PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: mTOR signaling pathway
Accession: PW:0000180
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Definition: The mTOR signaling pathway regulates cellular processes such as translation, ribosome biogenesis, cell growth and autophagy and is regulated by or responds to growth factors, energy metabolites and/or levels of nutrients.
Synonyms: related_synonym: MTOR signalling; TOR signaling
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AKT1
AKT serine/threonine kinase 1
ISO
PID
PID:200096
NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756
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AKT1S1
AKT1 substrate 1
ISO
PID RGD
PMID:19339977 PMID:22500797
PID:200096 RGD:11535033 RGD:2308795
NCBI chr19:46,882,073...46,890,404
Ensembl chr19:55,797,927...55,806,256
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ATG13
autophagy related 13
ISO
PID
PID:200096
NCBI chr11:46,567,728...46,623,609
Ensembl chr11:47,126,380...47,182,850
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BNIP3
BCL2 interacting protein 3
ISO
PID
PID:200096
NCBI chr10:128,671,663...128,685,952
Ensembl chr10:132,858,211...132,871,634
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BRAF
B-Raf proto-oncogene, serine/threonine kinase
ISO
PID
PID:200096
NCBI chr 7:132,651,908...132,855,422
Ensembl chr 7:145,138,510...145,327,115
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CASTOR1
cytosolic arginine sensor for mTORC1 subunit 1
ISO
RGD
PMID:27015302
RGD:11535047
NCBI chr22:11,321,259...11,325,787
Ensembl chr22:29,123,198...29,127,736
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CASTOR2
cytosolic arginine sensor for mTORC1 subunit 2
ISO
RGD
PMID:27015302
RGD:11535047
Ensembl chr 7:82,068,521...82,075,387
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CCNE1
cyclin E1
ISO
PID
PID:200096
NCBI chr19:26,739,285...26,751,630
Ensembl chr19:35,496,700...35,510,295
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CDK2
cyclin dependent kinase 2
ISO
PID
PID:200096
NCBI chr12:32,940,225...32,946,236
Ensembl chr12:33,189,934...33,195,945
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CLIP1
CAP-Gly domain containing linker protein 1
ISO
PID
PID:200096
NCBI chr12:119,873,105...120,024,222
Ensembl chr12:123,242,489...123,348,540
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CXCL8
C-X-C motif chemokine ligand 8
ISO
RGD
PMID:26078356
RGD:11526468
NCBI chr 4:50,452,857...50,456,015
Ensembl chr 4:56,286,708...56,288,083
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DDIT4
DNA damage inducible transcript 4
ISO
PID
PID:200096
NCBI chr10:68,796,712...68,798,840
Ensembl chr10:71,264,029...71,266,149
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DEPDC5
DEP domain containing 5, GATOR1 subcomplex subunit
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chr22:12,774,147...12,929,261
Ensembl chr22:30,630,110...30,781,578
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DEPTOR
DEP domain containing MTOR interacting protein
ISO
PID RGD
PMID:22500797
PID:200096 RGD:11535033
NCBI chr 8:116,563,935...116,743,843
Ensembl chr 8:119,311,942...119,492,127
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EEF2
eukaryotic translation elongation factor 2
ISO
PID
PID:200096
NCBI chr19:3,000,608...3,009,918
Ensembl chr19:3,950,772...3,960,172
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EEF2K
eukaryotic elongation factor 2 kinase
ISO
PID
PID:200096
NCBI chr16:16,443,579...16,526,061
Ensembl chr16:22,537,518...22,596,091
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EIF4A1
eukaryotic translation initiation factor 4A1
ISO
PID
PID:200096
NCBI chr17:7,604,331...7,610,302
Ensembl chr17:7,590,569...7,596,876
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EIF4B
eukaryotic translation initiation factor 4B
ISO
PID
PID:200096
NCBI chr12:35,714,260...35,749,991
Ensembl chr12:36,497,099...36,530,331
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EIF4E
eukaryotic translation initiation factor 4E
ISO
PID
PID:200096
NCBI chr 4:91,268,463...91,329,800
Ensembl chr 4:101,941,142...101,994,809
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EIF4EBP1
eukaryotic translation initiation factor 4E binding protein 1
ISO
PID RGD
PMID:16885148 PMID:19339977
PID:200096 RGD:1625616 RGD:2308795
NCBI chr 8:37,336,698...37,362,768
Ensembl chr 8:34,513,359...34,538,936
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FBXW11
F-box and WD repeat domain containing 11
ISO
PID
PID:200096
NCBI chr 5:167,207,643...167,354,730
Ensembl chr 5:174,124,499...174,271,977
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FKBP1A
FKBP prolyl isomerase 1A
ISO
RGD
PMID:22500797
RGD:11535033
