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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:folate metabolic pathway
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Accession:PW:0000140 term browser browse the term
Definition:Folate metabolism represents the various aspects of the folate cycle and the folate-mediated transfer reactions essential for several biosynthetic pathways. The folate cycle and the folate-mediated one-carbon pathways are part of folate metabolism. Folate compounds are water-soluble forms of vitamin B9.
Synonyms:related_synonym: folic acid metabolic process;   vitamin B9 metabolic pathway


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folate metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1L1 aldehyde dehydrogenase 1 family member L1 ISO SMPDB
RGD		 PMID:14729668 RGD:1547843 SMP:00053 NCBI chr 3:123,166,630...123,244,257
Ensembl chr 3:130,484,862...130,562,934 		JBrowse link
G DHFR dihydrofolate reductase ISO SMPDB
RGD		 PMID:11502523 RGD:1298877 SMP:00053 NCBI chr 5:34,663,210...34,689,467
Ensembl chr 5:34,938,548...34,967,003 		JBrowse link
G DMGDH dimethylglycine dehydrogenase ISO RGD PMID:15358367 RGD:1547831 NCBI chr 5:36,241,341...36,313,995
Ensembl chr 5:36,732,005...36,805,883 		JBrowse link
G FOLR2 folate receptor beta ISO RGD PMID:8445646 RGD:1540379 NCBI chr11:67,295,305...67,300,463
Ensembl chr11:70,518,931...70,524,088 		JBrowse link
G FPGS folylpolyglutamate synthase ISO SMPDB SMP:00053 NCBI chr 9:98,921,986...98,933,542
Ensembl chr 9:127,593,592...127,604,200 		JBrowse link
G FTCD formimidoyltransferase cyclodeaminase ISO SMPDB SMP:00053 NCBI chr21:32,481,042...32,501,932
Ensembl chr21:45,734,825...45,753,400 		JBrowse link
G GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase ISO RGD PMID:12450384 RGD:1547842 NCBI chr21:19,871,656...19,909,893
Ensembl chr21:33,244,457...33,282,331 		JBrowse link
G GGH gamma-glutamyl hydrolase ISO SMPDB SMP:00053 NCBI chr 8:59,547,821...59,571,523
Ensembl chr 8:61,222,194...61,246,252 		JBrowse link
G GNMT glycine N-methyltransferase ISO RGD PMID:15347642 RGD:1359070 NCBI chr 6:42,550,631...42,554,385
Ensembl chr 6:43,846,560...43,849,679 		JBrowse link
G MTFMT mitochondrial methionyl-tRNA formyltransferase ISO SMPDB SMP:00053 NCBI chr15:43,942,227...43,969,182
Ensembl chr15:62,225,620...62,253,612 		JBrowse link
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO SMPDB
RGD		 PMID:2186031 RGD:1299513 SMP:00053 NCBI chr14:44,969,573...45,041,296
Ensembl chr14:63,223,484...63,293,881 		JBrowse link
G MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like ISO SMPDB SMP:00053 NCBI chr 6:148,679,587...148,919,002
Ensembl chr 6:153,390,498...153,619,884 		JBrowse link
G MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase ISO SMPDB
RGD		 PMID:9454603 RGD:1540378 SMP:00053 NCBI chr2A:74,270,161...74,285,790
Ensembl chr2A:75,777,028...75,792,699 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase ISO SMPDB
RGD		 PMID:11933257 RGD:1535021 SMP:00053 NCBI chr 1:10,548,196...10,568,174
Ensembl chr 1:11,766,334...11,785,419 		JBrowse link
G MTHFS methenyltetrahydrofolate synthetase ISO SMPDB SMP:00053 NCBI chr15:58,810,966...58,864,831
Ensembl chr15:77,770,216...77,822,206 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:15845641 RGD:1359026 NCBI chr 1:212,353,195...212,463,304
