Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:mitogen activated protein kinase signaling pathway
go back to main search page
Accession:PW:0000007 term browser browse the term
Definition:The mitogen -activated protein kinase pathway groups several serine/threonine protein kinases mediated cascades in response to a number of extracellular stimuli. A characteristic feature of these cascades is the presence of at least three kinases in series leading to the activation of a multifunctional MAP kinase.
Synonyms:related_synonym: KEGG:04010;   MAPK signaling pathway

View Interactive Diagram


GViewer not supported for chinchilla.
show annotations for term's descendants       view all columns           Sort by:
 
mitogen activated protein kinase signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link NW_004955451 14,442,816 14,456,009 RGD:9068941
G Shc1 SHC adaptor protein 1 JBrowse link NW_004955545 1,468,391 1,479,209 RGD:9068941
G Tsc2 TSC complex subunit 2 JBrowse link NW_004955442 15,178,356 15,216,978 RGD:9068941
altered extracellular signal-regulated Raf/Mek/Erk signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link NW_004955494 2,567,238 2,712,708 RGD:9068941
G Kras KRAS proto-oncogene, GTPase JBrowse link NW_004955413 20,298,852 20,328,756 RGD:9068941
c-Jun N-terminal kinases MAPK signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdc42 cell division cycle 42 JBrowse link NW_004955452 2,255,940 2,299,042 RGD:9068941
G Map2k4 mitogen-activated protein kinase kinase 4 JBrowse link NW_004955467 5,188,036 5,295,570 RGD:9068941
G Map2k7 mitogen-activated protein kinase kinase 7 JBrowse link NW_004955563 1,352,638 1,361,598 RGD:9068941
G Map3k1 mitogen-activated protein kinase kinase kinase 1 JBrowse link NW_004955446 11,022,091 11,090,136 RGD:9068941
G Map3k11 mitogen-activated protein kinase kinase kinase 11 JBrowse link NW_004955422 19,651,371 19,666,468 RGD:9068941
G Map3k2 mitogen-activated protein kinase kinase kinase 2 JBrowse link NW_004955459 3,135,959 3,196,971 RGD:9068941
G Map3k3 mitogen-activated protein kinase kinase kinase 3 JBrowse link NW_004955478 8,122,999 8,185,138 RGD:9068941
G Map3k4 mitogen-activated protein kinase kinase kinase 4 JBrowse link NW_004955439 20,144,059 20,263,885 RGD:9068941
G Mapk10 mitogen-activated protein kinase 10 JBrowse link NW_004955474 3,451,656 3,772,405 RGD:9068941
G Mapk8 mitogen-activated protein kinase 8 JBrowse link NW_004955556 1,593,552 1,705,543 RGD:9068941
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 JBrowse link NW_004955422 2,064,010 2,081,681 RGD:9068941
G Mapk9 mitogen-activated protein kinase 9 JBrowse link NW_004955408 391,094 430,638 RGD:9068941
G Rac1 Rac family small GTPase 1 JBrowse link NW_004955460 13,270,159 13,295,562 RGD:9068941
G Rapgef1 Rap guanine nucleotide exchange factor 1 JBrowse link NW_004955513 1,224,418 1,328,176 RGD:9068941
G Spp1 secreted phosphoprotein 1 JBrowse link NW_004955474 1,914,477 1,922,025 RGD:9068941
Erk5 MAPK signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Map2k5 mitogen-activated protein kinase kinase 5 JBrowse link NW_004955450 8,207,577 8,458,258 RGD:9068941
G Mapk7 mitogen-activated protein kinase 7 JBrowse link NW_004955467 381,801 387,078 RGD:9068941
p38 MAPK signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adm adrenomedullin JBrowse link NW_004955414 25,951,473 25,953,593 RGD:9068941
G Atm ATM serine/threonine kinase JBrowse link NW_004955412 10,422,753 10,531,406 RGD:9068941
G Calm1 calmodulin 1 JBrowse link NW_004955438 12,842,437 12,854,028 RGD:9068941
G Calm2 calmodulin 2 JBrowse link NW_004955441 13,973,147 13,988,665 RGD:9068941
G Calm3 calmodulin 3 JBrowse link NW_004955574 672,441 680,924 RGD:9068941
G Camk2b calcium/calmodulin dependent protein kinase II beta JBrowse link NW_004955456 7,711,583 7,760,506 RGD:9068941
G Ccm2 CCM2 scaffold protein JBrowse link NW_004955456 7,232,224 7,251,012 RGD:9068941
G Gadd45a growth arrest and DNA damage inducible alpha JBrowse link NW_004955423 23,656,516 23,658,367 RGD:9068941
G Gadd45b growth arrest and DNA damage inducible beta JBrowse link NW_004955495 4,864,932 4,866,728 RGD:9068941
G Gadd45g growth arrest and DNA damage inducible gamma JBrowse link NW_004955515 2,423,137 2,424,851 RGD:9068941
G Irf1 interferon regulatory factor 1 JBrowse link NW_004955408 3,882,282 3,887,965 RGD:9068941
G Map2k3 mitogen-activated protein kinase kinase 3 JBrowse link NW_004955577 1,225,033 1,249,510 RGD:9068941
G Map2k6 mitogen-activated protein kinase kinase 6 JBrowse link NW_004955478 3,331,607 3,448,840 RGD:9068941
