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ONTOLOGY REPORT - ANNOTATIONS


Term:extrinsic apoptotic pathway
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Accession:PW:0000106 term browser browse the term
Definition:The apoptotic pathway involving the death receptors mediated route of caspase activation. Members of tumor necrosis superfamily such as the better known Tnf-alpha (Tnf), Fas ligand or Trail elicit apoptosis via receptor associated adapters.
Synonyms:related_synonym: death receptor mediated apoptotic pathway

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extrinsic apoptotic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CASP10 caspase 10 JBrowse link 15 104,858,082 104,895,941 RGD:9068941
G CASP3 caspase 3 JBrowse link 15 45,744,320 45,753,252 RGD:9068941
G CASP7 caspase 7 JBrowse link 14 124,017,776 124,050,369 RGD:9068941
G CASP8 caspase 8 JBrowse link 15 104,923,659 104,948,470 RGD:9068941
G FAS Fas cell surface death receptor JBrowse link 14 100,927,305 100,954,781 RGD:9068941
FasL mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AKT1 AKT serine/threonine kinase 1 RGD:9068941
G BID BH3 interacting domain death agonist JBrowse link 5 69,849,007 69,874,647 RGD:9068941
G BIRC3 baculoviral IAP repeat containing 3 JBrowse link 9 33,003,570 33,020,252 RGD:9068941
G BTK Bruton tyrosine kinase JBrowse link X 82,981,512 83,014,475 RGD:9068941
G CASP10 caspase 10 JBrowse link 15 104,858,082 104,895,941 RGD:9068941
G CASP3 caspase 3 JBrowse link 15 45,744,320 45,753,252 RGD:9068941
G CASP7 caspase 7 JBrowse link 14 124,017,776 124,050,369 RGD:9068941
G CASP8 caspase 8 JBrowse link 15 104,923,659 104,948,470 RGD:9068941
G CFLAR CASP8 and FADD like apoptosis regulator JBrowse link 15 104,780,744 104,835,631 RGD:9068941
G CHUK component of inhibitor of nuclear factor kappa B kinase complex JBrowse link 14 111,316,178 111,351,669 RGD:9068941
G CLTC clathrin heavy chain JBrowse link 12 35,848,894 35,926,028 RGD:9068941
G EZR ezrin JBrowse link 1 8,403,362 8,452,750 RGD:9068941
G FADD Fas associated via death domain JBrowse link 2 3,191,718 3,194,820 RGD:9068941
G FAIM2 Fas apoptotic inhibitory molecule 2 JBrowse link 5 15,779,329 15,813,029 RGD:9068941
G FAS Fas cell surface death receptor JBrowse link 14 100,927,305 100,954,781 RGD:9068941
G FASLG Fas ligand (TNF superfamily, member 6) JBrowse link 9 115,068,314 115,075,147 RGD:9068941
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 17 11,289,607 11,348,557 RGD:9068941
G IKBKG inhibitor of nuclear factor kappa B kinase regulatory subunit gamma JBrowse link X 125,035,575 125,056,445 RGD:9068941
G LOC100511937 phosphatidylinositol 3-kinase regulatory subunit gamma JBrowse link 6 165,268,260 165,402,668 RGD:9068941
G MAP2K6 mitogen-activated protein kinase kinase 6 JBrowse link 12 10,891,445 11,018,617 RGD:9068941
G MAP2K7 mitogen-activated protein kinase kinase 7 JBrowse link 2 71,299,010 71,308,432 RGD:9068941
G MAP3K1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 16 35,872,301 35,947,097 RGD:9068941
G MAPK10 mitogen-activated protein kinase 10 JBrowse link 8 132,445,818 132,751,575 RGD:9068941
G MAPK11 mitogen-activated protein kinase 11 JBrowse link 5 420,848 428,103 RGD:9068941
G MAPK14 mitogen-activated protein kinase 14 JBrowse link 7 31,791,398 31,861,544 RGD:9068941
G MAPK8 mitogen-activated protein kinase 8 JBrowse link 14 88,988,914 89,108,875 RGD:9068941
G MAPK9 mitogen-activated protein kinase 9 JBrowse link 2 78,338,466 78,399,108 RGD:9068941
G PDPK1 3-phosphoinositide dependent protein kinase 1 JBrowse link 3 39,429,928 39,512,623 RGD:9068941
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha JBrowse link 13 117,193,935 117,282,151 RGD:9068941
G PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta JBrowse link 13 79,427,033 79,610,840 RGD:9068941
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta JBrowse link 6 70,026,254 70,086,950 RGD:9068941
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 16 46,434,757 46,523,626 RGD:9068941
G PIK3R2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 2 59,637,363 59,652,075 RGD:9068941
G RFC1 replication factor C subunit 1 JBrowse link 8 30,552,369 30,635,932 RGD:9068941
