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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:mitogen activated protein kinase signaling pathway
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Accession:PW:0000007 term browser browse the term
Definition:The mitogen-activated protein kinase pathway groups several serine/threonine protein kinase mediated cascades in response to a number of extracellular stimuli. A characteristic feature of these cascades is the presence of at least three kinases in series leading to the activation of a multifunctional MAP kinase.
Synonyms:related_synonym: MAPK cascade;   MAPK family signaling cascades;   MAPK signaling pathway
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mitogen activated protein kinase signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO RGD PMID:16168116 RGD:1582137 NCBI chrNW_004955451:14,442,816...14,456,009
Ensembl chrNW_004955451:14,442,816...14,459,379 		JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 ISO RGD PMID:9779826 RGD:70317 NCBI chrNW_004955414:14,365,325...14,447,470
Ensembl chrNW_004955414:14,365,157...14,450,611 		JBrowse link
G Shc1 SHC adaptor protein 1 ISO RGD PMID:12837289 RGD:1304398 NCBI chrNW_004955545:1,468,391...1,479,209
Ensembl chrNW_004955545:1,468,391...1,476,814 		JBrowse link
G Tsc2 TSC complex subunit 2 ISO RGD PMID:14612383 RGD:1580517 NCBI chrNW_004955442:15,178,356...15,216,978
Ensembl chrNW_004955442:15,178,487...15,216,362 		JBrowse link
altered Erk5 MAPK signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Map2k5 mitogen-activated protein kinase kinase 5 ISO RGD PMID:16376520 RGD:2298532 NCBI chrNW_004955450:8,207,577...8,458,258
Ensembl chrNW_004955450:8,203,569...8,458,258 		JBrowse link
G Mapk7 mitogen-activated protein kinase 7 ISO RGD PMID:16376520 RGD:2298532 NCBI chrNW_004955467:381,801...387,078
Ensembl chrNW_004955467:378,156...386,532 		JBrowse link
altered extracellular signal-regulated Raf/Mek/Erk signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO RGD PMID:17126425 PMID:18098337 PMID:20951313 PMID:21277552 RGD:2293882 RGD:2298531 RGD:5133242 RGD:5133243 NCBI chrNW_004955494:2,567,238...2,712,708 JBrowse link
G Kras KRAS proto-oncogene, GTPase ISO RGD PMID:16112461 PMID:18772397 PMID:19078924 PMID:19506583 PMID:20951313 RGD:2306732 RGD:4143515 RGD:5133242 RGD:5490965 RGD:5490966 NCBI chrNW_004955413:20,298,852...20,328,756
Ensembl chrNW_004955413:20,298,824...20,328,758 		JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 ISO RGD PMID:20951313 PMID:21277552 RGD:5133242 RGD:5133243 NCBI chrNW_004955450:9,181,851...9,205,277
Ensembl chrNW_004955450:9,181,851...9,239,648 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO RGD PMID:17126425 RGD:2293882 NCBI chrNW_004955429:17,980,956...18,049,723
Ensembl chrNW_004955429:18,025,932...18,049,723 		JBrowse link
c-Jun N-terminal kinases MAPK signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc42 cell division cycle 42 ISO RGD PMID:8910292 PMID:9305638 RGD:2293876 RGD:2293879 NCBI chrNW_004955452:2,255,940...2,299,042
Ensembl chrNW_004955452:2,255,117...2,299,042 		JBrowse link
G Dusp1 dual specificity phosphatase 1 ISO RGD PMID:17208316 RGD:2293881 NCBI chrNW_004955408:25,481,294...25,484,381
Ensembl chrNW_004955408:25,481,294...25,484,381 		JBrowse link
G Dusp10 dual specificity phosphatase 10 ISO RGD PMID:17208316 RGD:2293881 NCBI chrNW_004955520:2,338,548...2,371,591