G Map3k1 mitogen-activated protein kinase kinase kinase 1 JBrowse link NW_004955446 11,022,091 11,090,136 RGD:9068941
G Map3k10 mitogen-activated protein kinase kinase kinase 10 JBrowse link NW_004955578 1,018,280 1,037,553 RGD:9068941
G Map3k3 mitogen-activated protein kinase kinase kinase 3 JBrowse link NW_004955478 8,122,999 8,185,138 RGD:9068941
G Map3k4 mitogen-activated protein kinase kinase kinase 4 JBrowse link NW_004955439 20,144,059 20,263,885 RGD:9068941
G Map3k5 mitogen-activated protein kinase kinase kinase 5 JBrowse link NW_004955439 162,499 376,919 RGD:9068941
G Map3k6 mitogen-activated protein kinase kinase kinase 6 JBrowse link NW_004955452 6,616,997 6,628,745 RGD:9068941
G Map3k7 mitogen-activated protein kinase kinase kinase 7 JBrowse link NW_004955411 17,177,335 17,229,957 RGD:9068941
G Mapk11 mitogen-activated protein kinase 11 JBrowse link NW_004955413 33,287,860 33,293,948 RGD:9068941
G Mapk14 mitogen-activated protein kinase 14 JBrowse link NW_004955437 3,836,331 3,884,083 RGD:9068941
G Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 JBrowse link NW_004955413 33,608,092 33,617,984 RGD:9068941
G Rac1 Rac family small GTPase 1 JBrowse link NW_004955460 13,270,159 13,295,562 RGD:9068941
G Tab1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 JBrowse link NW_004955413 25,290,733 25,315,267 RGD:9068941
G Tab2 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 JBrowse link NW_004955439 11,826,469 11,903,103 RGD:9068941
G Taok1 TAO kinase 1 JBrowse link NW_004955481 3,698,686 3,836,209 RGD:9068941
G Taok2 TAO kinase 2 JBrowse link NW_004955493 6,968,537 6,986,608 RGD:9068941
G Taok3 TAO kinase 3 JBrowse link NW_004955455 13,020,618 13,207,539 RGD:9068941
G Traf2 TNF receptor associated factor 2 JBrowse link NW_004955513 4,964,692 4,984,359 RGD:9068941
G Traf6 TNF receptor associated factor 6 JBrowse link NW_004955422 9,925,765 9,950,354 RGD:9068941
the extracellular signal-regulated Raf/Mek/Erk signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link NW_004955494 2,567,238 2,712,708 RGD:9068941
G Kras KRAS proto-oncogene, GTPase JBrowse link NW_004955413 20,298,852 20,328,756 RGD:9068941
G Map2k1 mitogen-activated protein kinase kinase 1 JBrowse link NW_004955450 9,181,851 9,205,277 RGD:9068941
G Map2k2 mitogen-activated protein kinase kinase 2 JBrowse link NW_004955495 4,695,239 4,718,380 RGD:9068941
G Map3k1 mitogen-activated protein kinase kinase kinase 1 JBrowse link NW_004955446 11,022,091 11,090,136 RGD:9068941
G Mapk1 mitogen-activated protein kinase 1 JBrowse link NW_004955442 17,284,232 17,380,026 RGD:9068941
G Mapk3 mitogen-activated protein kinase 3 JBrowse link NW_004955493 6,870,699 6,876,836 RGD:9068941
G Mknk1 MAPK interacting serine/threonine kinase 1 JBrowse link NW_004955464 11,697,946 11,750,258 RGD:9068941
G Pebp1 phosphatidylethanolamine binding protein 1 JBrowse link NW_004955455 13,217,012 13,222,370 RGD:9068941
G Prkcd protein kinase C delta JBrowse link NW_004955430 3,125,066 3,151,857 RGD:9068941
G Ptk2b protein tyrosine kinase 2 beta JBrowse link NW_004955403 49,856,056 49,970,800 RGD:9068941
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link NW_004955429 17,980,956 18,049,723 RGD:9068941
G S1pr1 sphingosine-1-phosphate receptor 1 JBrowse link NW_004955435 5,880,266 5,882,823 RGD:9068941
G Shc1 SHC adaptor protein 1 JBrowse link NW_004955545 1,468,391 1,479,209 RGD:9068941
G Smad1 SMAD family member 1 JBrowse link NW_004955428 1,357,398 1,429,521 RGD:9068941
G Spp1 secreted phosphoprotein 1 JBrowse link NW_004955474 1,914,477 1,922,025 RGD:9068941
G Tsc2 TSC complex subunit 2 JBrowse link NW_004955442 15,178,356 15,216,978 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 2237
    signaling pathway 1304
      mitogen activated protein kinase signaling pathway 60
        Erk5 MAPK signaling pathway + 2
        altered mitogen activated protein kinase pathway + 2
        stress-regulated MAPK signaling pathway + 42
        the extracellular signal-regulated Raf/Mek/Erk signaling pathway + 17
Path 2
Term Annotations click to browse term
  pathway 2237
    signaling pathway 1304
      kinase mediated signaling pathway 110
        serine/threonine-specific kinase mediated signaling pathway 104
          mitogen activated protein kinase signaling pathway 60
            Erk5 MAPK signaling pathway + 2
            altered mitogen activated protein kinase pathway + 2
            stress-regulated MAPK signaling pathway + 42
            the extracellular signal-regulated Raf/Mek/Erk signaling pathway + 17
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.