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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:folate metabolic pathway
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Accession:PW:0000140 term browser browse the term
Definition:Folate metabolism represents the various aspects of the folate cycle and the folate-mediated transfer reactions essential for several biosynthetic pathways. The folate cycle and the folate-mediated one-carbon pathways are part of folate metabolism. Folate compounds are water-soluble forms of vitamin B9.
Synonyms:related_synonym: folic acid metabolic process;   vitamin B9 metabolic pathway

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folate metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family member L1 ISO SMPDB
RGD		 PMID:14729668 RGD:1547843 SMP:00053 NCBI chrNW_004955421:21,420,264...21,506,004
Ensembl chrNW_004955421:21,420,147...21,527,037 		JBrowse link
G Dhfr dihydrofolate reductase ISO SMPDB
RGD		 PMID:11502523 RGD:1298877 SMP:00053 NCBI chrNW_004955418:29,274,170...29,283,028 JBrowse link
G Dmgdh dimethylglycine dehydrogenase ISO RGD PMID:15358367 RGD:1547831 NCBI chrNW_004955425:22,045,977...22,103,381
Ensembl chrNW_004955425:22,045,993...22,102,852 		JBrowse link
G Fpgs folylpolyglutamate synthase ISO SMPDB SMP:00053 NCBI chrNW_004955419:853,891...871,729
Ensembl chrNW_004955419:851,152...871,522 		JBrowse link
G Ftcd formimidoyltransferase cyclodeaminase ISO SMPDB SMP:00053 NCBI chrNW_004955407:42,608,249...42,617,167
Ensembl chrNW_004955407:42,607,872...42,617,166 		JBrowse link
G Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase ISO RGD PMID:12450384 RGD:1547842 NCBI chrNW_004955407:32,944,638...32,975,142
Ensembl chrNW_004955407:32,944,164...32,973,863 		JBrowse link
G Ggh gamma-glutamyl hydrolase ISO SMPDB SMP:00053 NCBI chrNW_004955444:15,901,225...15,930,358
Ensembl chrNW_004955444:15,900,485...15,931,338 		JBrowse link
G Gnmt glycine N-methyltransferase ISO RGD PMID:15347642 RGD:1359070 NCBI chrNW_004955437:8,944,288...8,946,642
Ensembl chrNW_004955437:8,944,047...8,946,642 		JBrowse link
G Mtfmt mitochondrial methionyl-tRNA formyltransferase ISO SMPDB SMP:00053 NCBI chrNW_004955450:10,399,472...10,415,813
Ensembl chrNW_004955450:10,399,470...10,415,872 		JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO SMPDB
RGD		 PMID:2186031 RGD:1299513 SMP:00053 NCBI chrNW_004955466:5,422,141...5,485,773
Ensembl chrNW_004955466:5,420,702...5,485,773 		JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like ISO SMPDB SMP:00053 NCBI chrNW_004955439:10,432,732...10,621,991
Ensembl chrNW_004955439:10,438,883...10,621,768 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase ISO SMPDB
RGD		 PMID:9454603 RGD:1540378 SMP:00053 NCBI chrNW_004955424:11,538,344...11,550,119
Ensembl chrNW_004955424:11,539,399...11,550,220 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO SMPDB
RGD		 PMID:11933257 RGD:1535021 SMP:00053 NCBI chrNW_004955486:2,096,379...2,112,240
Ensembl chrNW_004955486:2,096,379...2,112,240 		JBrowse link
G Mthfs methenyltetrahydrofolate synthetase ISO SMPDB SMP:00053 NCBI chrNW_004955533:720,255...756,893
Ensembl chrNW_004955533:720,353...756,893 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:15845641 RGD:1359026 NCBI chrNW_004955492:3,372,915...3,474,173
Ensembl chrNW_004955492:3,376,512...3,474,180 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:15979034 RGD:1359037 NCBI chrNW_004955504:5,412,290...5,435,409
Ensembl chrNW_004955504:5,413,586...5,435,645 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 ISO RGD PMID:15671219 RGD:1359815 NCBI chrNW_004955478:10,972,791...11,001,535
Ensembl chrNW_004955478:10,978,139...11,001,202 		JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 ISO RGD PMID:15671219 RGD:1359815 NCBI chrNW_004955458:4,957,614...4,962,691
Ensembl chrNW_004955458:4,957,602...4,962,691 		JBrowse link
G Slc19a1 solute carrier family 19 member 1 ISO RGD PMID:11600421 RGD:735239 NCBI chrNW_004955407:42,132,216...42,154,252
Ensembl chrNW_004955407:42,132,165...42,141,992 		JBrowse link
G Slc46a1 solute carrier family 46 member 1 ISO SMPDB SMP:00053 NCBI chrNW_004955481:4,735,325...4,741,810
Ensembl chrNW_004955481:4,734,967...4,745,586 		JBrowse link
G Tyms thymidylate synthetase ISO RGD PMID:9894005 RGD:1545055 NCBI chrNW_004955402:9,295,862...9,304,952
Ensembl chrNW_004955402:9,296,321...9,306,631 		JBrowse link
altered folate cycle metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family member L1 ISO RGD PMID:22353665 RGD:7242562 NCBI chrNW_004955421:21,420,264...21,506,004