Ensembl chrNW_004955520:2,339,521...2,372,400 		JBrowse link
G Dusp16 dual specificity phosphatase 16 ISO RGD PMID:17208316 RGD:2293881 NCBI chrNW_004955413:9,404,259...9,481,061
Ensembl chrNW_004955413:9,385,100...9,474,711 		JBrowse link
G Dusp19 dual specificity phosphatase 19 ISO RGD PMID:11959862 RGD:2314491 NCBI chrNW_004955403:14,421,057...14,439,829
Ensembl chrNW_004955403:14,420,243...14,440,210 		JBrowse link
G Dusp8 dual specificity phosphatase 8 ISO RGD PMID:17208316 RGD:2293881 NCBI chrNW_004955476:10,816,647...10,826,787
Ensembl chrNW_004955476:10,813,336...10,826,801 		JBrowse link
G Map2k4 mitogen-activated protein kinase kinase 4 ISO RGD PMID:10051439 PMID:17064355 PMID:17306896 RGD:2293875 RGD:2298561 RGD:2298577 NCBI chrNW_004955467:5,188,036...5,295,570
Ensembl chrNW_004955467:5,187,356...5,307,692 		JBrowse link
G Map2k7 mitogen-activated protein kinase kinase 7 ISO RGD PMID:10051439 PMID:15680699 PMID:17064355 PMID:17306896 RGD:2293875 RGD:2298561 RGD:2298567 RGD:2298577 NCBI chrNW_004955563:1,352,638...1,361,598
Ensembl chrNW_004955563:1,352,638...1,361,598 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 ISO RGD PMID:9305638 PMID:17306896 RGD:2293875 RGD:2293879 NCBI chrNW_004955446:11,022,091...11,090,136
Ensembl chrNW_004955446:11,021,971...11,090,136 		JBrowse link
G Map3k10 mitogen-activated protein kinase kinase kinase 10 ISO RGD PMID:17306896 RGD:2293875 NCBI chrNW_004955578:1,018,280...1,037,553
Ensembl chrNW_004955578:1,018,560...1,036,901 		JBrowse link
G Map3k11 mitogen-activated protein kinase kinase kinase 11 ISO RGD PMID:8910292 PMID:15680699 PMID:17064355 PMID:17306896 RGD:2293875 RGD:2293876 RGD:2298567 RGD:2298577 NCBI chrNW_004955422:19,651,371...19,666,468
Ensembl chrNW_004955422:19,651,372...19,667,924 		JBrowse link
G Map3k12 mitogen-activated protein kinase kinase kinase 12 ISO RGD PMID:17306896 RGD:2293875 NCBI chrNW_004955458:774,478...793,654
Ensembl chrNW_004955458:774,478...785,226 		JBrowse link
G Map3k13 mitogen-activated protein kinase kinase kinase 13 ISO RGD PMID:17306896 RGD:2293875 NCBI chrNW_004955420:22,064,384...22,190,662
Ensembl chrNW_004955420:22,064,384...22,224,789 		JBrowse link
G Map3k2 mitogen-activated protein kinase kinase kinase 2 ISO RGD PMID:9305638 PMID:17306896 RGD:2293875 RGD:2293879 NCBI chrNW_004955459:3,135,959...3,196,971
Ensembl chrNW_004955459:3,136,010...3,196,971 		JBrowse link
G Map3k20 mitogen-activated protein kinase kinase kinase 20 ISO RGD PMID:17306896 RGD:2293875 NCBI chrNW_004955449:1,976,186...2,139,044 JBrowse link
G Map3k21 mitogen-activated protein kinase kinase kinase 21 ISO RGD PMID:17306896 RGD:2293875 NCBI chrNW_004955492:5,987,338...6,029,323
Ensembl chrNW_004955492:5,987,070...6,028,995 		JBrowse link
G Map3k3 mitogen-activated protein kinase kinase kinase 3 ISO RGD PMID:9305638 PMID:17306896 RGD:2293875 RGD:2293879 NCBI chrNW_004955478:8,122,999...8,185,138
Ensembl chrNW_004955478:8,125,436...8,199,253 		JBrowse link
G Map3k4 mitogen-activated protein kinase kinase kinase 4 ISO RGD PMID:9305638 PMID:17306896 RGD:2293875 RGD:2293879 NCBI chrNW_004955439:20,144,059...20,263,885
Ensembl chrNW_004955439:20,144,059...20,263,879 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 ISO RGD PMID:12215209 PMID:17306896 RGD:2293875 RGD:2296020 NCBI chrNW_004955439:162,499...376,919
Ensembl chrNW_004955439:163,103...377,808 		JBrowse link
