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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:mTOR signaling pathway
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Accession:PW:0000180 term browser browse the term
Definition:The mTOR signaling pathway regulates cellular processes such as translation, ribosome biogenesis, cell growth and autophagy and is regulated by or responds to growth factors, energy metabolites and/or levels of nutrients.
Synonyms:related_synonym: MTOR signalling;   TOR signaling

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mTOR signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 ISO PID PID:200096 NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756
JBrowse link
G AKT1S1 AKT1 substrate 1 ISO PID
RGD
PMID:19339977 PMID:22500797 PID:200096 RGD:11535033 RGD:2308795 NCBI chr19:46,882,073...46,890,404
Ensembl chr19:55,797,927...55,806,256
JBrowse link
G ATG13 autophagy related 13 ISO PID PID:200096 NCBI chr11:46,567,728...46,623,609
Ensembl chr11:47,126,380...47,182,850
JBrowse link
G BNIP3 BCL2 interacting protein 3 ISO PID PID:200096 NCBI chr10:128,671,663...128,685,952
Ensembl chr10:132,858,211...132,871,634
JBrowse link
G BRAF B-Raf proto-oncogene, serine/threonine kinase ISO PID PID:200096 NCBI chr 7:132,651,908...132,855,422
Ensembl chr 7:145,138,510...145,327,115
JBrowse link
G CASTOR1 cytosolic arginine sensor for mTORC1 subunit 1 ISO RGD PMID:27015302 RGD:11535047 NCBI chr22:11,321,259...11,325,787
Ensembl chr22:29,123,198...29,127,736
JBrowse link
G CASTOR2 cytosolic arginine sensor for mTORC1 subunit 2 ISO RGD PMID:27015302 RGD:11535047 Ensembl chr 7:82,068,521...82,075,387 JBrowse link
G CCNE1 cyclin E1 ISO PID PID:200096 NCBI chr19:26,739,285...26,751,630
Ensembl chr19:35,496,700...35,510,295
JBrowse link
G CDK2 cyclin dependent kinase 2 ISO PID PID:200096 NCBI chr12:32,940,225...32,946,236
Ensembl chr12:33,189,934...33,195,945
JBrowse link
G CLIP1 CAP-Gly domain containing linker protein 1 ISO PID PID:200096 NCBI chr12:119,873,105...120,024,222
Ensembl chr12:123,242,489...123,348,540
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 ISO RGD PMID:26078356 RGD:11526468 NCBI chr 4:50,452,857...50,456,015
Ensembl chr 4:56,286,708...56,288,083
JBrowse link
G DDIT4 DNA damage inducible transcript 4 ISO PID PID:200096 NCBI chr10:68,796,712...68,798,840
Ensembl chr10:71,264,029...71,266,149
JBrowse link
G DEPDC5 DEP domain containing 5, GATOR1 subcomplex subunit ISO RGD PMID:24698685 RGD:11535043 NCBI chr22:12,774,147...12,929,261
Ensembl chr22:30,630,110...30,781,578
JBrowse link
G DEPTOR DEP domain containing MTOR interacting protein ISO PID
RGD
PMID:22500797 PID:200096 RGD:11535033 NCBI chr 8:116,563,935...116,743,843
Ensembl chr 8:119,311,942...119,492,127
JBrowse link
G EEF2 eukaryotic translation elongation factor 2 ISO PID PID:200096 NCBI chr19:3,000,608...3,009,918
Ensembl chr19:3,950,772...3,960,172
JBrowse link
G EEF2K eukaryotic elongation factor 2 kinase ISO PID PID:200096 NCBI chr16:16,443,579...16,526,061
Ensembl chr16:22,537,518...22,596,091
JBrowse link
G EIF4A1 eukaryotic translation initiation factor 4A1 ISO PID PID:200096 NCBI chr17:7,604,331...7,610,302
