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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:folate metabolic pathway
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Accession:PW:0000140 term browser browse the term
Definition:Folate metabolism represents the various aspects of the folate cycle and the folate-mediated transfer reactions essential for several biosynthetic pathways. The folate cycle and the folate-mediated one-carbon pathways are part of folate metabolism. Folate compounds are water-soluble forms of vitamin B9.
Synonyms:related_synonym: folic acid metabolic process;   vitamin B9 metabolic pathway


show annotations for term's descendants           Sort by:
folate metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akp3 alkaline phosphatase 3, intestine, not Mn requiring IEA KEGG mmu:00790 NCBI chr 1:87,052,676...87,056,450
Ensembl chr 1:87,052,695...87,055,634 		JBrowse link
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 ISO SMPDB SMP:00053 NCBI chr 6:90,527,751...90,576,153
Ensembl chr 6:90,463,409...90,577,185 		JBrowse link
G Alpi alkaline phosphatase, intestinal IEA KEGG mmu:00790 NCBI chr 1:87,025,724...87,029,328
Ensembl chr 1:87,025,724...87,029,328 		JBrowse link
G Alpl alkaline phosphatase, liver/bone/kidney IEA KEGG mmu:00790 NCBI chr 4:137,469,042...137,523,695
Ensembl chr 4:137,469,044...137,523,695 		JBrowse link
G Alppl2 alkaline phosphatase, placental-like 2 IEA KEGG mmu:00790 NCBI chr 1:87,014,412...87,023,656
Ensembl chr 1:87,014,416...87,017,650 		JBrowse link
G Dhfr dihydrofolate reductase IEA
ISO		 KEGG
SMPDB		 SMP:00053 mmu:00790 NCBI chr13:92,491,291...92,525,561
Ensembl chr13:92,491,234...92,525,561 		JBrowse link
G Dmgdh dimethylglycine dehydrogenase precursor ISO RGD PMID:15358367 RGD:1547831 NCBI chr13:93,810,944...93,889,331
Ensembl chr13:93,810,941...93,889,341 		JBrowse link
G Folh1 folate hydrolase 1 ISO RGD PMID:9816319 RGD:151347637 NCBI chr 7:86,365,733...86,425,171
Ensembl chr 7:86,368,185...86,425,151 		JBrowse link
G Folr2 folate receptor beta ISO RGD PMID:8445646 RGD:1540379 NCBI chr 7:101,489,195...101,506,397
Ensembl chr 7:101,489,195...101,506,401 		JBrowse link
G Fpgs folylpolyglutamyl synthetase IEA
ISO		 KEGG
SMPDB		 SMP:00053 mmu:00790 NCBI chr 2:32,572,621...32,594,163
Ensembl chr 2:32,572,621...32,594,157 		JBrowse link
G Ftcd formiminotransferase cyclodeaminase ISO SMPDB SMP:00053 NCBI chr10:76,411,482...76,426,172
Ensembl chr10:76,411,482...76,426,172 		JBrowse link
G Gart phosphoribosylglycinamide formyltransferase ISO RGD PMID:12450384 RGD:1547842 NCBI chr16:91,418,283...91,444,505
Ensembl chr16:91,418,074...91,443,840 		JBrowse link
G Gch1 GTP cyclohydrolase 1 IEA KEGG mmu:00790 NCBI chr14:47,391,352...47,426,870
Ensembl chr14:47,391,352...47,426,870 		JBrowse link
G Ggh gamma-glutamyl hydrolase IEA
ISO		 KEGG
SMPDB		 SMP:00053 mmu:00790 NCBI chr 4:20,041,963...20,066,111
Ensembl chr 4:20,042,052...20,066,750 		JBrowse link
G Gnmt glycine N-methyltransferase ISO RGD PMID:15347642 RGD:1359070 NCBI chr17:47,036,590...47,040,091
Ensembl chr17:47,036,590...47,040,094 		JBrowse link
G Mocs1 molybdenum cofactor synthesis 1 IEA KEGG mmu:00790 NCBI chr17:49,735,378...49,762,463
Ensembl chr17:49,735,390...49,762,463 		JBrowse link
