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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:mTOR signaling pathway
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Accession:PW:0000180 term browser browse the term
Definition:The mTOR signaling pathway regulates cellular processes such as translation, ribosome biogenesis, cell growth and autophagy and is regulated by or responds to growth factors, energy metabolites and/or levels of nutrients.
Synonyms:related_synonym: MTOR signalling;   TOR signaling

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mTOR signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO PID PID:200096 NCBI chrNW_004955538:3,208,711...3,224,386
Ensembl chrNW_004955538:3,208,710...3,229,904
JBrowse link
G Akt1s1 AKT1 substrate 1 ISO PID
RGD
PMID:19339977 PMID:22500797 PID:200096 RGD:11535033 RGD:2308795 NCBI chrNW_004955559:1,055,998...1,063,192
Ensembl chrNW_004955559:1,056,357...1,063,192
JBrowse link
G Atg13 autophagy related 13 ISO PID PID:200096 NCBI chrNW_004955422:1,398,646...1,432,440
Ensembl chrNW_004955422:1,398,593...1,432,438
JBrowse link
G Bnip3 BCL2 interacting protein 3 ISO PID PID:200096 NCBI chrNW_004955477:9,621,812...9,630,406
Ensembl chrNW_004955477:9,621,812...9,638,099
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO PID PID:200096 NCBI chrNW_004955494:2,567,238...2,712,708 JBrowse link
G Castor1 cytosolic arginine sensor for mTORC1 subunit 1 ISO RGD PMID:27015302 RGD:11535047 NCBI chrNW_004955455:4,530,842...4,535,358
Ensembl chrNW_004955455:4,531,325...4,535,217
JBrowse link
G Castor2 cytosolic arginine sensor for mTORC1 subunit 2 ISO RGD PMID:27015302 RGD:11535047 NCBI chrNW_004955456:13,242,401...13,282,469
Ensembl chrNW_004955456:13,242,401...13,282,469
JBrowse link
G Ccne1 cyclin E1 ISO PID PID:200096 NCBI chrNW_004955468:7,803,610...7,814,872
Ensembl chrNW_004955468:7,803,346...7,814,872
JBrowse link
G Cdk2 cyclin dependent kinase 2 ISO PID PID:200096 NCBI chrNW_004955458:3,555,603...3,561,063
Ensembl chrNW_004955458:3,555,603...3,562,120
JBrowse link
G Clip1 CAP-Gly domain containing linker protein 1 ISO PID PID:200096 NCBI chrNW_004955482:6,213,363...6,330,601
Ensembl chrNW_004955482:6,244,752...6,330,978
JBrowse link
G Cxcl8 C-X-C motif chemokine ligand 8 ISO RGD PMID:26078356 RGD:11526468 NCBI chrNW_004955474:247,326...250,355
Ensembl chrNW_004955474:241,501...250,643
JBrowse link
G Ddit4 DNA damage inducible transcript 4 ISO PID PID:200096 NCBI chrNW_004955437:19,322,407...19,324,562
Ensembl chrNW_004955437:19,322,407...19,324,562
JBrowse link
G Depdc5 DEP domain containing 5, GATOR1 subcomplex subunit ISO RGD PMID:24698685 RGD:11535043 NCBI chrNW_004955455:5,881,631...6,005,514
Ensembl chrNW_004955455:5,881,691...6,003,035
JBrowse link
G Deptor DEP domain containing MTOR interacting protein ISO PID
RGD
PMID:22500797 PID:200096 RGD:11535033 NCBI chrNW_004955417:25,538,609...25,563,374
Ensembl chrNW_004955417:25,538,578...25,566,772
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 ISO PID PID:200096 NCBI chrNW_004955495:4,800,103...4,807,714
Ensembl chrNW_004955495:4,799,922...4,807,252
JBrowse link
G Eef2k eukaryotic elongation factor 2 kinase ISO PID PID:200096 NCBI chrNW_004955493:865,830...922,765
Ensembl chrNW_004955493:865,830...922,765
JBrowse link
G Eif4a1 eukaryotic translation initiation factor 4A1 ISO PID PID:200096 NCBI chrNW_004955467:9,344,629...9,351,028
Ensembl chrNW_004955467:9,345,153...9,350,955
JBrowse link
G Eif4b eukaryotic translation initiation factor 4B ISO PID PID:200096 NCBI chrNW_004955458:296,242...325,451
