PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: mTOR signaling pathway
Accession: PW:0000180
browse the term
Definition: The mTOR signaling pathway regulates cellular processes such as translation, ribosome biogenesis, cell growth and autophagy and is regulated by or responds to growth factors, energy metabolites and/or levels of nutrients.
Synonyms: related_synonym: MTOR signalling; TOR signaling
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Akt1
AKT serine/threonine kinase 1
ISO
PID
PID:200096
NCBI chrNW_004955538:3,208,711...3,224,386
Ensembl chrNW_004955538:3,208,710...3,229,904
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Akt1s1
AKT1 substrate 1
ISO
PID RGD
PMID:19339977 PMID:22500797
PID:200096 RGD:11535033 RGD:2308795
NCBI chrNW_004955559:1,055,998...1,063,192
Ensembl chrNW_004955559:1,056,357...1,063,192
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Atg13
autophagy related 13
ISO
PID
PID:200096
NCBI chrNW_004955422:1,398,646...1,432,440
Ensembl chrNW_004955422:1,398,593...1,432,438
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Bnip3
BCL2 interacting protein 3
ISO
PID
PID:200096
NCBI chrNW_004955477:9,621,812...9,630,406
Ensembl chrNW_004955477:9,621,812...9,638,099
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Braf
B-Raf proto-oncogene, serine/threonine kinase
ISO
PID
PID:200096
NCBI chrNW_004955494:2,567,238...2,712,708
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Castor1
cytosolic arginine sensor for mTORC1 subunit 1
ISO
RGD
PMID:27015302
RGD:11535047
NCBI chrNW_004955455:4,530,842...4,535,358
Ensembl chrNW_004955455:4,531,325...4,535,217
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Castor2
cytosolic arginine sensor for mTORC1 subunit 2
ISO
RGD
PMID:27015302
RGD:11535047
NCBI chrNW_004955456:13,242,401...13,282,469
Ensembl chrNW_004955456:13,242,401...13,282,469
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Ccne1
cyclin E1
ISO
PID
PID:200096
NCBI chrNW_004955468:7,803,610...7,814,872
Ensembl chrNW_004955468:7,803,346...7,814,872
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Cdk2
cyclin dependent kinase 2
ISO
PID
PID:200096
NCBI chrNW_004955458:3,555,603...3,561,063
Ensembl chrNW_004955458:3,555,603...3,562,120
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Clip1
CAP-Gly domain containing linker protein 1
ISO
PID
PID:200096
NCBI chrNW_004955482:6,213,363...6,330,601
Ensembl chrNW_004955482:6,244,752...6,330,978
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Cxcl8
C-X-C motif chemokine ligand 8
ISO
RGD
PMID:26078356
RGD:11526468
NCBI chrNW_004955474:247,326...250,355
Ensembl chrNW_004955474:241,501...250,643
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Ddit4
DNA damage inducible transcript 4
ISO
PID
PID:200096
NCBI chrNW_004955437:19,322,407...19,324,562
Ensembl chrNW_004955437:19,322,407...19,324,562
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Depdc5
DEP domain containing 5, GATOR1 subcomplex subunit
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chrNW_004955455:5,881,631...6,005,514
Ensembl chrNW_004955455:5,881,691...6,003,035
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Deptor
DEP domain containing MTOR interacting protein
ISO
PID RGD
PMID:22500797
PID:200096 RGD:11535033
NCBI chrNW_004955417:25,538,609...25,563,374
Ensembl chrNW_004955417:25,538,578...25,566,772
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Eef2
eukaryotic translation elongation factor 2
ISO
PID
PID:200096
NCBI chrNW_004955495:4,800,103...4,807,714
Ensembl chrNW_004955495:4,799,922...4,807,252
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Eef2k
eukaryotic elongation factor 2 kinase
ISO
PID
PID:200096
NCBI chrNW_004955493:865,830...922,765
Ensembl chrNW_004955493:865,830...922,765
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Eif4a1
eukaryotic translation initiation factor 4A1
ISO
PID
PID:200096
NCBI chrNW_004955467:9,344,629...9,351,028
Ensembl chrNW_004955467:9,345,153...9,350,955
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Eif4b
eukaryotic translation initiation factor 4B
ISO
PID
PID:200096
NCBI chrNW_004955458:296,242...325,451
Ensembl chrNW_004955458:296,244...325,451
