PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: Hedgehog signaling pathway
Accession: PW:0000122
browse the term
Definition: The Hedgehog signaling pathway (Hh) plays important roles in vertebrate embryogenesis, particularly in the differentiation of the neural tube, in vasculogenesis and in angiogenesis. Post-embryonically it is believed to play a homeostatic role in the maintenance of stem cells. Alteration of the pathway has been implicated in a number of human cancers.
Synonyms: related_synonym: Signaling by Hedgehog; smoothened signaling pathway
View Interactive Diagram
G
Akt1
AKT serine/threonine kinase 1
ISO
PID
PID:200168 PID:200172
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
G
Arrb2
arrestin, beta 2
ISO
PID
PID:200168 PID:200172
NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
G
Bmp2
bone morphogenetic protein 2
IEA
KEGG
rno:04340
NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
G
Bmp4
bone morphogenetic protein 4
IEA
KEGG
rno:04340
NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
G
Bmp5
bone morphogenetic protein 5
IEA
KEGG
rno:04340
NCBI chr 8:76,517,164...76,639,925
Ensembl chr 8:76,517,164...76,639,925
G
Bmp6
bone morphogenetic protein 6
IEA
KEGG
rno:04340
NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365
G
Bmp7
bone morphogenetic protein 7
IEA
KEGG
rno:04340
NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788
G
Bmp8a
bone morphogenetic protein 8a
IEA
KEGG
rno:04340
NCBI chr 5:135,589,839...135,617,785
Ensembl chr 5:135,591,716...135,617,785
G
Boc
BOC cell adhesion associated, oncogene regulated
ISO
RGD
PMID:20844013
RGD:5510025
NCBI chr11:56,122,697...56,198,060
Ensembl chr11:56,122,750...56,198,059
G
Btrc
beta-transducin repeat containing E3 ubiquitin protein ligase
ISO IEA
KEGG RGD
PMID:20635334
rno:04340, RGD:5510026
NCBI chr 1:244,210,299...244,380,126
Ensembl chr 1:244,210,314...244,376,721
G
Cdon
cell adhesion associated, oncogene regulated
ISO
PID RGD
PMID:20844013
PID:200168, RGD:5510025
NCBI chr 8:33,775,123...33,861,635
Ensembl chr 8:33,806,183...33,859,033
G
Crebbp
CREB binding protein
ISO
PID
PID:200172
NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
G
Csnk1a1
casein kinase 1, alpha 1
ISO IEA
PID KEGG
PID:200172 rno:04340
NCBI chr18:55,017,049...55,050,184
Ensembl chr18:55,017,055...55,049,271
G
Csnk1d
casein kinase 1, delta
ISO IEA
PID KEGG
PID:200172 rno:04340
NCBI chr10:106,221,992...106,256,620
Ensembl chr10:106,221,992...106,256,614
G
Csnk1e
casein kinase 1, epsilon
ISO IEA
PID KEGG
PID:200172 rno:04340
NCBI chr 7:110,983,322...111,006,926
Ensembl chr 7:110,983,318...111,006,794
G
Csnk1g1
casein kinase 1, gamma 1
ISO IEA
PID KEGG
PID:200172 rno:04340
NCBI chr 8:66,439,760...66,577,247
Ensembl chr 8:66,439,864...66,572,826
G
Csnk1g2
casein kinase 1, gamma 2
ISO IEA
PID KEGG
PID:200172 rno:04340
NCBI chr 7:9,076,739...9,095,082
Ensembl chr 7:9,076,740...9,095,052
G
Csnk1g3
casein kinase 1, gamma 3
ISO IEA
PID KEGG
PID:200172 rno:04340
NCBI chr18:47,299,547...47,386,538
Ensembl chr18:47,299,579...47,386,535
G
Dhh
desert hedgehog signaling molecule
IMP IEA ISO
KEGG PID RGD