Ensembl chrNW_004955458:296,244...325,451
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E ISO PID PID:200096 NCBI chrNW_004955405:9,122,960...9,159,095
Ensembl chrNW_004955405:9,122,228...9,159,711
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 ISO PID
RGD
PMID:16885148 PMID:19339977 PID:200096 RGD:1625616 RGD:2308795 NCBI chrNW_004955463:13,702,434...13,720,875
Ensembl chrNW_004955463:13,702,434...13,720,875
JBrowse link
G Fbxw11 F-box and WD repeat domain containing 11 ISO PID PID:200096 NCBI chrNW_004955408:24,703,477...24,834,522
Ensembl chrNW_004955408:24,687,493...24,834,345
JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A ISO RGD PMID:22500797 RGD:11535033 NCBI chrNW_004955596:580,106...606,210
Ensembl chrNW_004955596:580,106...603,255
JBrowse link
G Flcn folliculin ISO RGD PMID:27076075 RGD:11535042 NCBI chrNW_004955577:672,774...694,140
Ensembl chrNW_004955577:672,410...694,140
JBrowse link
G Fnip1 folliculin interacting protein 1 ISO RGD PMID:27076075 RGD:11535042 NCBI chrNW_004955408:3,117,258...3,238,223
Ensembl chrNW_004955408:3,117,277...3,238,223
JBrowse link
G Fnip2 folliculin interacting protein 2 ISO RGD PMID:27076075 RGD:11535042 NCBI chrNW_004955471:12,329,686...12,444,782
Ensembl chrNW_004955471:12,378,827...12,445,207
JBrowse link
G Hras HRas proto-oncogene, GTPase ISO PID PID:200096 NCBI chrNW_004955476:11,508,446...11,510,333
Ensembl chrNW_004955476:11,508,126...11,510,333
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta ISO PID PID:200096 NCBI chrNW_004955536:611,965...658,647
Ensembl chrNW_004955536:612,774...658,647
JBrowse link
G Irs1 insulin receptor substrate 1 ISO PID PID:200096 NCBI chrNW_004955453:7,685,715...7,742,262
Ensembl chrNW_004955453:7,685,715...7,742,262
JBrowse link
G Lamtor1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 ISO RGD PMID:24698685 RGD:11535043 NCBI chrNW_004955414:19,228,615...19,235,523
Ensembl chrNW_004955414:19,228,615...19,247,765
JBrowse link
G Lamtor2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 ISO RGD PMID:24698685 RGD:11535043 NCBI chrNW_004955545:2,237,506...2,242,070
Ensembl chrNW_004955545:2,236,868...2,242,137
JBrowse link
G Lamtor3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 ISO RGD PMID:24698685 RGD:11535043 NCBI chrNW_004955496:7,789,210...7,809,143
Ensembl chrNW_004955496:7,788,997...7,809,143
JBrowse link
G Lamtor4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 ISO RGD PMID:24698685 RGD:11535043 NCBI chrNW_004955573:649,604...653,185
Ensembl chrNW_004955573:645,587...694,661
JBrowse link
G Lamtor5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 ISO RGD PMID:24698685 RGD:11535043 NCBI chrNW_004955435:13,896,320...13,900,742
Ensembl chrNW_004955435:13,896,320...13,900,754
JBrowse link
G LOC102023786 cytochrome c, somatic ISO PID PID:200096 NCBI chrNW_004955410:27,086,405...27,089,255
Ensembl chrNW_004955410:27,086,405...27,089,255
JBrowse link
G Lpin1 lipin 1 ISO RGD PMID:11792863 RGD:1641823 NCBI chrNW_004955487:6,139,188...6,207,316
Ensembl chrNW_004955487:6,138,926...6,210,012
JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 ISO PID PID:200096 NCBI chrNW_004955450:9,181,851...9,205,277
Ensembl chrNW_004955450:9,181,851...9,239,648
JBrowse link
G Map2k2 mitogen-activated protein kinase kinase 2 ISO PID PID:200096 NCBI chrNW_004955495:4,695,239...4,718,380
Ensembl chrNW_004955495:4,695,768...4,722,098
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 ISO PID PID:200096 NCBI chrNW_004955442:17,284,232...17,380,026
Ensembl chrNW_004955442:17,284,232...17,380,020