G Mocs2 molybdenum cofactor synthesis 2 IEA KEGG mmu:00790 NCBI chr13:114,954,707...114,965,960
Ensembl chr13:114,954,772...114,968,811 		JBrowse link
G Mtfmt mitochondrial methionyl-tRNA formyltransferase ISO SMPDB SMP:00053 NCBI chr 9:65,343,064...65,360,336
Ensembl chr 9:65,343,064...65,360,336 		JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase ISO SMPDB SMP:00053 NCBI chr12:76,301,180...76,366,594
Ensembl chr12:76,302,072...76,366,577 		JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like ISO SMPDB SMP:00053 NCBI chr10:3,918,282...4,117,081
Ensembl chr10:3,923,118...4,117,081 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase ISO SMPDB SMP:00053 NCBI chr 6:83,282,686...83,302,926
Ensembl chr 6:83,282,673...83,302,890 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO SMPDB SMP:00053 NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008 		JBrowse link
G Mthfs 5, 10-methenyltetrahydrofolate synthetase ISO SMPDB SMP:00053 NCBI chr 9:89,093,243...89,122,278
Ensembl chr 9:89,092,729...89,259,766 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:15845641 RGD:1359026 NCBI chr13:12,196,217...12,273,090
Ensembl chr13:12,197,598...12,272,999 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:15979034 RGD:1359037 NCBI chr13:68,708,897...68,730,273
Ensembl chr13:68,708,899...68,730,268 		JBrowse link
G Pts 6-pyruvoyl-tetrahydropterin synthase IEA KEGG mmu:00790 NCBI chr 9:50,432,917...50,440,017
Ensembl chr 9:50,432,917...50,440,024 		JBrowse link
G Qdpr quinoid dihydropteridine reductase IEA KEGG mmu:00790 NCBI chr 5:45,591,374...45,607,571
Ensembl chr 5:45,591,363...45,607,578 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 (soluble) ISO RGD PMID:15671219 RGD:1359815 NCBI chr11:60,679,723...60,702,062
Ensembl chr11:60,678,930...60,702,544 		JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 (mitochondrial) ISO RGD PMID:15671219 RGD:1359815 NCBI chr10:127,352,992...127,358,313
Ensembl chr10:127,352,992...127,358,313 		JBrowse link
G Slc19a1 solute carrier family 19 (folate transporter), member 1 ISO RGD PMID:11600421 RGD:735239 NCBI chr10:76,868,103...76,886,266
Ensembl chr10:76,868,075...76,896,836 		JBrowse link
G Slc46a1 solute carrier family 46, member 1 ISO SMPDB SMP:00053 NCBI chr11:78,356,527...78,362,771
Ensembl chr11:78,356,523...78,362,885 		JBrowse link
G Spr sepiapterin reductase IEA KEGG mmu:00790 NCBI chr 6:85,110,662...85,114,746
Ensembl chr 6:85,107,158...85,114,748 		JBrowse link
G Tyms thymidylate synthase ISO RGD PMID:9894005 RGD:1545055 NCBI chr 5:30,243,544...30,279,261
Ensembl chr 5:30,263,200...30,278,615 		JBrowse link
altered folate cycle metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 ISO RGD PMID:22353665 RGD:7242562 NCBI chr 6:90,527,751...90,576,153
Ensembl chr 6:90,463,409...90,577,185 		JBrowse link
G Dhfr dihydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr13:92,491,291...92,525,561
Ensembl chr13:92,491,234...92,525,561 		JBrowse link
G Folr1 folate receptor alpha ISO RGD PMID:22108709 RGD:7242557 NCBI chr 7:101,507,551...101,519,974
Ensembl chr 7:101,507,538...101,519,995 		JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase ISO RGD PMID:22108709 RGD:7242557 NCBI chr12:76,301,180...76,366,594