Ensembl chr 1:217,358,050...217,460,946 		JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:15979034 RGD:1359037 NCBI chr 5:8,195,868...8,228,071
Ensembl chr 5:8,017,403...8,049,322 		JBrowse link
G SHMT1 serine hydroxymethyltransferase 1 ISO RGD PMID:15671219 RGD:1359815 NCBI chr17:32,870,949...32,905,690
Ensembl chr17:37,849,206...37,884,220 		JBrowse link
G SHMT2 serine hydroxymethyltransferase 2 ISO RGD PMID:15671219 RGD:1359815 NCBI chr12:31,692,451...31,697,727
Ensembl chr12:31,944,785...31,950,138 		JBrowse link
G SLC19A1 solute carrier family 19 member 1 ISO RGD PMID:11600421 RGD:735239 NCBI chr21:31,836,774...31,883,829
Ensembl chr21:45,090,595...45,134,752 		JBrowse link
G SLC46A1 solute carrier family 46 member 1 ISO SMPDB SMP:00053 NCBI chr17:28,367,674...28,379,618
Ensembl chr17:28,870,678...28,877,632 		JBrowse link
G TYMS thymidylate synthetase ISO RGD PMID:9894005 RGD:1545055 NCBI chr18:13,653,085...13,668,478
Ensembl chr18:17,295,182...17,310,320 		JBrowse link
altered folate cycle metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1L1 aldehyde dehydrogenase 1 family member L1 ISO RGD PMID:22353665 RGD:7242562 NCBI chr 3:123,166,630...123,244,257
Ensembl chr 3:130,484,862...130,562,934 		JBrowse link
G DHFR dihydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr 5:34,663,210...34,689,467
Ensembl chr 5:34,938,548...34,967,003 		JBrowse link
G LOC100994139 folate receptor alpha ISO RGD PMID:22108709 RGD:7242557 NCBI chr11:67,268,721...67,275,498
Ensembl chr11:70,492,039...70,498,665 		JBrowse link
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO RGD PMID:22108709 RGD:7242557 NCBI chr14:44,969,573...45,041,296
Ensembl chr14:63,223,484...63,293,881 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr 1:10,548,196...10,568,174
Ensembl chr 1:11,766,334...11,785,419 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:22108709 RGD:7242557 NCBI chr 1:212,353,195...212,463,304
Ensembl chr 1:217,358,050...217,460,946 		JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr 5:8,195,868...8,228,071
Ensembl chr 5:8,017,403...8,049,322 		JBrowse link
G SLC46A1 solute carrier family 46 member 1 ISO RGD PMID:22108709 RGD:7242557 NCBI chr17:28,367,674...28,379,618
Ensembl chr17:28,870,678...28,877,632 		JBrowse link
altered folate mediated one-carbon metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO RGD PMID:22353665 RGD:7242562 NCBI chr14:44,969,573...45,041,296
Ensembl chr14:63,223,484...63,293,881 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase ISO RGD PMID:22353665 RGD:7242562 NCBI chr 1:10,548,196...10,568,174
Ensembl chr 1:11,766,334...11,785,419 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:22353665 RGD:7242562 NCBI chr 1:212,353,195...212,463,304
Ensembl chr 1:217,358,050...217,460,946 		JBrowse link
folate cycle metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1L1 aldehyde dehydrogenase 1 family member L1 ISO RGD PMID:22353665 RGD:7242562 NCBI chr 3:123,166,630...123,244,257
Ensembl chr 3:130,484,862...130,562,934 		JBrowse link
G AMT aminomethyltransferase ISO RGD PMID:20645850 RGD:7242560 NCBI chr 3:49,344,590...49,350,383
Ensembl chr 3:50,589,193...50,594,968 		JBrowse link
G DHFR dihydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr 5:34,663,210...34,689,467
Ensembl chr 5:34,938,548...34,967,003 		JBrowse link
G DLD dihydrolipoamide dehydrogenase ISO RGD PMID:20645850 RGD:7242560 NCBI chr 7:99,872,020...99,901,884