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 ISO PID PID:200096 NCBI chrNW_004955493:6,870,699...6,876,836
Ensembl chrNW_004955493:6,869,668...6,879,152
JBrowse link
G Mapkap1 MAPK associated protein 1 ISO PID
RGD
PMID:19339977 PMID:22500797 PID:200096 RGD:11535033 RGD:2308795 NCBI chrNW_004955419:2,656,662...2,887,505
Ensembl chrNW_004955419:2,657,741...2,888,607
JBrowse link
G Mios meiosis regulator for oocyte development ISO RGD PMID:24698685 RGD:11535043 NCBI chrNW_004955432:14,658,624...14,693,116
Ensembl chrNW_004955432:14,657,973...14,693,116
JBrowse link
G Mlst8 MTOR associated protein, LST8 homolog ISO PID
RGD
PMID:12718876 PMID:19339977 PMID:22500797 PID:200096 RGD:11535033 RGD:1626104 RGD:2308795 NCBI chrNW_004955442:15,056,363...15,060,300
Ensembl chrNW_004955442:15,056,363...15,060,300
JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO PID
RGD
PMID:16885148 PMID:17110594 PMID:17142137 PMID:19339977 PMID:22500797 PID:200096 RGD:11535033 RGD:1625611 RGD:1625616 RGD:2307383 RGD:2308795 NCBI chrNW_004955486:2,487,642...2,599,694
Ensembl chrNW_004955486:2,487,642...2,599,694
JBrowse link
G Nprl2 NPR2 like, GATOR1 complex subunit ISO RGD PMID:24698685 RGD:11535043 NCBI chrNW_004955532:2,148,950...2,152,671
Ensembl chrNW_004955532:2,148,950...2,152,671
JBrowse link
G Nprl3 NPR3 like, GATOR1 complex subunit ISO RGD PMID:24698685 RGD:11535043 NCBI chrNW_004955442:17,025,232...17,068,399
Ensembl chrNW_004955442:17,025,194...17,070,753
JBrowse link
G Nras NRAS proto-oncogene, GTPase ISO PID PID:200096 NCBI chrNW_004955435:18,001,517...18,009,105
Ensembl chrNW_004955435:18,001,517...18,009,103
JBrowse link
G Pdcd4 programmed cell death 4 ISO PID PID:200096 NCBI chrNW_004955485:530,642...553,508
Ensembl chrNW_004955485:529,860...553,601
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase 1 ISO PID PID:200096 NCBI chrNW_004955442:14,685,089...14,772,870
Ensembl chrNW_004955442:14,685,153...14,772,870
JBrowse link
G Pld1 phospholipase D1 ISO PID PID:200096 NCBI chrNW_004955420:1,697,716...1,892,741
Ensembl chrNW_004955420:1,696,751...1,892,741
JBrowse link
G Pld2 phospholipase D2 ISO PID PID:200096 NCBI chrNW_004955467:10,239,177...10,250,516
Ensembl chrNW_004955467:10,239,177...10,250,890
JBrowse link
G Pml PML nuclear body scaffold ISO PID PID:200096 NCBI chrNW_004955450:3,654,854...3,692,057
Ensembl chrNW_004955450:3,656,498...3,692,406
JBrowse link
G Poldip3 DNA polymerase delta interacting protein 3 ISO PID PID:200096 NCBI chrNW_004955413:27,944,109...27,968,156
Ensembl chrNW_004955413:27,943,520...27,968,156
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha ISO PID PID:200096 NCBI chrNW_004955480:543,397...1,188,376
Ensembl chrNW_004955480:1,078,322...1,188,435
JBrowse link
G Prkca protein kinase C alpha ISO PID PID:200096 NCBI chrNW_004955478:5,686,639...6,090,356
Ensembl chrNW_004955478:5,686,640...6,083,967
JBrowse link
G Prr5 proline rich 5 ISO PID
RGD
PMID:22500797 PID:200096 RGD:11535033 NCBI chrNW_004955413:29,360,125...29,379,196
Ensembl chrNW_004955413:29,348,303...29,379,659
JBrowse link
G Prr5l proline rich 5 like ISO RGD PMID:22500797 RGD:11535033 NCBI chrNW_004955422:9,972,588...10,069,411
Ensembl chrNW_004955422:9,972,588...10,048,669
JBrowse link
G Pxn paxillin ISO PID PID:200096 NCBI chrNW_004955455:11,387,140...11,401,178
Ensembl chrNW_004955455:11,388,378...11,403,082
JBrowse link
G Rac1 Rac family small GTPase 1 ISO PID PID:200096 NCBI chrNW_004955460:13,270,159...13,295,562
Ensembl chrNW_004955460:13,270,159...13,311,351