Ensembl chrNW_004955421:21,420,147...21,527,037 		JBrowse link
G Dhfr dihydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004955418:29,274,170...29,283,028 JBrowse link
G Folr1 folate receptor alpha ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004955414:19,188,830...19,197,728
Ensembl chrNW_004955414:19,187,388...19,197,728 		JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004955466:5,422,141...5,485,773
Ensembl chrNW_004955466:5,420,702...5,485,773 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004955486:2,096,379...2,112,240
Ensembl chrNW_004955486:2,096,379...2,112,240 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004955492:3,372,915...3,474,173
Ensembl chrNW_004955492:3,376,512...3,474,180 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004955504:5,412,290...5,435,409
Ensembl chrNW_004955504:5,413,586...5,435,645 		JBrowse link
G Slc46a1 solute carrier family 46 member 1 ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004955481:4,735,325...4,741,810
Ensembl chrNW_004955481:4,734,967...4,745,586 		JBrowse link
altered folate mediated one-carbon metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO RGD PMID:22353665 RGD:7242562 NCBI chrNW_004955466:5,422,141...5,485,773
Ensembl chrNW_004955466:5,420,702...5,485,773 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO RGD PMID:22353665 RGD:7242562 NCBI chrNW_004955486:2,096,379...2,112,240
Ensembl chrNW_004955486:2,096,379...2,112,240 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:22353665 RGD:7242562 NCBI chrNW_004955492:3,372,915...3,474,173
Ensembl chrNW_004955492:3,376,512...3,474,180 		JBrowse link
folate cycle metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family member L1 ISO RGD PMID:22353665 RGD:7242562 NCBI chrNW_004955421:21,420,264...21,506,004
Ensembl chrNW_004955421:21,420,147...21,527,037 		JBrowse link
G Amt aminomethyltransferase ISO RGD PMID:20645850 RGD:7242560 NCBI chrNW_004955532:1,351,743...1,358,220
Ensembl chrNW_004955532:1,351,743...1,358,220 		JBrowse link
G Dhfr dihydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004955418:29,274,170...29,283,028 JBrowse link
G Dld dihydrolipoamide dehydrogenase ISO RGD PMID:20645850 RGD:7242560 NCBI chrNW_004955410:12,212,981...12,238,561
Ensembl chrNW_004955410:12,212,963...12,238,561 		JBrowse link
G Dmgdh dimethylglycine dehydrogenase ISO RGD PMID:20645850 RGD:7242560 NCBI chrNW_004955425:22,045,977...22,103,381
Ensembl chrNW_004955425:22,045,993...22,102,852 		JBrowse link
G Folr1 folate receptor alpha ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004955414:19,188,830...19,197,728
Ensembl chrNW_004955414:19,187,388...19,197,728 		JBrowse link
G Fpgs folylpolyglutamate synthase ISO RGD PMID:16859665 RGD:7242559 NCBI chrNW_004955419:853,891...871,729
Ensembl chrNW_004955419:851,152...871,522 		JBrowse link
G Gcsh glycine cleavage system protein H ISO RGD PMID:20645850 RGD:7242560 NCBI chrNW_004955522:3,858,156...3,869,730
Ensembl chrNW_004955522:3,857,628...3,870,228 		JBrowse link
G Ggh gamma-glutamyl hydrolase ISO RGD PMID:16859665 RGD:7242559 NCBI chrNW_004955444:15,901,225...15,930,358
Ensembl chrNW_004955444:15,900,485...15,931,338 		JBrowse link
G Gldc glycine decarboxylase ISO RGD PMID:20645850 RGD:7242560 NCBI chrNW_004955434:10,431,434...10,533,118
Ensembl chrNW_004955434:10,431,983...10,533,002 		JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004955466:5,422,141...5,485,773
Ensembl chrNW_004955466:5,420,702...5,485,773 		JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004955439:10,432,732...10,621,991
Ensembl chrNW_004955439:10,438,883...10,621,768 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase ISO RGD PMID:20645850 PMID:22108709 RGD:7242557 RGD:7242560 NCBI chrNW_004955424:11,538,344...11,550,119
Ensembl chrNW_004955424:11,539,399...11,550,220 		JBrowse link
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004955474:450,676...558,659
Ensembl chrNW_004955474:450,680...558,716 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004955486:2,096,379...2,112,240
Ensembl chrNW_004955486:2,096,379...2,112,240 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004955492:3,372,915...3,474,173
Ensembl chrNW_004955492:3,376,512...3,474,180 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004955504:5,412,290...5,435,409
Ensembl chrNW_004955504:5,413,586...5,435,645 		JBrowse link
G Sardh sarcosine dehydrogenase ISO RGD PMID:20645850 RGD:7242560 NCBI chrNW_004955513:2,933,918...2,975,645