G Map3k7 mitogen-activated protein kinase kinase kinase 7 ISO RGD PMID:17306896 RGD:2293875 NCBI chrNW_004955411:17,177,335...17,229,957
Ensembl chrNW_004955411:17,177,335...17,229,957 		JBrowse link
G Map3k9 mitogen-activated protein kinase kinase kinase 9 ISO RGD PMID:17306896 RGD:2293875 NCBI chrNW_004955523:4,326,315...4,387,390
Ensembl chrNW_004955523:4,326,317...4,385,544 		JBrowse link
G Mapk10 mitogen-activated protein kinase 10 ISO RGD PMID:10051439 PMID:15680699 PMID:17306896 RGD:2293875 RGD:2298561 RGD:2298567 NCBI chrNW_004955474:3,451,656...3,772,405
Ensembl chrNW_004955474:3,624,679...3,772,458 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO RGD PMID:10051439 PMID:17064355 PMID:17306896 RGD:2293875 RGD:2298561 RGD:2298577 NCBI chrNW_004955556:1,593,552...1,705,543
Ensembl chrNW_004955556:1,593,494...1,665,784 		JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 ISO RGD PMID:15816852 PMID:17726577 RGD:1579811 RGD:2293880 NCBI chrNW_004955422:2,064,010...2,081,681
Ensembl chrNW_004955422:2,061,851...2,082,514 		JBrowse link
G Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 ISO RGD PMID:17726577 RGD:2293880 NCBI chrNW_004955413:33,608,092...33,617,984
Ensembl chrNW_004955413:33,608,655...33,617,255 		JBrowse link
G Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 ISO RGD PMID:17726577 RGD:2293880 NCBI chrNW_004955442:15,498,909...15,545,298
Ensembl chrNW_004955442:15,498,909...15,545,298 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 ISO RGD PMID:10051439 PMID:17064355 PMID:17306896 RGD:2293875 RGD:2298561 RGD:2298577 NCBI chrNW_004955408:391,094...430,638
Ensembl chrNW_004955408:391,094...430,981 		JBrowse link
G Rac1 Rac family small GTPase 1 ISO RGD PMID:8910292 PMID:9305638 RGD:2293876 RGD:2293879 NCBI chrNW_004955460:13,270,159...13,295,562
Ensembl chrNW_004955460:13,270,159...13,311,351 		JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 ISO RGD PMID:10811109 RGD:11534984 NCBI chrNW_004955513:1,224,418...1,328,176
Ensembl chrNW_004955513:1,226,205...1,315,922 		JBrowse link
G Spp1 secreted phosphoprotein 1 ISO RGD PMID:15757900 RGD:1581337 NCBI chrNW_004955474:1,914,477...1,922,025
Ensembl chrNW_004955474:1,913,829...1,922,016 		JBrowse link
G Traf2 TNF receptor associated factor 2 ISO RGD PMID:12215209 RGD:2296020 NCBI chrNW_004955513:4,964,692...4,984,359
Ensembl chrNW_004955513:4,967,984...4,983,987 		JBrowse link
Erk5 MAPK signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Map2k5 mitogen-activated protein kinase kinase 5 ISO RGD PMID:15631999 PMID:16376520 RGD:1582263 RGD:2298532 NCBI chrNW_004955450:8,207,577...8,458,258
Ensembl chrNW_004955450:8,203,569...8,458,258 		JBrowse link
G Map3k2 mitogen-activated protein kinase kinase kinase 2 ISO RGD PMID:16376520 RGD:2298532 NCBI chrNW_004955459:3,135,959...3,196,971
Ensembl chrNW_004955459:3,136,010...3,196,971 		JBrowse link
G Map3k3 mitogen-activated protein kinase kinase kinase 3 ISO RGD PMID:16376520 RGD:2298532 NCBI chrNW_004955478:8,122,999...8,185,138
Ensembl chrNW_004955478:8,125,436...8,199,253 		JBrowse link
G Mapk7 mitogen-activated protein kinase 7 ISO RGD PMID:11782488 PMID:16376520 RGD:2298532 RGD:2298794 NCBI chrNW_004955467:381,801...387,078
Ensembl chrNW_004955467:378,156...386,532 		JBrowse link
G Sh2d2a SH2 domain containing 2A ISO RGD PMID:16376520 RGD:2298532 NCBI chrNW_004955545:2,881,954...2,891,021
