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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:folate metabolic pathway
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Accession:PW:0000140 term browser browse the term
Definition:Folate metabolism represents the various aspects of the folate cycle and the folate-mediated transfer reactions essential for several biosynthetic pathways. The folate cycle and the folate-mediated one-carbon pathways are part of folate metabolism. Folate compounds are water-soluble forms of vitamin B9.
Synonyms:related_synonym: folic acid metabolic process;   vitamin B9 metabolic pathway

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folate metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family member L1 ISO SMPDB
RGD		 PMID:14729668 RGD:1547843 SMP:00053 NCBI chrNW_004936898:456,299...484,681
Ensembl chrNW_004936898:456,521...484,282 		JBrowse link
G Dhfr dihydrofolate reductase ISO RGD
SMPDB		 PMID:11502523 RGD:1298877 SMP:00053 NCBI chrNW_004936469:67,962...83,116 JBrowse link
G Dmgdh dimethylglycine dehydrogenase ISO RGD PMID:15358367 RGD:1547831 NCBI chrNW_004936549:6,838,773...6,899,961
Ensembl chrNW_004936549:6,839,295...6,899,911 		JBrowse link
G Folr2 folate receptor beta ISO RGD PMID:8445646 RGD:1540379 NCBI chrNW_004936498:1,516,719...1,522,187
Ensembl chrNW_004936498:1,516,710...1,522,347 		JBrowse link
G Fpgs folylpolyglutamate synthase ISO SMPDB SMP:00053 NCBI chrNW_004936487:15,453,010...15,466,591
Ensembl chrNW_004936487:15,453,032...15,468,985 		JBrowse link
G Ftcd formimidoyltransferase cyclodeaminase ISO SMPDB SMP:00053 NCBI chrNW_004936778:375,800...390,764
Ensembl chrNW_004936778:375,800...390,554 		JBrowse link
G Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase ISO RGD PMID:12450384 RGD:1547842 NCBI chrNW_004936500:8,750,928...8,782,303
Ensembl chrNW_004936500:8,753,463...8,786,236 		JBrowse link
G Ggh gamma-glutamyl hydrolase ISO SMPDB SMP:00053 NCBI chrNW_004936496:10,485,528...10,505,506
Ensembl chrNW_004936496:10,485,504...10,505,842 		JBrowse link
G Gnmt glycine N-methyltransferase ISO RGD PMID:15347642 RGD:1359070 NCBI chrNW_004936476:16,961,734...16,965,487
Ensembl chrNW_004936476:16,957,270...16,965,346 		JBrowse link
G Mtfmt mitochondrial methionyl-tRNA formyltransferase ISO SMPDB SMP:00053 NCBI chrNW_004936471:25,334,544...25,352,520
Ensembl chrNW_004936471:25,335,068...25,352,480 		JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO SMPDB
RGD		 PMID:2186031 RGD:1299513 SMP:00053 NCBI chrNW_004936495:8,100,977...8,170,244
Ensembl chrNW_004936495:8,100,912...8,171,800 		JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like ISO SMPDB SMP:00053 NCBI chrNW_004936489:3,877,423...4,060,129
Ensembl chrNW_004936489:3,876,680...4,051,933 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase ISO SMPDB
RGD		 PMID:9454603 RGD:1540378 SMP:00053 NCBI chrNW_004936556:462,998...475,092
Ensembl chrNW_004936556:462,974...475,159 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO SMPDB
RGD		 PMID:11933257 RGD:1535021 SMP:00053 NCBI chrNW_004936474:623,438...637,849
Ensembl chrNW_004936474:623,291...638,193 		JBrowse link
G Mthfs methenyltetrahydrofolate synthetase ISO SMPDB SMP:00053 NCBI chrNW_004936471:37,910,856...37,964,655
Ensembl chrNW_004936471:37,902,554...37,964,812 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:15845641 RGD:1359026 NCBI chrNW_004936484:16,087,924...16,180,089
Ensembl chrNW_004936484:16,087,923...16,180,148 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:15979034 RGD:1359037 NCBI chrNW_004936643:379,790...410,034
Ensembl chrNW_004936643:380,968...409,464 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 ISO RGD PMID:15671219 RGD:1359815 NCBI chrNW_004936741:1,849,239...1,877,724
Ensembl chrNW_004936741:1,849,609...1,877,727 		JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 ISO RGD PMID:15671219 RGD:1359815 NCBI chrNW_004936646:1,422,844...1,427,929
Ensembl chrNW_004936646:1,422,817...1,429,037 		JBrowse link
G Slc19a1 solute carrier family 19 member 1 ISO RGD PMID:11600421 RGD:735239 NCBI chrNW_004936778:823,376...846,843
Ensembl chrNW_004936778:829,550...848,833 		JBrowse link
G Slc46a1 solute carrier family 46 member 1 ISO SMPDB SMP:00053 NCBI chrNW_004936538:4,549,032...4,642,870
Ensembl chrNW_004936538:4,549,599...4,555,415 		JBrowse link
G Tyms thymidylate synthetase ISO RGD PMID:9894005 RGD:1545055 NCBI chrNW_004936550:33,797...42,233
Ensembl chrNW_004936550:34,048...41,840 		JBrowse link
