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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:tryptophan metabolic pathway
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Accession:PW:0000054 term browser browse the term
Definition:Those metabolic reactions that are involved in the synthesis, utilization and/or degradation of tryptophan - a dietary essential amino acid and precursor for several important compounds. Along with phenylalanine and tyrosine, it is one of the three aromatic amino acids.
Synonyms:related_synonym: tryptophan metabolic process


show annotations for term's descendants           Sort by:
tryptophan metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AADAT aminoadipate aminotransferase ISO
EXP
IEA		 SMPDB
KEGG
RGD		 PMID:6466295 PMID:3400092 SMP:00063 hsa:00380, RGD:2290312, RGD:2290313 NCBI chr 4:170,060,222...170,094,292
Ensembl chr 4:170,060,222...170,091,699 		JBrowse link
G AANAT aralkylamine N-acetyltransferase IEA
EXP		 KEGG
SMPDB		 SMP:00063 hsa:00380 NCBI chr17:76,453,351...76,470,117
Ensembl chr17:76,453,351...76,470,117 		JBrowse link
G ACAT1 acetyl-CoA acetyltransferase 1 IEA KEGG hsa:00380 NCBI chr11:108,116,705...108,147,603
Ensembl chr11:108,116,695...108,147,603 		JBrowse link
G ACAT2 acetyl-CoA acetyltransferase 2 IEA KEGG hsa:00380 NCBI chr 6:159,762,045...159,779,112
Ensembl chr 6:159,762,045...159,779,112 		JBrowse link
G ACMSD aminocarboxymuconate semialdehyde decarboxylase IEA
EXP		 KEGG
SMPDB		 SMP:00063 hsa:00380 NCBI chr 2:134,838,616...134,902,034
Ensembl chr 2:134,838,616...134,902,034 		JBrowse link
G AFMID arylformamidase IEA
EXP		 KEGG
SMPDB		 SMP:00063 hsa:00380 NCBI chr17:78,187,362...78,207,702
Ensembl chr17:78,187,358...78,207,702 		JBrowse link
G ALDH1B1 aldehyde dehydrogenase 1 family member B1 IEA KEGG hsa:00380 NCBI chr 9:38,392,702...38,398,661
Ensembl chr 9:38,392,702...38,398,661 		JBrowse link
G ALDH2 aldehyde dehydrogenase 2 family member IEA
EXP		 KEGG
SMPDB		 SMP:00063 hsa:00380 NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532 		JBrowse link
G ALDH3A2 aldehyde dehydrogenase 3 family member A2 IEA KEGG hsa:00380 NCBI chr17:19,648,136...19,677,596
Ensembl chr17:19,648,136...19,685,760 		JBrowse link
G ALDH7A1 aldehyde dehydrogenase 7 family member A1 IEA KEGG hsa:00380 NCBI chr 5:126,541,841...126,595,219
Ensembl chr 5:126,531,200...126,595,362 		JBrowse link
G ALDH9A1 aldehyde dehydrogenase 9 family member A1 IEA KEGG hsa:00380 NCBI chr 1:165,662,216...165,698,562
Ensembl chr 1:165,662,216...165,698,562 		JBrowse link
G AOC1 amine oxidase copper containing 1 IEA KEGG hsa:00380 NCBI chr 7:150,852,120...150,861,504
Ensembl chr 7:150,824,627...150,861,504 		JBrowse link
G AOX1 aldehyde oxidase 1 IEA
EXP		 KEGG
SMPDB		 SMP:00063 hsa:00380 NCBI chr 2:200,586,014...200,682,241
Ensembl chr 2:200,586,014...200,677,064 		JBrowse link
G ASMT acetylserotonin O-methyltransferase IEA
EXP		 KEGG
SMPDB		 SMP:00063 hsa:00380 NCBI chr  X:1,615,059...1,643,081
NCBI chr  Y:1,615,059...1,643,081
Ensembl chr  Y:1,615,059...1,643,081
Ensembl chr  X:1,615,059...1,643,081 		JBrowse link
G CAT catalase IEA
EXP		 KEGG
SMPDB		 SMP:00063 hsa:00380 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 IEA
EXP		 KEGG