G RIPK1 receptor interacting serine/threonine kinase 1 JBrowse link 7 1,841,143 1,880,705 RGD:9068941
G SMPD1 sphingomyelin phosphodiesterase 1 JBrowse link 9 3,324,091 3,328,493 RGD:9068941
G SRC SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 17 40,470,970 40,524,862 RGD:9068941
G SYK spleen associated tyrosine kinase JBrowse link 14 2,103,706 2,160,886 RGD:9068941
Trail mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BID BH3 interacting domain death agonist JBrowse link 5 69,849,007 69,874,647 RGD:9068941
G CASP10 caspase 10 JBrowse link 15 104,858,082 104,895,941 RGD:9068941
G CASP3 caspase 3 JBrowse link 15 45,744,320 45,753,252 RGD:9068941
G CASP7 caspase 7 JBrowse link 14 124,017,776 124,050,369 RGD:9068941
G CASP8 caspase 8 JBrowse link 15 104,923,659 104,948,470 RGD:9068941
G CFLAR CASP8 and FADD like apoptosis regulator JBrowse link 15 104,780,744 104,835,631 RGD:9068941
G CHUK component of inhibitor of nuclear factor kappa B kinase complex JBrowse link 14 111,316,178 111,351,669 RGD:9068941
G DAP3 death associated protein 3 JBrowse link 4 94,256,460 94,298,492 RGD:9068941
G FADD Fas associated via death domain JBrowse link 2 3,191,718 3,194,820 RGD:9068941
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 17 11,289,607 11,348,557 RGD:9068941
G IKBKG inhibitor of nuclear factor kappa B kinase regulatory subunit gamma JBrowse link X 125,035,575 125,056,445 RGD:9068941
G LOC100511937 phosphatidylinositol 3-kinase regulatory subunit gamma JBrowse link 6 165,268,260 165,402,668 RGD:9068941
G MAP2K4 mitogen-activated protein kinase kinase 4 JBrowse link 12 56,402,029 56,516,217 RGD:9068941
G MAP3K1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 16 35,872,301 35,947,097 RGD:9068941
G MAPK1 mitogen-activated protein kinase 1 JBrowse link 14 50,083,079 50,165,528 RGD:9068941
G MAPK3 mitogen-activated protein kinase 3 JBrowse link 3 18,291,444 18,299,410 RGD:9068941
G MAPK8 mitogen-activated protein kinase 8 JBrowse link 14 88,988,914 89,108,875 RGD:9068941
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha JBrowse link 13 117,193,935 117,282,151 RGD:9068941
G PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta JBrowse link 13 79,427,033 79,610,840 RGD:9068941
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta JBrowse link 6 70,026,254 70,086,950 RGD:9068941
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 16 46,434,757 46,523,626 RGD:9068941
G PIK3R2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 2 59,637,363 59,652,075 RGD:9068941
G RIPK1 receptor interacting serine/threonine kinase 1 JBrowse link 7 1,841,143 1,880,705 RGD:9068941
G SMPD1 sphingomyelin phosphodiesterase 1 JBrowse link 9 3,324,091 3,328,493 RGD:9068941
G TNFSF10 TNF superfamily member 10 JBrowse link 13 111,021,952 111,103,060 RGD:9068941
G TRADD TNFRSF1A associated via death domain JBrowse link 6 27,797,594 27,804,654 RGD:9068941
G TRAF2 TNF receptor associated factor 2 RGD:9068941
tumor necrosis factor mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ADAM17 ADAM metallopeptidase domain 17 JBrowse link 3 126,795,513 126,853,995 RGD:9068941
G BAG4 BAG cochaperone 4 JBrowse link 15 48,299,456 48,348,810 RGD:9068941
G BIRC3 baculoviral IAP repeat containing 3 JBrowse link 9 33,003,570 33,020,252 RGD:9068941
G CASP8 caspase 8 JBrowse link 15 104,923,659 104,948,470 RGD:9068941
G CAV1 caveolin 1 JBrowse link 18 29,648,120 29,682,451 RGD:9068941
G CHUK component of inhibitor of nuclear factor kappa B kinase complex JBrowse link 14 111,316,178 111,351,669 RGD:9068941
G CYLD CYLD lysine 63 deubiquitinase JBrowse link 6 34,058,091 34,121,939 RGD:9068941
G FADD Fas associated via death domain JBrowse link 2 3,191,718 3,194,820 RGD:9068941
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 17 11,289,607 11,348,557 RGD:9068941
G IKBKG inhibitor of nuclear factor kappa B kinase regulatory subunit gamma JBrowse link X 125,035,575 125,056,445 RGD:9068941
G ITCH itchy E3 ubiquitin protein ligase JBrowse link 17 37,810,113 37,918,963 RGD:9068941
G MADD MAP kinase activating death domain JBrowse link 2 15,270,783 15,315,459 RGD:9068941
G MAP2K3 mitogen-activated protein kinase kinase 3 JBrowse link 12 61,396,337 61,417,333 RGD:9068941