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Eif4e
eukaryotic translation initiation factor 4E
ISO
PID
PID:200096
NCBI chrNW_004955405:9,122,960...9,159,095
Ensembl chrNW_004955405:9,122,228...9,159,711
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Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
ISO
PID RGD
PMID:16885148 PMID:19339977
PID:200096 RGD:1625616 RGD:2308795
NCBI chrNW_004955463:13,702,434...13,720,875
Ensembl chrNW_004955463:13,702,434...13,720,875
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Fbxw11
F-box and WD repeat domain containing 11
ISO
PID
PID:200096
NCBI chrNW_004955408:24,703,477...24,834,522
Ensembl chrNW_004955408:24,687,493...24,834,345
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Fkbp1a
FKBP prolyl isomerase 1A
ISO
RGD
PMID:22500797
RGD:11535033
NCBI chrNW_004955596:580,106...606,210
Ensembl chrNW_004955596:580,106...603,255
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Flcn
folliculin
ISO
RGD
PMID:27076075
RGD:11535042
NCBI chrNW_004955577:672,774...694,140
Ensembl chrNW_004955577:672,410...694,140
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Fnip1
folliculin interacting protein 1
ISO
RGD
PMID:27076075
RGD:11535042
NCBI chrNW_004955408:3,117,258...3,238,223
Ensembl chrNW_004955408:3,117,277...3,238,223
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Fnip2
folliculin interacting protein 2
ISO
RGD
PMID:27076075
RGD:11535042
NCBI chrNW_004955471:12,329,686...12,444,782
Ensembl chrNW_004955471:12,378,827...12,445,207
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Hras
HRas proto-oncogene, GTPase
ISO
PID
PID:200096
NCBI chrNW_004955476:11,508,446...11,510,333
Ensembl chrNW_004955476:11,508,126...11,510,333
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Ikbkb
inhibitor of nuclear factor kappa B kinase subunit beta
ISO
PID
PID:200096
NCBI chrNW_004955536:611,965...658,647
Ensembl chrNW_004955536:612,774...658,647
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Irs1
insulin receptor substrate 1
ISO
PID
PID:200096
NCBI chrNW_004955453:7,685,715...7,742,262
Ensembl chrNW_004955453:7,685,715...7,742,262
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Lamtor1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chrNW_004955414:19,228,615...19,235,523
Ensembl chrNW_004955414:19,228,615...19,247,765
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Lamtor2
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chrNW_004955545:2,237,506...2,242,070
Ensembl chrNW_004955545:2,236,868...2,242,137
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Lamtor3
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chrNW_004955496:7,789,210...7,809,143
Ensembl chrNW_004955496:7,788,997...7,809,143
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Lamtor4
late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chrNW_004955573:649,604...653,185
Ensembl chrNW_004955573:645,587...694,661
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Lamtor5
late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chrNW_004955435:13,896,320...13,900,742
Ensembl chrNW_004955435:13,896,320...13,900,754
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LOC102023786
cytochrome c, somatic
ISO
PID
PID:200096
NCBI chrNW_004955410:27,086,405...27,089,255
Ensembl chrNW_004955410:27,086,405...27,089,255
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Lpin1
lipin 1
ISO
RGD
PMID:11792863
RGD:1641823
NCBI chrNW_004955487:6,139,188...6,207,316
Ensembl chrNW_004955487:6,138,926...6,210,012
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Map2k1
mitogen-activated protein kinase kinase 1
ISO
PID
PID:200096
NCBI chrNW_004955450:9,181,851...9,205,277
Ensembl chrNW_004955450:9,181,851...9,239,648
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Map2k2
mitogen-activated protein kinase kinase 2
ISO
PID
PID:200096
NCBI chrNW_004955495:4,695,239...4,718,380
Ensembl chrNW_004955495:4,695,768...4,722,098
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Mapk1
mitogen-activated protein kinase 1
ISO
PID
PID:200096
NCBI chrNW_004955442:17,284,232...17,380,026
Ensembl chrNW_004955442:17,284,232...17,380,020
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Mapk3
