folliculin interacting protein 2 ISO RGD PMID:27076075 RGD:11535042 NCBI chr 7:105,344,950...105,445,313
Ensembl chr 7:105,345,920...105,445,452 		JBrowse link
G HRAS HRas proto-oncogene, GTPase ISO PID PID:200096 NCBI chr 1:343,613...345,782
Ensembl chr 1:343,506...346,637 		JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta ISO PID PID:200096 NCBI chr 8:40,267,532...40,325,282
Ensembl chr 8:40,268,079...40,326,381 		JBrowse link
G IRS1 insulin receptor substrate 1 ISO PID PID:200096 NCBI chr10:112,748,283...112,812,368 JBrowse link
G LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 ISO RGD PMID:24698685 RGD:11535043 NCBI chr 1:63,301,354...63,307,716
Ensembl chr 1:63,301,885...63,307,553 		JBrowse link
G LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 ISO RGD PMID:24698685 RGD:11535043 NCBI chr20:7,806,509...7,810,296
Ensembl chr20:7,806,510...7,810,456 		JBrowse link
G LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 ISO RGD PMID:24698685 RGD:11535043 NCBI chr 7:48,009,857...48,025,783 JBrowse link
G LAMTOR4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 ISO RGD PMID:24698685 RGD:11535043 NCBI chr28:12,916,152...12,923,647
Ensembl chr28:12,916,148...12,923,609 		JBrowse link
G LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 ISO RGD PMID:24698685 RGD:11535043 NCBI chr20:23,134,847...23,140,527
Ensembl chr20:23,134,843...23,138,934 		JBrowse link
G LOC103226354 cytochrome c ISO PID PID:200096 NCBI chr21:33,251,825...33,253,298 JBrowse link
G LOC103227202 SCO-spondin ISO PID PID:200096 NCBI chr21:118,339,676...118,399,716 JBrowse link
G LPIN1 lipin 1 ISO RGD PMID:11792863 RGD:1641823 NCBI chr14:95,777,976...95,926,420
Ensembl chr14:95,780,478...95,926,419 		JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 ISO PID PID:200096 NCBI chr26:17,059,122...17,168,787
Ensembl chr26:17,060,054...17,168,782 		JBrowse link
G MAP2K2 mitogen-activated protein kinase kinase 2 ISO PID PID:200096 NCBI chr 6:3,848,441...3,881,367
Ensembl chr 6:3,848,401...3,881,412 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 ISO PID PID:200096 NCBI chr19:4,246,144...4,352,648
Ensembl chr19:4,246,122...4,353,325 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 ISO PID PID:200096 NCBI chr 5:26,536,471...26,545,666
Ensembl chr 5:26,536,532...26,546,461 		JBrowse link
G MAPKAP1 MAPK associated protein 1 ISO RGD
PID		 PMID:19339977 PMID:22500797 PID:200096 RGD:11535033 RGD:2308795 NCBI chr12:12,441,135...12,706,465
Ensembl chr12:12,441,150...12,707,804 		JBrowse link
G MIOS meiosis regulator for oocyte development ISO RGD PMID:24698685 RGD:11535043 NCBI chr21:50,591,080...50,639,869
Ensembl chr21:50,603,462...50,634,327 		JBrowse link
G MLST8 MTOR associated protein, LST8 homolog ISO RGD
PID		 PMID:12718876 PMID:19339977 PMID:22500797 PID:200096 RGD:11535033 RGD:1626104 RGD:2308795 NCBI chr 5:2,101,044...2,105,272
Ensembl chr 5:2,101,891...2,105,739 		JBrowse link
G MTOR mechanistic target of rapamycin kinase ISO PID