Ensembl chr 7:112,593,934...112,623,629 		JBrowse link
G DMGDH dimethylglycine dehydrogenase ISO RGD PMID:20645850 RGD:7242560 NCBI chr 5:36,241,341...36,313,995
Ensembl chr 5:36,732,005...36,805,883 		JBrowse link
G FOLR2 folate receptor beta ISO RGD PMID:22108709 RGD:7242557 NCBI chr11:67,295,305...67,300,463
Ensembl chr11:70,518,931...70,524,088 		JBrowse link
G FPGS folylpolyglutamate synthase ISO RGD PMID:16859665 RGD:7242559 NCBI chr 9:98,921,986...98,933,542
Ensembl chr 9:127,593,592...127,604,200 		JBrowse link
G GCSH glycine cleavage system protein H ISO RGD PMID:20645850 RGD:7242560 NCBI chr16:61,688,959...61,702,364 JBrowse link
G GGH gamma-glutamyl hydrolase ISO RGD PMID:16859665 RGD:7242559 NCBI chr 8:59,547,821...59,571,523
Ensembl chr 8:61,222,194...61,246,252 		JBrowse link
G GLDC glycine decarboxylase ISO RGD PMID:20645850 RGD:7242560 NCBI chr 9:6,347,381...6,456,042
Ensembl chr 9:6,527,242...6,635,779 		JBrowse link
G LOC100994139 folate receptor alpha ISO RGD PMID:22108709 RGD:7242557 NCBI chr11:67,268,721...67,275,498
Ensembl chr11:70,492,039...70,498,665 		JBrowse link
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO RGD PMID:22108709 RGD:7242557 NCBI chr14:44,969,573...45,041,296
Ensembl chr14:63,223,484...63,293,881 		JBrowse link
G MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like ISO RGD PMID:22108709 RGD:7242557 NCBI chr 6:148,679,587...148,919,002
Ensembl chr 6:153,390,498...153,619,884 		JBrowse link
G MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase ISO RGD PMID:20645850 PMID:22108709 RGD:7242557 RGD:7242560 NCBI chr2A:74,270,161...74,285,790
Ensembl chr2A:75,777,028...75,792,699 		JBrowse link
G MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like ISO RGD PMID:22108709 RGD:7242557 NCBI chr 4:49,889,607...50,034,860
Ensembl chr 4:55,722,237...55,867,117 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr 1:10,548,196...10,568,174
Ensembl chr 1:11,766,334...11,785,419 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:22108709 RGD:7242557 NCBI chr 1:212,353,195...212,463,304
Ensembl chr 1:217,358,050...217,460,946 		JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr 5:8,195,868...8,228,071
Ensembl chr 5:8,017,403...8,049,322 		JBrowse link
G SARDH sarcosine dehydrogenase ISO RGD PMID:20645850 RGD:7242560 NCBI chr 9:104,786,774...104,864,480
Ensembl chr 9:133,398,806...133,473,642 		JBrowse link
G SHMT1 serine hydroxymethyltransferase 1 ISO RGD PMID:22108709 RGD:7242557 NCBI chr17:32,870,949...32,905,690
Ensembl chr17:37,849,206...37,884,220 		JBrowse link
G SHMT2 serine hydroxymethyltransferase 2 ISO RGD PMID:20645850 PMID:22108709 RGD:7242557 RGD:7242560 NCBI chr12:31,692,451...31,697,727
Ensembl chr12:31,944,785...31,950,138 		JBrowse link
G SLC19A1 solute carrier family 19 member 1 ISO RGD PMID:20814827 PMID:22108709 RGD:7242426 RGD:7242557 NCBI chr21:31,836,774...31,883,829
Ensembl chr21:45,090,595...45,134,752 		JBrowse link
G SLC25A32 solute carrier family 25 member 32 ISO RGD PMID:22332074 RGD:7242561 NCBI chr 8:100,054,560...100,071,016
Ensembl chr 8:102,210,068...102,226,732 		JBrowse link
G SLC46A1 solute carrier family 46 member 1 ISO RGD PMID:20814827 PMID:22108709 RGD:7242426 RGD:7242557 NCBI chr17:28,367,674...28,379,618
Ensembl chr17:28,870,678...28,877,632 		JBrowse link