NCBI chr20:1,519,330...1,548,473
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FLCN
folliculin
ISO
RGD
PMID:27076075
RGD:11535042
NCBI chr17:34,057,127...34,081,637
Ensembl chr17:38,988,518...39,013,160
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FNIP1
folliculin interacting protein 1
ISO
RGD
PMID:27076075
RGD:11535042
NCBI chr 5:127,070,906...127,219,548
Ensembl chr 5:133,235,501...133,384,218
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FNIP2
folliculin interacting protein 2
ISO
RGD
PMID:27076075
RGD:11535042
NCBI chr 4:151,086,854...151,224,192
Ensembl chr 4:162,896,805...163,032,167
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HRAS
HRas proto-oncogene, GTPase
ISO
PID
PID:200096
NCBI chr11:537,488...540,810
Ensembl chr11:568,305...571,078
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IKBKB
inhibitor of nuclear factor kappa B kinase subunit beta
ISO
PID
PID:200096
NCBI chr 8:41,515,613...41,576,229
Ensembl chr 8:38,960,594...39,020,971
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IRS1
insulin receptor substrate 1
ISO
PID
PID:200096
NCBI chr2B:113,973,191...114,041,127
Ensembl chr2B:232,849,239...232,852,967
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LAMTOR1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chr11:67,177,580...67,183,631
Ensembl chr11:70,390,141...70,407,246
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LAMTOR2
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chr 1:131,396,937...131,400,695
Ensembl chr 1:135,226,400...135,230,167
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LAMTOR3
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chr 4:92,304,115...92,317,461
Ensembl chr 4:102,965,111...102,978,205
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LAMTOR4
late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chr 7:92,183,617...92,188,967
Ensembl chr 7:105,616,074...105,621,685
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LAMTOR5
late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chr 1:113,050,671...113,057,368
Ensembl chr 1:127,285,553...127,292,233
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LOC100986481
cytochrome c
ISO
PID
PID:200096
NCBI chr 7:25,784,900...25,791,598
Ensembl chr 7:25,396,013...25,398,549
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LPIN1
lipin 1
ISO
RGD
PMID:11792863
RGD:1641823
NCBI chr2A:11,664,727...11,815,497
Ensembl chr2A:11,857,961...11,961,551
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MAP2K1
mitogen-activated protein kinase kinase 1
ISO
PID
PID:200096
NCBI chr15:45,337,117...45,438,826
Ensembl chr15:63,613,961...63,714,161
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MAP2K2
mitogen-activated protein kinase kinase 2
ISO
PID
PID:200096
NCBI chr19:3,114,445...3,148,619
Ensembl chr19:4,064,626...4,097,933
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MAPK1
mitogen-activated protein kinase 1
ISO
PID
PID:200096
NCBI chr22:3,883,119...3,990,368
Ensembl chr22:20,365,487...20,450,335
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MAPK3
mitogen-activated protein kinase 3
ISO
PID
PID:200096
Ensembl chr16:30,489,362...30,498,017
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MAPKAP1
MAPK associated protein 1
ISO
PID RGD
PMID:19339977 PMID:22500797
PID:200096 RGD:11535033 RGD:2308795
NCBI chr 9:96,561,157...96,825,478
Ensembl chr 9:125,072,137...125,336,658
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MIOS
meiosis regulator for oocyte development
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chr 7:8,291,307...8,346,822
Ensembl chr 7:7,643,780...7,684,246
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MLST8
MTOR associated protein, LST8 homolog
ISO
PID RGD
PMID:12718876 PMID:19339977 PMID:22500797
PID:200096 RGD:11535033 RGD:1626104 RGD:2308795
NCBI chr16:1,063,534...1,067,706
Ensembl chr16:2,306,451...2,310,828
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MTOR
mechanistic target of rapamycin kinase
ISO
PID RGD
PMID:16885148 PMID:17110594 PMID:17142137 PMID:19339977 PMID:22500797
PID:200096 RGD:11535033 RGD:1625611 RGD:1625616 RGD:2307383 RGD:2308795
NCBI chr 1:9,871,700...10,028,704
Ensembl chr 1:11,093,765...11,249,841
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NPRL2
NPR2 like, GATOR1 complex subunit
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chr 3:50,273,611...50,277,175
Ensembl chr 3:51,508,932...51,512,776
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NPRL3
NPR3 like, GATOR1 complex subunit
ISO
RGD
PMID:24698685
RGD:11535043
Ensembl chr16:75,187...129,220
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NRAS
NRAS proto-oncogene, GTPase
ISO
PID
PID:200096
NCBI chr 1:87,837,146...87,850,013