Ensembl chr12:76,302,072...76,366,577 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:22108709 PMID:22108709 RGD:7242557, RGD:7242557 NCBI chr13:12,196,217...12,273,090
Ensembl chr13:12,197,598...12,272,999 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr13:68,708,897...68,730,273
Ensembl chr13:68,708,899...68,730,268 		JBrowse link
G Slc46a1 solute carrier family 46, member 1 ISO RGD PMID:22108709 RGD:7242557 NCBI chr11:78,356,527...78,362,771
Ensembl chr11:78,356,523...78,362,885 		JBrowse link
altered folate mediated one-carbon metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase ISO RGD PMID:22353665 RGD:7242562 NCBI chr12:76,301,180...76,366,594
Ensembl chr12:76,302,072...76,366,577 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO RGD PMID:22353665 RGD:7242562 NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:22353665 RGD:7242562 NCBI chr13:12,196,217...12,273,090
Ensembl chr13:12,197,598...12,272,999 		JBrowse link
folate cycle metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 ISO RGD PMID:22353665 RGD:7242562 NCBI chr 6:90,527,751...90,576,153
Ensembl chr 6:90,463,409...90,577,185 		JBrowse link
G Amt aminomethyltransferase ISO RGD PMID:20645850 RGD:7242560 NCBI chr 9:108,174,104...108,179,501
Ensembl chr 9:108,174,052...108,179,501 		JBrowse link
G Dhfr dihydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr13:92,491,291...92,525,561
Ensembl chr13:92,491,234...92,525,561 		JBrowse link
G Dld dihydrolipoamide dehydrogenase ISO RGD PMID:20645850 RGD:7242560 NCBI chr12:31,381,561...31,401,470
Ensembl chr12:31,381,276...31,401,452 		JBrowse link
G Dmgdh dimethylglycine dehydrogenase precursor ISO RGD PMID:20645850 RGD:7242560 NCBI chr13:93,810,944...93,889,331
Ensembl chr13:93,810,941...93,889,341 		JBrowse link
G Folh1 folate hydrolase 1 ISO RGD PMID:20814827 PMID:16859665 RGD:7242426, RGD:7242559 NCBI chr 7:86,365,733...86,425,171
Ensembl chr 7:86,368,185...86,425,151 		JBrowse link
G Folr1 folate receptor alpha ISO RGD PMID:22108709 RGD:7242557 NCBI chr 7:101,507,551...101,519,974
Ensembl chr 7:101,507,538...101,519,995 		JBrowse link
G Folr2 folate receptor beta ISO RGD PMID:22108709 RGD:7242557 NCBI chr 7:101,489,195...101,506,397
Ensembl chr 7:101,489,195...101,506,401 		JBrowse link
G Fpgs folylpolyglutamyl synthetase ISO RGD PMID:16859665 RGD:7242559 NCBI chr 2:32,572,621...32,594,163
Ensembl chr 2:32,572,621...32,594,157 		JBrowse link
G Gcsh glycine cleavage system protein H (aminomethyl carrier) ISO RGD PMID:20645850 RGD:7242560 NCBI chr 8:117,708,706...117,720,237
Ensembl chr 8:117,708,549...117,720,276 		JBrowse link
G Ggh gamma-glutamyl hydrolase ISO RGD PMID:16859665 RGD:7242559 NCBI chr 4:20,041,963...20,066,111
Ensembl chr 4:20,042,052...20,066,750 		JBrowse link
G Gldc glycine decarboxylase ISO RGD PMID:20645850 RGD:7242560 NCBI chr19:30,075,847...30,152,829
Ensembl chr19:30,075,847...30,152,829 		JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase ISO RGD PMID:22108709 RGD:7242557 NCBI chr12:76,301,180...76,366,594
Ensembl chr12:76,302,072...76,366,577 		JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like ISO RGD PMID:22108709 RGD:7242557 NCBI chr10:3,918,282...4,117,081