Ensembl chrNW_004955545:2,881,563...2,891,509 		JBrowse link
G Wnk1 WNK lysine deficient protein kinase 1 ISO RGD PMID:16376520 RGD:2298532 NCBI chrNW_004955454:6,228,492...6,358,690
Ensembl chrNW_004955454:6,228,492...6,358,637 		JBrowse link
p38 MAPK signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin ISO RGD PMID:16157033 RGD:1625329 NCBI chrNW_004955414:25,951,473...25,953,593
Ensembl chrNW_004955414:25,951,349...25,953,645 		JBrowse link
G Atm ATM serine/threonine kinase ISO PID PID:200018 NCBI chrNW_004955412:10,422,753...10,531,406
Ensembl chrNW_004955412:10,426,135...10,530,545 		JBrowse link
G Bnip2 BCL2 interacting protein 2 ISO RGD PMID:20626350 RGD:7240533 NCBI chrNW_004955450:15,157,411...15,180,069
Ensembl chrNW_004955450:15,157,226...15,180,069 		JBrowse link
G Calm1 calmodulin 1 ISO PID PID:200018 NCBI chrNW_004955438:12,842,437...12,854,028
Ensembl chrNW_004955438:12,842,437...12,854,028 		JBrowse link
G Calm2 calmodulin 2 ISO PID PID:200018 NCBI chrNW_004955441:13,973,147...13,988,665 JBrowse link
G Calm3 calmodulin 3 ISO PID PID:200018 NCBI chrNW_004955574:672,441...680,924
Ensembl chrNW_004955574:672,300...680,924 		JBrowse link
G Camk2b calcium/calmodulin dependent protein kinase II beta ISO PID PID:200018 NCBI chrNW_004955456:7,711,583...7,760,506
Ensembl chrNW_004955456:7,713,552...7,760,207 		JBrowse link
G Ccm2 CCM2 scaffold protein ISO PID
RGD		 PMID:17481747 PMID:20626350 PID:200018 RGD:2293891 RGD:7240533 NCBI chrNW_004955456:7,232,224...7,251,012
Ensembl chrNW_004955456:7,227,667...7,256,206 		JBrowse link
G Cdc42 cell division cycle 42 ISO RGD PMID:20626350 RGD:7240533 NCBI chrNW_004955452:2,255,940...2,299,042
Ensembl chrNW_004955452:2,255,117...2,299,042 		JBrowse link
G Cdon cell adhesion associated, oncogene regulated ISO RGD PMID:20626350 RGD:7240533 NCBI chrNW_004955412:27,004,391...27,093,968
Ensembl chrNW_004955412:27,003,919...27,065,989 		JBrowse link
G Dlk1 delta like non-canonical Notch ligand 1 ISO RGD PMID:20626350 RGD:7240533 NCBI chrNW_004955627:37,886...43,730
Ensembl chrNW_004955627:38,128...43,728 		JBrowse link
G Dusp1 dual specificity phosphatase 1 ISO RGD PMID:20626350 RGD:7240533 NCBI chrNW_004955408:25,481,294...25,484,381
Ensembl chrNW_004955408:25,481,294...25,484,381 		JBrowse link
G Dusp10 dual specificity phosphatase 10 ISO RGD PMID:20626350 RGD:7240533 NCBI chrNW_004955520:2,338,548...2,371,591
Ensembl chrNW_004955520:2,339,521...2,372,400 		JBrowse link
G Dusp16 dual specificity phosphatase 16 ISO RGD PMID:20626350 RGD:7240533 NCBI chrNW_004955413:9,404,259...9,481,061
Ensembl chrNW_004955413:9,385,100...9,474,711 		JBrowse link
G Dusp9 dual specificity phosphatase 9 ISO RGD PMID:20626350 RGD:7240533 NCBI chrNW_004955580:388,277...392,269
Ensembl chrNW_004955580:388,850...391,455 		JBrowse link
G Gadd45a growth arrest and DNA damage inducible alpha ISO PID PID:200018 NCBI chrNW_004955423:23,656,516...23,658,367
Ensembl chrNW_004955423:23,656,458...23,658,367 		JBrowse link
G Gadd45b growth arrest and DNA damage inducible beta ISO PID PID:200018 NCBI chrNW_004955495:4,864,932...4,866,728
Ensembl chrNW_004955495:4,864,868...4,867,658 		JBrowse link
G Gadd45g growth arrest and DNA damage inducible gamma ISO PID PID:200018 NCBI chrNW_004955515:2,423,137...2,424,851
Ensembl chrNW_004955515:2,422,998...2,424,851 		JBrowse link
G Irf1 interferon regulatory factor 1 ISO RGD PMID:15141302 RGD:5128786 NCBI chrNW_004955408:3,882,282...3,887,965