mitogen-activated protein kinase 3
ISO
PID
PID:200096
NCBI chrNW_004955493:6,870,699...6,876,836
Ensembl chrNW_004955493:6,869,668...6,879,152
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Mapkap1
MAPK associated protein 1
ISO
PID RGD
PMID:19339977 PMID:22500797
PID:200096 RGD:11535033 RGD:2308795
NCBI chrNW_004955419:2,656,662...2,887,505
Ensembl chrNW_004955419:2,657,741...2,888,607
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Mios
meiosis regulator for oocyte development
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chrNW_004955432:14,658,624...14,693,116
Ensembl chrNW_004955432:14,657,973...14,693,116
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Mlst8
MTOR associated protein, LST8 homolog
ISO
PID RGD
PMID:12718876 PMID:19339977 PMID:22500797
PID:200096 RGD:11535033 RGD:1626104 RGD:2308795
NCBI chrNW_004955442:15,056,363...15,060,300
Ensembl chrNW_004955442:15,056,363...15,060,300
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Mtor
mechanistic target of rapamycin kinase
ISO
PID RGD
PMID:16885148 PMID:17110594 PMID:17142137 PMID:19339977 PMID:22500797
PID:200096 RGD:11535033 RGD:1625611 RGD:1625616 RGD:2307383 RGD:2308795
NCBI chrNW_004955486:2,487,642...2,599,694
Ensembl chrNW_004955486:2,487,642...2,599,694
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Nprl2
NPR2 like, GATOR1 complex subunit
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chrNW_004955532:2,148,950...2,152,671
Ensembl chrNW_004955532:2,148,950...2,152,671
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Nprl3
NPR3 like, GATOR1 complex subunit
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chrNW_004955442:17,025,232...17,068,399
Ensembl chrNW_004955442:17,025,194...17,070,753
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Nras
NRAS proto-oncogene, GTPase
ISO
PID
PID:200096
NCBI chrNW_004955435:18,001,517...18,009,105
Ensembl chrNW_004955435:18,001,517...18,009,103
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Pdcd4
programmed cell death 4
ISO
PID
PID:200096
NCBI chrNW_004955485:530,642...553,508
Ensembl chrNW_004955485:529,860...553,601
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Pdpk1
3-phosphoinositide dependent protein kinase 1
ISO
PID
PID:200096
NCBI chrNW_004955442:14,685,089...14,772,870
Ensembl chrNW_004955442:14,685,153...14,772,870
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Pld1
phospholipase D1
ISO
PID
PID:200096
NCBI chrNW_004955420:1,697,716...1,892,741
Ensembl chrNW_004955420:1,696,751...1,892,741
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Pld2
phospholipase D2
ISO
PID
PID:200096
NCBI chrNW_004955467:10,239,177...10,250,516
Ensembl chrNW_004955467:10,239,177...10,250,890
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Pml
PML nuclear body scaffold
ISO
PID
PID:200096
NCBI chrNW_004955450:3,654,854...3,692,057
Ensembl chrNW_004955450:3,656,498...3,692,406
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Poldip3
DNA polymerase delta interacting protein 3
ISO
PID
PID:200096
NCBI chrNW_004955413:27,944,109...27,968,156
Ensembl chrNW_004955413:27,943,520...27,968,156
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Ppargc1a
PPARG coactivator 1 alpha
ISO
PID
PID:200096
NCBI chrNW_004955480:543,397...1,188,376
Ensembl chrNW_004955480:1,078,322...1,188,435
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Prkca
protein kinase C alpha
ISO
PID
PID:200096
NCBI chrNW_004955478:5,686,639...6,090,356
Ensembl chrNW_004955478:5,686,640...6,083,967
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Prr5
proline rich 5
ISO
PID RGD
PMID:22500797
PID:200096 RGD:11535033
NCBI chrNW_004955413:29,360,125...29,379,196
Ensembl chrNW_004955413:29,348,303...29,379,659
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Prr5l
proline rich 5 like
ISO
RGD
PMID:22500797
RGD:11535033
NCBI chrNW_004955422:9,972,588...10,069,411
Ensembl chrNW_004955422:9,972,588...10,048,669
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Pxn
paxillin
ISO
PID
PID:200096
NCBI chrNW_004955455:11,387,140...11,401,178
Ensembl chrNW_004955455:11,388,378...11,403,082
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Rac1