Ensembl chr10:3,923,118...4,117,081 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase ISO RGD PMID:20645850 PMID:22108709 RGD:7242560, RGD:7242557 NCBI chr 6:83,282,686...83,302,926
Ensembl chr 6:83,282,673...83,302,890 		JBrowse link
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like ISO RGD PMID:22108709 RGD:7242557 NCBI chr 5:91,078,704...91,169,227
Ensembl chr 5:91,078,976...91,169,227 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:22108709 RGD:7242557 NCBI chr13:12,196,217...12,273,090
Ensembl chr13:12,197,598...12,272,999 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr13:68,708,897...68,730,273
Ensembl chr13:68,708,899...68,730,268 		JBrowse link
G Sardh sarcosine dehydrogenase ISO RGD PMID:20645850 RGD:7242560 NCBI chr 2:27,078,405...27,138,344
Ensembl chr 2:27,078,405...27,138,349 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 (soluble) ISO RGD PMID:22108709 RGD:7242557 NCBI chr11:60,679,723...60,702,062
Ensembl chr11:60,678,930...60,702,544 		JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 (mitochondrial) ISO RGD PMID:20645850 PMID:22108709 RGD:7242560, RGD:7242557 NCBI chr10:127,352,992...127,358,313
Ensembl chr10:127,352,992...127,358,313 		JBrowse link
G Slc19a1 solute carrier family 19 (folate transporter), member 1 ISO RGD PMID:22108709 PMID:20814827 RGD:7242557, RGD:7242426 NCBI chr10:76,868,103...76,886,266
Ensembl chr10:76,868,075...76,896,836 		JBrowse link
G Slc25a32 solute carrier family 25, member 32 ISO RGD PMID:22332074 RGD:7242561 NCBI chr15:38,954,625...38,976,213
Ensembl chr15:38,954,626...38,976,111 		JBrowse link
G Slc46a1 solute carrier family 46, member 1 ISO RGD PMID:22108709 PMID:20814827 RGD:7242557, RGD:7242426 NCBI chr11:78,356,527...78,362,771
Ensembl chr11:78,356,523...78,362,885 		JBrowse link
folate mediated one-carbon metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 IEA KEGG mmu:00670 NCBI chr 6:90,527,751...90,576,153
Ensembl chr 6:90,463,409...90,577,185 		JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 IEA KEGG mmu:00670 NCBI chr10:83,320,386...83,370,008
Ensembl chr10:83,323,314...83,370,004 		JBrowse link
G Amt aminomethyltransferase IEA KEGG mmu:00670 NCBI chr 9:108,174,104...108,179,501
Ensembl chr 9:108,174,052...108,179,501 		JBrowse link
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase IEA
ISO		 KEGG
RGD		 PMID:9332377 PMID:22332074 mmu:00670, RGD:70804, RGD:7242561 NCBI chr 1:71,596,315...71,618,562
Ensembl chr 1:71,596,309...71,618,790 		JBrowse link
G Dhfr dihydrofolate reductase IEA
ISO		 KEGG
RGD		 PMID:22332074 mmu:00670, RGD:7242561 NCBI chr13:92,491,291...92,525,561
Ensembl chr13:92,491,234...92,525,561 		JBrowse link
G Dmgdh dimethylglycine dehydrogenase precursor ISO RGD PMID:15358367 RGD:1547831 NCBI chr13:93,810,944...93,889,331
Ensembl chr13:93,810,941...93,889,341 		JBrowse link
G Folh1 folate hydrolase 1 ISO RGD PMID:9501243 RGD:728645 NCBI chr 7:86,365,733...86,425,171
Ensembl chr 7:86,368,185...86,425,151 		JBrowse link
G Ftcd formiminotransferase cyclodeaminase IEA KEGG mmu:00670 NCBI chr10:76,411,482...76,426,172
Ensembl chr10:76,411,482...76,426,172 		JBrowse link
G Gart phosphoribosylglycinamide formyltransferase IEA
ISO		 KEGG
RGD		 PMID:22332074 mmu:00670, RGD:7242561 NCBI chr16:91,418,283...91,444,505