Ensembl chrNW_004955408:3,880,155...3,887,973 		JBrowse link
G Map2k3 mitogen-activated protein kinase kinase 3 ISO RGD
PID		 PMID:16183734 PMID:17481747 PID:200018 RGD:2293891 RGD:2298758 NCBI chrNW_004955577:1,225,033...1,249,510
Ensembl chrNW_004955577:1,237,287...1,248,541 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 ISO RGD
PID		 PMID:16183734 PMID:17481747 PID:200018 RGD:2293891 RGD:2298758 NCBI chrNW_004955478:3,331,607...3,448,840
Ensembl chrNW_004955478:3,331,607...3,448,842 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 ISO PID PID:200018 NCBI chrNW_004955446:11,022,091...11,090,136
Ensembl chrNW_004955446:11,021,971...11,090,136 		JBrowse link
G Map3k10 mitogen-activated protein kinase kinase kinase 10 ISO PID PID:200018 NCBI chrNW_004955578:1,018,280...1,037,553
Ensembl chrNW_004955578:1,018,560...1,036,901 		JBrowse link
G Map3k11 mitogen-activated protein kinase kinase kinase 11 ISO RGD PMID:20626350 RGD:7240533 NCBI chrNW_004955422:19,651,371...19,666,468
Ensembl chrNW_004955422:19,651,372...19,667,924 		JBrowse link
G Map3k20 mitogen-activated protein kinase kinase kinase 20 ISO RGD PMID:20626350 RGD:7240533 NCBI chrNW_004955449:1,976,186...2,139,044 JBrowse link
G Map3k3 mitogen-activated protein kinase kinase kinase 3 ISO PID
RGD		 PMID:17481747 PMID:20626350 PID:200018 RGD:2293891 RGD:7240533 NCBI chrNW_004955478:8,122,999...8,185,138
Ensembl chrNW_004955478:8,125,436...8,199,253 		JBrowse link
G Map3k4 mitogen-activated protein kinase kinase kinase 4 ISO PID
RGD		 PMID:20626350 PID:200018 RGD:7240533 NCBI chrNW_004955439:20,144,059...20,263,885
Ensembl chrNW_004955439:20,144,059...20,263,879 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 ISO PID
RGD		 PMID:12215209 PMID:17481747 PMID:20626350 PID:200018 RGD:2293891 RGD:2296020 RGD:7240533 NCBI chrNW_004955439:162,499...376,919
Ensembl chrNW_004955439:163,103...377,808 		JBrowse link
G Map3k6 mitogen-activated protein kinase kinase kinase 6 ISO PID PID:200018 NCBI chrNW_004955452:6,616,997...6,628,745
Ensembl chrNW_004955452:6,616,997...6,629,206 		JBrowse link
G Map3k7 mitogen-activated protein kinase kinase kinase 7 ISO RGD
PID		 PMID:16183734 PMID:17481747 PMID:20626350 PID:200018 RGD:2293891 RGD:2298758 RGD:7240533 NCBI chrNW_004955411:17,177,335...17,229,957
Ensembl chrNW_004955411:17,177,335...17,229,957 		JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 ISO RGD PMID:20626350 RGD:7240533 NCBI chrNW_004955429:21,717,153...21,739,349
Ensembl chrNW_004955429:21,716,958...21,741,585 		JBrowse link
G Mapk11 mitogen-activated protein kinase 11 ISO PID
RGD		 PMID:17481747 PID:200018 RGD:2293891 NCBI chrNW_004955413:33,287,860...33,293,948
Ensembl chrNW_004955413:33,286,390...33,294,227 		JBrowse link
G Mapk12 mitogen-activated protein kinase 12 ISO RGD PMID:17481747 RGD:2293891 NCBI chrNW_004955413:33,278,913...33,285,920
Ensembl chrNW_004955413:33,279,344...33,286,422 		JBrowse link
G Mapk13 mitogen-activated protein kinase 13 ISO RGD PMID:17481747 RGD:2293891 NCBI chrNW_004955437:3,899,988...3,907,781
Ensembl chrNW_004955437:3,899,950...3,909,114 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 ISO RGD
PID		 PMID:16407200 PMID:17481747 PID:200018 RGD:1580544 RGD:2293891 NCBI chrNW_004955437:3,836,331...3,884,083
Ensembl chrNW_004955437:3,838,232...3,884,083 		JBrowse link
G Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 ISO RGD PMID:12024021 PMID:17481747 RGD:2293891 RGD:2302280 NCBI chrNW_004955413:33,608,092...33,617,984
Ensembl chrNW_004955413:33,608,655...33,617,255 		JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 ISO RGD PMID:16421520 RGD:2315047 NCBI chrNW_004955406:42,231,858...42,276,477
Ensembl chrNW_004955406:42,231,858...42,276,477 		JBrowse link
G Mapkapk3 MAPK activated protein kinase 3 ISO RGD PMID:16421520 RGD:2315047 NCBI chrNW_004955532:2,392,539...2,419,219
Ensembl chrNW_004955532:2,392,539...2,420,604 		JBrowse link
G Mapkapk5 MAPK activated protein kinase 5 ISO RGD PMID:16421520 RGD:2315047 NCBI chrNW_004955482:8,409,192...8,434,907 JBrowse link
G Mknk1 MAPK interacting serine/threonine kinase 1 ISO RGD PMID:16421520 RGD:2315047 NCBI chrNW_004955464:11,697,946...11,750,258
Ensembl chrNW_004955464:11,707,614...11,750,562 		JBrowse link
G Mknk2 MAPK interacting serine/threonine kinase 2 ISO RGD PMID:16421520 RGD:2315047 NCBI chrNW_004955495:6,048,346...6,061,579
Ensembl chrNW_004955495:6,048,128...6,062,913 		JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent 1D ISO RGD PMID:20626350 RGD:7240533 NCBI chrNW_004955451:1,878,110...1,915,794
Ensembl chrNW_004955451:1,878,629...1,915,654 		JBrowse link
G Rac1 Rac family small GTPase 1 ISO PID
RGD		 PMID:17481747 PID:200018 RGD:2293891 NCBI chrNW_004955460:13,270,159...13,295,562
Ensembl chrNW_004955460:13,270,159...13,311,351 		JBrowse link
G Rps6ka4 ribosomal protein S6 kinase A4 ISO RGD PMID:16421520 RGD:2315047 NCBI chrNW_004955422:20,726,286...20,736,841
Ensembl chrNW_004955422:20,725,814...20,736,841 		JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 ISO RGD PMID:16421520 RGD:2315047 NCBI chrNW_004955438:13,218,451...13,392,080
Ensembl chrNW_004955438:13,217,222...13,392,674 		JBrowse link
G Spag9 sperm associated antigen 9 ISO RGD PMID:20626350 RGD:7240533 NCBI chrNW_004955451:10,800,251...10,895,400
Ensembl chrNW_004955451:10,800,128...10,895,400 		JBrowse link
G Tab1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 ISO PID PID:200018 NCBI chrNW_004955413:25,290,733...25,315,267
Ensembl chrNW_004955413:25,290,828...25,313,969 		JBrowse link
G Tab2 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 ISO PID PID:200018 NCBI chrNW_004955439:11,826,469...11,903,103
Ensembl chrNW_004955439:11,826,469...11,903,103 		JBrowse link
G Taok1 TAO kinase 1 ISO PID
RGD		 PMID:20626350 PID:200018 RGD:7240533 NCBI chrNW_004955481:3,698,686...3,836,209
Ensembl chrNW_004955481:3,705,202...3,772,116 		JBrowse link
G Taok2 TAO kinase 2 ISO PID
RGD		 PMID:20626350 PID:200018 RGD:7240533 NCBI chrNW_004955493:6,968,537...6,986,608
Ensembl chrNW_004955493:6,969,096...6,985,878 		JBrowse link
G Taok3 TAO kinase 3 ISO PID PID:200018 NCBI chrNW_004955455:13,020,618...13,207,539
Ensembl chrNW_004955455:13,103,357...13,211,315 		JBrowse link
G Traf2 TNF receptor associated factor 2 ISO PID
RGD		 PMID:12215209 PID:200018 RGD:2296020 NCBI chrNW_004955513:4,964,692...4,984,359
Ensembl chrNW_004955513:4,967,984...4,983,987 		JBrowse link
G Traf6 TNF receptor associated factor 6 ISO PID
RGD		 PMID:20626350 PID:200018 RGD:7240533 NCBI chrNW_004955422:9,925,765...9,950,354
Ensembl chrNW_004955422:9,932,680...9,949,100 		JBrowse link
the extracellular signal-regulated Raf/Mek/Erk signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Araf A-Raf proto-oncogene, serine/threonine kinase ISO RGD PMID:22177953 RGD:5686410 NCBI chrNW_004955516:521,479...532,980
