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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:methionine cycle/metabolic pathway
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Accession:PW:0000048 term browser browse the term
Definition:Those metabolic reactions involved in the synthesis (remethylation), utilization and/or degradation of methionine, an essential amino acid for humans. The cycle produces S-adenosylmethionine (AdoMet), the major methyl donor for proteins, nucleic acids, lipids and other small molecules. The cycle also produces homocysteine (Hcy) which either regenerates methionine via the remethylation pathway or leads to the synthesis of cysteine and derivatives via the transsulfuration pathway. Homocysteine and folate metabolic pathways are intimately related to the methionine cycle.
Synonyms:related_synonym: SMP:00033

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methionine cycle/metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahcy S-adenosylhomocysteine hydrolase ISS
ISO
SMPDB
RGD
PMID:11741948 PMID:23073625 PMID:2292587 SMP:00033, RGD:730275, RGD:7242425, RGD:7242932 NCBI chr 2:154,901,230...154,916,417
Ensembl chr 2:154,901,230...154,916,417
JBrowse link
G Amd1 S-adenosylmethionine decarboxylase 1 ISO SMPDB
RGD
PMID:23073625 PMID:2292587 SMP:00033, RGD:7242425, RGD:7242932 NCBI chr10:40,163,454...40,178,184
Ensembl chr10:40,163,454...40,178,184
JBrowse link
G As3mt arsenite methyltransferase ISO RGD PMID:11790780 RGD:625365 NCBI chr19:46,695,124...46,729,538
Ensembl chr19:46,695,897...46,729,538
JBrowse link
G Asmt acetylserotonin O-methyltransferase ISO RGD PMID:12198599 RGD:1359073 NCBI chr  X:169,106,379...169,111,787
Ensembl chr  X:169,106,280...169,112,125
JBrowse link
G Bhmt betaine-homocysteine methyltransferase ISO SMPDB
RGD
PMID:23073625 SMP:00033, RGD:7242425 NCBI chr13:93,753,399...93,774,266
Ensembl chr13:93,753,183...93,774,469
JBrowse link
G Carm1 coactivator-associated arginine methyltransferase 1 ISO RGD PMID:21074527 RGD:7242552 NCBI chr 9:21,458,163...21,500,763
Ensembl chr 9:21,458,190...21,503,919
JBrowse link
G Cbs cystathionine beta-synthase ISO SMPDB SMP:00033 NCBI chr17:31,831,602...31,856,170
Ensembl chr17:31,827,868...31,856,212
JBrowse link
G Chdh choline dehydrogenase ISO SMPDB SMP:00033 NCBI chr14:29,730,957...29,762,423
Ensembl chr14:29,730,980...29,762,484
JBrowse link
G Comt catechol-O-methyltransferase ISO RGD PMID:12584150 RGD:1359089 NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602
JBrowse link
G Cth cystathionine gamma lyase ISO SMPDB SMP:00033 NCBI chr 3:157,599,885...157,630,718
Ensembl chr 3:157,599,885...157,630,714
JBrowse link
G Dnmt1 DNA methyltransferase 1 ISO SMPDB
RGD
PMID:22342103 SMP:00033, RGD:7242551 NCBI chr 9:20,818,501...20,871,084
Ensembl chr 9:20,818,505...20,871,184
JBrowse link
G Dnmt3a DNA methyltransferase 3A ISO RGD PMID:22342103 RGD:7242551 NCBI chr12:3,851,559...3,964,442
Ensembl chr12:3,856,007...3,964,443
JBrowse link
G Dnmt3b DNA methyltransferase 3B ISO RGD PMID:22342103 RGD:7242551 NCBI chr 2:153,491,332...153,529,650
Ensembl chr 2:153,491,370...153,529,650
JBrowse link
G Dot1l DOT1 like histone lysine methyltransferase ISO RGD PMID:22194015 RGD:7242554 NCBI chr10:80,590,935...80,631,295
Ensembl chr10:80,591,040...80,631,295
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit ISO RGD PMID:22194015 RGD:7242554 NCBI chr 6:47,507,208...47,613,843