Ensembl chr17:7,590,569...7,596,876
JBrowse link
G EIF4B eukaryotic translation initiation factor 4B ISO PID PID:200096 NCBI chr12:35,714,260...35,749,991
Ensembl chr12:36,497,099...36,530,331
JBrowse link
G EIF4E eukaryotic translation initiation factor 4E ISO PID PID:200096 NCBI chr 4:91,268,463...91,329,800
Ensembl chr 4:101,941,142...101,994,809
JBrowse link
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 ISO PID
RGD
PMID:16885148 PMID:19339977 PID:200096 RGD:1625616 RGD:2308795 NCBI chr 8:37,336,698...37,362,768
Ensembl chr 8:34,513,359...34,538,936
JBrowse link
G FBXW11 F-box and WD repeat domain containing 11 ISO PID PID:200096 NCBI chr 5:167,207,643...167,354,730
Ensembl chr 5:174,124,499...174,271,977
JBrowse link
G FKBP1A FKBP prolyl isomerase 1A ISO RGD PMID:22500797 RGD:11535033 NCBI chr20:1,519,330...1,548,473 JBrowse link
G FLCN folliculin ISO RGD PMID:27076075 RGD:11535042 NCBI chr17:34,057,127...34,081,637
Ensembl chr17:38,988,518...39,013,160
JBrowse link
G FNIP1 folliculin interacting protein 1 ISO RGD PMID:27076075 RGD:11535042 NCBI chr 5:127,070,906...127,219,548
Ensembl chr 5:133,235,501...133,384,218
JBrowse link
G FNIP2 folliculin interacting protein 2 ISO RGD PMID:27076075 RGD:11535042 NCBI chr 4:151,086,854...151,224,192
Ensembl chr 4:162,896,805...163,032,167
JBrowse link
G HRAS HRas proto-oncogene, GTPase ISO PID PID:200096 NCBI chr11:537,488...540,810
Ensembl chr11:568,305...571,078
JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta ISO PID PID:200096 NCBI chr 8:41,515,613...41,576,229
Ensembl chr 8:38,960,594...39,020,971
JBrowse link
G IRS1 insulin receptor substrate 1 ISO PID PID:200096 NCBI chr2B:113,973,191...114,041,127
Ensembl chr2B:232,849,239...232,852,967
JBrowse link
G LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 ISO RGD PMID:24698685 RGD:11535043 NCBI chr11:67,177,580...67,183,631
Ensembl chr11:70,390,141...70,407,246
JBrowse link
G LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 ISO RGD PMID:24698685 RGD:11535043 NCBI chr 1:131,396,937...131,400,695
Ensembl chr 1:135,226,400...135,230,167
JBrowse link
G LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 ISO RGD PMID:24698685 RGD:11535043 NCBI chr 4:92,304,115...92,317,461
Ensembl chr 4:102,965,111...102,978,205
JBrowse link
G LAMTOR4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 ISO RGD PMID:24698685 RGD:11535043 NCBI chr 7:92,183,617...92,188,967
Ensembl chr 7:105,616,074...105,621,685
JBrowse link
G LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 ISO RGD PMID:24698685 RGD:11535043 NCBI chr 1:113,050,671...113,057,368
Ensembl chr 1:127,285,553...127,292,233
JBrowse link
G LOC100986481 cytochrome c ISO PID PID:200096 NCBI chr 7:25,784,900...25,791,598
Ensembl chr 7:25,396,013...25,398,549
JBrowse link
G LPIN1 lipin 1 ISO RGD PMID:11792863 RGD:1641823 NCBI chr2A:11,664,727...11,815,497
Ensembl chr2A:11,857,961...11,961,551
JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 ISO PID PID:200096 NCBI chr15:45,337,117...45,438,826
Ensembl chr15:63,613,961...63,714,161
JBrowse link
G MAP2K2 mitogen-activated protein kinase kinase 2 ISO PID PID:200096 NCBI chr19:3,114,445...3,148,619
Ensembl chr19:4,064,626...4,097,933