Ensembl chrNW_004955513:2,933,918...2,976,931 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 ISO RGD PMID:22108709 RGD:7242557 NCBI chrNW_004955478:10,972,791...11,001,535
Ensembl chrNW_004955478:10,978,139...11,001,202 		JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 ISO RGD PMID:20645850 PMID:22108709 RGD:7242557 RGD:7242560 NCBI chrNW_004955458:4,957,614...4,962,691
Ensembl chrNW_004955458:4,957,602...4,962,691 		JBrowse link
G Slc19a1 solute carrier family 19 member 1 ISO RGD PMID:20814827 PMID:22108709 RGD:7242426 RGD:7242557 NCBI chrNW_004955407:42,132,216...42,154,252
Ensembl chrNW_004955407:42,132,165...42,141,992 		JBrowse link
G Slc25a32 solute carrier family 25 member 32 ISO RGD PMID:22332074 RGD:7242561 NCBI chrNW_004955417:27,530,806...27,545,103
Ensembl chrNW_004955417:27,527,144...27,546,043 		JBrowse link
G Slc46a1 solute carrier family 46 member 1 ISO RGD PMID:20814827 PMID:22108709 RGD:7242426 RGD:7242557 NCBI chrNW_004955481:4,735,325...4,741,810
Ensembl chrNW_004955481:4,734,967...4,745,586 		JBrowse link
folate mediated one-carbon metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family member L1 ISO RGD PMID:14729668 RGD:1547843 NCBI chrNW_004955421:21,420,264...21,506,004
Ensembl chrNW_004955421:21,420,147...21,527,037 		JBrowse link
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase ISO RGD PMID:9332377 PMID:22332074 RGD:70804 RGD:7242561 NCBI chrNW_004955457:704,213...729,702
Ensembl chrNW_004955457:704,213...730,134 		JBrowse link
G Dhfr dihydrofolate reductase ISO RGD PMID:11502523 PMID:22332074 RGD:1298877 RGD:7242561 NCBI chrNW_004955418:29,274,170...29,283,028 JBrowse link
G Dmgdh dimethylglycine dehydrogenase ISO RGD PMID:15358367 RGD:1547831 NCBI chrNW_004955425:22,045,977...22,103,381
Ensembl chrNW_004955425:22,045,993...22,102,852 		JBrowse link
G Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase ISO RGD PMID:12450384 PMID:22332074 RGD:1547842 RGD:7242561 NCBI chrNW_004955407:32,944,638...32,975,142
Ensembl chrNW_004955407:32,944,164...32,973,863 		JBrowse link
G Gnmt glycine N-methyltransferase ISO RGD PMID:8278367 RGD:1545057 NCBI chrNW_004955437:8,944,288...8,946,642
Ensembl chrNW_004955437:8,944,047...8,946,642 		JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO RGD PMID:2186031 PMID:22332074 RGD:1299513 RGD:7242561 NCBI chrNW_004955466:5,422,141...5,485,773
Ensembl chrNW_004955466:5,420,702...5,485,773 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase ISO RGD PMID:9454603 RGD:1540378 NCBI chrNW_004955424:11,538,344...11,550,119
Ensembl chrNW_004955424:11,539,399...11,550,220 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO RGD PMID:11933257 PMID:22332074 RGD:1535021 RGD:7242561 NCBI chrNW_004955486:2,096,379...2,112,240
Ensembl chrNW_004955486:2,096,379...2,112,240 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:15845641 PMID:20814827 RGD:1359026 RGD:7242426 NCBI chrNW_004955492:3,372,915...3,474,173
Ensembl chrNW_004955492:3,376,512...3,474,180 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:20814827 RGD:7242426 NCBI chrNW_004955504:5,412,290...5,435,409
Ensembl chrNW_004955504:5,413,586...5,435,645 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 ISO RGD PMID:3110140 PMID:15671219 PMID:22332074 RGD:1359815 RGD:2300383 RGD:7242561 NCBI chrNW_004955478:10,972,791...11,001,535
Ensembl chrNW_004955478:10,978,139...11,001,202 		JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 ISO RGD PMID:3110140 PMID:15671219 PMID:22332074 RGD:1359815 RGD:2300383 RGD:7242561 NCBI chrNW_004955458:4,957,614...4,962,691
Ensembl chrNW_004955458:4,957,602...4,962,691 		JBrowse link
G Tyms thymidylate synthetase ISO RGD PMID:9894005 PMID:22332074 RGD:1545055 RGD:7242561 NCBI chrNW_004955402:9,295,862...9,304,952
Ensembl chrNW_004955402:9,296,321...9,306,631 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3924
    classic metabolic pathway 967
      metabolic pathway of cofactors, vitamins, nutrients 226
        folate metabolic pathway 30
          altered folate metabolic pathway + 8
          folate cycle metabolic pathway + 23
          folate mediated one-carbon metabolic pathway + 14
Path 2
Term Annotations click to browse term
  pathway 3924
    regulatory pathway 2432
      homeostasis pathway 1271
        organic chemical homeostasis pathway 345
          S-adenosylmethionine homeostasis pathway 258
            folate metabolic pathway 30
              altered folate metabolic pathway + 8
              folate cycle metabolic pathway + 23
              folate mediated one-carbon metabolic pathway + 14
paths to the root