PMID:11118005 PMID:20844013 PMID:20716670
PID:200168 rno:04340, RGD:634737 , RGD:5510025 , RGD:5510013
NCBI chr 7:130,050,910...130,056,406
Ensembl chr 7:130,050,910...130,056,406
G
Disp1
dispatched RND transporter family member 1
ISO
RGD
PMID:20635334
RGD:5510026
NCBI chr13:94,720,928...94,866,695
Ensembl chr13:94,720,928...94,866,702
G
Fbxw11
F-box and WD repeat domain containing 11
ISO IEA
PID KEGG
PID:200172 rno:04340
NCBI chr10:17,232,735...17,330,574
Ensembl chr10:17,227,181...17,330,571
G
Foxa2
forkhead box A2
ISO
PID
PID:200172
NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326
G
Gas1
growth arrest-specific 1
ISO
PID RGD
PMID:20844013
PID:200168 RGD:5510025
NCBI chr17:4,482,168...4,485,153
G
Gli1
GLI family zinc finger 1
ISO IEA
KEGG PID RGD
PMID:20716670 PMID:20635334
PID:200172 rno:04340, RGD:5510013 , RGD:5510026
NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251
G
Gli2
GLI family zinc finger 2
ISO IEA
KEGG PID RGD
PMID:20716670 PMID:20635334
PID:200168 PID:200172 rno:04340, RGD:5510013 , RGD:5510026
NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574
G
Gli3
GLI family zinc finger 3
TAS IEA ISO
KEGG PID RGD
PMID:15328011 PMID:20635334 PMID:20716670
PID:200172 rno:04340, RGD:1303367 , RGD:5510026 , RGD:5510013
NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712
G
Gnai1
G protein subunit alpha i1
ISO
PID
PID:200172
NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417
G
Gnai2
G protein subunit alpha i2
ISO
PID
PID:200172
NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
G
Gnai3
G protein subunit alpha i3
ISO
PID
PID:200172
NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742
G
Gnao1
G protein subunit alpha o1
ISO
PID
PID:200172
NCBI chr19:11,034,874...11,192,531
Ensembl chr19:11,035,956...11,192,493
G
Gnaz
G protein subunit alpha z
ISO
PID
PID:200172
NCBI chr20:13,643,473...13,694,240
Ensembl chr20:13,644,640...13,669,907
G
Gnb1
G protein subunit beta 1
ISO
PID
PID:200172
NCBI chr 5:166,075,508...166,142,223
Ensembl chr 5:166,075,629...166,142,124
G
Gng2
G protein subunit gamma 2
ISO
PID
PID:200172
NCBI chr15:4,316,038...4,416,918
Ensembl chr15:4,316,059...4,417,183
G
Gpc1
glypican 1
ISO
RGD
PMID:20231458
RGD:5510027
NCBI chr 9:93,396,234...93,424,047
Ensembl chr 9:93,396,234...93,424,047
G
Gpc2
glypican 2
IMP
RGD
PMID:20231458
RGD:5510027
NCBI chr12:17,277,875...17,284,297
Ensembl chr12:17,277,875...17,284,208
G
Gpc3
glypican 3
ISO
RGD
PMID:20231458
RGD:5510027
NCBI chr X:131,868,986...132,236,824
Ensembl chr X:131,868,990...132,236,798
G
Gpc4
glypican 4
ISO
RGD
PMID:20231458
RGD:5510027
NCBI chr X:131,644,711...131,755,349
Ensembl chr X:131,644,704...131,755,284
G
Gpc5
glypican 5
ISO
RGD
PMID:20231458
RGD:5510027
NCBI chr15:92,207,275...93,644,054
Ensembl chr15:92,239,176...93,643,282
G
Gpc6
glypican 6
ISO
RGD
PMID:20231458
RGD:5510027
NCBI chr15:94,030,218...95,027,883
Ensembl chr15:94,029,884...95,024,006
G
Grk2
G protein-coupled receptor kinase 2
ISO
PID
PID:200168
NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582
G
Gsk3b
glycogen synthase kinase 3 beta
ISO IEA
KEGG PID RGD
PMID:20635334
PID:200172 rno:04340, RGD:5510026
