PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: methionine cycle/metabolic pathway
Accession: PW:0000048
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Definition: Those metabolic reactions involved in the synthesis (remethylation), utilization and/or degradation of methionine, an essential amino acid for humans. The cycle produces S-adenosylmethionine (AdoMet), the major methyl donor for proteins, nucleic acids, lipids and other small molecules. The cycle also produces homocysteine (Hcy) which either regenerates methionine via the remethylation pathway or leads to the synthesis of cysteine and derivatives via the transsulfuration pathway. Homocysteine and folate metabolic pathways are intimately related to the methionine cycle.
Synonyms: related_synonym: SMP:00033
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Ahcy
S-adenosylhomocysteine hydrolase
ISS ISO
SMPDB RGD
PMID:11741948 PMID:23073625 PMID:2292587
SMP:00033, RGD:730275 , RGD:7242425 , RGD:7242932
NCBI chr 2:154,901,230...154,916,417
Ensembl chr 2:154,901,230...154,916,417
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Amd1
S-adenosylmethionine decarboxylase 1
ISO
SMPDB RGD
PMID:23073625 PMID:2292587
SMP:00033, RGD:7242425 , RGD:7242932
NCBI chr10:40,163,454...40,178,184
Ensembl chr10:40,163,454...40,178,184
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As3mt
arsenite methyltransferase
ISO
RGD
PMID:11790780
RGD:625365
NCBI chr19:46,695,124...46,729,538
Ensembl chr19:46,695,897...46,729,538
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Asmt
acetylserotonin O-methyltransferase
ISO
RGD
PMID:12198599
RGD:1359073
NCBI chr X:169,106,379...169,111,787
Ensembl chr X:169,106,280...169,112,125
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Bhmt
betaine-homocysteine methyltransferase
ISO
SMPDB RGD
PMID:23073625
SMP:00033, RGD:7242425
NCBI chr13:93,753,399...93,774,266
Ensembl chr13:93,753,183...93,774,469
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Carm1
coactivator-associated arginine methyltransferase 1
ISO
RGD
PMID:21074527
RGD:7242552
NCBI chr 9:21,458,163...21,500,763
Ensembl chr 9:21,458,190...21,503,919
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Cbs
cystathionine beta-synthase
ISO
SMPDB
SMP:00033
NCBI chr17:31,831,602...31,856,170
Ensembl chr17:31,827,868...31,856,212
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Chdh
choline dehydrogenase
ISO
SMPDB
SMP:00033
NCBI chr14:29,730,957...29,762,423
Ensembl chr14:29,730,980...29,762,484
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Comt
catechol-O-methyltransferase
ISO
RGD
PMID:12584150
RGD:1359089
NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602
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Cth
cystathionine gamma lyase
ISO
SMPDB
SMP:00033
NCBI chr 3:157,599,885...157,630,718
Ensembl chr 3:157,599,885...157,630,714
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Dnmt1
DNA methyltransferase 1
ISO
SMPDB RGD
PMID:22342103
SMP:00033, RGD:7242551
NCBI chr 9:20,818,501...20,871,084
Ensembl chr 9:20,818,505...20,871,184
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Dnmt3a
DNA methyltransferase 3A
ISO
RGD
PMID:22342103
RGD:7242551
NCBI chr12:3,851,559...3,964,442
Ensembl chr12:3,856,007...3,964,443
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Dnmt3b
DNA methyltransferase 3B
ISO
RGD
PMID:22342103
RGD:7242551
NCBI chr 2:153,491,332...153,529,650
Ensembl chr 2:153,491,370...153,529,650
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Dot1l
DOT1 like histone lysine methyltransferase
ISO
RGD
PMID:22194015
RGD:7242554
NCBI chr10:80,590,935...80,631,295
Ensembl chr10:80,591,040...80,631,295
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Ezh2
enhancer of zeste 2 polycomb repressive complex 2 subunit
ISO
RGD