Ensembl chr 6:47,507,073...47,572,275
JBrowse link
G Gamt guanidinoacetate methyltransferase ISO RGD PMID:15533043 RGD:1359081 NCBI chr10:80,093,985...80,096,846
Ensembl chr10:80,093,985...80,096,846
JBrowse link
G Gnmt glycine N-methyltransferase ISO RGD PMID:23073625 PMID:22342103 RGD:7242425, RGD:7242551 NCBI chr17:47,036,590...47,040,091
Ensembl chr17:47,036,590...47,040,094
JBrowse link
G Hnmt histamine N-methyltransferase ISO RGD PMID:11566133 RGD:1359041 NCBI chr 2:23,892,923...23,939,756
Ensembl chr 2:23,892,922...23,939,406
JBrowse link
G Il4i1 interleukin 4 induced 1 ISO SMPDB SMP:00033 NCBI chr 7:44,485,712...44,490,233
Ensembl chr 7:44,465,811...44,490,233
JBrowse link
G Kmt5a lysine methyltransferase 5A ISO RGD PMID:22194015 RGD:7242554 NCBI chr 5:124,577,980...124,600,371
Ensembl chr 5:124,577,993...124,600,371
JBrowse link
G Mars1 methionine-tRNA synthetase 1 ISO SMPDB SMP:00033 NCBI chr10:127,132,090...127,147,655
Ensembl chr10:127,132,090...127,147,655
JBrowse link
G Mat1a methionine adenosyltransferase 1A ISO RGD PMID:23073625 PMID:2292587 RGD:7242425, RGD:7242932 NCBI chr14:40,826,969...40,846,385
Ensembl chr14:40,826,992...40,846,369
JBrowse link
G Mat2a methionine adenosyltransferase 2A ISO SMPDB
RGD
PMID:23073625 SMP:00033, RGD:7242425 NCBI chr 6:72,409,779...72,416,539
Ensembl chr 6:72,409,782...72,416,541
JBrowse link
G Mat2b methionine adenosyltransferase 2 non-catalytic beta subunit methionine ISO SMPDB
RGD
PMID:23073625 SMP:00033, RGD:7242425 NCBI chr11:40,570,141...40,586,030
Ensembl chr11:40,570,141...40,586,030
JBrowse link
G Mrm2 mitochondrial rRNA methyltransferase 2 ISO RGD PMID:11827451 RGD:1359074 NCBI chr 5:140,313,429...140,317,653
Ensembl chr 5:140,313,429...140,317,653
JBrowse link
G Msrb2 methionine sulfoxide reductase B2 ISO SMPDB SMP:00033 NCBI chr 2:19,376,247...19,399,787
Ensembl chr 2:19,376,251...19,399,787
JBrowse link
G Msrb3 methionine sulfoxide reductase B3 ISO SMPDB SMP:00033 NCBI chr10:120,617,005...120,735,132
Ensembl chr10:120,617,001...120,735,006
JBrowse link
G Mtap methylthioadenosine phosphorylase ISO SMPDB
RGD
PMID:23073625 PMID:2292587 SMP:00033, RGD:7242425, RGD:7242932 NCBI chr 4:89,055,607...89,099,327
Ensembl chr 4:89,055,359...89,099,318
JBrowse link
G Mtfmt mitochondrial methionyl-tRNA formyltransferase ISO SMPDB SMP:00033 NCBI chr 9:65,343,064...65,360,336
Ensembl chr 9:65,343,064...65,360,336
JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO SMPDB SMP:00033 NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase ISO SMPDB
RGD
PMID:23073625 PMID:20814827 SMP:00033, RGD:7242425, RGD:7242426 NCBI chr13:12,196,217...12,273,090
Ensembl chr13:12,197,598...12,272,999
JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:20814827 RGD:7242426 NCBI chr13:68,708,897...68,730,273
Ensembl chr13:68,708,899...68,730,268
JBrowse link
G Nnmt nicotinamide N-methyltransferase ISO RGD PMID:15922112 RGD:1359084 NCBI chr 9:48,448,905...48,518,958
Ensembl chr 9:48,503,177...48,516,453
JBrowse link
G Pcmt1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 ISO RGD PMID:8263531 RGD:729481 NCBI chr10:7,503,608...7,556,922
Ensembl chr10:7,505,137...7,556,900
JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase ISO RGD PMID:8344945 RGD:729486 NCBI chr11:59,861,440...59,937,394
Ensembl chr11:59,861,440...59,937,315
JBrowse link