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
G
Hdac1
histone deacetylase 1
ISO
PID
PID:200172
NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
G
Hdac2
histone deacetylase 2
ISO
PID
PID:200172
NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609
G
Hhat
hedgehog acyltransferase
ISO
PID
PID:200168
NCBI chr13:104,024,507...104,283,580
Ensembl chr13:104,010,916...104,282,893
G
Hhip
Hedgehog-interacting protein
ISO IEA
KEGG PID RGD
PMID:20844013
PID:200168 rno:04340, RGD:5510025
NCBI chr19:27,863,684...27,952,528
Ensembl chr19:27,863,213...27,952,528
G
Hspg2
heparan sulfate proteoglycan 2
IDA
RGD
PMID:21720682
RGD:5510033
NCBI chr 5:149,677,437...149,778,594
Ensembl chr 5:149,677,476...149,778,594
G
Ift172
intraflagellar transport 172
ISO
PID
PID:200172
NCBI chr 6:25,081,933...25,121,271
Ensembl chr 6:25,081,980...25,120,860
G
Ift88
intraflagellar transport 88
ISO
PID
PID:200172
NCBI chr15:31,573,325...31,666,068
Ensembl chr15:31,573,376...31,672,147
G
Ihh
Indian hedgehog signaling molecule
ISO IEA
KEGG PID RGD
PMID:20716670 PMID:12082161 PMID:20844013
PID:200168 rno:04340, RGD:5510013 , RGD:1299259 , RGD:5510025
NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532
G
Kif3a
kinesin family member 3a
ISO
PID
PID:200172
NCBI chr10:37,725,930...37,761,183
Ensembl chr10:37,725,970...37,759,191
G
Lgals3
galectin 3
ISO
PID
PID:200172
NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
G
Lrp2
LDL receptor related protein 2
ISO IEA
KEGG PID RGD
PMID:20635334
PID:200168 rno:04340, RGD:5510026
NCBI chr 3:54,189,305...54,346,769
Ensembl chr 3:54,189,308...54,346,708
G
Lrpap1
LDL receptor related protein associated protein 1
ISO
PID
PID:200168
NCBI chr14:75,651,371...75,663,380
Ensembl chr14:75,651,376...75,665,414
G
Map2k1
mitogen activated protein kinase kinase 1
ISO
PID
PID:200172
NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
G
Mtss1
MTSS I-BAR domain containing 1
ISO
PID
PID:200172
NCBI chr 7:90,488,751...90,628,007
Ensembl chr 7:90,488,754...90,627,968
G
Pias1
protein inhibitor of activated STAT, 1
ISO
PID
PID:200172
NCBI chr 8:63,338,150...63,451,670
Ensembl chr 8:63,338,150...63,438,905
G
Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
ISO
PID
PID:200168
NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
G
Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
ISO
PID
PID:200168
NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
G
Prkaca
protein kinase cAMP-activated catalytic subunit alpha
ISO IEA
PID KEGG
PID:200172 rno:04340
NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430
G
Prkacb
protein kinase cAMP-activated catalytic subunit beta
IEA
KEGG
rno:04340
NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198
G
Prkcd
protein kinase C, delta
ISO
PID
PID:200172
NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
G
Prkx
protein kinase cAMP-dependent X-linked catalytic subunit
IEA
KEGG
rno:04340
NCBI chr X:41,823,349...41,866,844
Ensembl chr X:41,823,355...41,866,669
G
Ptch1
patched 1
ISO IEA
KEGG PID RGD
PMID:20716670 PMID:20635334
PID:200168 PID:200172 rno:04340, RGD:5510013 , RGD:5510026
NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333
G
Ptch2
patched 2
ISO
PID RGD
PMID:20635334 PMID:20716670
PID:200168 RGD:5510013 RGD:5510026
NCBI chr 5:130,571,956...130,592,506
Ensembl chr 5:130,572,312...130,592,405
G
Pthlh
parathyroid hormone-like hormone
ISO
PID
PID:200168
NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847
G
Rab23
RAB23, member RAS oncogene family
ISO IEA
PID KEGG
PID:200172 rno:04340
NCBI chr 9:35,943,522...35,967,367
Ensembl chr 9:35,944,085...35,966,927
G
Rbbp4
RB binding protein 4, chromatin remodeling factor
ISO
PID
PID:200172
NCBI chr 5:141,655,863...141,675,157
Ensembl chr 5:141,638,421...141,675,284
G
Rbbp7
RB binding protein 7, chromatin remodeling factor
ISO
PID
PID:200172
NCBI chr X:31,913,080...31,931,245
Ensembl chr X:31,913,081...31,931,226
G
Sap18
Sin3A associated protein 18
ISO
PID
PID:200172
NCBI chr15:31,943,228...31,947,534
Ensembl chr15:31,943,230...31,950,038 Ensembl chr10:31,943,230...31,950,038
G
Sap30
Sin3A associated protein 30
ISO
PID
PID:200172
NCBI chr16:32,747,777...32,753,114
Ensembl chr16:32,747,734...32,753,112
G
Shh
sonic hedgehog signaling molecule
ISO IEA
KEGG PID RGD
PMID:20716670 PMID:12417650 PMID:20844013
PID:200168 PID:200172 rno:04340, RGD:5510013 , RGD:628387 , RGD:5510025
NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
G
Sin3a
SIN3 transcription regulator family member A
ISO
PID
PID:200172
NCBI chr 8:57,481,539...57,536,195
Ensembl chr 8:57,481,573...57,536,192
G
Sin3b
SIN3 transcription regulator family member B
ISO
PID
PID:200172
NCBI chr16:17,123,277...17,159,978
Ensembl chr16:17,123,434...17,159,978
G
Smo
smoothened, frizzled class receptor
ISO IEA
KEGG PID RGD
PMID:20716670 PMID:9422511 PMID:20635334
PID:200168 PID:200172 rno:04340, RGD:5510013 , RGD:704355 , RGD:5510026
NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829
G
Spop
speckle type BTB/POZ protein
ISO
PID
PID:200172
NCBI chr10:80,358,121...80,438,983
Ensembl chr10:80,358,124...80,483,955
G
Sspo
SCO-spondin
ISO
PID
PID:200172
NCBI chr 4:77,394,915...77,450,526
Ensembl chr 4:77,397,059...77,450,412
G
Stil
STIL, centriolar assembly protein
ISO
PID
PID:200168
NCBI chr 5:128,520,837...128,573,732
Ensembl chr 5:128,520,953...128,573,730
G
Stk36
serine/threonine kinase 36
ISO IEA
PID KEGG
PID:200172 rno:04340
NCBI chr 9:76,176,922...76,204,423
Ensembl chr 9:76,176,920...76,204,422
G
Sufu
SUFU negative regulator of hedgehog signaling
ISO IEA
KEGG PID RGD
PMID:20716670
PID:200172 rno:04340, RGD:5510013
NCBI chr 1:245,257,725...245,355,576
Ensembl chr 1:245,257,768...245,355,577
G
Tgfb2
transforming growth factor, beta 2
ISO
PID
PID:200168
NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
G
Wnt1
Wnt family member 1
IEA
KEGG
rno:04340
NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651
G
Wnt10a
Wnt family member 10A
IEA
KEGG
rno:04340
NCBI chr 9:76,349,931...76,362,400
Ensembl chr 9:76,349,931...76,362,400
G
Wnt10b
Wnt family member 10B
IEA
KEGG
rno:04340
NCBI chr 7:129,922,088...129,927,892
Ensembl chr 7:129,922,088...129,927,892
G
Wnt11
Wnt family member 11
IEA
KEGG
rno:04340
NCBI chr 1:153,134,503...153,154,294