altered folate cycle metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family member L1 ISO RGD PMID:22353665 RGD:7242562 NCBI chrNW_004936898:456,299...484,681
Ensembl chrNW_004936898:456,521...484,282 		JBrowse link
G Dhfr dihydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004936469:67,962...83,116 JBrowse link
G Folr1 folate receptor alpha ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004936498:1,489,916...1,497,200
Ensembl chrNW_004936498:1,491,547...1,497,226 		JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004936495:8,100,977...8,170,244
Ensembl chrNW_004936495:8,100,912...8,171,800 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004936474:623,438...637,849
Ensembl chrNW_004936474:623,291...638,193 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004936484:16,087,924...16,180,089
Ensembl chrNW_004936484:16,087,923...16,180,148 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004936643:379,790...410,034
Ensembl chrNW_004936643:380,968...409,464 		JBrowse link
G Slc46a1 solute carrier family 46 member 1 ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004936538:4,549,032...4,642,870
Ensembl chrNW_004936538:4,549,599...4,555,415 		JBrowse link
altered folate mediated one-carbon metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO RGD PMID:22353665 RGD:7242562 NCBI chrNW_004936495:8,100,977...8,170,244
Ensembl chrNW_004936495:8,100,912...8,171,800 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO RGD PMID:22353665 RGD:7242562 NCBI chrNW_004936474:623,438...637,849
Ensembl chrNW_004936474:623,291...638,193 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:22353665 RGD:7242562 NCBI chrNW_004936484:16,087,924...16,180,089
Ensembl chrNW_004936484:16,087,923...16,180,148 		JBrowse link
folate cycle metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family member L1 ISO RGD PMID:22353665 RGD:7242562 NCBI chrNW_004936898:456,299...484,681
Ensembl chrNW_004936898:456,521...484,282 		JBrowse link
G Amt aminomethyltransferase ISO RGD PMID:20645850 RGD:7242560 NCBI chrNW_004936529:1,049,364...1,054,458 JBrowse link
G Dhfr dihydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004936469:67,962...83,116 JBrowse link
G Dld dihydrolipoamide dehydrogenase ISO RGD PMID:20645850 RGD:7242560 NCBI chrNW_004936479:16,247,230...16,271,597
Ensembl chrNW_004936479:16,243,829...16,271,616 		JBrowse link
G Dmgdh dimethylglycine dehydrogenase ISO RGD PMID:20645850 RGD:7242560 NCBI chrNW_004936549:6,838,773...6,899,961
Ensembl chrNW_004936549:6,839,295...6,899,911 		JBrowse link
G Folr1 folate receptor alpha ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004936498:1,489,916...1,497,200
Ensembl chrNW_004936498:1,491,547...1,497,226 		JBrowse link
G Folr2 folate receptor beta ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004936498:1,516,719...1,522,187
Ensembl chrNW_004936498:1,516,710...1,522,347 		JBrowse link
G Fpgs folylpolyglutamate synthase ISO RGD PMID:16859665 RGD:7242559 NCBI chrNW_004936487:15,453,010...15,466,591
Ensembl chrNW_004936487:15,453,032...15,468,985 		JBrowse link
G Gcsh glycine cleavage system protein H ISO RGD PMID:20645850 RGD:7242560 NCBI chrNW_004936475:28,749,545...28,760,242
Ensembl chrNW_004936475:28,749,580...28,760,230 		JBrowse link
G Ggh gamma-glutamyl hydrolase ISO RGD PMID:16859665 RGD:7242559 NCBI chrNW_004936496:10,485,528...10,505,506
Ensembl chrNW_004936496:10,485,504...10,505,842 		JBrowse link
G Gldc glycine decarboxylase ISO RGD PMID:20645850 RGD:7242560 NCBI chrNW_004936539:1,008,340...1,095,044
Ensembl chrNW_004936539:1,007,820...1,095,054 		JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004936495:8,100,977...8,170,244
Ensembl chrNW_004936495:8,100,912...8,171,800 		JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004936489:3,877,423...4,060,129
Ensembl chrNW_004936489:3,876,680...4,051,933 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase ISO RGD PMID:20645850 PMID:22108709 RGD:7242557 RGD:7242560 NCBI chrNW_004936556:462,998...475,092
Ensembl chrNW_004936556:462,974...475,159 		JBrowse link
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004936598:1,401,392...1,514,314
Ensembl chrNW_004936598:1,401,402...1,514,357 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004936474:623,438...637,849
Ensembl chrNW_004936474:623,291...638,193 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004936484:16,087,924...16,180,089
Ensembl chrNW_004936484:16,087,923...16,180,148 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004936643:379,790...410,034
Ensembl chrNW_004936643:380,968...409,464 		JBrowse link