G MAP2K7 mitogen-activated protein kinase kinase 7 JBrowse link 2 71,299,010 71,308,432 RGD:9068941
G MAP3K1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 16 35,872,301 35,947,097 RGD:9068941
G MAP3K3 mitogen-activated protein kinase kinase kinase 3 JBrowse link 12 15,228,979 15,298,784 RGD:9068941
G MAP3K5 mitogen-activated protein kinase kinase kinase 5 JBrowse link 1 27,380,143 27,600,500 RGD:9068941
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 JBrowse link 1 58,482,046 58,548,087 RGD:9068941
G MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 JBrowse link 2 7,365,184 7,378,999 RGD:9068941
G MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 JBrowse link 3 100,887,148 101,084,667 RGD:9068941
G MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 JBrowse link 3 52,483,028 52,649,480 RGD:9068941
G MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 JBrowse link 1 180,164,427 180,299,491 RGD:9068941
G NFKB1 nuclear factor kappa B subunit 1 JBrowse link 8 118,391,010 118,478,927 RGD:9068941
G NRK Nik related kinase JBrowse link X 86,534,467 86,663,340 RGD:9068941
G NSMAF neutral sphingomyelinase activation associated factor JBrowse link 4 74,231,488 74,296,681 RGD:9068941
G PRKCI protein kinase C iota JBrowse link 13 108,913,018 108,997,934 RGD:9068941
G PRKCZ protein kinase C zeta JBrowse link 6 64,073,343 64,159,187 RGD:9068941
G RACK1 receptor for activated C kinase 1 JBrowse link 2 57,280,192 57,284,846 RGD:9068941
G RBCK1 RANBP2-type and C3HC4-type zinc finger containing 1 JBrowse link 17 34,784,018 34,801,228 RGD:9068941
G RELA RELA proto-oncogene, NF-kB subunit JBrowse link 2 6,594,869 6,602,684 RGD:9068941
G RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase JBrowse link 12 40,075,259 40,151,034 RGD:9068941
G RIPK1 receptor interacting serine/threonine kinase 1 JBrowse link 7 1,841,143 1,880,705 RGD:9068941
G RNF11 ring finger protein 11 JBrowse link 6 160,875,868 160,911,713 RGD:9068941
G SHARPIN SHANK associated RH domain interactor JBrowse link 4 600,698 605,711 RGD:9068941
G SMPD1 sphingomyelin phosphodiesterase 1 JBrowse link 9 3,324,091 3,328,493 RGD:9068941
G SMPD2 sphingomyelin phosphodiesterase 2 JBrowse link 1 75,508,303 75,511,572 RGD:9068941
G SQSTM1 sequestosome 1 JBrowse link 2 78,752,768 78,763,998 RGD:9068941
G STAT1 signal transducer and activator of transcription 1 JBrowse link 15 95,593,201 95,646,324 RGD:9068941
G TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 JBrowse link 5 8,827,363 8,852,814 RGD:9068941
G TAB2 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 JBrowse link 1 16,533,364 16,611,879 RGD:9068941
G TAB3 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 JBrowse link X 26,632,547 26,729,039 RGD:9068941
G TAX1BP1 Tax1 binding protein 1 JBrowse link 18 44,827,908 44,910,265 RGD:9068941
G TNF tumor necrosis factor JBrowse link 7 23,699,635 23,702,393 RGD:9068941
G TNFAIP3 TNF alpha induced protein 3 JBrowse link 1 26,474,158 26,489,771 RGD:9068941
G TNFRSF1A TNF receptor superfamily member 1A JBrowse link 5 64,319,349 64,331,876 RGD:9068941
G TNFRSF1B TNF receptor superfamily member 1B JBrowse link 6 72,195,420 72,231,146 RGD:9068941
G TNIK TRAF2 and NCK interacting kinase JBrowse link 13 109,642,848 110,052,345 RGD:9068941
G TRADD TNFRSF1A associated via death domain JBrowse link 6 27,797,594 27,804,654 RGD:9068941
G TRAF1 TNF receptor associated factor 1 JBrowse link 1 260,948,191 260,973,978 RGD:9068941
G TRAF2 TNF receptor associated factor 2 RGD:9068941
G TRAF5 TNF receptor associated factor 5 JBrowse link 9 131,772,810 131,822,555 RGD:9068941
G TXN thioredoxin JBrowse link 1 251,264,180 251,278,000 RGD:9068941

Term paths to the root
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  pathway 5636
    regulatory pathway 3440
      cell death pathway 227
        programmed cell death pathway 227
          apoptotic cell death pathway 149
            extrinsic apoptotic pathway 85
              FasL mediated signaling pathway + 38
              Trail mediated signaling pathway + 27
              altered extrinsic apoptotic pathway + 0
              tumor necrosis factor mediated signaling pathway + 52
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.