Ensembl chr 1:122,890,505...122,903,585
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PDCD4
programmed cell death 4
ISO
PID
PID:200096
NCBI chr10:107,465,084...107,493,285
Ensembl chr10:110,914,222...110,942,394
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PDPK1
3-phosphoinositide dependent protein kinase 1
ISO
PID
PID:200096
NCBI chr16:1,394,447...1,463,735
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PLD1
phospholipase D1
ISO
PID
PID:200096
NCBI chr 3:168,606,342...168,816,383
Ensembl chr 3:176,790,753...176,961,033
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PLD2
phospholipase D2
ISO
PID
PID:200096
NCBI chr17:4,853,919...4,870,254
Ensembl chr17:4,843,217...4,858,425
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PML
PML nuclear body scaffold
ISO
PID
PID:200096
NCBI chr15:52,903,874...52,955,151
Ensembl chr15:71,658,884...71,710,883
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POLDIP3
DNA polymerase delta interacting protein 3
ISO
PID
PID:200096
NCBI chr22:23,478,786...23,510,074
Ensembl chr22:41,631,447...41,662,899
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PPARGC1A
PPARG coactivator 1 alpha
ISO
PID
PID:200096
NCBI chr 4:18,196,431...18,876,889
Ensembl chr 4:23,483,377...23,581,212
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PRKCA
protein kinase C alpha
ISO
PID
PID:200096
NCBI chr17:60,246,485...60,747,158
Ensembl chr17:65,454,907...65,947,903
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PRR5
proline rich 5
ISO
RGD PID
PMID:22500797
PID:200096 RGD:11535033
Ensembl chr22:43,760,203...43,820,836
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PRR5L
proline rich 5 like
ISO
RGD
PMID:22500797
RGD:11535033
NCBI chr11:36,269,291...36,438,954
Ensembl chr11:36,223,385...36,311,659
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PXN
paxillin
ISO
PID
PID:200096
NCBI chr12:117,785,614...117,840,816
Ensembl chr12:121,160,295...121,176,667
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RAC1
Rac family small GTPase 1
ISO
PID
PID:200096
NCBI chr 7:7,039,379...7,068,866
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RAF1
Raf-1 proto-oncogene, serine/threonine kinase
ISO
PID
PID:200096
NCBI chr 3:12,510,084...12,590,598
Ensembl chr 3:12,853,415...12,932,871
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RB1CC1
RB1 inducible coiled-coil 1
ISO
PID
PID:200096
NCBI chr 8:49,046,830...49,138,795
Ensembl chr 8:46,430,131...46,521,722
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RHEB
Ras homolog, mTORC1 binding
ISO
PID RGD
PMID:16354680 PMID:16885148 PMID:19339977 PMID:26159692
PID:200096 RGD:11535034 RGD:1625606 RGD:1625616 RGD:2308795
NCBI chr 7:143,054,747...143,108,011
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RHOA
ras homolog family member A
ISO
PID
PID:200096
NCBI chr 3:49,282,009...49,339,887
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RICTOR
RPTOR independent companion of MTOR complex 2
ISO
PID RGD
PMID:16885148 PMID:17110594 PMID:19339977 PMID:22500797
PID:200096 RGD:11535033 RGD:1625616 RGD:2307383 RGD:2308795
NCBI chr 5:71,299,215...71,435,290
Ensembl chr 5:76,389,130...76,469,830
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RPS6KA1
ribosomal protein S6 kinase A1
ISO
PID
PID:200096
NCBI chr 1:25,792,428...25,837,950
Ensembl chr 1:26,856,057...26,900,532
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RPS6KB1
ribosomal protein S6 kinase B1
ISO
PID RGD
PMID:11574531 PMID:16885148 PMID:19339977
PID:200096 RGD:1625616 RGD:1626103 RGD:2308795
NCBI chr17:53,958,807...54,014,752
Ensembl chr17:58,799,069...58,853,653
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RPS6KB2
ribosomal protein S6 kinase B2
ISO
RGD
PMID:11574531 PMID:16885148 PMID:19339977
RGD:1625616 RGD:1626103 RGD:2308795
NCBI chr11:62,786,866...62,793,826
Ensembl chr11:66,099,553...66,105,967
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RPTOR
regulatory associated protein of MTOR complex 1
ISO
RGD PID
PMID:16885148 PMID:17110594 PMID:19339977 PMID:22500797
PID:200096 RGD:11535033 RGD:1625616 RGD:2307383 RGD:2308795
NCBI chr17:74,973,420...75,389,339
Ensembl chr17:80,705,544...81,118,708
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RRAGA
Ras related GTP binding A
ISO
PID RGD
PMID:19339977 PMID:24698685
PID:200096 RGD:11535043 RGD:2308795
NCBI chr 9:18,868,781...18,870,356
Ensembl chr 9:19,362,599...19,363,540
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RRAGB
Ras related GTP binding B
ISO
PID RGD
PMID:19339977 PMID:24698685
PID:200096 RGD:11535043 RGD:2308795
NCBI chr X:48,003,566...48,042,285
Ensembl chr X:56,155,662...56,194,335
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RRAGC
Ras related GTP binding C