G Pnmt phenylethanolamine-N-methyltransferase ISO RGD PMID:12438084 RGD:1359087 NCBI chr11:98,277,449...98,279,006
Ensembl chr11:98,277,276...98,279,007
JBrowse link
G Prmt1 protein arginine N-methyltransferase 1 ISO RGD PMID:21074527 RGD:7242552 NCBI chr 7:44,626,179...44,635,844
Ensembl chr 7:44,625,413...44,635,992
JBrowse link
G Prmt2 protein arginine N-methyltransferase 2 ISO RGD PMID:21074527 RGD:7242552 NCBI chr10:76,043,060...76,073,699
Ensembl chr10:76,043,056...76,073,699
JBrowse link
G Prmt3 protein arginine N-methyltransferase 3 ISO RGD PMID:21074527 RGD:7242552 NCBI chr 7:49,428,067...49,508,016
Ensembl chr 7:49,428,094...49,508,013
JBrowse link
G Prmt5 protein arginine N-methyltransferase 5 ISO RGD PMID:21074527 RGD:7242552 NCBI chr14:54,744,639...54,754,927
Ensembl chr14:54,744,644...54,754,982
JBrowse link
G Prmt6 protein arginine N-methyltransferase 6 ISO RGD PMID:21074527 RGD:7242552 NCBI chr 3:110,153,420...110,158,315
Ensembl chr 3:110,153,425...110,158,314
JBrowse link
G Prmt7 protein arginine N-methyltransferase 7 ISO RGD PMID:21074527 RGD:7242552 NCBI chr 8:106,937,686...106,978,326
Ensembl chr 8:106,937,568...106,979,426
JBrowse link
G Rnmt RNA (guanine-7-) methyltransferase ISO RGD PMID:11472630 RGD:1359071 NCBI chr18:68,433,406...68,457,923
Ensembl chr18:68,433,426...68,457,923
JBrowse link
G Setd7 SET domain containing (lysine methyltransferase) 7 ISO RGD PMID:22194015 RGD:7242554 NCBI chr 3:51,422,740...51,468,519
Ensembl chr 3:51,422,740...51,468,300
JBrowse link
G Setdb1 SET domain, bifurcated 1 ISO RGD PMID:11959841 RGD:1359072 NCBI chr 3:95,230,836...95,264,513
Ensembl chr 3:95,230,836...95,264,513
JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 (soluble) ISO SMPDB SMP:00033 NCBI chr11:60,679,723...60,702,062
Ensembl chr11:60,678,930...60,702,544
JBrowse link
G Sms spermine synthase ISO RGD PMID:23073625 RGD:7242425 NCBI chr  X:156,226,847...156,275,283
Ensembl chr  X:156,226,851...156,275,283
JBrowse link
G Smyd2 SET and MYND domain containing 2 ISO RGD PMID:22194015 RGD:7242554 NCBI chr 1:189,612,689...189,654,758
Ensembl chr 1:189,612,689...189,654,560
JBrowse link
G Srm spermidine synthase ISO SMPDB
RGD
PMID:23073625 SMP:00033, RGD:7242425 NCBI chr 4:148,675,970...148,679,076
Ensembl chr 4:148,675,960...148,679,450
JBrowse link
G Suv39h1 suppressor of variegation 3-9 1 ISO RGD PMID:22194015 RGD:7242554 NCBI chr  X:7,927,401...7,940,994
Ensembl chr  X:7,927,410...7,940,999
JBrowse link
G Suv39h2 suppressor of variegation 3-9 2 ISO RGD PMID:22194015 RGD:7242554 NCBI chr 2:3,456,852...3,476,085
Ensembl chr 2:3,456,852...3,476,068
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6074
    classic metabolic pathway 1858
      amino acid metabolic pathway 320
        hydrophobic amino acid metabolic pathway 130
          methionine cycle/metabolic pathway 51
            altered methionine cycle/metabolic pathway 0
            methionine biosynthetic pathway 0
            methionine degradation pathway 0
Path 2
Term Annotations click to browse term
  pathway 6074
    regulatory pathway 3686
      homeostasis pathway 1721
        organic chemical homeostasis pathway 454
          S-adenosylmethionine homeostasis pathway 286
            methionine cycle/metabolic pathway 51
              altered methionine cycle/metabolic pathway 0
              methionine biosynthetic pathway 0
              methionine degradation pathway 0
paths to the root