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 ISO PID PID:200096 NCBI chr22:3,883,119...3,990,368
Ensembl chr22:20,365,487...20,450,335
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 ISO PID PID:200096 Ensembl chr16:30,489,362...30,498,017 JBrowse link
G MAPKAP1 MAPK associated protein 1 ISO PID
RGD
PMID:19339977 PMID:22500797 PID:200096 RGD:11535033 RGD:2308795 NCBI chr 9:96,561,157...96,825,478
Ensembl chr 9:125,072,137...125,336,658
JBrowse link
G MIOS meiosis regulator for oocyte development ISO RGD PMID:24698685 RGD:11535043 NCBI chr 7:8,291,307...8,346,822
Ensembl chr 7:7,643,780...7,684,246
JBrowse link
G MLST8 MTOR associated protein, LST8 homolog ISO PID
RGD
PMID:12718876 PMID:19339977 PMID:22500797 PID:200096 RGD:11535033 RGD:1626104 RGD:2308795 NCBI chr16:1,063,534...1,067,706
Ensembl chr16:2,306,451...2,310,828
JBrowse link
G MTOR mechanistic target of rapamycin kinase ISO PID
RGD
PMID:16885148 PMID:17110594 PMID:17142137 PMID:19339977 PMID:22500797 PID:200096 RGD:11535033 RGD:1625611 RGD:1625616 RGD:2307383 RGD:2308795 NCBI chr 1:9,871,700...10,028,704
Ensembl chr 1:11,093,765...11,249,841
JBrowse link
G NPRL2 NPR2 like, GATOR1 complex subunit ISO RGD PMID:24698685 RGD:11535043 NCBI chr 3:50,273,611...50,277,175
Ensembl chr 3:51,508,932...51,512,776
JBrowse link
G NPRL3 NPR3 like, GATOR1 complex subunit ISO RGD PMID:24698685 RGD:11535043 Ensembl chr16:75,187...129,220 JBrowse link
G NRAS NRAS proto-oncogene, GTPase ISO PID PID:200096 NCBI chr 1:87,837,146...87,850,013
Ensembl chr 1:122,890,505...122,903,585
JBrowse link
G PDCD4 programmed cell death 4 ISO PID PID:200096 NCBI chr10:107,465,084...107,493,285
Ensembl chr10:110,914,222...110,942,394
JBrowse link
G PDPK1 3-phosphoinositide dependent protein kinase 1 ISO PID PID:200096 NCBI chr16:1,394,447...1,463,735 JBrowse link
G PLD1 phospholipase D1 ISO PID PID:200096 NCBI chr 3:168,606,342...168,816,383
Ensembl chr 3:176,790,753...176,961,033
JBrowse link
G PLD2 phospholipase D2 ISO PID PID:200096 NCBI chr17:4,853,919...4,870,254
Ensembl chr17:4,843,217...4,858,425
JBrowse link
G PML PML nuclear body scaffold ISO PID PID:200096 NCBI chr15:52,903,874...52,955,151
Ensembl chr15:71,658,884...71,710,883
JBrowse link
G POLDIP3 DNA polymerase delta interacting protein 3 ISO PID PID:200096 NCBI chr22:23,478,786...23,510,074
Ensembl chr22:41,631,447...41,662,899
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha ISO PID PID:200096 NCBI chr 4:18,196,431...18,876,889
Ensembl chr 4:23,483,377...23,581,212
JBrowse link
G PRKCA protein kinase C alpha ISO PID PID:200096 NCBI chr17:60,246,485...60,747,158
Ensembl chr17:65,454,907...65,947,903
JBrowse link
G PRR5 proline rich 5 ISO RGD
PID
PMID:22500797 PID:200096 RGD:11535033 Ensembl chr22:43,760,203...43,820,836 JBrowse link
G PRR5L proline rich 5 like ISO RGD PMID:22500797 RGD:11535033 NCBI chr11:36,269,291...36,438,954
Ensembl chr11:36,223,385...36,311,659
JBrowse link
G PXN paxillin ISO PID PID:200096 NCBI chr12:117,785,614...117,840,816
Ensembl chr12:121,160,295...121,176,667
JBrowse link
G RAC1 Rac family small GTPase 1 ISO PID PID:200096 NCBI chr 7:7,039,379...7,068,866 JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase ISO PID PID:200096 NCBI chr 3:12,510,084...12,590,598