Rac family small GTPase 1
ISO
PID
PID:200096
NCBI chrNW_004955460:13,270,159...13,295,562
Ensembl chrNW_004955460:13,270,159...13,311,351
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Raf1
Raf-1 proto-oncogene, serine/threonine kinase
ISO
PID
PID:200096
NCBI chrNW_004955429:17,980,956...18,049,723
Ensembl chrNW_004955429:18,025,932...18,049,723
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Rb1cc1
RB1 inducible coiled-coil 1
ISO
PID
PID:200096
NCBI chrNW_004955454:12,201,566...12,257,383
Ensembl chrNW_004955454:12,200,750...12,257,389
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Rheb
Ras homolog, mTORC1 binding
ISO
RGD PID
PMID:16354680 PMID:16885148 PMID:19339977 PMID:26159692
PID:200096 RGD:11535034 RGD:1625606 RGD:1625616 RGD:2308795
NCBI chrNW_004955491:5,795,040...5,833,897
Ensembl chrNW_004955491:5,794,911...5,834,912
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Rhoa
ras homolog family member A
ISO
PID
PID:200096
NCBI chrNW_004955532:1,300,821...1,347,453
Ensembl chrNW_004955532:1,300,462...1,347,451
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Rictor
RPTOR independent companion of MTOR complex 2
ISO
PID RGD
PMID:16885148 PMID:17110594 PMID:19339977 PMID:22500797
PID:200096 RGD:11535033 RGD:1625616 RGD:2307383 RGD:2308795
NCBI chrNW_004955426:23,468,112...23,582,587
Ensembl chrNW_004955426:23,468,112...23,582,587
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Rps6ka1
ribosomal protein S6 kinase A1
ISO
PID
PID:200096
NCBI chrNW_004955452:5,905,561...5,938,096
Ensembl chrNW_004955452:5,904,762...5,939,091
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Rps6kb1
ribosomal protein S6 kinase B1
ISO
PID RGD
PMID:11574531 PMID:16885148 PMID:19339977
PID:200096 RGD:1625616 RGD:1626103 RGD:2308795
NCBI chrNW_004955451:3,181,085...3,225,610
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Rps6kb2
ribosomal protein S6 kinase B2
ISO
RGD
PMID:11574531 PMID:16885148 PMID:19339977
RGD:1625616 RGD:1626103 RGD:2308795
NCBI chrNW_004955422:18,043,785...18,050,406
Ensembl chrNW_004955422:18,041,729...18,050,406
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Rptor
regulatory associated protein of MTOR complex 1
ISO
PID RGD
PMID:16885148 PMID:17110594 PMID:19339977 PMID:22500797
PID:200096 RGD:11535033 RGD:1625616 RGD:2307383 RGD:2308795
NCBI chrNW_004955506:2,009,422...2,401,775
Ensembl chrNW_004955506:2,008,044...2,401,775
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Rraga
Ras related GTP binding A
ISO
PID RGD
PMID:19339977 PMID:24698685
PID:200096 RGD:11535043 RGD:2308795
NCBI chrNW_004955434:21,509,528...21,510,885
Ensembl chrNW_004955434:21,509,529...21,510,470
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Rragb
Ras related GTP binding B
ISO
PID RGD
PMID:19339977 PMID:24698685
PID:200096 RGD:11535043 RGD:2308795
NCBI chrNW_004955475:2,662,969...2,692,253
Ensembl chrNW_004955475:2,662,868...2,696,364
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Rragc
Ras related GTP binding C
ISO
PID RGD
PMID:19339977 PMID:24698685
PID:200096 RGD:11535043 RGD:2308795
NCBI chrNW_004955452:16,469,426...16,486,336
Ensembl chrNW_004955452:16,466,453...16,486,336
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Rragd
Ras related GTP binding D
ISO
PID RGD
PMID:19339977 PMID:24698685
PID:200096 RGD:11535043 RGD:2308795
NCBI chrNW_004955411:16,111,931...16,155,662
Ensembl chrNW_004955411:16,114,755...16,138,433
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Rrn3
RRN3 homolog, RNA polymerase I transcription factor
ISO
PID
PID:200096
NCBI chrNW_004955442:129,106...166,258
Ensembl chrNW_004955442:129,106...166,258
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Sesn2
sestrin 2
ISO
RGD
PMID:27076075
RGD:11535042
NCBI chrNW_004955452:7,392,644...7,417,204
Ensembl chrNW_004955452:7,393,007...7,417,304
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Sfn
stratifin
ISO
PID
PID:200096
NCBI chrNW_004955452:6,217,519...6,218,481
Ensembl chrNW_004955452:6,217,698...6,218,444
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Sgk1
serum/glucocorticoid regulated kinase 1
ISO
PID
PID:200096
NCBI chrNW_004955439:2,399,992...2,406,587