RGD		 PMID:16885148 PMID:17110594 PMID:17142137 PMID:19339977 PMID:22500797 PID:200096 RGD:11535033 RGD:1625611 RGD:1625616 RGD:2307383 RGD:2308795 NCBI chr20:120,522,667...120,678,988
Ensembl chr20:120,525,737...120,679,020 		JBrowse link
G NPRL2 NPR2 like, GATOR1 complex subunit ISO RGD PMID:24698685 RGD:11535043 NCBI chr22:11,735,853...11,739,325 JBrowse link
G NPRL3 NPR3 like, GATOR1 complex subunit ISO RGD PMID:24698685 RGD:11535043 NCBI chr 5:40,674...94,265
Ensembl chr 5:43,150...94,174 		JBrowse link
G NRAS NRAS proto-oncogene, GTPase ISO PID PID:200096 NCBI chr20:18,953,273...18,966,002
Ensembl chr20:18,953,883...18,961,931 		JBrowse link
G PDCD4 programmed cell death 4 ISO PID PID:200096 NCBI chr 9:103,809,005...103,836,402
Ensembl chr 9:103,813,211...103,836,002 		JBrowse link
G PDPK1 3-phosphoinositide dependent protein kinase 1 ISO PID PID:200096
G PLD1 phospholipase D1 ISO PID PID:200096 NCBI chr15:17,667,079...17,871,452
Ensembl chr15:17,706,030...17,870,266 		JBrowse link
G PLD2 phospholipase D2 ISO PID PID:200096 NCBI chr16:4,283,248...4,298,034
Ensembl chr16:4,283,521...4,298,632 		JBrowse link
G PML PML nuclear body scaffold ISO PID PID:200096 NCBI chr26:9,441,998...9,494,949
Ensembl chr26:9,451,112...9,494,931 		JBrowse link
G POLDIP3 DNA polymerase delta interacting protein 3 ISO PID PID:200096 NCBI chr19:25,137,631...25,167,669
Ensembl chr19:25,137,008...25,167,859 		JBrowse link
G PPARGC1A PPARG coactivator 1 alpha ISO PID PID:200096 NCBI chr27:25,882,385...26,563,530
Ensembl chr27:26,465,499...26,564,582 		JBrowse link
G PRKCA protein kinase C alpha ISO PID PID:200096 NCBI chr16:54,638,548...55,144,372
Ensembl chr16:54,642,729...54,948,256 		JBrowse link
G PRR5 proline rich 5 ISO RGD
PID		 PMID:22500797 PID:200096 RGD:11535033 NCBI chr19:27,164,900...27,225,398
Ensembl chr19:27,165,278...27,226,907 		JBrowse link
G PRR5L proline rich 5 like ISO RGD PMID:22500797 RGD:11535033 NCBI chr 1:28,771,858...28,951,201
Ensembl chr 1:28,771,793...28,841,572 		JBrowse link
G PXN paxillin ISO PID PID:200096 NCBI chr11:115,560,859...115,619,093
Ensembl chr11:115,560,662...115,619,029 		JBrowse link
G RAC1 Rac family small GTPase 1 ISO PID PID:200096 NCBI chr28:15,583,609...15,610,753
Ensembl chr28:15,583,516...15,610,328 		JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase ISO PID PID:200096 NCBI chr22:48,560,270...48,643,537
Ensembl chr22:48,561,161...48,618,020 		JBrowse link
G RB1CC1 RB1 inducible coiled-coil 1 ISO PID PID:200096 NCBI chr 8:48,726,551...48,818,027
Ensembl chr 8:48,724,393...48,817,928 		JBrowse link
G RHEB Ras homolog, mTORC1 binding ISO RGD
PID		 PMID:16354680 PMID:16885148 PMID:19339977 PMID:26159692 PID:200096 RGD:11535034 RGD:1625606 RGD:1625616 RGD:2308795 NCBI chr21:119,652,692...119,704,833
Ensembl chr21:119,652,127...119,703,458 		JBrowse link
G RHOA ras homolog family member A ISO PID PID:200096 NCBI chr22:10,757,381...10,809,257
Ensembl chr22:10,757,337...10,772,704 		JBrowse link