ISO
PID RGD
PMID:19339977 PMID:24698685
PID:200096 RGD:11535043 RGD:2308795
NCBI chr 1:38,110,578...38,132,179
Ensembl chr 1:39,456,768...39,478,244
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RRAGD
Ras related GTP binding D
ISO
PID RGD
PMID:19339977 PMID:24698685
PID:200096 RGD:11535043 RGD:2308795
NCBI chr 6:87,237,442...87,285,579
Ensembl chr 6:90,511,250...90,558,822
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RRN3
RRN3 homolog, RNA polymerase I transcription factor
ISO
PID
PID:200096
NCBI chr16:13,664,478...13,700,942
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SESN2
sestrin 2
ISO
RGD
PMID:27076075
RGD:11535042
NCBI chr 1:27,518,248...27,541,264
Ensembl chr 1:28,555,072...28,577,931
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SFN
stratifin
ISO
PID
PID:200096
NCBI chr 1:26,126,212...26,127,761
Ensembl chr 1:27,182,834...27,183,580
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SGK1
serum/glucocorticoid regulated kinase 1
ISO
PID
PID:200096
NCBI chr 6:131,936,397...132,082,670
Ensembl chr 6:136,033,851...136,180,121
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SLC7A5
solute carrier family 7 member 5
ISO
RGD
PMID:25049270
RGD:151361107
NCBI chr16:68,512,407...68,552,763
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SREBF1
sterol regulatory element binding transcription factor 1
ISO
PID
PID:200096
NCBI chr17:33,458,196...33,484,643
Ensembl chr17:38,405,794...38,432,045
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SSPOP
SCO-spondin, pseudogene
ISO
PID
PID:200096
NCBI chr 7:141,477,578...141,537,109
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TBC1D7
TBC1 domain family member 7
ISO
RGD
PMID:26159692
RGD:11535034
NCBI chr 6:13,150,677...13,174,661
Ensembl chr 6:13,491,734...13,546,853
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TELO2
telomere maintenance 2
ISO
RGD
PMID:22500797
RGD:11535033
NCBI chr16:112,856...130,175
Ensembl chr16:1,548,212...1,566,337
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TSC1
TSC complex subunit 1
ISO
PID RGD
PMID:16885148 PMID:19339977 PMID:26159692
PID:200096 RGD:11535034 RGD:1625616 RGD:2308795
NCBI chr 9:104,007,708...104,060,938
Ensembl chr 9:132,638,003...132,675,759
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TSC2
TSC complex subunit 2
ISO
RGD PID
PMID:12869586 PMID:16885148 PMID:19339977 PMID:26159692
PID:200096 RGD:11535034 RGD:1580520 RGD:1625616 RGD:2308795
NCBI chr16:615,776...655,411
Ensembl chr16:2,135,696...2,175,569
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TTI1
TELO2 interacting protein 1
ISO
RGD
PMID:22500797
RGD:11535033
NCBI chr20:34,304,137...34,354,615
Ensembl chr20:35,417,502...35,467,918
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ULK1
unc-51 like autophagy activating kinase 1
ISO
PID
PID:200096
NCBI chr12:129,549,399...129,579,087
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ULK2
unc-51 like autophagy activating kinase 2
ISO
PID
PID:200096
NCBI chr17:31,262,168...31,362,251
Ensembl chr17:36,409,312...36,507,786
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WDR24
WD repeat domain 24
ISO
RGD
PMID:24698685
RGD:11535043
Ensembl chr16:699,142...704,869
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WDR59
WD repeat domain 59
ISO
RGD
PMID:24698685
RGD:11535043
NCBI chr16:55,438,945...55,553,937
Ensembl chr16:74,792,207...74,905,582
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YWHAB
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
ISO
PID
PID:200096
NCBI chr20:41,216,071...41,238,893
Ensembl chr20:42,309,155...42,331,695
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YWHAE
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
ISO
PID
PID:200096
NCBI chr17:1,332,004...1,387,120
Ensembl chr17:1,229,080...1,285,470
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YWHAG
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
ISO
PID
PID:200096
NCBI chr 7:67,661,589...67,693,814
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YWHAH
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
ISO
PID
PID:200096
NCBI chr22:12,966,653...12,979,695
Ensembl chr22:30,819,821...30,831,804
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YWHAQ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
ISO
PID
PID:200096
NCBI chr2A:9,573,413...9,620,495
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YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
ISO
PID
PID:200096
NCBI chr 8:97,560,251...97,595,117
Ensembl chr 8:99,730,393...99,762,990
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YY1
YY1 transcription factor
ISO
PID
PID:200096
NCBI chr14:80,859,491...80,903,651
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