PMID:22194015
RGD:7242554
NCBI chr 6:47,507,208...47,613,843
Ensembl chr 6:47,507,073...47,572,275
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Gamt
guanidinoacetate methyltransferase
ISO
RGD
PMID:15533043
RGD:1359081
NCBI chr10:80,093,985...80,096,846
Ensembl chr10:80,093,985...80,096,846
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Gnmt
glycine N-methyltransferase
ISO
RGD
PMID:23073625 PMID:22342103
RGD:7242425 , RGD:7242551
NCBI chr17:47,036,590...47,040,091
Ensembl chr17:47,036,590...47,040,094
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Hnmt
histamine N-methyltransferase
ISO
RGD
PMID:11566133
RGD:1359041
NCBI chr 2:23,892,923...23,939,756
Ensembl chr 2:23,892,922...23,939,406
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Il4i1
interleukin 4 induced 1
ISO
SMPDB
SMP:00033
NCBI chr 7:44,485,712...44,490,233
Ensembl chr 7:44,465,811...44,490,233
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Kmt5a
lysine methyltransferase 5A
ISO
RGD
PMID:22194015
RGD:7242554
NCBI chr 5:124,577,980...124,600,371
Ensembl chr 5:124,577,993...124,600,371
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Mars1
methionine-tRNA synthetase 1
ISO
SMPDB
SMP:00033
NCBI chr10:127,132,090...127,147,655
Ensembl chr10:127,132,090...127,147,655
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Mat1a
methionine adenosyltransferase 1A
ISO
RGD
PMID:23073625 PMID:2292587
RGD:7242425 , RGD:7242932
NCBI chr14:40,826,969...40,846,385
Ensembl chr14:40,826,992...40,846,369
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Mat2a
methionine adenosyltransferase 2A
ISO
SMPDB RGD
PMID:23073625
SMP:00033, RGD:7242425
NCBI chr 6:72,409,779...72,416,539
Ensembl chr 6:72,409,782...72,416,541
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Mat2b
methionine adenosyltransferase 2 non-catalytic beta subunit methionine
ISO
SMPDB RGD
PMID:23073625
SMP:00033, RGD:7242425
NCBI chr11:40,570,141...40,586,030
Ensembl chr11:40,570,141...40,586,030
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Mrm2
mitochondrial rRNA methyltransferase 2
ISO
RGD
PMID:11827451
RGD:1359074
NCBI chr 5:140,313,429...140,317,653
Ensembl chr 5:140,313,429...140,317,653
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Msrb2
methionine sulfoxide reductase B2
ISO
SMPDB
SMP:00033
NCBI chr 2:19,376,247...19,399,787
Ensembl chr 2:19,376,251...19,399,787
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Msrb3
methionine sulfoxide reductase B3
ISO
SMPDB
SMP:00033
NCBI chr10:120,617,005...120,735,132
Ensembl chr10:120,617,001...120,735,006
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Mtap
methylthioadenosine phosphorylase
ISO
SMPDB RGD
PMID:23073625 PMID:2292587
SMP:00033, RGD:7242425 , RGD:7242932
NCBI chr 4:89,055,607...89,099,327
Ensembl chr 4:89,055,359...89,099,318
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Mtfmt
mitochondrial methionyl-tRNA formyltransferase
ISO
SMPDB
SMP:00033
NCBI chr 9:65,343,064...65,360,336
Ensembl chr 9:65,343,064...65,360,336
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Mthfr
methylenetetrahydrofolate reductase
ISO
SMPDB
SMP:00033
NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008
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Mtr
5-methyltetrahydrofolate-homocysteine methyltransferase
ISO
SMPDB RGD
PMID:23073625 PMID:20814827
SMP:00033, RGD:7242425 , RGD:7242426
NCBI chr13:12,196,217...12,273,090
Ensembl chr13:12,197,598...12,272,999
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Mtrr
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
ISO
RGD
PMID:20814827
RGD:7242426
NCBI chr13:68,708,897...68,730,273
Ensembl chr13:68,708,899...68,730,268
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Nnmt
nicotinamide N-methyltransferase
ISO
RGD
PMID:15922112
RGD:1359084