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO PID PID:200096 NCBI chrNW_004955429:17,980,956...18,049,723
Ensembl chrNW_004955429:18,025,932...18,049,723
JBrowse link
G Rb1cc1 RB1 inducible coiled-coil 1 ISO PID PID:200096 NCBI chrNW_004955454:12,201,566...12,257,383
Ensembl chrNW_004955454:12,200,750...12,257,389
JBrowse link
G Rheb Ras homolog, mTORC1 binding ISO RGD
PID
PMID:16354680 PMID:16885148 PMID:19339977 PMID:26159692 PID:200096 RGD:11535034 RGD:1625606 RGD:1625616 RGD:2308795 NCBI chrNW_004955491:5,795,040...5,833,897
Ensembl chrNW_004955491:5,794,911...5,834,912
JBrowse link
G Rhoa ras homolog family member A ISO PID PID:200096 NCBI chrNW_004955532:1,300,821...1,347,453
Ensembl chrNW_004955532:1,300,462...1,347,451
JBrowse link
G Rictor RPTOR independent companion of MTOR complex 2 ISO PID
RGD
PMID:16885148 PMID:17110594 PMID:19339977 PMID:22500797 PID:200096 RGD:11535033 RGD:1625616 RGD:2307383 RGD:2308795 NCBI chrNW_004955426:23,468,112...23,582,587
Ensembl chrNW_004955426:23,468,112...23,582,587
JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 ISO PID PID:200096 NCBI chrNW_004955452:5,905,561...5,938,096
Ensembl chrNW_004955452:5,904,762...5,939,091
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 ISO PID
RGD
PMID:11574531 PMID:16885148 PMID:19339977 PID:200096 RGD:1625616 RGD:1626103 RGD:2308795 NCBI chrNW_004955451:3,181,085...3,225,610 JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 ISO RGD PMID:11574531 PMID:16885148 PMID:19339977 RGD:1625616 RGD:1626103 RGD:2308795 NCBI chrNW_004955422:18,043,785...18,050,406
Ensembl chrNW_004955422:18,041,729...18,050,406
JBrowse link
G Rptor regulatory associated protein of MTOR complex 1 ISO PID
RGD
PMID:16885148 PMID:17110594 PMID:19339977 PMID:22500797 PID:200096 RGD:11535033 RGD:1625616 RGD:2307383 RGD:2308795 NCBI chrNW_004955506:2,009,422...2,401,775
Ensembl chrNW_004955506:2,008,044...2,401,775
JBrowse link
G Rraga Ras related GTP binding A ISO PID
RGD
PMID:19339977 PMID:24698685 PID:200096 RGD:11535043 RGD:2308795 NCBI chrNW_004955434:21,509,528...21,510,885
Ensembl chrNW_004955434:21,509,529...21,510,470
JBrowse link
G Rragb Ras related GTP binding B ISO PID
RGD
PMID:19339977 PMID:24698685 PID:200096 RGD:11535043 RGD:2308795 NCBI chrNW_004955475:2,662,969...2,692,253
Ensembl chrNW_004955475:2,662,868...2,696,364
JBrowse link
G Rragc Ras related GTP binding C ISO PID
RGD
PMID:19339977 PMID:24698685 PID:200096 RGD:11535043 RGD:2308795 NCBI chrNW_004955452:16,469,426...16,486,336
Ensembl chrNW_004955452:16,466,453...16,486,336
JBrowse link
G Rragd Ras related GTP binding D ISO PID
RGD
PMID:19339977 PMID:24698685 PID:200096 RGD:11535043 RGD:2308795 NCBI chrNW_004955411:16,111,931...16,155,662
Ensembl chrNW_004955411:16,114,755...16,138,433
JBrowse link
G Rrn3 RRN3 homolog, RNA polymerase I transcription factor ISO PID PID:200096 NCBI chrNW_004955442:129,106...166,258
Ensembl chrNW_004955442:129,106...166,258
JBrowse link
G Sesn2 sestrin 2 ISO RGD PMID:27076075 RGD:11535042 NCBI chrNW_004955452:7,392,644...7,417,204
Ensembl chrNW_004955452:7,393,007...7,417,304
JBrowse link
G Sfn stratifin ISO PID PID:200096 NCBI chrNW_004955452:6,217,519...6,218,481
Ensembl chrNW_004955452:6,217,698...6,218,444
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 ISO PID PID:200096 NCBI chrNW_004955439:2,399,992...2,406,587
Ensembl chrNW_004955439:2,290,035...2,406,587
JBrowse link
G Slc7a5 solute carrier family 7 member 5 ISO RGD PMID:25049270 RGD:151361107 NCBI chrNW_004955541:2,103,437...2,129,668
Ensembl chrNW_004955541:2,103,384...2,130,310