Ensembl chr 3:12,853,415...12,932,871
JBrowse link
G RB1CC1 RB1 inducible coiled-coil 1 ISO PID PID:200096 NCBI chr 8:49,046,830...49,138,795
Ensembl chr 8:46,430,131...46,521,722
JBrowse link
G RHEB Ras homolog, mTORC1 binding ISO PID
RGD
PMID:16354680 PMID:16885148 PMID:19339977 PMID:26159692 PID:200096 RGD:11535034 RGD:1625606 RGD:1625616 RGD:2308795 NCBI chr 7:143,054,747...143,108,011 JBrowse link
G RHOA ras homolog family member A ISO PID PID:200096 NCBI chr 3:49,282,009...49,339,887 JBrowse link
G RICTOR RPTOR independent companion of MTOR complex 2 ISO PID
RGD
PMID:16885148 PMID:17110594 PMID:19339977 PMID:22500797 PID:200096 RGD:11535033 RGD:1625616 RGD:2307383 RGD:2308795 NCBI chr 5:71,299,215...71,435,290
Ensembl chr 5:76,389,130...76,469,830
JBrowse link
G RPS6KA1 ribosomal protein S6 kinase A1 ISO PID PID:200096 NCBI chr 1:25,792,428...25,837,950
Ensembl chr 1:26,856,057...26,900,532
JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 ISO PID
RGD
PMID:11574531 PMID:16885148 PMID:19339977 PID:200096 RGD:1625616 RGD:1626103 RGD:2308795 NCBI chr17:53,958,807...54,014,752
Ensembl chr17:58,799,069...58,853,653
JBrowse link
G RPS6KB2 ribosomal protein S6 kinase B2 ISO RGD PMID:11574531 PMID:16885148 PMID:19339977 RGD:1625616 RGD:1626103 RGD:2308795 NCBI chr11:62,786,866...62,793,826
Ensembl chr11:66,099,553...66,105,967
JBrowse link
G RPTOR regulatory associated protein of MTOR complex 1 ISO RGD
PID
PMID:16885148 PMID:17110594 PMID:19339977 PMID:22500797 PID:200096 RGD:11535033 RGD:1625616 RGD:2307383 RGD:2308795 NCBI chr17:74,973,420...75,389,339
Ensembl chr17:80,705,544...81,118,708
JBrowse link
G RRAGA Ras related GTP binding A ISO PID
RGD
PMID:19339977 PMID:24698685 PID:200096 RGD:11535043 RGD:2308795 NCBI chr 9:18,868,781...18,870,356
Ensembl chr 9:19,362,599...19,363,540
JBrowse link
G RRAGB Ras related GTP binding B ISO PID
RGD
PMID:19339977 PMID:24698685 PID:200096 RGD:11535043 RGD:2308795 NCBI chr  X:48,003,566...48,042,285
Ensembl chr  X:56,155,662...56,194,335
JBrowse link
G RRAGC Ras related GTP binding C ISO PID
RGD
PMID:19339977 PMID:24698685 PID:200096 RGD:11535043 RGD:2308795 NCBI chr 1:38,110,578...38,132,179
Ensembl chr 1:39,456,768...39,478,244
JBrowse link
G RRAGD Ras related GTP binding D ISO PID
RGD
PMID:19339977 PMID:24698685 PID:200096 RGD:11535043 RGD:2308795 NCBI chr 6:87,237,442...87,285,579
Ensembl chr 6:90,511,250...90,558,822
JBrowse link
G RRN3 RRN3 homolog, RNA polymerase I transcription factor ISO PID PID:200096 NCBI chr16:13,664,478...13,700,942 JBrowse link
G SESN2 sestrin 2 ISO RGD PMID:27076075 RGD:11535042 NCBI chr 1:27,518,248...27,541,264
Ensembl chr 1:28,555,072...28,577,931
JBrowse link
G SFN stratifin ISO PID PID:200096 NCBI chr 1:26,126,212...26,127,761
Ensembl chr 1:27,182,834...27,183,580
JBrowse link
G SGK1 serum/glucocorticoid regulated kinase 1 ISO PID PID:200096 NCBI chr 6:131,936,397...132,082,670
Ensembl chr 6:136,033,851...136,180,121
JBrowse link
G SLC7A5 solute carrier family 7 member 5 ISO RGD PMID:25049270 RGD:151361107 NCBI chr16:68,512,407...68,552,763 JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 ISO PID PID:200096 NCBI chr17:33,458,196...33,484,643