G RICTOR RPTOR independent companion of MTOR complex 2 ISO PID
RGD		 PMID:16885148 PMID:17110594 PMID:19339977 PMID:22500797 PID:200096 RGD:11535033 RGD:1625616 RGD:2307383 RGD:2308795 NCBI chr 4:37,758,531...37,885,323
Ensembl chr 4:37,762,901...37,873,766 		JBrowse link
G RPS6KA1 ribosomal protein S6 kinase A1 ISO PID PID:200096 NCBI chr20:106,180,708...106,226,636
Ensembl chr20:106,180,418...106,226,552 		JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 ISO PID
RGD		 PMID:11574531 PMID:16885148 PMID:19339977 PID:200096 RGD:1625616 RGD:1626103 RGD:2308795 NCBI chr16:33,498,098...33,556,553
Ensembl chr16:33,497,392...33,556,453 		JBrowse link
G RPS6KB2 ribosomal protein S6 kinase B2 ISO RGD PMID:11574531 PMID:16885148 PMID:19339977 RGD:1625616 RGD:1626103 RGD:2308795 NCBI chr 1:6,828,413...6,836,176
Ensembl chr 1:6,828,682...6,836,143 		JBrowse link
G RPTOR regulatory associated protein of MTOR complex 1 ISO RGD
PID		 PMID:16885148 PMID:17110594 PMID:19339977 PMID:22500797 PID:200096 RGD:11535033 RGD:1625616 RGD:2307383 RGD:2308795 NCBI chr16:72,513,593...72,916,950
Ensembl chr16:72,513,619...72,918,416 		JBrowse link
G RRAGA Ras related GTP binding A ISO PID
RGD		 PMID:19339977 PMID:24698685 PID:200096 RGD:11535043 RGD:2308795 NCBI chr12:60,669,841...60,671,482 JBrowse link
G RRAGB Ras related GTP binding B ISO PID
RGD		 PMID:19339977 PMID:24698685 PID:200096 RGD:11535043 RGD:2308795 NCBI chr  X:51,806,561...51,848,263
Ensembl chr  X:51,806,596...51,848,502 		JBrowse link
G RRAGC Ras related GTP binding C ISO PID
RGD		 PMID:19339977 PMID:24698685 PID:200096 RGD:11535043 RGD:2308795 NCBI chr20:94,030,875...94,051,776
Ensembl chr20:94,030,961...94,053,653 		JBrowse link
G RRAGD Ras related GTP binding D ISO PID
RGD		 PMID:19339977 PMID:24698685 PID:200096 RGD:11535043 RGD:2308795 NCBI chr13:14,129,167...14,167,066
Ensembl chr13:14,132,224...14,166,730 		JBrowse link
G RRN3 RRN3 homolog, RNA polymerase I transcription factor ISO PID PID:200096 NCBI chr 5:14,235,368...14,271,790
Ensembl chr 5:14,235,414...14,272,020 		JBrowse link
G SESN2 sestrin 2 ISO RGD PMID:27076075 RGD:11535042 NCBI chr20:104,521,131...104,544,161
Ensembl chr20:104,521,132...104,544,001 		JBrowse link
G SFN stratifin ISO PID PID:200096 NCBI chr20:105,902,481...105,904,313
Ensembl chr20:105,902,974...105,903,720 		JBrowse link
G SGK1 serum/glucocorticoid regulated kinase 1 ISO PID PID:200096 NCBI chr13:39,152,289...39,306,190
Ensembl chr13:39,300,567...39,306,183 		JBrowse link
G SLC7A5 solute carrier family 7 member 5 ISO RGD PMID:25049270 RGD:151361107 NCBI chr 5:73,229,953...73,269,801
Ensembl chr 5:73,229,951...73,269,754 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 ISO PID PID:200096 NCBI chr16:16,847,603...16,874,239
Ensembl chr16:16,845,491...16,859,554 		JBrowse link
G TBC1D7 TBC1 domain family member 7 ISO RGD PMID:26159692 RGD:11535034 NCBI chr17:58,822,288...58,844,659
Ensembl chr17:58,822,415...58,846,047 		JBrowse link