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 ISO PID PID:200096 NCBI chrNW_004955577:171,425...183,669
Ensembl chrNW_004955577:171,425...186,046
JBrowse link
G Sspo SCO-spondin ISO PID PID:200096 NCBI chrNW_004955491:4,840,657...4,889,060 JBrowse link
G Tbc1d7 TBC1 domain family member 7 ISO RGD PMID:26159692 RGD:11535034 NCBI chrNW_004955465:1,362,453...1,380,814
Ensembl chrNW_004955465:1,362,759...1,382,190
JBrowse link
G Telo2 telomere maintenance 2 ISO RGD PMID:22500797 RGD:11535033 NCBI chrNW_004955442:15,719,082...15,733,527
Ensembl chrNW_004955442:15,719,521...15,734,087
JBrowse link
G Tsc1 TSC complex subunit 1 ISO PID
RGD
PMID:16885148 PMID:19339977 PMID:26159692 PID:200096 RGD:11535034 RGD:1625616 RGD:2308795 NCBI chrNW_004955513:2,197,037...2,244,992
Ensembl chrNW_004955513:2,197,037...2,244,992
JBrowse link
G Tsc2 TSC complex subunit 2 ISO RGD
PID
PMID:12869586 PMID:16885148 PMID:19339977 PMID:26159692 PID:200096 RGD:11535034 RGD:1580520 RGD:1625616 RGD:2308795 NCBI chrNW_004955442:15,178,356...15,216,978
Ensembl chrNW_004955442:15,178,487...15,216,362
JBrowse link
G Tti1 TELO2 interacting protein 1 ISO RGD PMID:22500797 RGD:11535033 NCBI chrNW_004955445:18,676,285...18,729,512
Ensembl chrNW_004955445:18,675,434...18,729,512
JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 ISO PID PID:200096 NCBI chrNW_004955482:760,200...777,133
Ensembl chrNW_004955482:761,811...777,133
JBrowse link
G Ulk2 unc-51 like autophagy activating kinase 2 ISO PID PID:200096 NCBI chrNW_004955467:818,975...894,103
Ensembl chrNW_004955467:818,076...894,106
JBrowse link
G Wdr24 WD repeat domain 24 ISO RGD PMID:24698685 RGD:11535043 NCBI chrNW_004955442:16,513,074...16,519,296
Ensembl chrNW_004955442:16,513,448...16,519,296
JBrowse link
G Wdr59 WD repeat domain 59 ISO RGD PMID:24698685 RGD:11535043 NCBI chrNW_004955484:2,576,505...2,668,001
Ensembl chrNW_004955484:2,576,208...2,670,324
JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta ISO PID PID:200096 NCBI chrNW_004955445:12,451,644...12,474,251
Ensembl chrNW_004955445:12,448,760...12,474,251
JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon ISO PID PID:200096 NCBI chrNW_004955481:1,752,778...1,805,700
Ensembl chrNW_004955481:1,752,778...1,808,583
JBrowse link
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma ISO PID PID:200096 NCBI chrNW_004955456:14,939,130...14,970,248
Ensembl chrNW_004955456:14,939,084...14,970,248
JBrowse link
G Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta ISO PID PID:200096 NCBI chrNW_004955455:6,045,919...6,057,729
Ensembl chrNW_004955455:6,045,919...6,057,729
JBrowse link
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta ISO PID PID:200096 NCBI chrNW_004955487:5,229,485...5,263,749
Ensembl chrNW_004955487:5,230,506...5,263,752
JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta ISO PID PID:200096 NCBI chrNW_004955417:16,047,263...16,070,506
Ensembl chrNW_004955417:16,047,263...16,072,854
JBrowse link
G Yy1 YY1 transcription factor ISO PID PID:200096 NCBI chrNW_004955438:21,341,374...21,377,674 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3924
    regulatory pathway 2432
      pathway pertinent to DNA replication and repair, cell cycle, maintenance of genomic integrity, RNA and protein biosynthesis 1319
        mTOR signaling pathway 94
          altered mTOR signaling pathway 0
Path 2
Term Annotations click to browse term
  pathway 3924
    regulatory pathway 2432
      homeostasis pathway 1271
        energy homeostasis pathway 233
          mTOR signaling pathway 94
            altered mTOR signaling pathway 0
paths to the root