Ensembl chrNW_004955516:521,479...533,212 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO RGD PMID:16508002 PMID:17310240 PMID:22177953 RGD:1580106 RGD:1626216 RGD:5686410 NCBI chrNW_004955494:2,567,238...2,712,708 JBrowse link
G Dusp6 dual specificity phosphatase 6 ISO RGD PMID:17208316 RGD:2293881 NCBI chrNW_004955405:26,662,018...26,666,314
Ensembl chrNW_004955405:26,662,018...26,666,314 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 ISO RGD PMID:20445128 RGD:4892084 NCBI chrNW_004955460:8,790,798...8,794,902
Ensembl chrNW_004955460:8,790,798...8,794,902 		JBrowse link
G Hras HRas proto-oncogene, GTPase ISO RGD PMID:22177953 RGD:5686410 NCBI chrNW_004955476:11,508,446...11,510,333
Ensembl chrNW_004955476:11,508,126...11,510,333 		JBrowse link
G Kras KRAS proto-oncogene, GTPase ISO RGD PMID:12388314 PMID:22177953 RGD:5686410 RGD:628557 NCBI chrNW_004955413:20,298,852...20,328,756
Ensembl chrNW_004955413:20,298,824...20,328,758 		JBrowse link
G Ksr1 kinase suppressor of ras 1 ISO RGD PMID:17726577 PMID:22177953 RGD:2293880 RGD:5686410 NCBI chrNW_004955481:5,768,166...5,913,557
Ensembl chrNW_004955481:5,770,911...5,913,240 		JBrowse link
G Ksr2 kinase suppressor of ras 2 ISO RGD PMID:22177953 RGD:5686410 NCBI chrNW_004955455:13,375,306...13,777,681
Ensembl chrNW_004955455:13,374,729...13,773,392 		JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 ISO RGD PMID:9779826 PMID:12835716 PMID:17310240 RGD:1357969 RGD:1626216 RGD:70317 NCBI chrNW_004955450:9,181,851...9,205,277
Ensembl chrNW_004955450:9,181,851...9,239,648 		JBrowse link
G Map2k2 mitogen-activated protein kinase kinase 2 ISO RGD PMID:17310240 RGD:1626216 NCBI chrNW_004955495:4,695,239...4,718,380
Ensembl chrNW_004955495:4,695,768...4,722,098 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 ISO RGD PMID:9305638 PMID:12835716 RGD:1357969 RGD:2293879 NCBI chrNW_004955446:11,022,091...11,090,136
Ensembl chrNW_004955446:11,021,971...11,090,136 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 ISO RGD PMID:12097495 PMID:12835716 PMID:16955078 PMID:17310240 RGD:1357969 RGD:1626216 RGD:628468 RGD:8553011 NCBI chrNW_004955442:17,284,232...17,380,026
Ensembl chrNW_004955442:17,284,232...17,380,020 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 ISO RGD PMID:12097495 PMID:12835716 PMID:16955078 PMID:17310240 PMID:20080775 RGD:1357969 RGD:1626216 RGD:5508172 RGD:628468 RGD:8553011 NCBI chrNW_004955493:6,870,699...6,876,836
Ensembl chrNW_004955493:6,869,668...6,879,152 		JBrowse link
G Mknk1 MAPK interacting serine/threonine kinase 1 ISO RGD PMID:16421520 PMID:16955078 RGD:2315047 RGD:8553011 NCBI chrNW_004955464:11,697,946...11,750,258
Ensembl chrNW_004955464:11,707,614...11,750,562 		JBrowse link
G Mknk2 MAPK interacting serine/threonine kinase 2 ISO RGD PMID:16421520 RGD:2315047 NCBI chrNW_004955495:6,048,346...6,061,579
Ensembl chrNW_004955495:6,048,128...6,062,913 		JBrowse link
G Nras NRAS proto-oncogene, GTPase ISO RGD PMID:22177953 RGD:5686410 NCBI chrNW_004955435:18,001,517...18,009,105
Ensembl chrNW_004955435:18,001,517...18,009,103 		JBrowse link
G Pebp1 phosphatidylethanolamine binding protein 1 ISO RGD PMID:10490027 PMID:17126425 RGD:2293882 RGD:2302807 NCBI chrNW_004955455:13,217,012...13,222,370 JBrowse link
G Prkcd protein kinase C delta ISO RGD PMID:12790799 RGD:1642529 NCBI chrNW_004955430:3,125,066...3,151,857