SMPDB		 SMP:00063 hsa:00380 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 IEA KEGG hsa:00380 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 IEA KEGG hsa:00380 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902 		JBrowse link
G DDC dopa decarboxylase IEA
EXP		 KEGG
SMPDB		 SMP:00063 hsa:00380 NCBI chr 7:50,458,442...50,565,405
Ensembl chr 7:50,458,436...50,565,405 		JBrowse link
G ECHS1 enoyl-CoA hydratase, short chain 1 IEA KEGG hsa:00380 NCBI chr10:133,362,485...133,373,354
Ensembl chr10:133,362,485...133,373,354 		JBrowse link
G EHHADH enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase IEA KEGG hsa:00380 NCBI chr 3:185,190,624...185,254,049
Ensembl chr 3:185,190,624...185,281,990 		JBrowse link
G GCDH glutaryl-CoA dehydrogenase IEA KEGG hsa:00380 NCBI chr19:12,891,129...12,899,999
Ensembl chr19:12,891,160...12,914,207 		JBrowse link
G HAAO 3-hydroxyanthranilate 3,4-dioxygenase IEA
EXP		 KEGG
SMPDB		 SMP:00063 hsa:00380 NCBI chr 2:42,767,089...42,792,583
Ensembl chr 2:42,767,089...42,792,593 		JBrowse link
G HADH hydroxyacyl-CoA dehydrogenase IEA KEGG hsa:00380 NCBI chr 4:107,989,889...108,035,171
Ensembl chr 4:107,989,714...108,035,241 		JBrowse link
G HADHA hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha IEA KEGG hsa:00380 NCBI chr 2:26,190,635...26,244,632
Ensembl chr 2:26,190,635...26,244,672 		JBrowse link
G IDO1 indoleamine 2,3-dioxygenase 1 ISO
EXP
IEA		 SMPDB
KEGG
RGD		 PMID:10719243 PMID:3400092 SMP:00063 hsa:00380, RGD:2290190, RGD:2290313 NCBI chr 8:39,913,891...39,928,790
Ensembl chr 8:39,902,275...39,928,790 		JBrowse link
G IDO2 indoleamine 2,3-dioxygenase 2 IEA KEGG hsa:00380 NCBI chr 8:39,934,651...40,016,392
Ensembl chr 8:39,934,614...40,016,392 		JBrowse link
G IL4I1 interleukin 4 induced 1 IEA KEGG hsa:00380 NCBI chr19:49,889,654...49,929,504
Ensembl chr19:49,889,654...49,929,539 		JBrowse link
G INMT indolethylamine N-methyltransferase IEA
EXP		 KEGG
SMPDB		 SMP:00063 hsa:00380 NCBI chr 7:30,752,135...30,757,602
Ensembl chr 7:30,697,985...30,757,602 		JBrowse link
G KMO kynurenine 3-monooxygenase ISO
EXP
IEA		 SMPDB
KEGG
RGD		 PMID:6466295 PMID:3400092 SMP:00063 hsa:00380, RGD:2290312, RGD:2290313 NCBI chr 1:241,532,378...241,595,642
Ensembl chr 1:241,532,134...241,595,642 		JBrowse link
G KYAT1 kynurenine aminotransferase 1 IEA KEGG hsa:00380 NCBI chr 9:128,832,942...128,882,523
Ensembl chr 9:128,832,942...128,882,494
Ensembl chr 9:128,832,942...128,882,494 		JBrowse link
G KYAT3 kynurenine aminotransferase 3 IEA KEGG hsa:00380 NCBI chr 1:88,921,044...88,992,960
Ensembl chr 1:88,935,773...88,992,953 		JBrowse link
G KYNU kynureninase ISO
EXP
IEA		 SMPDB
KEGG
RGD		 PMID:6466295 PMID:7236232 PMID:3400092 SMP:00063 hsa:00380, RGD:2290312, RGD:2303721, RGD:2290313 NCBI chr 2:142,877,664...143,055,833
Ensembl chr 2:142,877,657...143,055,833 		JBrowse link
G MAOA monoamine oxidase A IEA KEGG hsa:00380 NCBI chr  X:43,655,006...43,746,817
Ensembl chr  X:43,654,907...43,746,817 		JBrowse link
G MAOB monoamine oxidase B IEA KEGG hsa:00380 NCBI chr  X:43,766,610...43,882,450
Ensembl chr  X:43,766,610...43,882,450 		JBrowse link
G OGDH oxoglutarate dehydrogenase IEA KEGG hsa:00380 NCBI chr 7:44,606,627...44,709,066
Ensembl chr 7:44,606,572...44,709,066 		JBrowse link
G OGDHL oxoglutarate dehydrogenase L IEA KEGG hsa:00380 NCBI chr10:49,734,641...49,762,379
Ensembl chr10:49,734,641...49,762,379 		JBrowse link
G TDO2 tryptophan 2,3-dioxygenase ISO
EXP
IEA		 SMPDB