G Sardh sarcosine dehydrogenase ISO RGD PMID:20645850 RGD:7242560 NCBI chrNW_004936669:3,244,302...3,297,906
Ensembl chrNW_004936669:3,243,762...3,297,905 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004936741:1,849,239...1,877,724
Ensembl chrNW_004936741:1,849,609...1,877,727 		JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 ISO RGD PMID:20645850 PMID:22108709 RGD:7242557 RGD:7242560 NCBI chrNW_004936646:1,422,844...1,427,929
Ensembl chrNW_004936646:1,422,817...1,429,037 		JBrowse link
G Slc19a1 solute carrier family 19 member 1 ISO RGD PMID:20814827 PMID:22108709 RGD:7242426 RGD:7242557 NCBI chrNW_004936778:823,376...846,843
Ensembl chrNW_004936778:829,550...848,833 		JBrowse link
G Slc25a32 solute carrier family 25 member 32 ISO RGD PMID:22332074 RGD:7242561 NCBI chrNW_004936470:40,357,066...40,370,514
Ensembl chrNW_004936470:40,357,446...40,370,514 		JBrowse link
G Slc46a1 solute carrier family 46 member 1 ISO RGD PMID:20814827 PMID:22108709 RGD:7242426 RGD:7242557 NCBI chrNW_004936538:4,549,032...4,642,870
Ensembl chrNW_004936538:4,549,599...4,555,415 		JBrowse link
folate mediated one-carbon metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family member L1 ISO RGD PMID:14729668 RGD:1547843 NCBI chrNW_004936898:456,299...484,681
Ensembl chrNW_004936898:456,521...484,282 		JBrowse link
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase ISO RGD PMID:9332377 PMID:22332074 RGD:70804 RGD:7242561 NCBI chrNW_004936586:1,782,581...1,809,458
Ensembl chrNW_004936586:1,782,528...1,810,010 		JBrowse link
G Dhfr dihydrofolate reductase ISO RGD PMID:11502523 PMID:22332074 RGD:1298877 RGD:7242561 NCBI chrNW_004936469:67,962...83,116 JBrowse link
G Dmgdh dimethylglycine dehydrogenase ISO RGD PMID:15358367 RGD:1547831 NCBI chrNW_004936549:6,838,773...6,899,961
Ensembl chrNW_004936549:6,839,295...6,899,911 		JBrowse link
G Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase ISO RGD PMID:12450384 PMID:22332074 RGD:1547842 RGD:7242561 NCBI chrNW_004936500:8,750,928...8,782,303
Ensembl chrNW_004936500:8,753,463...8,786,236 		JBrowse link
G Gnmt glycine N-methyltransferase ISO RGD PMID:8278367 RGD:1545057 NCBI chrNW_004936476:16,961,734...16,965,487
Ensembl chrNW_004936476:16,957,270...16,965,346 		JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO RGD PMID:2186031 PMID:22332074 RGD:1299513 RGD:7242561 NCBI chrNW_004936495:8,100,977...8,170,244
Ensembl chrNW_004936495:8,100,912...8,171,800 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase ISO RGD PMID:9454603 RGD:1540378 NCBI chrNW_004936556:462,998...475,092
Ensembl chrNW_004936556:462,974...475,159 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO RGD PMID:11933257 PMID:22332074 RGD:1535021 RGD:7242561 NCBI chrNW_004936474:623,438...637,849
Ensembl chrNW_004936474:623,291...638,193 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:15845641 PMID:20814827 RGD:1359026 RGD:7242426 NCBI chrNW_004936484:16,087,924...16,180,089
Ensembl chrNW_004936484:16,087,923...16,180,148 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:20814827 RGD:7242426 NCBI chrNW_004936643:379,790...410,034
Ensembl chrNW_004936643:380,968...409,464 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 ISO RGD PMID:3110140 PMID:15671219 PMID:22332074 RGD:1359815 RGD:2300383 RGD:7242561 NCBI chrNW_004936741:1,849,239...1,877,724
Ensembl chrNW_004936741:1,849,609...1,877,727 		JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 ISO RGD PMID:3110140 PMID:15671219 PMID:22332074 RGD:1359815 RGD:2300383 RGD:7242561 NCBI chrNW_004936646:1,422,844...1,427,929
Ensembl chrNW_004936646:1,422,817...1,429,037 		JBrowse link
G Tyms thymidylate synthetase ISO RGD PMID:9894005 PMID:22332074 RGD:1545055 RGD:7242561 NCBI chrNW_004936550:33,797...42,233
Ensembl chrNW_004936550:34,048...41,840 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3945
    classic metabolic pathway 974
      metabolic pathway of cofactors, vitamins, nutrients 227
        folate metabolic pathway 31
          altered folate metabolic pathway + 8
          folate cycle metabolic pathway + 24
          folate mediated one-carbon metabolic pathway + 14
Path 2
Term Annotations click to browse term
  pathway 3945
    regulatory pathway 2439
      homeostasis pathway 1275
        organic chemical homeostasis pathway 353
          S-adenosylmethionine homeostasis pathway 262
            folate metabolic pathway 31
              altered folate metabolic pathway + 8
              folate cycle metabolic pathway + 24
              folate mediated one-carbon metabolic pathway + 14
paths to the root