Ensembl chr17:38,405,794...38,432,045
JBrowse link
G SSPOP SCO-spondin, pseudogene ISO PID PID:200096 NCBI chr 7:141,477,578...141,537,109 JBrowse link
G TBC1D7 TBC1 domain family member 7 ISO RGD PMID:26159692 RGD:11535034 NCBI chr 6:13,150,677...13,174,661
Ensembl chr 6:13,491,734...13,546,853
JBrowse link
G TELO2 telomere maintenance 2 ISO RGD PMID:22500797 RGD:11535033 NCBI chr16:112,856...130,175
Ensembl chr16:1,548,212...1,566,337
JBrowse link
G TSC1 TSC complex subunit 1 ISO PID
RGD
PMID:16885148 PMID:19339977 PMID:26159692 PID:200096 RGD:11535034 RGD:1625616 RGD:2308795 NCBI chr 9:104,007,708...104,060,938
Ensembl chr 9:132,638,003...132,675,759
JBrowse link
G TSC2 TSC complex subunit 2 ISO RGD
PID
PMID:12869586 PMID:16885148 PMID:19339977 PMID:26159692 PID:200096 RGD:11535034 RGD:1580520 RGD:1625616 RGD:2308795 NCBI chr16:615,776...655,411
Ensembl chr16:2,135,696...2,175,569
JBrowse link
G TTI1 TELO2 interacting protein 1 ISO RGD PMID:22500797 RGD:11535033 NCBI chr20:34,304,137...34,354,615
Ensembl chr20:35,417,502...35,467,918
JBrowse link
G ULK1 unc-51 like autophagy activating kinase 1 ISO PID PID:200096 NCBI chr12:129,549,399...129,579,087 JBrowse link
G ULK2 unc-51 like autophagy activating kinase 2 ISO PID PID:200096 NCBI chr17:31,262,168...31,362,251
Ensembl chr17:36,409,312...36,507,786
JBrowse link
G WDR24 WD repeat domain 24 ISO RGD PMID:24698685 RGD:11535043 Ensembl chr16:699,142...704,869 JBrowse link
G WDR59 WD repeat domain 59 ISO RGD PMID:24698685 RGD:11535043 NCBI chr16:55,438,945...55,553,937
Ensembl chr16:74,792,207...74,905,582
JBrowse link
G YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta ISO PID PID:200096 NCBI chr20:41,216,071...41,238,893
Ensembl chr20:42,309,155...42,331,695
JBrowse link
G YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon ISO PID PID:200096 NCBI chr17:1,332,004...1,387,120
Ensembl chr17:1,229,080...1,285,470
JBrowse link
G YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma ISO PID PID:200096 NCBI chr 7:67,661,589...67,693,814 JBrowse link
G YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta ISO PID PID:200096 NCBI chr22:12,966,653...12,979,695
Ensembl chr22:30,819,821...30,831,804
JBrowse link
G YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta ISO PID PID:200096 NCBI chr2A:9,573,413...9,620,495 JBrowse link
G YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta ISO PID PID:200096 NCBI chr 8:97,560,251...97,595,117
Ensembl chr 8:99,730,393...99,762,990
JBrowse link
G YY1 YY1 transcription factor ISO PID PID:200096 NCBI chr14:80,859,491...80,903,651 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4064
    regulatory pathway 2507
      pathway pertinent to DNA replication and repair, cell cycle, maintenance of genomic integrity, RNA and protein biosynthesis 1338
        mTOR signaling pathway 94
          altered mTOR signaling pathway 0
Path 2
Term Annotations click to browse term
  pathway 4064
    regulatory pathway 2507
      homeostasis pathway 1306
        energy homeostasis pathway 234
          mTOR signaling pathway 94
            altered mTOR signaling pathway 0
paths to the root