Ensembl chrNW_004955439:2,290,035...2,406,587
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Slc7a5
solute carrier family 7 member 5
ISO
RGD
PMID:25049270
RGD:151361107
NCBI chrNW_004955541:2,103,437...2,129,668
Ensembl chrNW_004955541:2,103,384...2,130,310
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Srebf1
sterol regulatory element binding transcription factor 1
ISO
PID
PID:200096
NCBI chrNW_004955577:171,425...183,669
Ensembl chrNW_004955577:171,425...186,046
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Sspo
SCO-spondin
ISO
PID
PID:200096
NCBI chrNW_004955491:4,840,657...4,889,060
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Tbc1d7
TBC1 domain family member 7
ISO
RGD
PMID:26159692
RGD:11535034
NCBI chrNW_004955465:1,362,453...1,380,814
Ensembl chrNW_004955465:1,362,759...1,382,190
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Telo2
telomere maintenance 2
ISO
RGD
PMID:22500797
RGD:11535033
NCBI chrNW_004955442:15,719,082...15,733,527
Ensembl chrNW_004955442:15,719,521...15,734,087
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Tsc1
TSC complex subunit 1
ISO
PID RGD
PMID:16885148 PMID:19339977 PMID:26159692
PID:200096 RGD:11535034 RGD:1625616 RGD:2308795
NCBI chrNW_004955513:2,197,037...2,244,992
Ensembl chrNW_004955513:2,197,037...2,244,992
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Tsc2
TSC complex subunit 2
ISO
RGD PID
PMID:12869586 PMID:16885148 PMID:19339977 PMID:26159692
PID:200096 RGD:11535034 RGD:1580520 RGD:1625616 RGD:2308795
NCBI chrNW_004955442:15,178,356...15,216,978
Ensembl chrNW_004955442:15,178,487...15,216,362
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Tti1
TELO2 interacting protein 1
ISO
RGD
PMID:22500797
RGD:11535033
NCBI chrNW_004955445:18,676,285...18,729,512
Ensembl chrNW_004955445:18,675,434...18,729,512
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Ulk1
unc-51 like autophagy activating kinase 1
ISO
PID
PID:200096
NCBI chrNW_004955482:760,200...777,133
Ensembl chrNW_004955482:761,811...777,133
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Ulk2
unc-51 like autophagy activating kinase 2
ISO
PID
PID:200096
NCBI chrNW_004955467:818,975...894,103
Ensembl chrNW_004955467:818,076...894,106
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Wdr24
WD repeat domain 24
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chrNW_004955442:16,513,074...16,519,296
Ensembl chrNW_004955442:16,513,448...16,519,296
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Wdr59
WD repeat domain 59
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chrNW_004955484:2,576,505...2,668,001
Ensembl chrNW_004955484:2,576,208...2,670,324
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Ywhab
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
ISO
PID
PID:200096
NCBI chrNW_004955445:12,451,644...12,474,251
Ensembl chrNW_004955445:12,448,760...12,474,251
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Ywhae
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
ISO
PID
PID:200096
NCBI chrNW_004955481:1,752,778...1,805,700
Ensembl chrNW_004955481:1,752,778...1,808,583
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Ywhag
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
ISO
PID
PID:200096
NCBI chrNW_004955456:14,939,130...14,970,248
Ensembl chrNW_004955456:14,939,084...14,970,248
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Ywhah
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
ISO
PID
PID:200096
NCBI chrNW_004955455:6,045,919...6,057,729
Ensembl chrNW_004955455:6,045,919...6,057,729
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Ywhaq
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
ISO
PID
PID:200096
NCBI chrNW_004955487:5,229,485...5,263,749
Ensembl chrNW_004955487:5,230,506...5,263,752
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Ywhaz
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
ISO
PID
PID:200096
NCBI chrNW_004955417:16,047,263...16,070,506
Ensembl chrNW_004955417:16,047,263...16,072,854
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Yy1
YY1 transcription factor
ISO
PID
PID:200096
NCBI chrNW_004955438:21,341,374...21,377,674
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all