NCBI chr 9:48,448,905...48,518,958
Ensembl chr 9:48,503,177...48,516,453
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Pcmt1
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
ISO
RGD
PMID:8263531
RGD:729481
NCBI chr10:7,503,608...7,556,922
Ensembl chr10:7,505,137...7,556,900
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Pemt
phosphatidylethanolamine N-methyltransferase
ISO
RGD
PMID:8344945
RGD:729486
NCBI chr11:59,861,440...59,937,394
Ensembl chr11:59,861,440...59,937,315
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Pnmt
phenylethanolamine-N-methyltransferase
ISO
RGD
PMID:12438084
RGD:1359087
NCBI chr11:98,277,449...98,279,006
Ensembl chr11:98,277,276...98,279,007
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Prmt1
protein arginine N-methyltransferase 1
ISO
RGD
PMID:21074527
RGD:7242552
NCBI chr 7:44,626,179...44,635,844
Ensembl chr 7:44,625,413...44,635,992
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Prmt2
protein arginine N-methyltransferase 2
ISO
RGD
PMID:21074527
RGD:7242552
NCBI chr10:76,043,060...76,073,699
Ensembl chr10:76,043,056...76,073,699
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Prmt3
protein arginine N-methyltransferase 3
ISO
RGD
PMID:21074527
RGD:7242552
NCBI chr 7:49,428,067...49,508,016
Ensembl chr 7:49,428,094...49,508,013
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Prmt5
protein arginine N-methyltransferase 5
ISO
RGD
PMID:21074527
RGD:7242552
NCBI chr14:54,744,639...54,754,927
Ensembl chr14:54,744,644...54,754,982
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Prmt6
protein arginine N-methyltransferase 6
ISO
RGD
PMID:21074527
RGD:7242552
NCBI chr 3:110,153,420...110,158,315
Ensembl chr 3:110,153,425...110,158,314
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Prmt7
protein arginine N-methyltransferase 7
ISO
RGD
PMID:21074527
RGD:7242552
NCBI chr 8:106,937,686...106,978,326
Ensembl chr 8:106,937,568...106,979,426
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Rnmt
RNA (guanine-7-) methyltransferase
ISO
RGD
PMID:11472630
RGD:1359071
NCBI chr18:68,433,406...68,457,923
Ensembl chr18:68,433,426...68,457,923
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Setd7
SET domain containing (lysine methyltransferase) 7
ISO
RGD
PMID:22194015
RGD:7242554
NCBI chr 3:51,422,740...51,468,519
Ensembl chr 3:51,422,740...51,468,300
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Setdb1
SET domain, bifurcated 1
ISO
RGD
PMID:11959841
RGD:1359072
NCBI chr 3:95,230,836...95,264,513
Ensembl chr 3:95,230,836...95,264,513
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Shmt1
serine hydroxymethyltransferase 1 (soluble)
ISO
SMPDB
SMP:00033
NCBI chr11:60,679,723...60,702,062
Ensembl chr11:60,678,930...60,702,544
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Sms
spermine synthase
ISO
RGD
PMID:23073625
RGD:7242425
NCBI chr X:156,226,847...156,275,283
Ensembl chr X:156,226,851...156,275,283
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Smyd2
SET and MYND domain containing 2
ISO
RGD
PMID:22194015
RGD:7242554
NCBI chr 1:189,612,689...189,654,758
Ensembl chr 1:189,612,689...189,654,560
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Srm
spermidine synthase
ISO
SMPDB RGD
PMID:23073625
SMP:00033, RGD:7242425
NCBI chr 4:148,675,970...148,679,076
Ensembl chr 4:148,675,960...148,679,450
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Suv39h1
suppressor of variegation 3-9 1
ISO
RGD
PMID:22194015
RGD:7242554
NCBI chr X:7,927,401...7,940,994
Ensembl chr X:7,927,410...7,940,999
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Suv39h2
suppressor of variegation 3-9 2
ISO
RGD
PMID:22194015
RGD:7242554
NCBI chr 2:3,456,852...3,476,085
Ensembl chr 2:3,456,852...3,476,068
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