folate mediated one-carbon metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1L1 aldehyde dehydrogenase 1 family member L1 ISO RGD PMID:14729668 RGD:1547843 NCBI chr 3:123,166,630...123,244,257
Ensembl chr 3:130,484,862...130,562,934 		JBrowse link
G ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase ISO RGD PMID:9332377 PMID:22332074 RGD:70804 RGD:7242561 NCBI chr2B:102,574,700...102,612,492
Ensembl chr2B:221,159,439...221,197,360 		JBrowse link
G DHFR dihydrofolate reductase ISO RGD PMID:11502523 PMID:22332074 RGD:1298877 RGD:7242561 NCBI chr 5:34,663,210...34,689,467
Ensembl chr 5:34,938,548...34,967,003 		JBrowse link
G DMGDH dimethylglycine dehydrogenase ISO RGD PMID:15358367 RGD:1547831 NCBI chr 5:36,241,341...36,313,995
Ensembl chr 5:36,732,005...36,805,883 		JBrowse link
G GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase ISO RGD PMID:12450384 PMID:22332074 RGD:1547842 RGD:7242561 NCBI chr21:19,871,656...19,909,893
Ensembl chr21:33,244,457...33,282,331 		JBrowse link
G GNMT glycine N-methyltransferase ISO RGD PMID:8278367 RGD:1545057 NCBI chr 6:42,550,631...42,554,385
Ensembl chr 6:43,846,560...43,849,679 		JBrowse link
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO RGD PMID:2186031 PMID:22332074 RGD:1299513 RGD:7242561 NCBI chr14:44,969,573...45,041,296
Ensembl chr14:63,223,484...63,293,881 		JBrowse link
G MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase ISO RGD PMID:9454603 RGD:1540378 NCBI chr2A:74,270,161...74,285,790
Ensembl chr2A:75,777,028...75,792,699 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase ISO RGD PMID:11933257 PMID:22332074 RGD:1535021 RGD:7242561 NCBI chr 1:10,548,196...10,568,174
Ensembl chr 1:11,766,334...11,785,419 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:15845641 PMID:20814827 RGD:1359026 RGD:7242426 NCBI chr 1:212,353,195...212,463,304
Ensembl chr 1:217,358,050...217,460,946 		JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:20814827 RGD:7242426 NCBI chr 5:8,195,868...8,228,071
Ensembl chr 5:8,017,403...8,049,322 		JBrowse link
G SHMT1 serine hydroxymethyltransferase 1 ISO RGD PMID:3110140 PMID:15671219 PMID:22332074 RGD:1359815 RGD:2300383 RGD:7242561 NCBI chr17:32,870,949...32,905,690
Ensembl chr17:37,849,206...37,884,220 		JBrowse link
G SHMT2 serine hydroxymethyltransferase 2 ISO RGD PMID:3110140 PMID:15671219 PMID:22332074 RGD:1359815 RGD:2300383 RGD:7242561 NCBI chr12:31,692,451...31,697,727
Ensembl chr12:31,944,785...31,950,138 		JBrowse link
G TYMS thymidylate synthetase ISO RGD PMID:9894005 PMID:22332074 RGD:1545055 RGD:7242561 NCBI chr18:13,653,085...13,668,478
Ensembl chr18:17,295,182...17,310,320 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4064
    classic metabolic pathway 1016
      metabolic pathway of cofactors, vitamins, nutrients 239
        folate metabolic pathway 31
          altered folate metabolic pathway + 8
          folate cycle metabolic pathway + 24
          folate mediated one-carbon metabolic pathway + 14
Path 2
Term Annotations click to browse term
  pathway 4064
    regulatory pathway 2507
      homeostasis pathway 1306
        organic chemical homeostasis pathway 364
          S-adenosylmethionine homeostasis pathway 265
            folate metabolic pathway 31
              altered folate metabolic pathway + 8
              folate cycle metabolic pathway + 24
              folate mediated one-carbon metabolic pathway + 14
paths to the root