Ensembl chr 1:153,138,197...153,154,294
G
Wnt16
Wnt family member 16
IEA
KEGG
rno:04340
NCBI chr 4:50,820,968...50,831,380
Ensembl chr 4:50,820,968...50,831,380
G
Wnt2
Wnt family member 2
IEA
KEGG
rno:04340
NCBI chr 4:46,328,408...46,374,673
Ensembl chr 4:46,333,998...46,374,402
G
Wnt2b
Wnt family member 2B
IEA
KEGG
rno:04340
NCBI chr 2:192,454,226...192,468,599
Ensembl chr 2:192,453,824...192,470,308
G
Wnt3
Wnt family member 3
IEA
KEGG
rno:04340
NCBI chr10:88,680,198...88,724,170
Ensembl chr10:88,680,248...88,724,099
G
Wnt3a
Wnt family member 3A
IEA
KEGG
rno:04340
NCBI chr10:44,034,174...44,078,366
Ensembl chr10:44,034,194...44,078,324
G
Wnt4
Wnt family member 4
IEA
KEGG
rno:04340
NCBI chr 5:149,513,573...149,535,415
Ensembl chr 5:149,514,018...149,532,859
G
Wnt5a
Wnt family member 5A
IEA
KEGG
rno:04340
NCBI chr16:3,697,032...3,718,230
Ensembl chr16:3,697,032...3,718,234
G
Wnt5b
Wnt family member 5B
IEA
KEGG
rno:04340
NCBI chr 4:152,609,566...152,733,790
Ensembl chr 4:152,609,569...152,733,407
G
Wnt6
Wnt family member 6
IEA
KEGG
rno:04340
NCBI chr 9:76,329,882...76,343,523
Ensembl chr 9:76,329,882...76,343,523
G
Wnt7a
Wnt family member 7A
IEA
KEGG
rno:04340
NCBI chr 4:123,863,108...123,908,981
Ensembl chr 4:123,863,108...123,908,981
G
Wnt7b
Wnt family member 7B
IEA
KEGG
rno:04340
NCBI chr 7:116,634,817...116,679,459
Ensembl chr 7:116,634,814...116,679,581
G
Wnt8a
Wnt family member 8A
IEA
KEGG
rno:04340
NCBI chr18:26,137,690...26,143,283
Ensembl chr18:26,137,690...26,143,283
G
Wnt8b
Wnt family member 8B
IEA
KEGG
rno:04340
NCBI chr 1:243,354,145...243,376,000
Ensembl chr 1:243,354,086...243,374,286
G
Wnt9a
Wnt family member 9A
IEA
KEGG
rno:04340
NCBI chr10:44,094,140...44,121,134
Ensembl chr10:44,094,140...44,121,133
G
Wnt9b
Wnt family member 9B
IEA
KEGG
rno:04340
NCBI chr10:88,635,330...88,657,035
Ensembl chr10:88,635,331...88,657,035
G
Xpo1
exportin 1
ISO
PID
PID:200172
NCBI chr14:97,233,282...97,275,536
Ensembl chr14:97,233,270...97,275,498
G
Zic2
Zic family member 2
IEA
KEGG
rno:04340
NCBI chr15:99,576,697...99,581,522
Ensembl chr15:99,576,697...99,581,522
G
Boc
BOC cell adhesion associated, oncogene regulated
ISO
RGD
PMID:18772397
RGD:5490966
NCBI chr11:56,122,697...56,198,060
Ensembl chr11:56,122,750...56,198,059
G
Dhh
desert hedgehog signaling molecule
IMP
RGD
PMID:11118005
RGD:634737
NCBI chr 7:130,050,910...130,056,406
Ensembl chr 7:130,050,910...130,056,406
G
Gli1
GLI family zinc finger 1
ISO
RGD
PMID:21186299 PMID:18772397
RGD:5491005 , RGD:5490966
NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251
G
Gli3
GLI family zinc finger 3
ISS ISO
RGD
PMID:15328011 PMID:18772397
RGD:1303367 , RGD:5490966
NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712
G
Lrp2
LDL receptor related protein 2
ISO
RGD
PMID:18772397
RGD:5490966
NCBI chr 3:54,189,305...54,346,769
Ensembl chr 3:54,189,308...54,346,708
G
Shh
sonic hedgehog signaling molecule
ISO
RGD
PMID:19506583
RGD:5490965
NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
G
Smo
smoothened, frizzled class receptor
ISO
RGD
PMID:9422511
RGD:704355
NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all