Ensembl chrNW_004955430:3,124,738...3,153,274 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta ISO RGD PMID:15096502 RGD:1642630 NCBI chrNW_004955403:49,856,056...49,970,800
Ensembl chrNW_004955403:49,855,541...49,973,225 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO RGD PMID:9779826 PMID:12835716 PMID:16508002 PMID:17310240 PMID:22177953 RGD:1357969 RGD:1580106 RGD:1626216 RGD:5686410 RGD:70317 NCBI chrNW_004955429:17,980,956...18,049,723
Ensembl chrNW_004955429:18,025,932...18,049,723 		JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 ISO RGD PMID:16421520 RGD:2315047 NCBI chrNW_004955452:5,905,561...5,938,096
Ensembl chrNW_004955452:5,904,762...5,939,091 		JBrowse link
G Rps6ka2 ribosomal protein S6 kinase A2 ISO RGD PMID:16421520 RGD:2315047 NCBI chrNW_004955439:15,210,882...15,487,305
Ensembl chrNW_004955439:15,332,165...15,487,305 		JBrowse link
G Rps6ka3 ribosomal protein S6 kinase A3 ISO RGD PMID:16421520 RGD:2315047 NCBI chrNW_004955509:600,415...701,833
Ensembl chrNW_004955509:600,284...701,837 		JBrowse link
G Rps6ka4 ribosomal protein S6 kinase A4 ISO RGD PMID:16421520 RGD:2315047 NCBI chrNW_004955422:20,726,286...20,736,841
Ensembl chrNW_004955422:20,725,814...20,736,841 		JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 ISO RGD PMID:16421520 RGD:2315047 NCBI chrNW_004955438:13,218,451...13,392,080
Ensembl chrNW_004955438:13,217,222...13,392,674 		JBrowse link
G Rps6ka6 ribosomal protein S6 kinase A6 ISO RGD PMID:16421520 RGD:2315047 NCBI chrNW_004955529:3,115,652...3,296,505
Ensembl chrNW_004955529:3,149,407...3,296,105 		JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 ISO RGD PMID:14711826 RGD:1304283 NCBI chrNW_004955435:5,880,266...5,882,823
Ensembl chrNW_004955435:5,880,288...5,881,436 		JBrowse link
G Shc1 SHC adaptor protein 1 ISO RGD PMID:16699171 RGD:1643182 NCBI chrNW_004955545:1,468,391...1,479,209
Ensembl chrNW_004955545:1,468,391...1,476,814 		JBrowse link
G Smad1 SMAD family member 1 ISO RGD PMID:16427075 RGD:1643230 NCBI chrNW_004955428:1,357,398...1,429,521
Ensembl chrNW_004955428:1,361,085...1,429,948 		JBrowse link
G Spp1 secreted phosphoprotein 1 ISO RGD PMID:15757900 RGD:1581337 NCBI chrNW_004955474:1,914,477...1,922,025
Ensembl chrNW_004955474:1,913,829...1,922,016 		JBrowse link
G Tsc2 TSC complex subunit 2 ISO RGD PMID:15150271 RGD:1580097 NCBI chrNW_004955442:15,178,356...15,216,978
Ensembl chrNW_004955442:15,178,487...15,216,362 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3930
    signaling pathway 1892
      mitogen activated protein kinase signaling pathway 100
        Erk5 MAPK signaling pathway + 6
        altered mitogen activated protein kinase pathway + 6
        stress-regulated MAPK signaling pathway + 69
        the extracellular signal-regulated Raf/Mek/Erk signaling pathway + 31
Path 2
Term Annotations click to browse term
  pathway 3930
    signaling pathway 1892
      kinase mediated signaling pathway 310
        serine/threonine-specific kinase mediated signaling pathway 286
          mitogen activated protein kinase signaling pathway 100
            Erk5 MAPK signaling pathway + 6
            altered mitogen activated protein kinase pathway + 6
            stress-regulated MAPK signaling pathway + 69
            the extracellular signal-regulated Raf/Mek/Erk signaling pathway + 31
paths to the root