G TELO2 telomere maintenance 2 ISO RGD PMID:22500797 RGD:11535033 NCBI chr 5:1,403,373...1,419,459
Ensembl chr 5:1,403,385...1,421,128 		JBrowse link
G TSC1 TSC complex subunit 1 ISO RGD
PID		 PMID:16885148 PMID:19339977 PMID:26159692 PID:200096 RGD:11535034 RGD:1625616 RGD:2308795 NCBI chr12:5,195,604...5,249,042
Ensembl chr12:5,195,675...5,244,157 		JBrowse link
G TSC2 TSC complex subunit 2 ISO RGD
PID		 PMID:12869586 PMID:16885148 PMID:19339977 PMID:26159692 PID:200096 RGD:11535034 RGD:1580520 RGD:1625616 RGD:2308795 NCBI chr 5:1,946,534...1,985,168
Ensembl chr 5:1,946,927...1,987,682 		JBrowse link
G TTI1 TELO2 interacting protein 1 ISO RGD PMID:22500797 RGD:11535033 NCBI chr 2:25,717,089...25,768,128
Ensembl chr 2:25,717,118...25,768,610 		JBrowse link
G ULK1 unc-51 like autophagy activating kinase 1 ISO PID PID:200096 NCBI chr11:127,276,172...127,304,270
Ensembl chr11:127,276,210...127,304,497 		JBrowse link
G ULK2 unc-51 like autophagy activating kinase 2 ISO PID PID:200096 NCBI chr16:18,335,095...18,434,031
Ensembl chr16:18,335,235...18,433,578 		JBrowse link
G WDR24 WD repeat domain 24 ISO RGD PMID:24698685 RGD:11535043 NCBI chr 5:604,412...610,665
Ensembl chr 5:604,545...610,359 		JBrowse link
G WDR59 WD repeat domain 59 ISO RGD PMID:24698685 RGD:11535043 NCBI chr 5:52,718,039...52,836,337
Ensembl chr 5:52,718,085...52,836,474 		JBrowse link
G YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta ISO PID PID:200096 NCBI chr 2:18,904,588...18,927,461
Ensembl chr 2:18,906,666...18,927,374 		JBrowse link
G YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon ISO PID PID:200096 NCBI chr16:1,031,840...1,086,950
Ensembl chr16:1,035,250...1,087,013 		JBrowse link
G YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma ISO PID PID:200096 NCBI chr28:10,462,984...10,494,500
Ensembl chr28:10,462,859...10,494,457 		JBrowse link
G YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta ISO PID PID:200096 NCBI chr19:14,825,963...14,839,668
Ensembl chr19:14,826,135...14,840,325 		JBrowse link
G YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta ISO PID PID:200096 NCBI chr14:98,017,300...98,064,973 JBrowse link
G YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta ISO PID PID:200096 NCBI chr 8:95,786,197...95,821,270
Ensembl chr 8:95,788,305...95,819,197 		JBrowse link
G YY1 YY1 transcription factor ISO PID PID:200096 NCBI chr24:78,199,172...78,243,081
Ensembl chr24:78,199,039...78,237,165 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4028
    regulatory pathway 2488
      pathway pertinent to DNA replication and repair, cell cycle, maintenance of genomic integrity, RNA and protein biosynthesis 1327
        mTOR signaling pathway 94
          altered mTOR signaling pathway 0
Path 2
Term Annotations click to browse term
  pathway 4028
    regulatory pathway 2488
      homeostasis pathway 1295
        energy homeostasis pathway 234
          mTOR signaling pathway 94
            altered mTOR signaling pathway 0
paths to the root