Ensembl chr16:91,418,074...91,443,840 		JBrowse link
G Gnmt glycine N-methyltransferase ISO RGD PMID:8278367 RGD:1545057 NCBI chr17:47,036,590...47,040,091
Ensembl chr17:47,036,590...47,040,094 		JBrowse link
G Mtfmt mitochondrial methionyl-tRNA formyltransferase IEA KEGG mmu:00670 NCBI chr 9:65,343,064...65,360,336
Ensembl chr 9:65,343,064...65,360,336 		JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase IEA
ISO		 KEGG
RGD		 PMID:22332074 mmu:00670, RGD:7242561 NCBI chr12:76,301,180...76,366,594
Ensembl chr12:76,302,072...76,366,577 		JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like IEA KEGG mmu:00670 NCBI chr10:3,918,282...4,117,081
Ensembl chr10:3,923,118...4,117,081 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase IEA KEGG mmu:00670 NCBI chr 6:83,282,686...83,302,926
Ensembl chr 6:83,282,673...83,302,890 		JBrowse link
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like IEA KEGG mmu:00670 NCBI chr 5:91,078,704...91,169,227
Ensembl chr 5:91,078,976...91,169,227 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase IEA
ISO		 KEGG
RGD		 PMID:22332074 mmu:00670, RGD:7242561 NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008 		JBrowse link
G Mthfs 5, 10-methenyltetrahydrofolate synthetase IEA KEGG mmu:00670 NCBI chr 9:89,093,243...89,122,278
Ensembl chr 9:89,092,729...89,259,766 		JBrowse link
G Mthfsl 5, 10-methenyltetrahydrofolate synthetase-like IEA KEGG mmu:00670 NCBI chr 9:88,567,696...88,602,381
Ensembl chr 9:88,570,655...88,602,349 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase IEA
ISO		 KEGG
RGD		 PMID:20814827 mmu:00670, RGD:7242426 NCBI chr13:12,196,217...12,273,090
Ensembl chr13:12,197,598...12,272,999 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:20814827 RGD:7242426 NCBI chr13:68,708,897...68,730,273
Ensembl chr13:68,708,899...68,730,268 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 (soluble) ISO
IEA		 KEGG
RGD		 PMID:3110140 PMID:22332074 mmu:00670, RGD:2300383, RGD:7242561 NCBI chr11:60,679,723...60,702,062
Ensembl chr11:60,678,930...60,702,544 		JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 (mitochondrial) ISO
IEA		 KEGG
RGD		 PMID:3110140 PMID:22332074 mmu:00670, RGD:2300383, RGD:7242561 NCBI chr10:127,352,992...127,358,313
Ensembl chr10:127,352,992...127,358,313 		JBrowse link
G Tyms thymidylate synthase IEA
ISO		 KEGG
RGD		 PMID:22332074 mmu:00670, RGD:7242561 NCBI chr 5:30,243,544...30,279,261
Ensembl chr 5:30,263,200...30,278,615 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6072
    classic metabolic pathway 1858
      metabolic pathway of cofactors, vitamins, nutrients 391
        folate metabolic pathway 44
          altered folate metabolic pathway + 8
          folate cycle metabolic pathway + 25
          folate mediated one-carbon metabolic pathway + 23
Path 2
Term Annotations click to browse term
  pathway 6072
    regulatory pathway 3689
      homeostasis pathway 1721
        organic chemical homeostasis pathway 454
          S-adenosylmethionine homeostasis pathway 286
            folate metabolic pathway 44
              altered folate metabolic pathway + 8
              folate cycle metabolic pathway + 25
              folate mediated one-carbon metabolic pathway + 23
paths to the root