KEGG
RGD		 PMID:10719243 PMID:7236232 PMID:3400092 SMP:00063 hsa:00380, RGD:2290190, RGD:2303721, RGD:2290313 NCBI chr 4:155,903,696...155,920,406
Ensembl chr 4:155,854,738...155,920,406 		JBrowse link
G TPH1 tryptophan hydroxylase 1 IEA
EXP		 KEGG
SMPDB		 SMP:00063 hsa:00380 NCBI chr11:18,017,555...18,046,269
Ensembl chr11:18,017,555...18,046,269 		JBrowse link
G TPH2 tryptophan hydroxylase 2 IEA KEGG hsa:00380 NCBI chr12:71,938,845...72,032,440
Ensembl chr12:71,938,845...72,186,618 		JBrowse link
G WARS1 tryptophanyl-tRNA synthetase 1 IEA
EXP		 KEGG
SMPDB		 SMP:00063 hsa:00380 NCBI chr14:100,333,790...100,376,327
Ensembl chr14:100,333,790...100,376,805 		JBrowse link
G WARS2 tryptophanyl tRNA synthetase 2, mitochondrial IEA
EXP		 KEGG
SMPDB		 SMP:00063 hsa:00380 NCBI chr 1:119,031,216...119,140,672
Ensembl chr 1:119,031,216...119,140,654 		JBrowse link
kynurenine metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AADAT aminoadipate aminotransferase TAS RGD PMID:19826765 RGD:11081066 NCBI chr 4:170,060,222...170,094,292
Ensembl chr 4:170,060,222...170,091,699 		JBrowse link
G ACMSD aminocarboxymuconate semialdehyde decarboxylase TAS RGD PMID:25773161 RGD:11062165 NCBI chr 2:134,838,616...134,902,034
Ensembl chr 2:134,838,616...134,902,034 		JBrowse link
G AFMID arylformamidase TAS RGD PMID:25773161 RGD:11062165 NCBI chr17:78,187,362...78,207,702
Ensembl chr17:78,187,358...78,207,702 		JBrowse link
G GOT2 glutamic-oxaloacetic transaminase 2 TAS RGD PMID:19826765 RGD:11081066 NCBI chr16:58,707,131...58,734,316
Ensembl chr16:58,707,131...58,734,342 		JBrowse link
G HAAO 3-hydroxyanthranilate 3,4-dioxygenase TAS RGD PMID:25773161 RGD:11062165 NCBI chr 2:42,767,089...42,792,583
Ensembl chr 2:42,767,089...42,792,593 		JBrowse link
G IDO1 indoleamine 2,3-dioxygenase 1 TAS
IEP		 RGD PMID:25773161 PMID:32369456 PMID:26186743 RGD:11062165, RGD:39939073, RGD:11081068 NCBI chr 8:39,913,891...39,928,790
Ensembl chr 8:39,902,275...39,928,790 		JBrowse link
G IDO2 indoleamine 2,3-dioxygenase 2 TAS RGD PMID:25773161 RGD:11062165 NCBI chr 8:39,934,651...40,016,392
Ensembl chr 8:39,934,614...40,016,392 		JBrowse link
G KMO kynurenine 3-monooxygenase TAS RGD PMID:25773161 PMID:26589832 RGD:11062165, RGD:11081069 NCBI chr 1:241,532,378...241,595,642
Ensembl chr 1:241,532,134...241,595,642 		JBrowse link
G KYAT1 kynurenine aminotransferase 1 TAS RGD PMID:19826765 RGD:11081066 NCBI chr 9:128,832,942...128,882,523
Ensembl chr 9:128,832,942...128,882,494
Ensembl chr 9:128,832,942...128,882,494 		JBrowse link
G KYAT3 kynurenine aminotransferase 3 TAS RGD PMID:19826765 RGD:11081066 NCBI chr 1:88,921,044...88,992,960
Ensembl chr 1:88,935,773...88,992,953 		JBrowse link
G KYNU kynureninase TAS RGD PMID:25773161 RGD:11062165 NCBI chr 2:142,877,664...143,055,833
Ensembl chr 2:142,877,657...143,055,833 		JBrowse link
G TDO2 tryptophan 2,3-dioxygenase TAS RGD PMID:25773161 PMID:27072164 RGD:11062165, RGD:11081067 NCBI chr 4:155,903,696...155,920,406
Ensembl chr 4:155,854,738...155,920,406 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5958
    classic metabolic pathway 1803
      amino acid metabolic pathway 319
        amino acid metabolic pathway (KEGG) 281
          tryptophan metabolic pathway 43
            tryptophan biosynthetic pathway 0
            tryptophan degradation pathway + 12
paths to the root